Peptides identify the critical hotspots involved in the biological activation of the insulin receptor

Journal of Biological Chemistry

Volumn 277, Issue 25, 2002, Pages 22590-22594

  Pillutla, Renuka C ^a   Hsiao, Ku Chuan ^b   Beasley, James R ^c   Brandt, Jakob ^a,b   Østergaard, Søren ^b   Hansen, Per Hertz ^c   Spetzler, Jane C ^a   Danielsen, Gillian M ^a,b,c,d   Andersen, Asser S ^a   Brissette, Renee E ^b   Lennick, Michael ^a,c   Fletcher, Paul W ^a,b   Blume, Arthur J ^b   Schäffer, Lauge ^b   Goldstein, Neil I ^a,d  

^a Departments of Molecular Biology   (United States)

^b Protein Technologies   (United States)

^c NOVO NORDISK A S   (Denmark)

^d PHARMACOPEIA INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; CHEMICAL ACTIVATION; ENZYME KINETICS; INSULIN; PROTEINS;

PEPTIDES;

BIOCHEMISTRY;

INSULIN RECEPTOR; PEPTIDE;

ADIPOCYTE; ANIMAL CELL; ARTICLE; BINDING COMPETITION; ENZYME ACTIVATION; ENZYME ACTIVITY; HORMONE RECEPTOR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RECEPTOR INTRINSIC ACTIVITY; STRUCTURE ANALYSIS;

ADIPOCYTES; AMINO ACID MOTIFS; ANIMALS; BINDING SITES; BINDING, COMPETITIVE; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; KINETICS; MICE; MUTAGENESIS, SITE-DIRECTED; PEPTIDE BIOSYNTHESIS; PEPTIDE LIBRARY; PEPTIDES; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, INSULIN;

ANIMALIA;

EID: 0037151087     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M202119200     Document Type: Article

References (21)