메뉴 건너뛰기




Volumn 5, Issue 11, 2008, Pages 715-724

Interplay between impaired calcium regulation and insulin signaling abnormalities in diabetic cardiomyopathy

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ACTIN; ATRIAL NATRIURETIC FACTOR; CALCIUM CHANNEL L TYPE; CALCIUM ION; GLUCOSE; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE; MYOSIN ADENOSINE TRIPHOSPHATASE; MYOSIN HEAVY CHAIN ALPHA; MYOSIN HEAVY CHAIN BETA; N ACETYLGLUCOSAMINE; PARVOVIRUS VECTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLAMBAN; POTASSIUM ION; PROTEIN KINASE C; RYANODINE RECEPTOR; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SODIUM CALCIUM EXCHANGE PROTEIN; SODIUM ION;

EID: 55149083279     PISSN: 17434297     EISSN: 17434300     Source Type: Journal    
DOI: 10.1038/ncpcardio1347     Document Type: Review
Times cited : (95)

References (72)
  • 1
    • 0242284429 scopus 로고    scopus 로고
    • International Diabetes Federation online, 3rd edition
    • International Diabetes Federation (online 2006) Diabetes Atlas, 3rd edition [http://www.eatlas.idf.org/media]
    • (2006) Diabetes Atlas
  • 2
    • 0035050460 scopus 로고    scopus 로고
    • Diabetes, hypertension, and cardiovascular disease: An update
    • Sowers J R et al. (2001) Diabetes, hypertension, and cardiovascular disease: An update. Hypertension 7: 1053-1059
    • (2001) Hypertension , vol.7 , pp. 1053-1059
    • Sowers, J.R.1
  • 3
    • 34347352169 scopus 로고    scopus 로고
    • Diabetic cardiomyopathy revisited
    • Boudina S and Abel ED (2007) Diabetic cardiomyopathy revisited. Circulation 115: 3213-3223
    • (2007) Circulation , vol.115 , pp. 3213-3223
    • Boudina, S.1    Abel, E.D.2
  • 4
    • 34247483998 scopus 로고    scopus 로고
    • Increasing cardiovascular disease burden due to diabetes mellitus: The Framingham Heart Study
    • Fox CS et al. (2007) Increasing cardiovascular disease burden due to diabetes mellitus: The Framingham Heart Study. Circulation 115: 1544-1550
    • (2007) Circulation , vol.115 , pp. 1544-1550
    • Fox, C.S.1
  • 5
    • 0015498586 scopus 로고
    • A new type of cardlomyopathy associated with diabetic glomerulosclerosis
    • Rubler S et al. (1972) A new type of cardlomyopathy associated with diabetic glomerulosclerosis. Am J Cardiol 30: 595-602
    • (1972) Am J Cardiol , vol.30 , pp. 595-602
    • Rubler, S.1
  • 6
    • 0026321248 scopus 로고
    • Echocardiographic evidence for the existence of a distinct diabetic cardiomyopathy (the Framingham Heart Study)
    • Gaiderisi M et al. (1991) Echocardiographic evidence for the existence of a distinct diabetic cardiomyopathy (the Framingham Heart Study). Am J Cardiol 68: 85-89
    • (1991) Am J Cardiol , vol.68 , pp. 85-89
    • Gaiderisi, M.1
  • 7
    • 13544258770 scopus 로고    scopus 로고
    • Diabetic cardiomyopathy: Recent evidence from mouse models of type 1 and type 2 diabetes
    • Severson D (2004) Diabetic cardiomyopathy: Recent evidence from mouse models of type 1 and type 2 diabetes. Can J Physiol Pharmacol 82: 813-823
    • (2004) Can J Physiol Pharmacol , vol.82 , pp. 813-823
    • Severson, D.1
  • 8
    • 33645280925 scopus 로고    scopus 로고
    • Poomima IG net al. (2006) Diabetic cardiomyopathy: The search for a unifying hypothesis. Circ Res 98: 596-605
