-
1
-
-
18244407799
-
Steps toward mapping the human vasculature by phage display
-
Arap W, Kolonin MG, Trepel M, Lahdenranta J, Cardó-Vila M, et al. (2002) Steps toward mapping the human vasculature by phage display. Nat Med 8: 121-127.
-
(2002)
Nat Med
, vol.8
, pp. 121-127
-
-
Arap, W.1
Kolonin, M.G.2
Trepel, M.3
Lahdenranta, J.4
Cardó-Vila, M.5
-
2
-
-
1642475187
-
Combinatorial screenings in patients: The interleukin-11 receptor alpha as a candidate target in the progression of human prostate cancer
-
Zurita AJ, Troncoso P, Cardó-Vila M, Logothetis CJ, Pasqualini R, et al. (2004) Combinatorial screenings in patients: the interleukin-11 receptor alpha as a candidate target in the progression of human prostate cancer. Cancer Res 64: 435-439.
-
(2004)
Cancer Res
, vol.64
, pp. 435-439
-
-
Zurita, A.J.1
Troncoso, P.2
Cardó-Vila, M.3
Logothetis, C.J.4
Pasqualini, R.5
-
3
-
-
0032535999
-
Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model
-
Arap W, Pasqualini R, Ruoslahti E (1998) Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model. Science 279: 377-380.
-
(1998)
Science
, vol.279
, pp. 377-380
-
-
Arap, W.1
Pasqualini, R.2
Ruoslahti, E.3
-
4
-
-
0032819838
-
Anti-cancer activity of targeted pro-apoptotic peptides
-
Ellerby HM, Arap W, Ellerby LM, Kain R, Andrusiak R, et al. (1999) Anti-cancer activity of targeted pro-apoptotic peptides. Nat Med 5: 1032-1038.
-
(1999)
Nat Med
, vol.5
, pp. 1032-1038
-
-
Ellerby, H.M.1
Arap, W.2
Ellerby, L.M.3
Kain, R.4
Andrusiak, R.5
-
5
-
-
0032842567
-
Tumor targeting with a selective gelatinase inhibitor
-
Koivunen E, Arap W, Valtanen H, Rainisalo A, Medina OP, et al. (1999) Tumor targeting with a selective gelatinase inhibitor. Nat Biotechnol 17: 768-774.
-
(1999)
Nat Biotechnol
, vol.17
, pp. 768-774
-
-
Koivunen, E.1
Arap, W.2
Valtanen, H.3
Rainisalo, A.4
Medina, O.P.5
-
6
-
-
0035160267
-
Biopanning and rapid analysis of selective interactive ligands
-
Giordano RJ, Cardó-Vila M, Lahdenranta J, Pasqualini R, Arap W (2001) Biopanning and rapid analysis of selective interactive ligands. Nat Med 7: 1249-1253.
-
(2001)
Nat Med
, vol.7
, pp. 1249-1253
-
-
Giordano, R.J.1
Cardó-Vila, M.2
Lahdenranta, J.3
Pasqualini, R.4
Arap, W.5
-
7
-
-
10744220098
-
Aminopeptidase A is a functional target in angiogenic blood vessels
-
Marchiò S, Lahdenranta J, Schlingemann RO, Valdembri D, Wesseling P, et al. (2004) Aminopeptidase A is a functional target in angiogenic blood vessels. Cancer Cell 5: 151-162.
-
(2004)
Cancer Cell
, vol.5
, pp. 151-162
-
-
Marchiò, S.1
Lahdenranta, J.2
Schlingemann, R.O.3
Valdembri, D.4
Wesseling, P.5
-
8
-
-
2942703809
-
Reversal of obesity by targeted ablation of adipose tissue
-
Kolonin MG, Saha PK, Chan L, Pasqualini R, Arap W (2004) Reversal of obesity by targeted ablation of adipose tissue. Nat Med 10: 625-632.
