Protein/DNA vaccine-induced antigen-specific Treg confer protection against asthma

European Journal of Immunology

Volumn 38, Issue 9, 2008, Pages 2451-2463

  Jin, Huali ^a,b   Xiao, Chong ^a   Geng, Shuang ^a   Hu, Yanxin ^a   She, Ruiping ^a   Yu, Yang ^a   Kang, Youmin ^a   Wang, Bin ^a  

^a CHINA AGRICULTURAL UNIVERSITY   (China)

^b UNIVERSITY OF ILLINOIS   (United States)

Author keywords

Asthma; Immune regulation; Tolerance; Treg cell; Vaccination

Indexed keywords

ALLERGEN; DNA VACCINE; EPITOPE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 10 ANTIBODY; OVALBUMIN; PEPTIDE VACCINE; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA ANTIBODY;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN ANTIBODY REACTION; ANTIGEN SPECIFICITY; ARTICLE; ASTHMA; CD4+ CD25+ T LYMPHOCYTE; CONTROLLED STUDY; DRUG EFFICACY; EOSINOPHIL; FEMALE; IMMUNOTHERAPY; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE SUBPOPULATION; LYMPHOCYTIC INFILTRATION; MALE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RECURRENT DISEASE; REGULATORY T LYMPHOCYTE; RESPIRATORY TRACT INFLAMMATION; ANIMAL; BAGG ALBINO MOUSE; CD4+ T LYMPHOCYTE; DISEASE MODEL; GENETICS; IMMUNOLOGY; METABOLISM; MOUSE; VACCINATION;

ADOPTIVE TRANSFER; ALLERGENS; ANIMALS; ASTHMA; CD4-POSITIVE T-LYMPHOCYTES; DISEASE MODELS, ANIMAL; EPITOPES; FEMALE; INTERFERON TYPE II; INTERLEUKIN-10; MICE; MICE, INBRED BALB C; OVALBUMIN; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA; VACCINATION; VACCINES, DNA;

EID: 55249126683     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.200737899     Document Type: Article

References (54)