    • Poomima IG net al. (2006) Diabetic cardiomyopathy: The search for a unifying hypothesis. Circ Res 98: 596-605
  • 9
    • 37849047917 scopus 로고    scopus 로고
    • Insuhn-resistant cardiomyopathy clinical evidence, mechanisms, and treatment options
    • Witteles RM and Fowler MB (2008) Insuhn-resistant cardiomyopathy clinical evidence, mechanisms, and treatment options. J Am Coll Cardiol 51: 93-102
    • (2008) J Am Coll Cardiol , vol.51 , pp. 93-102
    • Witteles, R.M.1    Fowler, M.B.2
  • 10
    • 33749321945 scopus 로고    scopus 로고
    • Role of changes in cardiac metabolism in development of diabetic cardiomyopathy
    • An D and Rodrigues B (2006) Role of changes in cardiac metabolism in development of diabetic cardiomyopathy. Am J Physiol Heart Circ Physiol 291: H1489-H1506
    • (2006) Am J Physiol Heart Circ Physiol , vol.291
    • An, D.1    Rodrigues, B.2
  • 11
    • 0019240363 scopus 로고
    • Diabetes mellitus induces changes in cardiac myosin of the rat
    • Dillmann W (1980) Diabetes mellitus induces changes in cardiac myosin of the rat. Diabetes 29: 579-582
    • (1980) Diabetes , vol.29 , pp. 579-582
    • Dillmann, W.1
  • 12
    • 0028818405 scopus 로고
    • Molecular biology of protein kinase C signaling in cardiac myocytes
    • Malhotra A et al. (1995) Molecular biology of protein kinase C signaling in cardiac myocytes. Mol Cell Biochem 151: 165-172
    • (1995) Mol Cell Biochem , vol.151 , pp. 165-172
    • Malhotra, A.1
  • 13
    • 33846977064 scopus 로고    scopus 로고
    • Restoration of diabetes-induced abnormal local Ca2+ release in cardiornyocytes by angiotensin II receptor blockade
    • Yaras N et al. (2007) Restoration of diabetes-induced abnormal local Ca2+ release in cardiornyocytes by angiotensin II receptor blockade. Am J Physiol Heart Circ Physiol 292: H912-H920
    • (2007) Am J Physiol Heart Circ Physiol , vol.292
    • Yaras, N.1
  • 14
    • 0031021679 scopus 로고    scopus 로고
    • Diabetes rapidly induces contractile dysfunctions in isolated ventricular myocytes
    • Ren J and Davidoff AJ (1997) Diabetes rapidly induces contractile dysfunctions in isolated ventricular myocytes. Am J Physiol 272 H148-H158
    • (1997) Am J Physiol , vol.272
    • Ren, J.1    Davidoff, A.J.2
  • 15
    • 0033393197 scopus 로고    scopus 로고
    • Alterations in contractile properties and Ca2+ handling in streptozotocin-induced diabetic rat myocardium
    • Ishikawa T et al. (1999) Alterations in contractile properties and Ca2+ handling in streptozotocin-induced diabetic rat myocardium. Am J Physiol Heart Circ Physiol 277: H2185-H2194
    • (1999) Am J Physiol Heart Circ Physiol , vol.277
    • Ishikawa, T.1
  • 16
    • 0027371176 scopus 로고
    • Calcium and potassium currents in ventricular myocytes isolated from diabetic rats
    • Jourdon P and Feuvray D (1993) Calcium and potassium currents in ventricular myocytes isolated from diabetic rats. J Physiol 470 411-429
    • (1993) J Physiol , vol.470 , pp. 411-429
    • Jourdon, P.1    Feuvray, D.2
  • 17
    • 0019471815 scopus 로고
    • Depressed cardiac sarcoplasmic reticulum function from diabetic rats
    • Penpargkul S et al. (1981) Depressed cardiac sarcoplasmic reticulum function from diabetic rats. J Mol Cell Cardiol 13 303-309
