1.9 Å crystal structure of interleukin 6: Implications for a novel mode of receptor dimerization and signaling

EMBO Journal

Volumn 16, Issue 5, 1997, Pages 989-997

  Somers, William ^a   Stahl, Mark ^a   Seehra, Jasbir S ^a  

^a PFIZER INC   (United States)

Author keywords

Crystal structure; Interleukin 6; Receptor; Signaling

Indexed keywords

GLYCOPROTEIN GP 130; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; DISULFIDE; GRANULOCYTE COLONY STIMULATING FACTOR; HUMAN GROWTH HORMONE; INTERLEUKIN RECEPTOR; LEUKOCYTE ANTIGEN; RECOMBINANT PROTEIN; WATER;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DIMERIZATION; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN PURIFICATION; PROTEIN STRUCTURE; RECEPTOR BINDING; SIGNAL TRANSDUCTION; X RAY CRYSTALLOGRAPHY; CHEMICAL STRUCTURE; CHEMISTRY; CRYSTALLIZATION; ESCHERICHIA COLI; GENE EXPRESSION; GENETICS; HUMAN; HYDROGEN BOND; ISOLATION AND PURIFICATION; METABOLISM; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE;

ANTIGENS, CD; BINDING SITES; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; DISULFIDES; ESCHERICHIA COLI; GENE EXPRESSION; GRANULOCYTE COLONY-STIMULATING FACTOR; HUMAN GROWTH HORMONE; HUMANS; HYDROGEN BONDING; INTERLEUKIN-6; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-6; RECOMBINANT PROTEINS; WATER;

EID: 0031041014     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/16.5.989     Document Type: Article

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