-
(2004)
Nat Med
, vol.10
, pp. 625-632
-
-
Kolonin, M.G.1
Saha, P.K.2
Chan, L.3
Pasqualini, R.4
Arap, W.5
-
9
-
-
4544255170
-
Cell surface expression of the stress response chaperone GRP78 enables tumor targeting by circulating ligands
-
Arap MA, Lahdenranta J, Mintz PJ, Hajitou A, Sarkis AS, et al. (2004) Cell surface expression of the stress response chaperone GRP78 enables tumor targeting by circulating ligands. Cancer Cell 6: 275-284.
-
(2004)
Cancer Cell
, vol.6
, pp. 275-284
-
-
Arap, M.A.1
Lahdenranta, J.2
Mintz, P.J.3
Hajitou, A.4
Sarkis, A.S.5
-
10
-
-
33646034578
-
A hybrid vector for ligand-directed tumor targeting and molecular imaging
-
Hajitou A, Trepel M, Lilley CE, Soghomonyan S, Alauddin MM, et al. (2006) A hybrid vector for ligand-directed tumor targeting and molecular imaging. Cell 125: 385-398.
-
(2006)
Cell
, vol.125
, pp. 385-398
-
-
Hajitou, A.1
Trepel, M.2
Lilley, C.E.3
Soghomonyan, S.4
Alauddin, M.M.5
-
11
-
-
0038488950
-
A multigenic program mediating breast cancer metastasis to bone
-
Kang Y, Siegel PM, Shu W, Drobnjak M, Kakonen SM, et al. (2003) A multigenic program mediating breast cancer metastasis to bone. Cancer Cell 3: 537-549.
-
(2003)
Cancer Cell
, vol.3
, pp. 537-549
-
-
Kang, Y.1
Siegel, P.M.2
Shu, W.3
Drobnjak, M.4
Kakonen, S.M.5
-
12
-
-
0035144809
-
Increased expression of the interleukin-11 receptor and evidence of STAT3 activation in prostate carcinoma
-
Campbell CL, Jiang Z, Savarese DM, Savarese TM (2001) Increased expression of the interleukin-11 receptor and evidence of STAT3 activation in prostate carcinoma. Am J Pathol 158: 25-32.
-
(2001)
Am J Pathol
, vol.158
, pp. 25-32
-
-
Campbell, C.L.1
Jiang, Z.2
Savarese, D.M.3
Savarese, T.M.4
-
13
-
-
0030917254
-
Interleukin-11: Review of molecular, cell biology, and clinical use
-
Du X, Williams DA (1997) Interleukin-11: review of molecular, cell biology, and clinical use. Blood 89: 3897-3908.
-
(1997)
Blood
, vol.89
, pp. 3897-3908
-
-
Du, X.1
Williams, D.A.2
-
14
-
-
55149099160
-
-
http://www.fda.gov/cder/biologics/products/opregen112597.htm. Center for Drug Evaluation and Research. U.S. Food and Drug Administration, Drug Information.
-
http://www.fda.gov/cder/biologics/products/opregen112597.htm. Center for Drug Evaluation and Research. U.S. Food and Drug Administration, Drug Information.
-
-
-
-
15
-
-
0034213975
-
Receptor recognition by gp130 cytokines
-
Bravo J, Heath JK (2000) Receptor recognition by gp130 cytokines. Embo J 19: 2399-2411.
-
(2000)
Embo J
, vol.19
, pp. 2399-2411
-
-
Bravo, J.1
Heath, J.K.2
-
16
-
-
0041677606
-
Principles of interleukin (IL)-6-type cytokine signalling and its regulation
-
Heinrich PC, Behrmann I, Haan S, Hermanns HM, Muller-Newen G, et al. (2003) Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem J 374: 1-20.
-
(2003)
Biochem J
, vol.374
, pp. 1-20
-
-
Heinrich, P.C.1
Behrmann, I.2
Haan, S.3
Hermanns, H.M.4
Muller-Newen, G.5
-
17
-
-
0012253356
-
Definition of receptor binding sites on human interleukin-11 by molecular modeling-guided mutagenesis
-
Tacken I, Dahmen H, Boisteau O, Minvielle S, Jacques Y, et al. (1999) Definition of receptor binding sites on human interleukin-11 by molecular modeling-guided mutagenesis. Eur J Biochem 265: 645-655.