    • (1981) J Mol Cell Cardiol , vol.13 , pp. 303-309
    • Penpargkul, S.1
  • 18
    • 0033009546 scopus 로고    scopus 로고
    • Decrease in sodium-calcium exchange and calcium currents in diabetic rat ventricular myocytes
    • Chattou S et al. (1999) Decrease in sodium-calcium exchange and calcium currents in diabetic rat ventricular myocytes. Acta Physiol Scanda 166: 137-144
    • (1999) Acta Physiol Scanda , vol.166 , pp. 137-144
    • Chattou, S.1
  • 19
    • 33644677758 scopus 로고    scopus 로고
    • 2+ homeostasis in rat heart
    • 2+ homeostasis in rat heart. Diabetes 54: 3082-3088
    • (2005) Diabetes , vol.54 , pp. 3082-3088
    • Yaras, N.1
  • 20
    • 0030770245 scopus 로고    scopus 로고
    • Impaired contractile response to beta adrenoceptor stimulation in diabetic rat hearts: Alterations in beta adrenoceptors-G protein-adenylate cyclase system and phospholamban phosphorylation
    • Gando S et al. (1997) Impaired contractile response to beta adrenoceptor stimulation in diabetic rat hearts: Alterations in beta adrenoceptors-G protein-adenylate cyclase system and phospholamban phosphorylation. J Pharmacol Exp Ther 282: 475-84
    • (1997) J Pharmacol Exp Ther , vol.282 , pp. 475-484
    • Gando, S.1
  • 21
    • 0034822782 scopus 로고    scopus 로고
    • Altered SR protein expression associated with contractile dysfunction in diabetic rat hearts
    • Zhong Y et al. (2001) Altered SR protein expression associated with contractile dysfunction in diabetic rat hearts. Am J Physiol Heart Circ Physiol 281: H1137-H1147
    • (2001) Am J Physiol Heart Circ Physiol , vol.281
    • Zhong, Y.1
  • 22
    • 0028280927 scopus 로고
    • + currents in rat ventricular myocytes
    • + currents in rat ventricular myocytes. Circ Res 74: 620-628
    • (1994) Circ Res , vol.74 , pp. 620-628
    • Shimoni, Y.1
  • 23
    • 0028811097 scopus 로고
    • 2+ currents in ventricular myocytes from rats with chronic diabetes
    • 2+ currents in ventricular myocytes from rats with chronic diabetes. Am J Physiol 269: H1288-H1296
    • (1995) Am J Physiol , vol.269
    • Wang, D.W.1
  • 24
    • 35748963539 scopus 로고    scopus 로고
    • 2+ current in cardiac myocytes of type 1 diabetic Akita mice due to reduced phosphatidylinositol 3-kinase signaling
    • 2+ current in cardiac myocytes of type 1 diabetic Akita mice due to reduced phosphatidylinositol 3-kinase signaling. Diabetes 56: 2780-2789
    • (2007) Diabetes , vol.56 , pp. 2780-2789
    • Lu, Z.1
  • 25
    • 22244465203 scopus 로고    scopus 로고
    • Impaired SERCA function contributes to cardiomyocyte dysfunction in insulin resistant rats
    • Wold LE et al. (2005) Impaired SERCA function contributes to cardiomyocyte dysfunction in insulin resistant rats. J Mol Cell Cardiol 39: 297-307
    • (2005) J Mol Cell Cardiol , vol.39 , pp. 297-307
    • Wold, L.E.1
  • 26
    • 9444224416 scopus 로고    scopus 로고
    • Decreased sarcoplasmic reticulum activity and contractility in diabetic db/db mouse heart
    • Belke DD et al. (2004) Decreased sarcoplasmic reticulum activity and contractility in diabetic db/db mouse heart. Diabetes 53: 3201-3208
    • (2004) Diabetes , vol.53 , pp. 3201-3208
    • Belke, D.D.1
  • 27
    • 0036227758 scopus 로고    scopus 로고
