In vivo control of diabetogenic T-cells by regulatory CD4 +CD25+ T-cells expressing Foxp3

Diabetes

Volumn 54, Issue 4, 2005, Pages 1040-1047

  Lundsgaard, Dorthe ^a   Holm, Thomas Lindebo ^a   Hornum, Lars ^a   Markholst, Helle ^a  

^a HAGEDORN RESEARCH INSTITUTE   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; IONOMYCIN; PADGEM PROTEIN; PHORBOL 13 ACETATE 12 MYRISTATE; TRANSCRIPTION FACTOR FOXP3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DESTRUCTION; CELL TRANSFER; CONTROLLED STUDY; DIABETOGENESIS; FLOW CYTOMETRY; IMMUNOLOGICAL TOLERANCE; INSULIN DEPENDENT DIABETES MELLITUS; LEISHMANIA MAJOR; LYMPHOCYTE HOMING; NONHUMAN; NUCLEOTIDE SEQUENCE; ONSET AGE; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE; TH1 CELL; TH2 CELL;

ADOPTIVE TRANSFER; AGING; ANIMALS; ANTIGENS, CD4; DIABETES MELLITUS, TYPE 1; DNA-BINDING PROTEINS; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION; IONOMYCIN; LYMPHOCYTE ACTIVATION; PREDIABETIC STATE; RATS; RECEPTORS, INTERLEUKIN-2; T-LYMPHOCYTE SUBSETS; TETRADECANOYLPHORBOL ACETATE; TRANSCRIPTION FACTORS;

EID: 15944428160     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.54.4.1040     Document Type: Article

References (50)