-
(1999)
Eur J Biochem
, vol.265
, pp. 645-655
-
-
Tacken, I.1
Dahmen, H.2
Boisteau, O.3
Minvielle, S.4
Jacques, Y.5
-
18
-
-
0028924966
-
Structure-function relationships in human interleukin-11. Identification of regions involved in activity by chemical modification and site-directed mutagenesis
-
Czupryn MJ, McCoy JM, Scoble HA (1995) Structure-function relationships in human interleukin-11. Identification of regions involved in activity by chemical modification and site-directed mutagenesis. J Biol Chem 270: 978-985.
-
(1995)
J Biol Chem
, vol.270
, pp. 978-985
-
-
Czupryn, M.J.1
McCoy, J.M.2
Scoble, H.A.3
-
19
-
-
0029111495
-
Alanine-scanning mutagenesis of human interleukin-11: Identification of regions important for biological activity
-
Czupryn M, Bennett F, Dube J, Grant K, Scoble H, et al. (1995) Alanine-scanning mutagenesis of human interleukin-11: identification of regions important for biological activity. Ann N Y Acad Sci 762: 152-164.
-
(1995)
Ann N Y Acad Sci
, vol.762
, pp. 152-164
-
-
Czupryn, M.1
Bennett, F.2
Dube, J.3
Grant, K.4
Scoble, H.5
-
20
-
-
0141905910
-
Characterization of a potent human interleukin-11 agonist
-
Harmegnies D, Wang XM, Vandenbussche P, Leon A, Vusio P, et al. (2003) Characterization of a potent human interleukin-11 agonist. Biochem J 375: 23-32.
-
(2003)
Biochem J
, vol.375
, pp. 23-32
-
-
Harmegnies, D.1
Wang, X.M.2
Vandenbussche, P.3
Leon, A.4
Vusio, P.5
-
21
-
-
0033605109
-
Identification of three distinct receptor binding sites of murine interleukin-11
-
Barton VA, Hudson KR, Heath JK (1999) Identification of three distinct receptor binding sites of murine interleukin-11. J Biol Chem 274: 5755-5761.
-
(1999)
J Biol Chem
, vol.274
, pp. 5755-5761
-
-
Barton, V.A.1
Hudson, K.R.2
Heath, J.K.3
-
22
-
-
0032079686
-
Activation of the signal transducer gp130 by interleukin-11 and interleukin-6 is mediated by similar molecular interactions
-
Dahmen H, Horsten U, Kuster A, Jacques Y, Minvielle S, et al. (1998) Activation of the signal transducer gp130 by interleukin-11 and interleukin-6 is mediated by similar molecular interactions. Biochem J 331: 695-702.
-
(1998)
Biochem J
, vol.331
, pp. 695-702
-
-
Dahmen, H.1
Horsten, U.2
Kuster, A.3
Jacques, Y.4
Minvielle, S.5
-
23
-
-
0033083941
-
Activation of the signal transducer glycoprotein 130 by both IL-6 and IL-11 requires two distinct binding epitopes
-
Kurth I, Horsten, U, Pflanz S, Dahmen H, Kuster A, et al. (1999) Activation of the signal transducer glycoprotein 130 by both IL-6 and IL-11 requires two distinct binding epitopes. J Immunol 162: 1480-1487.
-
(1999)
J Immunol
, vol.162
, pp. 1480-1487
-
-
Kurth, I.1
Horsten, U.2
Pflanz, S.3
Dahmen, H.4
Kuster, A.5
-
24
-
-
0035895430
-
Identification of the domain in the human interleukin-11 receptor that mediates ligand binding
-
Schleinkofer K, Dingley A, Tacken I, Federwisch M, Muller-Newer G, et al. (2001) Identification of the domain in the human interleukin-11 receptor that mediates ligand binding. J Mol Biol 306: 263-274.
-
(2001)
J Mol Biol
, vol.306
, pp. 263-274
-
-
Schleinkofer, K.1
Dingley, A.2
Tacken, I.3
Federwisch, M.4
Muller-Newer, G.5
-
25
-
-
0038609651
-
Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex
-
Boulanger MJ, Chow DC, Brevnova EE, Garcia KC (2003) Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex. Science 300: 2101-2104.