    • (2+)-ATPase improves myocardial contractility in diabetic cardiomyopathy
    • (2+)-ATPase improves myocardial contractility in diabetic cardiomyopathy. Diabetes 51: 1166-1171
    • (2002) Diabetes , vol.51 , pp. 1166-1171
    • Trost, S.U.1
  • 28
    • 0033534053 scopus 로고    scopus 로고
    • Restoration of contractile function in isolated cardiomyocytes from failing human hearts by gene transfer of SERCA2a
    • del Monte F et al. (1999) Restoration of contractile function in isolated cardiomyocytes from failing human hearts by gene transfer of SERCA2a. Circulation 100: 2308-2311
    • (1999) Circulation , vol.100 , pp. 2308-2311
    • del Monte, F.1
  • 29
    • 0033837124 scopus 로고    scopus 로고
    • Diminished function and expression of the cardiac Na+-Ca2+ exchanger in diabetic rats: Implication in Ca2+ overload
    • Hattori Y et al. (2000) Diminished function and expression of the cardiac Na+-Ca2+ exchanger in diabetic rats: Implication in Ca2+ overload. J Physiol 527: 85-94
    • (2000) J Physiol , vol.527 , pp. 85-94
    • Hattori, Y.1
  • 30
    • 33644783906 scopus 로고    scopus 로고
    • i transient decrease in cardiomyopathy of db/db type 2 diabetic mice
    • i transient decrease in cardiomyopathy of db/db type 2 diabetic mice. Diabetes 55: 608-615
    • (2006) Diabetes , vol.55 , pp. 608-615
    • Pereira, L.1
  • 31
    • 0030950776 scopus 로고    scopus 로고
    • 2+ exchanger activity in the diabetic heart
    • 2+ exchanger activity in the diabetic heart. Cardiovasc Res 34: 129-136
    • (1997) Cardiovasc Res , vol.34 , pp. 129-136
    • Schaffer, S.W.1
  • 32
    • 0036545437 scopus 로고    scopus 로고
    • 2+-exchanger overexpression on excitation-contraction coupling in adult rabbit ventricular myocytes
    • 2+-exchanger overexpression on excitation-contraction coupling in adult rabbit ventricular myocytes. J Mol Cell Cardiol 34: 389-400
    • (2002) J Mol Cell Cardiol , vol.34 , pp. 389-400
    • Ranu, H.K.1
  • 33
    • 0036702693 scopus 로고    scopus 로고
    • Depressed PKA activity contributes to impaired SERCA function and is linked to the pathogenesis of glucose-induced cardiomyopathy
    • Dutta K et al. (2002) Depressed PKA activity contributes to impaired SERCA function and is linked to the pathogenesis of glucose-induced cardiomyopathy. J Mol Cell Cardiol 34: 985-996
    • (2002) J Mol Cell Cardiol , vol.34 , pp. 985-996
    • Dutta, K.1
  • 34
    • 0034973680 scopus 로고    scopus 로고
    • Ryanodine receptors/calcium release channels in heart failure and sudden cardiac death
    • Marks AR (2001) Ryanodine receptors/calcium release channels in heart failure and sudden cardiac death. J Mol Cell Cardiol 33: 615-624
    • (2001) J Mol Cell Cardiol , vol.33 , pp. 615-624
    • Marks, A.R.1
  • 35
    • 33746640458 scopus 로고    scopus 로고
    • Mitochondrial uncoupling: A key contributor to reduced cardiac efficiency in diabetes
    • Boudina S and Abel ED (2006) Mitochondrial uncoupling: A key contributor to reduced cardiac efficiency in diabetes. Physiology 21: 250-258
    • (2006) Physiology , vol.21 , pp. 250-258
    • Boudina, S.1    Abel, E.D.2
  • 36
    • 34147125312 scopus 로고    scopus 로고
    • Defective mitochondrial biogenesis: A hallmark of the high cardiovascular risk in the metabolic syndrome?