1. + immunoregulatory T-cells suppress polyclonal T-cell activation in-vitro by inhibiting interleukin-2 production. J Exp Med 188:287-296, 1998
2. + regulatory T-cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J Exp Med 192:303-309, 2000
3. + T-cells as immunoregulatory T-cells in vitro. Eur J Immunol 32:2365-2375, 2002
4. + T-cells: a population of T-cells with immune regulatory activities in vitro. Eur J Immunol 28:3435-3447, 1998
5. + immunoregulatory cells. J Immunol 167:1137-1140, 2001
6. + T-cells. Proc Natl Acad Sci USA 99:8832-8837, 2002
7. + T-cell responses. J Exp Med 196:1585-1592, 2002
8. Groux H, Ogarra A, Bigler M, Rouleau M, Antonenko S, Devries JE, Roncarolo MG: A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389:737-742, 1997
9. + T-cells inhibit both the induction and effector function of autoreactive T-cells and represent a unique lineage of immunoregulatory cells. J Immunol 160: 1212-1218, 1998
10. + regulatory T-cells suppress differentiation and functions of Th1 and Th2 cells, Leishmania major infection, and colitis in mice. J Immunol 170:394-399, 2003
11. + regulatory T-cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis. J Immunol 169:4712-4716, 2002
12. + regulatory T-cells. J Immunol 170:3939-3943, 2003
13. Shimada A, Charlton B, Rohane P, Taylor-Edwards C, Fathman CG: Immune regulation in type-1 diabetes. J Autoimmun 9:263-269, 1996
14. + cells correlate with cytokine profiles in the spontaneously autoimmune diabetic mouse. Diabetes 45:71-78, 1996
15. + T-cells that prevent diabetes onset in nonobese diabetic mice. J Immunol 164:240-247, 2000
16. + splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7. J Immunol 169:2461-2465, 2002
17. Burstein D, Mordes JP, Greiner DL, Stein D, Nakamura N, Handler ES, Rossini AA: Prevention of diabetes in BB/Wor rat by single transfusion of spleen cells: parameters that affect degree of protection. Diabetes 38:24-30, 1989
18. + helper/inducer T lymphocytes prevent spontaneous diabetes in the BB/W rat. Diabetologia 30:22-26, 1987
19. Ramanathan S, Poussier P: T-cell reconstitution of BB/W rats after the initiation of insulitis precipitates the onset of diabetes. J Immunol 162: 5134-5142, 1999
20. Mordes JP, Bortell R, Doukas J, Rigby M, Whalen B, Zipris D, Greiner DL, Rossini AA: The BB/Wor rat and the balance hypothesis of autoimmunity. Diabetes Metab Rev 12:103-109, 1996
21. + T lymphocytes induces diabetes in resistant biobreeding/Worcester (BB/W) rats. J Exp Med 166:461-475, 1987
22. Lundsgaard D, Markholst H: A co-transfer system in young prediabetic BB rats: reactivated autoreactive T-cells can be partly controlled. J Autoimmun 21:325-338, 2003
23. Greiner DL, Rossini AA, Mordes JP: Translating data from animal models into methods for preventing human autoimmune diabetes mellitus: caveat emptor and primum non nocere. Clin Immunol 100:134-143, 2001
24. + regulatory T-cells. Nat Immunol 4:330-336, 2003
25. Hori S, Nomura T, Sakaguchi S: Control of regulatory T-cell development by the transcription factor Foxp3. Science 299:1057-1061, 2003
26. + T regulatory cells. Nat Immunol 4:337-342, 2003
27. - T-cells. J Clin Invest 112:1437-1443, 2003
28. + T-cells. J Autoimmun 7:819-831, 1994
29. Whalen BJ, Love LC, Mordes JP, Rossini AA, Greiner DL: Intravital dye-labeled diabetogenic rat T-cells retain dye, home to the pancreas, and induce diabetes. Transplant Proc 31:1611-1614, 1999
30. Metroz-Dayer MD, Mouland A, Brideau C, Duhamel D, Poussier P: Adoptive transfer of diabetes in BB rats induced by CD4 T lymphocytes. Diabetes 39:928-932, 1990
31. + T-cells are required for adoptive transfer of the BB rat diabetic syndrome. Diabetes 42:390-397, 1993
32. MacKay P: Adoptive transfer of diabetes to and from old normoglycaemic BB rats. Diabetologia 38:145-152, 1995
33. Barthlott T, Kassiotis G, Stockinger B: T-cell regulation as a side effect of homeostasis and competition. J Exp Med 197:451-460, 2003
34. + T-cells induce wasting disease with multiple organ pathology: prevention by the OX-22low subset. J Exp Med 172:1701-1708, 1990
35. + T-cell subset that inhibits this autoimmune potential. J Exp Med 177:627-636, 1993
36. - thymocytes. J Exp Med 189:279-288, 1999
37. Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M: Immunologic self-tolerance maintained by activated T-cells expressing IL-2 receptor alpha-chains (CD25): breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 155:1151-1164, 1995
38. + T-cells regulate the expansion of peripheral CD4 T-cells through the production of IL-10. J Immunol 166:3008-3018, 2001
39. + T-cell populations. J Immunol 170:3592-3602, 2003
40. + subpopulations. J Immunol 165:3105-3110, 2000
41. + regulatory T-cells responsible for protection against diabetes. Proc Natl Acad Sci USA 101: 4572-4577, 2004
42. + suppressor T-cells in vivo. Nat Immunol 3:33-41, 2002
43. + regulatory T-cells. J Immunol 171:5678-5682, 2003
44. + Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signals. Immunity 16:183-191, 2002
45. Gagnerault MC, Luan JJ, Lotton C, Lepault F: Pancreatic lymph nodes are required for priming of beta cell reactive T-cells in NOD mice. J Exp Med 196:369-377, 2002
46. Fabien N, Bergerot I, Orgiazzi J, Thivolet C: Lymphocyte function-associated antigen-1, integrin alpha-4, and L-selectin mediate T-cell homing to the pancreas in the model of adoptive transfer of diabetes in NOD mice. Diabetes 45:1181-1186, 1996
47. Lepault F, Gagnerault MC, Faveeuw C, Bazin H, Boitard C: Lack of L-selectin expression by cells transferring diabetes in NOD mice: insights into the mechanisms involved in diabetes prevention by mel-14 antibody treatment. Eur J Immunol 25:1502-1507, 1995
48. Cooke A, Phillips JM, Parish NM: Tolerogenic strategies to halt or prevent type I diabetes. Nat Immunol 2:810-815, 2001
49. Masteller EL, Bluestone JA: Immunotherapy of insulin-dependent diabetes mellitus. Curr Opin Immunol 14:652-659, 2002
50. Polanski M, Melican NS, Zhang J, Weiner HL: Oral-administration of the immunodominant B-chain of insulin reduces diabetes in a co-transfer model of diabetes in the NOD mouse and is associated with a switch from Th1 to Th2 cytoMnes. J Autoimmun 10:339-346, 1997