-
(2003)
Science
, vol.300
, pp. 2101-2104
-
-
Boulanger, M.J.1
Chow, D.C.2
Brevnova, E.E.3
Garcia, K.C.4
-
26
-
-
0142168009
-
The cytokine receptor gp130: Faithfully promiscuous
-
Muller-Newen G (2003) The cytokine receptor gp130: faithfully promiscuous. Sci STKE PE40.
-
(2003)
Sci STKE
-
-
Muller-Newen, G.1
-
28
-
-
14144251446
-
Dynamics of the gp130 cytokine complex: A model for assembly on the cellular membrane
-
Schroers A, Hecht O, Kallen, KJ, Pachta M, Rose-John S, et al. (2005) Dynamics of the gp130 cytokine complex: a model for assembly on the cellular membrane. Protein Sci 14: 783-790.
-
(2005)
Protein Sci
, vol.14
, pp. 783-790
-
-
Schroers, A.1
Hecht, O.2
Kallen, K.J.3
Pachta, M.4
Rose-John, S.5
-
29
-
-
0038642195
-
IL-6 type cytokine receptor complexes: Hexamer, tetramer or both?
-
Grotzinger J, Kernebeck T, Kallen KJ, Rose-John S (1999) IL-6 type cytokine receptor complexes: hexamer, tetramer or both? Biol Chem 380: 803-813.
-
(1999)
Biol Chem
, vol.380
, pp. 803-813
-
-
Grotzinger, J.1
Kernebeck, T.2
Kallen, K.J.3
Rose-John, S.4
-
30
-
-
26944437077
-
Structural basis for the interaction of a vascular endothelial growth factor mimic peptide motif and its corresponding receptors
-
Giordano RJ, Anobom CD, Cardó-Vila M, Kalil J, Valente AP, et al. (2005) Structural basis for the interaction of a vascular endothelial growth factor mimic peptide motif and its corresponding receptors. Chem Biol 12: 1075-1083.
-
(2005)
Chem Biol
, vol.12
, pp. 1075-1083
-
-
Giordano, R.J.1
Anobom, C.D.2
Cardó-Vila, M.3
Kalil, J.4
Valente, A.P.5
-
31
-
-
33845287229
-
Implications of protein conformational diversity for binding and development of new biological active compounds
-
Valente AP, Miyamoto CA, Almeida FC (2006) Implications of protein conformational diversity for binding and development of new biological active compounds. Curr Med Chem 13: 3697-3703.
-
(2006)
Curr Med Chem
, vol.13
, pp. 3697-3703
-
-
Valente, A.P.1
Miyamoto, C.A.2
Almeida, F.C.3
-
32
-
-
0035861991
-
Solution structures of the YAP65 WW domain and the variant L30 K in complex with the peptides GTPPPPYTVG, N-(n-octyl)-GPPPY and PLPPY and the application of peptide libraries reveal a minimal binding epitope
-
Pires JR, Taha-Nejad F, Toepert F, Ast T, Hoffmuller U, et al. (2001) Solution structures of the YAP65 WW domain and the variant L30 K in complex with the peptides GTPPPPYTVG, N-(n-octyl)-GPPPY and PLPPY and the application of peptide libraries reveal a minimal binding epitope. J Mol Biol 314: 1147-1156.
-
(2001)
J Mol Biol
, vol.314
, pp. 1147-1156
-
-
Pires, J.R.1
Taha-Nejad, F.2
Toepert, F.3
Ast, T.4
Hoffmuller, U.5
-
33
-
-
36849088055
-
Structural biology of membrane-acting peptides: Conformational plasticity of anticoccidial peptide PW2 probed by solution NMR
-
Cruzeiro-Silva C, Gomes-Neto F, Tinoco LW, Cilli EM, Barros PV, et al. (2007) Structural biology of membrane-acting peptides: conformational plasticity of anticoccidial peptide PW2 probed by solution NMR. Biochim Biophys Acta 1768: 3182-3192.