    • Nisoli E et al. (2007). Defective mitochondrial biogenesis: A hallmark of the high cardiovascular risk in the metabolic syndrome? Circ Res 100: 795-806
    • (2007) Circ Res , vol.100 , pp. 795-806
    • Nisoli, E.1
  • 38
    • 0342276067 scopus 로고    scopus 로고
    • Regulation of contractile proteins in diabetic heart
    • Malhotra A and Sanghi V (1997) Regulation of contractile proteins in diabetic heart. Cardiovasc Res 34: 34-40
    • (1997) Cardiovasc Res , vol.34 , pp. 34-40
    • Malhotra, A.1    Sanghi, V.2
  • 39
    • 28144458155 scopus 로고    scopus 로고
    • Depressed cardiac myofilament function in human diabetes mellitus
    • Jweied EE et al. (2005) Depressed cardiac myofilament function in human diabetes mellitus. Am J Physiol Heart Circ Physiol 289 H2478-H2483
    • (2005) Am J Physiol Heart Circ Physiol , vol.289
    • Jweied, E.E.1
  • 40
    • 0037377559 scopus 로고    scopus 로고
    • + currents by angiotensin and endothelin. Am J Physiol Heart Circ Physiol 284: H1168-H1181
    • + currents by angiotensin and endothelin. Am J Physiol Heart Circ Physiol 284: H1168-H1181
  • 41
    • 0028988060 scopus 로고
    • Diminished Ca2+ sensitivity of skinned cardiac muscle contractility coincident with troponin T-band shifts in the diabetic rat
    • Akella AB et al. (1995) Diminished Ca2+ sensitivity of skinned cardiac muscle contractility coincident with troponin T-band shifts in the diabetic rat. Circ Res 76: 600-606
    • (1995) Circ Res , vol.76 , pp. 600-606
    • Akella, A.B.1
  • 42
    • 1642523851 scopus 로고    scopus 로고
    • Collagen cross-link breakers: A beginning of a new era in the treatment of cardiovascular changes associated with aging, diabetes, and hypertension
    • Susic D et al. (2004) Collagen cross-link breakers: A beginning of a new era in the treatment of cardiovascular changes associated with aging, diabetes, and hypertension. Curr Drug Targets Cardiovasc Haematol Disord 4:97-101
    • (2004) Curr Drug Targets Cardiovasc Haematol Disord , vol.4 , pp. 97-101
    • Susic, D.1
  • 43
    • 0842266824 scopus 로고    scopus 로고
    • Diabetes increases formation of advanced glycation end products on sarco(endo)plasmic reticulum Ca2+-ATPase
    • Bidasee KR et al. (2004) Diabetes increases formation of advanced glycation end products on sarco(endo)plasmic reticulum Ca2+-ATPase. Diabetes 53: 463-473
    • (2004) Diabetes , vol.53 , pp. 463-473
    • Bidasee, K.R.1
  • 44
    • 0038729509 scopus 로고    scopus 로고
    • Chronic diabetes increases advanced glycation end products on cardiac ryanodine receptors/calcium-release channels
    • Bidasee KR et al. (2003) Chronic diabetes increases advanced glycation end products on cardiac ryanodine receptors/calcium-release channels. Diabetes 52: 1825-1836
    • (2003) Diabetes , vol.52 , pp. 1825-1836
    • Bidasee, K.R.1
  • 45
    • 33845582766 scopus 로고    scopus 로고
    • Role of protein O-linked N-acetyl-glucosamine in mediating cell function and survival in the cardiovascular system
    • F-dsulöp N et al. (2007) Role of protein O-linked N-acetyl-glucosamine in mediating cell function and survival in the cardiovascular system. Cardiovasc Res 73: 288-297
    • (2007) Cardiovasc Res , vol.73 , pp. 288-297
    • F-dsulöp, N.1
  • 46
    • 0019853313 scopus 로고