1. Robinson, D. S., Hamid, Q., Ying, S., Tsicopoulos, A., Barkans, J., Bentley, A. M., Corrigan, C. et al., Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N. Engl. J. Med. 1992. 326: 298-304.
2. Umetsu, D. T. and DeKruyff, R. H., TH1 and TH2 CD4+ cells in human allergic diseases. J. Allergy Clin. Immunol. 1997. 100: 1-6.
3. Wills-Karp, M. and Ewart, S., The genetics of allergen-induced airway hyperresponsiveness in mice. Am. J. Respir. Crit. Care Med. 1997. 156: 89S-896.
4. Abbas, A. K., Murphy, K. M. and Sher, A., Functional diversity of helper T lymphocytes. Nature 1996. 383: 787-793.
5. Coffman, R. L., Seymour, B.W., Lebman, D. A., Hiraki, D. D., Christiansen, J. A., Shrader, B., Cherwinski, H. M. et al., The role of helper T cell products in mouse B cell differentiation and isotype regulation. Immunol. Rev. 1988. 102: 5-28.
6. Jilek, S., Barbey, C., Spertini, F. and Corthesy, B., Antigen-independent suppression of the allergic immune response to bee venom phospholipase A2 by DNA vaccination in CBA/J mice. J. Immunol. 2001. 166: 3612-3621.
7. Oro, A. S., Guarino, T. J., Driver, R., Steinman, L. and Umetsu, D. T., Regulation of disease susceptibility: Decreased prevalence of IgE-mediated allergic disease in patients with multiple sclerosis. J. Allergy Clin. Immunol. 1996. 97: 1402-1408.
8. Shirakawa, T., Enomoto, T., Shimazu, S.-i. and Hopkin, J. M., The inverse association between tuberculin responses and atopic disorder. Science 1997. 275: 77-79.
9. Hansen, G., Berry, G., DeKruyff, R. H. and Umetsu, D. T., Allergen-specific Th1 cells fail to counterbalance Th2 cell induced airway hyperreactivity but cause severe airway inflammation. J. Clin. Invest. 1999. 103: 175-183.
10. Proksch, P., Giaisi, M., Treiber, M. K., Palfi, K., Merling, A., Spring, H., Krammer, P. H. and Li-Weber, M., Rocaglamide derivatives are immunosuppressive phytochemicals that target NF-AT activity in T cells. J. Immunol. 2005. 174: 7075-7084.
11. Van Oosterhout, A. J., Hofstra, C. L., Shields, R., Chan, B., Van Ark, I., Jardieu, P. M. and Nijkamp, F. P., Murine CTLA4-IgG treatment inhibits airway eosinophilia and hyperresponsiveness and attenuates IgE upregulation in a murine model of allergic asthma. Am. J. Respir. Cell Mol. Biol. 1997. 17: 386-392.
12. Milgrom, H., Fick, R. B., Su, J. Q., Reimann, J. D., Bush, R. K., Watrous, M. L., Metzger, W. J. and The rhuMb-E25 Study Group, Treatment of allergic asthma with monoclonal anti-IgE antibody. N Engl. J. Med. 1999. 341: 1966-1973.
13. Ling, E. M., Smith, T., Nguyen, X. D., Pridgeon, C., Dallman, M., Arbery, J., Carr, V. A. and Robinson, D. S., Relation of CD4+ CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease. Lancet 2004. 363: 608-615.
14. Kearley, J., Barker, J. E., Robinson, D. S. and Lloyd, C. M., Resolution of airway inflammation and hyperreactivity after in vivo transfer of CD4+ CD25+ regulatory T cells is interleukin 10 dependent. J. Exp. Med. 2005. 202: 1539-1547.
15. Lundsgaard, D., Holm, T. L., Hornum, L. and Markholst, H., In vivo control of diabetogenic T-cells by regulatory CD4+ CD25+ T-cells expressing Foxp3. Diabetes 2005. 54: 1040-1047.
16. McGeachy, M. J., Stephens, L. A. and Anderton, S. M., Natural recovery and protection from autoimmune encephalomyelitis: Contribution of CD4+ CD25+ regulatory cells within the central nervous system. J. Immunol. 2005. 175: 3025-3032.
17. Groux, H., O'Garra, A., Bigler, M., Rouleau, M., Antonenko, S., de Vries, J. E. and Roncarolo, M. G., A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 1997. 389: 737-742.
18. Roncarolo, M. G., Bacchetta, R., Bordignon, C., Narula, S. and Levings, M. K., Type 1 T regulatory cells. Immunol. Rev. 2001. 182: 68-79.