-
(2007)
Biochim Biophys Acta
, vol.1768
, pp. 3182-3192
-
-
Cruzeiro-Silva, C.1
Gomes-Neto, F.2
Tinoco, L.W.3
Cilli, E.M.4
Barros, P.V.5
-
34
-
-
37249032102
-
Dynamic personalities of proteins
-
Henzler-Wildman K, Kern D (2007) Dynamic personalities of proteins. Nature 450: 964-972.
-
(2007)
Nature
, vol.450
, pp. 964-972
-
-
Henzler-Wildman, K.1
Kern, D.2
-
35
-
-
36849048228
-
Intrinsic motions along an enzymatic reaction trajectory
-
Henzler-Wildman KA, Thai V, Lei M, Ott M, Wolf-Watz M, et al. (2007) Intrinsic motions along an enzymatic reaction trajectory. Nature 450: 838-844.
-
(2007)
Nature
, vol.450
, pp. 838-844
-
-
Henzler-Wildman, K.A.1
Thai, V.2
Lei, M.3
Ott, M.4
Wolf-Watz, M.5
-
36
-
-
0028107420
-
Involvement of gp130/interleukin-6 receptor transducing component in interleukin-11 receptor
-
Fourcin M, Chevalier S, Lebrun JJ, Kelly P, Pouplard A, et al. (1994) Involvement of gp130/interleukin-6 receptor transducing component in interleukin-11 receptor. Eur J Immunol 24: 277-280.
-
(1994)
Eur J Immunol
, vol.24
, pp. 277-280
-
-
Fourcin, M.1
Chevalier, S.2
Lebrun, J.J.3
Kelly, P.4
Pouplard, A.5
-
37
-
-
0038750557
-
Revisiting ethical guidelines for research with terminal wean and brain-dead participants
-
Pentz RD, Flamm AL, Pasqualini R, Logothetis CJ, Arap W (2003) Revisiting ethical guidelines for research with terminal wean and brain-dead participants. Hastings Cent Rep 33: 20-26.
-
(2003)
Hastings Cent Rep
, vol.33
, pp. 20-26
-
-
Pentz, R.D.1
Flamm, A.L.2
Pasqualini, R.3
Logothetis, C.J.4
Arap, W.5
-
38
-
-
30744466652
-
Ethics guidelines for research with the recently dead
-
Pentz RD, Cohen CB, Wicclair M, DeVita MA, Flamm AL, et al. (2005) Ethics guidelines for research with the recently dead. Nat Med 11: 1145-1149.
-
(2005)
Nat Med
, vol.11
, pp. 1145-1149
-
-
Pentz, R.D.1
Cohen, C.B.2
Wicclair, M.3
DeVita, M.A.4
Flamm, A.L.5
-
39
-
-
0031041014
-
1.9 A crystal structure of interleukin 6: Implications for a novel mode of receptor dimerization and signaling
-
Somers W, Stahl M, Seehra JS (1997) 1.9 A crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling. Embo J 16: 989-997.
-
(1997)
Embo J
, vol.16
, pp. 989-997
-
-
Somers, W.1
Stahl, M.2
Seehra, J.S.3
-
40
-
-
0029046795
-
Crystal structure of dimeric human ciliary neurotrophic factor determined by MAD phasing
-
McDonald NQ, Panayotatos N, Hendrickson WA (1995) Crystal structure of dimeric human ciliary neurotrophic factor determined by MAD phasing. Embo J 14: 2689-2699.
-
(1995)
Embo J
, vol.14
, pp. 2689-2699
-
-
McDonald, N.Q.1
Panayotatos, N.2
Hendrickson, W.A.3
-
41
-
-
0029070065
-
Localization of functional receptor epitopes on the structure of ciliary neurotrophic factor indicates a conserved, function-related epitope topography among helical cytokines
-
Panayotatos N, Radziejewska E, Acheson A, Somogyi R, Thadani A, et al. (1995) Localization of functional receptor epitopes on the structure of ciliary neurotrophic factor indicates a conserved, function-related epitope topography among helical cytokines. J Biol Chem 270: 14007-14014.