    • Reversibility of diabetic cardiomyopathy with insulin in rats
    • Fein FS et al. (1981) Reversibility of diabetic cardiomyopathy with insulin in rats. Circ Res 49: 1251-1261
    • (1981) Circ Res , vol.49 , pp. 1251-1261
    • Fein, F.S.1
  • 47
    • 20044375212 scopus 로고    scopus 로고
    • Myocardial insulin resistance and cardiac complications of diabetes
    • Abel ED (2005) Myocardial insulin resistance and cardiac complications of diabetes. Curr Dnig Targets Immune Endocr Metabol Disord 5 219-226
    • (2005) Curr Dnig Targets Immune Endocr Metabol Disord , vol.5 , pp. 219-226
    • Abel, E.D.1
  • 48
    • 33645074682 scopus 로고    scopus 로고
    • Convergence of glucose- and fatty acid-induced abnormal myocardial excitation-contraction coupling and insulin signalling
    • Davidoff AJ (2006) Convergence of glucose- and fatty acid-induced abnormal myocardial excitation-contraction coupling and insulin signalling. Clin Exp Pharmacol Physiol 33: 152-158
    • (2006) Clin Exp Pharmacol Physiol , vol.33 , pp. 152-158
    • Davidoff, A.J.1
  • 49
    • 34250192264 scopus 로고    scopus 로고
    • Myocardial insulin action and the contribution of insulin resistance to the pathogenesis of diabetic cardiomyopathy
    • Ouwen DM and Diamant M (2007) Myocardial insulin action and the contribution of insulin resistance to the pathogenesis of diabetic cardiomyopathy. Arch Physiol Biochem 113:76-86
    • (2007) Arch Physiol Biochem , vol.113 , pp. 76-86
    • Ouwen, D.M.1    Diamant, M.2
  • 50
    • 33745887531 scopus 로고    scopus 로고
    • Insulin resistance and cardiovascular risk: New insights from molecular and cellular biology
    • Morisco C et al. (2006) Insulin resistance and cardiovascular risk: New insights from molecular and cellular biology. Trends Cardiovasc Med. 16: 183-188
    • (2006) Trends Cardiovasc Med , vol.16 , pp. 183-188
    • Morisco, C.1
  • 51
    • 0036192939 scopus 로고    scopus 로고
    • Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression
    • Belke DD et al. (2002) Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression. J Clin Invest 109: 629-639
    • (2002) J Clin Invest , vol.109 , pp. 629-639
    • Belke, D.D.1
  • 52
    • 27644512904 scopus 로고    scopus 로고
    • Contractile dysfunction in hypertrophied hearts with deficient insulin receptor signaling: Possible role of reduced capillary density
    • McQueen AP et al. (2005) Contractile dysfunction in hypertrophied hearts with deficient insulin receptor signaling: Possible role of reduced capillary density. J Mol Cell Cardiol 39: 882-892
    • (2005) J Mol Cell Cardiol , vol.39 , pp. 882-892
    • McQueen, A.P.1
  • 53
    • 0343314906 scopus 로고    scopus 로고
    • Characterization of signal transduction and glucose transport in skeletal muscle from type 2 diabetic patients
    • Krook A et al. (2000) Characterization of signal transduction and glucose transport in skeletal muscle from type 2 diabetic patients. Diabetes 49: 284-292
    • (2000) Diabetes , vol.49 , pp. 284-292
    • Krook, A.1
  • 54
    • 0030815973 scopus 로고    scopus 로고
    • Molecular analysis of insulin resistance in isolated ventricular cardiomyocytes of obese Zucker rats
    • Kolter T et al. (1997) Molecular analysis of insulin resistance in isolated ventricular cardiomyocytes of obese Zucker rats. Am J Physiol Endocrinol Metab 273: E59-E67