19. Fukaura, H., Kent, S. C., Pietrusewicz, M. J., Khoury, S. J., Weiner, H. L. and Hafler, D. A., Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta 1-secreting Th3 T cells by oral administration ofmyelin in multiple sclerosis patients. J. Clin. Invest. 1996. 98: 70-77.
20. van Oosterhout, A. J. M. and Bloksma, N., Regulatory T-lymphocytes in asthma. Eur. Respir. J. 2005. 26: 918-932.
21. Jin, H., Kang, Y., Zheng, G., Xie, Q., Xiao, C., Zhang, X., Yu, Y. et al., Induction of active immune suppression by co-immunization with DNA- and protein-based vaccines. Virology 2005. 337: 183-191.
22. - regulatory T cells. Biophys. Biochem. Res. Commun. 2007. 353: 1034-1039.
23. Oh, S.-W., Pae, C. I., Lee, D.-K., Jones, F., Chiang, G. K. S., Kim, H.-O., Moon, S.-H. et al., Tryptase inhibition blocks airway inflammation in a mouse asthma model. J. Immunol. 2002. 168: 1992-2000.
24. Sears, M. R., Burrows, B., Flannery, E. M., Herbison, G. P., Hewitt, C. J. and Holdaway, M. D., Relation between airway responsiveness and serum IgE in children with asthma and in apparently normal children. N. Engl. J. Med. 1991. 325: 1067-1071.
25. Hoeger, P. H., Niggemann, B. and Haeuser, G., Age related IgG subclass concentrations in asthma. Arch. Dis. Child. 1994. 70: 179-182.
26. Sunyer, J., Anto, J. M., Castellsague, J., Soriano, J. B. and Roca, J., Total serum IgE is associated with asthma independently of specific IgE levels. The Spanish Group of the European Study of Asthma. Eur. Respir. J. 1996. 9: 1880-1884.
27. Huang, S. K., Xiao, H. Q., Kleine-Tebbe, J., Paciotti, G., Marsh, D. G., Lichtenstein, L. M. and Liu, M. C., IL-13 expression at the sites of allergen challenge in patients with asthma. J. Immunol. 1995. 155: 2688-2694.
28. Humbert, M., Durham, S. R., Ying, S., Kimmitt, P., Barkans, J., Assoufi, B., Pfister, R. et al., IL-4 and IL-5 mRNA and protein in bronchial biopsies from patients with atopic and nonatopic asthma: evidence against "intrinsic" asthma being a distinct immunopathologic entity. Am. J. Respir. Crit. Care Med. 1996. 154: 1497-1504.
29. Humbert, M., Corrigan, C., Kimmitt, P., Till, S., Kay, A. B. and Durham, S., Relationship between IL-4 and IL-5 mRNA expression and disease severity in atopic asthma. Am. J. Respir. Crit. Care Med. 1997. 156: 704-708.
30. Heinzmann, A., Mao, X. Q., Akaiwa, M., Kreomer, R. T., Gao, P. S., Ohshima, K., Umeshita, R. et al., Genetic variants of IL-13 signalling and human asthma and atopy. Hum. Mol. Genet. 2000. 9: 549-559.
31. Fontenot, J. D., Gavin, M. A. and Rudensky, A. Y., Foxp3 programs the development and function of CD4+ CD25+ regulatory T cells. Nat. Immunol. 2003. 4: 330-336.
32. Stock, P., Akbari, O., Berry, G., Freeman, G. J., Dekruyff, R. H. and Umetsu, D. T., Induction of T helper type 1-like regulatory cells that express Foxp3 and protect against airway hyper-reactivity. Nat. Immunol. 2004. 5: 1149-1156.
33. Zuany-Amorim, C., Sawicka, E., Manlius, C., Le Moine, A., Brunet, L. R., Kemeny, D. M., Bowen, G. et al., Suppression of airway eosinophilia by killed Mycobacterium vaccae-induced allergen-specific regulatory T-cells. Nat. Med. 2002. 8: 625-629.
34. Liu, Y., Teige, I., Birnir, B. and Issazadeh-Navikas, S., Neuron-mediated generation of regulatory T cells from encephalitogenic T cells suppresses EAE. Nat. Med. 2006. 12: 518-525.
35. Harrington, L. E., Hatton, R. D., Mangan, P. R., Turner, H., Murphy, T. L., Murphy, K. M. and Weaver, C. T., Interleukin 17-producing CD4+effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat. Immunol. 2005. 6: 1123-1132.