-
(1995)
J Biol Chem
, vol.270
, pp. 14007-14014
-
-
Panayotatos, N.1
Radziejewska, E.2
Acheson, A.3
Somogyi, R.4
Thadani, A.5
-
42
-
-
0030940098
-
Interleukin-6: Structure-function relationships
-
Simpson, RJ, Hammacher A, Smith DK, Matthews JM, Ward LD (1997) Interleukin-6: structure-function relationships. Protein Sci 6: 929-955.
-
(1997)
Protein Sci
, vol.6
, pp. 929-955
-
-
Simpson, R.J.1
Hammacher, A.2
Smith, D.K.3
Matthews, J.M.4
Ward, L.D.5
-
43
-
-
15844420218
-
Characterization of the receptor binding sites of human leukemia inhibitory factor and creation of antagonists
-
Hudson KR, Vernallis AB, Heath JK (1996) Characterization of the receptor binding sites of human leukemia inhibitory factor and creation of antagonists. J Biol Chem 271: 11971-11978.
-
(1996)
J Biol Chem
, vol.271
, pp. 11971-11978
-
-
Hudson, K.R.1
Vernallis, A.B.2
Heath, J.K.3
-
44
-
-
0029595393
-
Definition of a composite binding site for gp130 in human interleukin-6
-
Ciapponi L, Graziani R, Paonessa G, Lahm A, Ciliberto G, et al. (1995) Definition of a composite binding site for gp130 in human interleukin-6. J Biol Chem 270: 31249-31254.
-
(1995)
J Biol Chem
, vol.270
, pp. 31249-31254
-
-
Ciapponi, L.1
Graziani, R.2
Paonessa, G.3
Lahm, A.4
Ciliberto, G.5
-
45
-
-
0035896394
-
Structure of an extracellular gp130 cytokine receptor signaling complex
-
Chow D, He X, Snow AL, Rose-John S, Garcia KC (2001) Structure of an extracellular gp130 cytokine receptor signaling complex. Science 291: 2150-2155.
-
(2001)
Science
, vol.291
, pp. 2150-2155
-
-
Chow, D.1
He, X.2
Snow, A.L.3
Rose-John, S.4
Garcia, K.C.5
-
46
-
-
0040886437
-
Receptor recognition sites of cytokines are organized as exchangeable modules. Transfer of the leukemia inhibitory factor receptor-binding site from ciliary neurotrophic factor to interleukin-6
-
Kallen KJ, Grotzinger J, Lelievre E, Vollmer P, Aasland D, et al. (1999) Receptor recognition sites of cytokines are organized as exchangeable modules. Transfer of the leukemia inhibitory factor receptor-binding site from ciliary neurotrophic factor to interleukin-6. J Biol Chem 274: 11850-11867.
-
(1999)
J Biol Chem
, vol.274
, pp. 11850-11867
-
-
Kallen, K.J.1
Grotzinger, J.2
Lelievre, E.3
Vollmer, P.4
Aasland, D.5
-
47
-
-
0345735665
-
Molecular mechanisms for viral mimicry of a human cytokine: Activation of gp130 by HHV-8 interleukin-6
-
Boulanger MJ, Cho DC, Brevnova E, Martick M, Sandford G, et al. (2004) Molecular mechanisms for viral mimicry of a human cytokine: activation of gp130 by HHV-8 interleukin-6. J Mol Biol 335: 641-654.
-
(2004)
J Mol Biol
, vol.335
, pp. 641-654
-
-
Boulanger, M.J.1
Cho, D.C.2
Brevnova, E.3
Martick, M.4
Sandford, G.5
-
48
-
-
0031589131
-
Reconstitution of two isoforms of the human interleukin-11 receptor and comparison of their functional properties
-
Lebeau B, Montero Julian FA, Wijdenes J, Muller-Newen G, Dahmen H, et al. (1997) Reconstitution of two isoforms of the human interleukin-11 receptor and comparison of their functional properties. FEBS Lett 407: 141-147.