    • (1997) Am J Physiol Endocrinol Metab , vol.273
    • Kolter, T.1
  • 55
    • 33645074450 scopus 로고    scopus 로고
    • Etiology of insulin resistance
    • Petersen KF and Shulman GI (2006) Etiology of insulin resistance. Am J Med 119 (Suppl 1): S10-S16
    • (2006) Am J Med , vol.119 , Issue.SUPPL. 1
    • Petersen, K.F.1    Shulman, G.I.2
  • 56
    • 34548850040 scopus 로고    scopus 로고
    • A conserved role for phosphatidylinositol 3-kinase but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy
    • O'Neill BT et al. (2007) A conserved role for phosphatidylinositol 3-kinase but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy. Cell Metab 6: 294-306
    • (2007) Cell Metab , vol.6 , pp. 294-306
    • O'Neill, B.T.1
  • 57
    • 34247583996 scopus 로고    scopus 로고
    • Cycling of O-linked beta-N-acetylglucosamine on nucleocytoplasmic proteins
    • Hart GW et al. (2007) Cycling of O-linked beta-N-acetylglucosamine on nucleocytoplasmic proteins. Nature 446: 1017-1022
    • (2007) Nature , vol.446 , pp. 1017-1022
    • Hart, G.W.1
  • 58
    • 33645901857 scopus 로고    scopus 로고
    • Mechanical and metabolic rescue in a type II diabetes model of cardiomyopathy by targeted gene transfer
    • Sakata S et al. (2006) Mechanical and metabolic rescue in a type II diabetes model of cardiomyopathy by targeted gene transfer. Mol Ther 13: 987-996
    • (2006) Mol Ther , vol.13 , pp. 987-996
    • Sakata, S.1
  • 59
    • 0030813544 scopus 로고    scopus 로고
    • 2+-ATPases in muscle and heart
    • 2+-ATPases in muscle and heart. J Biol Chem 272: 23696-23702
    • (1997) J Biol Chem , vol.272 , pp. 23696-23702
    • Algenstaedt, P.1
  • 60
    • 21344455935 scopus 로고    scopus 로고
    • Cardiac dysfunction induced by high-fat diet is associated with altered myocardial insulin signalling in rats
    • Ouwens DM et al. (2005) Cardiac dysfunction induced by high-fat diet is associated with altered myocardial insulin signalling in rats. Diabetologia 48: 1229-1237
    • (2005) Diabetologia , vol.48 , pp. 1229-1237
    • Ouwens, D.M.1
  • 61
    • 4344692221 scopus 로고    scopus 로고
    • Diabetic cardiomyocyte dysfunction and myocyte insulin resistance: Role of glucose-induced PKC activity
    • Davidoff AJ et al. (2004) Diabetic cardiomyocyte dysfunction and myocyte insulin resistance: Role of glucose-induced PKC activity. Mol Cell Biochem 262: 155-163
    • (2004) Mol Cell Biochem , vol.262 , pp. 155-163
    • Davidoff, A.J.1
  • 62
    • 33748543968 scopus 로고    scopus 로고
    • Insulin improves cardiomyocyte contractile function through enhancement of SERCA2a activity in simulated ischemia/ reperfusion
    • Yu J et al. (2006) Insulin improves cardiomyocyte contractile function through enhancement of SERCA2a activity in simulated ischemia/ reperfusion. Acta Pharmacol Sin 27: 919-926
    • (2006) Acta Pharmacol Sin , vol.27 , pp. 919-926
    • Yu, J.1
  • 63
    • 2442714120 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3β regulates growth, calcium homeostasis, and diastolic function in the heart
    • Michael A et al. (2004) Glycogen synthase kinase-3β regulates growth, calcium homeostasis, and diastolic function in the heart. J Biol Chem 279: 21383-21393