36. Park, H., Li, Z., Yang, X. O., Chang, S. H., Nurieva, R., Wang, Y. H., Wang, Y. et al., A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat. Immunol. 2005. 6: 1133-1141.
37. O'Garra, A. and Vieira, P., T(H)1 cells control themselves by producing interleuldn-10. Nat. Rev. Immunol. 2007. 7: 425-428.
38. Akdis, C. A., Blesken, T., Akdis, M., Wuthrich, B. and Blaser, K., Role of Interleukin 10 in specific immunotherapy. J. Clin. Invest. 1998. 102: 98-106.
39. Levings, M. K., Sangregorio, R. and Roncarolo, M.-G., Human CD25+ CD4+T regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J. Exp. Med. 2001. 193: 1295-1302.
40. Akdis, C. A., Joss, A., Akdis, M., Faith, A. and Blaser, K., A molecular basis for T cell suppression by IL-10: CD28-associated IL-10 receptor inhibits CD28 tyrosine phosphorylation and phosphatidylinositol. 3-kinase binding. FASEB J. 2000. 99-0874fje.
41. Jutel, M., Akdis, M., Budak, F., Aebischer-Casault, C., Wrzyszcz, M., Blaser, K. and Akdis, C. A., IL-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy. Eur. J. Immunol. 2003. 33: 1205-1214.
42. - T cells through Foxp3 induction and down-regulation of Smad7. J. Immunol. 2004. 172: 5149-5153.
43. Vigouroux, S., Yvon, E., Biagi, E. and Brenner, M. K., Antigen-induced regulatory T cells. Blood 2004. 104: 26-33.
44. Akbari, O., DeKruyff, R. H. and Umetsu, D. T., Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen. Nat. Immunol. 2001. 2: 725-731.
45. Bynoe, M., Evans, J., Viret, C. and Janeway, C., Epicutaneous immunization with autoantigenic peptides induces T suppressor cells that prevent experimental allergic encephalomyelitis. Immunity 2003. 19: 317-328.
46. Trowbridge, I. S., Lesley, J. and Schulte, R., Murine cell surface transferrin receptor: Studies with an anti-receptor monoclonal antibody. J. Cell. Physiol. 1982. 112: 403-410.
47. van der Poll, T., Marchant, A., Buurman, W. A., Berman, L., Keogh, C. V., Lazarus, D. D., Nguyen, L. et al., Endogenous IL-10 protects mice from death during septic peritonitis. J. Immunol. 1995. 155: 5397-5401.
48. Spitalny, G. L. and Havell, E. A., Monoclonal antibody to murine gamma interferon inhibits lymphokine-induced antiviral and macrophage tumoricidal activities. J. Exp. Med. 1984. 159: 1560-1565.
49. Chen, K., Wei, Y., Sharp, G. C. and Braley-Mullen, H., Inhibition of TGFβ1 by Anti-TGFβ1 antibody or Lisinopril reduces thyroid fibrosis in granulomatous experimental autoimmune thyroiditis. J. Immunol. 2002. 169: 6530-6538.
50. Moisan, J., Camateros, P., Thuraisingam, T., Marion, D., Koohsari, H., Martin, P., Boghdady, M. L. et al., TLR7 ligand prevents allergen-induced airway hyperresponsiveness and eosinophilia in allergic asthma by a MYD88-dependent and MK2-independent pathway. Am. J. Physiol. Lung Cell Mol. Physiol. 2006. 290: L987-L995.
51. Lutz, M. B., Kukutsch, N., Ogilvie, A. L., Rossner, S., Koch, F., Romani, N. and Schuler, G., An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J. Immunol. Methods 1999. 223: 77-92.
52. Autenrieth, I. B., Bucheler, N., Bohn, E., Heinze, G. and Horak, I., Cytokine mRNA expression in intestinal tissue of interleukin-2 deficient mice with bowel inflammation. Gut 1997. 41: 793-800.
53. Mattes, J., Yang, M., Mahalingam, S., Kuehr, J., Webb, D. C., Simson, L., Hogan, S. P. et al., Intrinsic defect in T cell production of interleukin (IL)-13 in the absence of both IL-5 and eotaxin precludes the development of eosinophilia and airways hyperreactivity in experimental asthma. J. Exp. Med. 2002. 195: 1433-1444.
54. Mascher, B., Schlenke, P. and Seyfarth, M., Expression and kinetics of cytokines determined by intracellular staining using flow cytometry. J. Immunol. Methods 1999. 223: 115-121.