-
(1997)
FEBS Lett
, vol.407
, pp. 141-147
-
-
Lebeau, B.1
Montero Julian, F.A.2
Wijdenes, J.3
Muller-Newen, G.4
Dahmen, H.5
-
49
-
-
9444236174
-
Small peptides as potent mimetics of the protein hormone erythropoietin
-
Wrighton NC, Farrell FX, Chang R, Kashyap AK, Barbone FP, et al. (1996) Small peptides as potent mimetics of the protein hormone erythropoietin. Science 273: 458-464.
-
(1996)
Science
, vol.273
, pp. 458-464
-
-
Wrighton, N.C.1
Farrell, F.X.2
Chang, R.3
Kashyap, A.K.4
Barbone, F.P.5
-
50
-
-
0029798402
-
Functional mimicry of a protein hormone by a peptide agonist: The EPO receptor complex at 2.8 A
-
Livnah O, Stura EA, Johnson DL, Middleton SA, Mulcahy LS, et al. (1996) Functional mimicry of a protein hormone by a peptide agonist: the EPO receptor complex at 2.8 A. Science 273: 464-471.
-
(1996)
Science
, vol.273
, pp. 464-471
-
-
Livnah, O.1
Stura, E.A.2
Johnson, D.L.3
Middleton, S.A.4
Mulcahy, L.S.5
-
51
-
-
0030773876
-
Peptide agonist of the thrombopoietin receptor as potent as the natural cytokine
-
Cwirla SE, Balasubramanian P, Duffin DJ, Wagstrom CR, Gates CM, et al. (1997) Peptide agonist of the thrombopoietin receptor as potent as the natural cytokine. Science 276: 1696-1699.
-
(1997)
Science
, vol.276
, pp. 1696-1699
-
-
Cwirla, S.E.1
Balasubramanian, P.2
Duffin, D.J.3
Wagstrom, C.R.4
Gates, C.M.5
-
52
-
-
0031766635
-
An antagonist peptide-EPO receptor complex suggests that receptor dimerization is not sufficient for activation
-
Livnah O, Johnson DL, Stura EA, Farrell FX, Barbone FP, et al. (1998) An antagonist peptide-EPO receptor complex suggests that receptor dimerization is not sufficient for activation. Nat Struct Biol 5: 993-1004.
-
(1998)
Nat Struct Biol
, vol.5
, pp. 993-1004
-
-
Livnah, O.1
Johnson, D.L.2
Stura, E.A.3
Farrell, F.X.4
Barbone, F.P.5
-
53
-
-
0344413478
-
Active and inactive orientations of the transmembrane and cytosolic domains of the erythropoietin receptor dimer
-
Seubert N, Royer Y, Staerk J, Kubatzky KF, Moucadel V, et al. (2003) Active and inactive orientations of the transmembrane and cytosolic domains of the erythropoietin receptor dimer. Mol Cell 12: 1239-1250.
-
(2003)
Mol Cell
, vol.12
, pp. 1239-1250
-
-
Seubert, N.1
Royer, Y.2
Staerk, J.3
Kubatzky, K.F.4
Moucadel, V.5
-
54
-
-
0037151087
-
Peptides identify the critical hotspots involved in the biological activation of the insulin receptor
-
Pillutla RC, Hsiao KC, Beasley JR, Brandt J, Ostergaard S, et al. (2002) Peptides identify the critical hotspots involved in the biological activation of the insulin receptor. J Biol Chem 277: 22590-22594.
-
(2002)
J Biol Chem
, vol.277
, pp. 22590-22594
-
-
Pillutla, R.C.1
Hsiao, K.C.2
Beasley, J.R.3
Brandt, J.4
Ostergaard, S.5
-
55
-
-
18744394296
-
Structure of the extracellullar domains of the human interleukin-6 receptor alpha-chain
-
Varghese JN, Moritz RL, Lou MZ, Van Donkelaar A, Ji H, et al. (2002) Structure of the extracellullar domains of the human interleukin-6 receptor alpha-chain. Proc Natl Acad Sci U S A 99: 15959-15964.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 15959-15964
-
-
Varghese, J.N.1
Moritz, R.L.2
Lou, M.Z.3
Van Donkelaar, A.4
Ji, H.5
-
56
-
-
0037434888
-
The human interleukin-6 (IL-6) receptor exists as a preformed dimer in the plasma membrane
-
Schuster B, Meinert W, Rose-John S, Kallen KJ (2003) The human interleukin-6 (IL-6) receptor exists as a preformed dimer in the plasma membrane. FEBS Lett 538: 113-116.
