Oxygenase activity in the self-hydroxylation of (S)-2- hydroxypropylphosphonic acid epoxidase involved in fosfomycin biosynthesis

Journal of the American Chemical Society

Volumn 126, Issue 33, 2004, Pages 10306-10312

  Liu, Pinghua ^a   Mehn, Mark P ^b   Yan, Feng ^a   Zhao, Zongbao ^a   Que Jr , Lawrence ^b   Liu, Hung Wen ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b University of Minnesota   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABSORPTION; BIOSYNTHESIS; CATALYSIS; CHROMOPHORES; ENZYMES; PROTEINS;

ASCORBATE; FOSFOMYCIN; IRON-DEPENDENT ENZYME;

HYDROXYLATION;

2 HYDROXYPROPYLPHOSPHONIC ACID EPOXIDASE; APOENZYME; ASCORBIC ACID; DOPA; ENZYME; EPOXIDE; FERROUS ION; FOSFOMYCIN; HYDROPEROXIDE; IRON COMPLEX; NON HEME IRON ENZYME; OXYGEN 18; OXYGENASE; PHOSPHONIC ACID DERIVATIVE; TYROSINE; UNCLASSIFIED DRUG;

ANTIBIOTIC BIOSYNTHESIS; ARTICLE; COLOR; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME RECONSTITUTION; HYDROXYLATION; RAMAN SPECTROMETRY; SITE DIRECTED MUTAGENESIS; STREPTOMYCES; STREPTOMYCES WEDMORENSIS;

AMINO ACID SEQUENCE; ASCORBIC ACID; DIHYDROXYPHENYLALANINE; FOSFOMYCIN; HYDROXYLATION; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; OXIDOREDUCTASES; OXYGEN; PROTEIN PROCESSING, POST-TRANSLATIONAL; PSEUDOMONAS SYRINGAE; SPECTRUM ANALYSIS, RAMAN; STREPTOMYCES;

EID: 4143091496     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0475050     Document Type: Article

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