    • (2004) J Biol Chem , vol.279 , pp. 21383-21393
    • Michael, A.1
  • 64
    • 19644366915 scopus 로고    scopus 로고
    • Insulin causes [Ca2+]i-dependent and [Ca2+]i-independent positive inotropic effects in failing human myocardium
    • Von Lewinski D et al. (2005) Insulin causes [Ca2+]i-dependent and [Ca2+]i-independent positive inotropic effects in failing human myocardium. Circulation 111: 2588-2595
    • (2005) Circulation , vol.111 , pp. 2588-2595
    • Von Lewinski, D.1
  • 65
    • 0037067463 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase functionally compartmentalizes the concurrent G(s) signaling during β2-adrenergic stimulation
    • Jo SH et al. (2002) Phosphatidylinositol 3-kinase functionally compartmentalizes the concurrent G(s) signaling during β2-adrenergic stimulation. Circ Res 91: 46-53
    • (2002) Circ Res , vol.91 , pp. 46-53
    • Jo, S.H.1
  • 66
    • 0037125980 scopus 로고    scopus 로고
    • Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice
    • Condorelli G et al. (2002) Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice. Proc Natl Acad Sci USA 99: 12333-12338
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 12333-12338
    • Condorelli, G.1
  • 67
    • 18644372367 scopus 로고    scopus 로고
    • Regulation of myocardial contractility and cell size by distinct P13K-PTEN signaling pathways
    • Crackower MA et al. (2002) Regulation of myocardial contractility and cell size by distinct P13K-PTEN signaling pathways. Cell 110: 737-749
    • (2002) Cell , vol.110 , pp. 737-749
    • Crackower, M.A.1
  • 68
    • 20344388816 scopus 로고    scopus 로고
    • Cardiac sarcoplasmic reticulum calcium release and load are enhanced by subcellular cAMP elevations in PI3Kgamma-deficient mice
    • Kerfant BG et al. (2005) Cardiac sarcoplasmic reticulum calcium release and load are enhanced by subcellular cAMP elevations in PI3Kgamma-deficient mice. Circ Res 96: 1079-1086
    • (2005) Circ Res , vol.96 , pp. 1079-1086
    • Kerfant, B.G.1
  • 69
    • 33644699984 scopus 로고    scopus 로고
    • Nuclear targeting of Akt enhances ventricular function and myocyte contractility
    • Rota M et al. (2005) Nuclear targeting of Akt enhances ventricular function and myocyte contractility. Circ Res 97: 1332-1341
    • (2005) Circ Res , vol.97 , pp. 1332-1341
    • Rota, M.1
  • 70
    • 10744225737 scopus 로고    scopus 로고
    • Mechanism of enhanced cardiac function in mice with hypertrophy induced by overexpressed Akt
    • Kim YK et al. (2003) Mechanism of enhanced cardiac function in mice with hypertrophy induced by overexpressed Akt. J Biol Chem 278: 47622-47628
    • (2003) J Biol Chem , vol.278 , pp. 47622-47628
    • Kim, Y.K.1
  • 71
    • 33745387361 scopus 로고    scopus 로고
    • 2+ currents via increased PI3Kalpha/PKB signaling
    • 2+ currents via increased PI3Kalpha/PKB signaling. Circ Res 98: 1390-1397
    • (2006) Circ Res , vol.98 , pp. 1390-1397
    • Sun, H.1
  • 72
    • 0032924246 scopus 로고    scopus 로고
    • Insulin resistance in patients with cardiac hypertrophy
    • Paternostro G et al. (1999) Insulin resistance in patients with cardiac hypertrophy. Cardiovasc Res 42: 246-253
    • (1999) Cardiovasc Res , vol.42 , pp. 246-253
    • Paternostro, G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.