-
(2003)
FEBS Lett
, vol.538
, pp. 113-116
-
-
Schuster, B.1
Meinert, W.2
Rose-John, S.3
Kallen, K.J.4
-
57
-
-
0037178889
-
Orientational constraints of the gp130 intracellular juxtamembrane domain for signaling
-
Greiser JS, Stross C, Heinrich PC, Behrmann I, Hermanns HM (2002) Orientational constraints of the gp130 intracellular juxtamembrane domain for signaling. J Biol Chem 277: 26959-26965.
-
(2002)
J Biol Chem
, vol.277
, pp. 26959-26965
-
-
Greiser, J.S.1
Stross, C.2
Heinrich, P.C.3
Behrmann, I.4
Hermanns, H.M.5
-
58
-
-
0040357273
-
Studies on the interleukin-6-type cytokine signal transducer gp130 reveal a novel mechanism of receptor activation by monoclonal antibodies
-
Muller-Newen G, Kuster A, Wijdenes J, Schaper F, Heinrich PC (2000) Studies on the interleukin-6-type cytokine signal transducer gp130 reveal a novel mechanism of receptor activation by monoclonal antibodies. J Biol Chem 275: 4579-4586.
-
(2000)
J Biol Chem
, vol.275
, pp. 4579-4586
-
-
Muller-Newen, G.1
Kuster, A.2
Wijdenes, J.3
Schaper, F.4
Heinrich, P.C.5
-
59
-
-
22444442637
-
Signaling conformations of the tall cytokine receptor gp130 when in complex with IL-6 and IL-6 receptor
-
Skiniotis G, Boulanger MJ, Garcia KC, Walz T (2005) Signaling conformations of the tall cytokine receptor gp130 when in complex with IL-6 and IL-6 receptor. Nat Struct Mol Biol 12: 545-551.
-
(2005)
Nat Struct Mol Biol
, vol.12
, pp. 545-551
-
-
Skiniotis, G.1
Boulanger, M.J.2
Garcia, K.C.3
Walz, T.4
-
60
-
-
0027266779
-
Libraries of peptides and proteins displayed on filamentous phage
-
Smith GP, Scott JK (1993) Libraries of peptides and proteins displayed on filamentous phage. Meth Enzymol 217: 228-257.
-
(1993)
Meth Enzymol
, vol.217
, pp. 228-257
-
-
Smith, G.P.1
Scott, J.K.2
-
61
-
-
0026951903
-
Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions
-
Piotto M, Saudek V, Sklenar V (1992) Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions. J Biomol NMR 2: 661-665.
-
(1992)
J Biomol NMR
, vol.2
, pp. 661-665
-
-
Piotto, M.1
Saudek, V.2
Sklenar, V.3
-
62
-
-
5144233105
-
Mlev-17-Based Two-Dimensional Homonuclear Magnetization Transfer Spectroscopy
-
Bax A, Davis DG (1985) Mlev-17-Based Two-Dimensional Homonuclear Magnetization Transfer Spectroscopy. J Magn Reson 65: 355-360.
-
(1985)
J Magn Reson
, vol.65
, pp. 355-360
-
-
Bax, A.1
Davis, D.G.2
-
63
-
-
0001350902
-
Gradient-tailored water suppression for H-1-N-15 Hsqe experiments optimized to retain full sensitivity
-
Sklenar V, Piotto M, Leppik R, Saudek V (1993) Gradient-tailored water suppression for H-1-N-15 Hsqe experiments optimized to retain full sensitivity. J Magn Reson Series A 102: 241-245.
-
(1993)
J Magn Reson Series A
, vol.102
, pp. 241-245
-
-
Sklenar, V.1
Piotto, M.2
Leppik, R.3
Saudek, V.4
|