Effects of Na+/Ca2+-exchanger overexpression on excitation-contraction coupling in adult rabbit ventricular myocytes

Journal of Molecular and Cellular Cardiology

Volumn 34, Issue 4, 2002, Pages 389-400

  Ranu, Hardeep K ^a   Terracciano, Cesare M N ^a   Davia, Kerry ^a   Bernobich, Elena ^a,b   Chaudhri, Babar ^a   Robinson, Susan E ^a   Kang, Zhao Bin ^c   Hajjar, Roger J ^c   MacLeod, Kenneth T ^a   Harding, Sian E ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b UNIVERSITY OF TRIESTE   (Italy)

^c NONE

Author keywords

Adenovirus; Gene transfer; Na+ Ca2+ exchanger; Rabbit

Indexed keywords

ADENOVIRUS VECTOR; CALCIUM CHANNEL L TYPE; CALCIUM ION; GREEN FLUORESCENT PROTEIN; SODIUM CALCIUM EXCHANGE PROTEIN; SODIUM ION; SODIUM;

ACTION POTENTIAL; ADENOVIRUS; ANIMAL CELL; ARTICLE; CALCIUM DEPLETION; CALCIUM TRANSPORT; CONTROLLED STUDY; DIASTOLE; EXCITATION CONTRACTION COUPLING; EXTRACELLULAR CALCIUM; GENE OVEREXPRESSION; GENE TRANSFER; GENETIC TRANSFECTION; HEART MUSCLE CONTRACTILE FORCE; HEART MUSCLE CONTRACTILITY; HEART MUSCLE FIBER MEMBRANE POTENTIAL; MALE; MEMBRANE STEADY POTENTIAL; MUSCLE CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RABBIT; SARCOPLASMIC RETICULUM; SODIUM CALCIUM EXCHANGE; SYSTOLE; VIRUS GENE; VIRUS INFECTION; ANIMAL; BIOSYNTHESIS; GENE VECTOR; GENETICS; HEART CONTRACTION; HEART FUNCTION TEST; HEART VENTRICLE; METABOLISM; PHYSIOLOGY;

ADENOVIRIDAE; ORYCTOLAGUS CUNICULUS;

ADENOVIRIDAE; ANIMALS; ELECTROPHYSIOLOGIC TECHNIQUES, CARDIAC; GENETIC VECTORS; HEART VENTRICLES; MALE; MUSCLE FIBERS; MYOCARDIAL CONTRACTION; RABBITS; SARCOPLASMIC RETICULUM; SODIUM; SODIUM-CALCIUM EXCHANGER;

EID: 0036545437     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmcc.2001.1521     Document Type: Article

References (41)

1. Bers, DM, Excitation-contraction coupling and cardiac contractile force. Dordrecht, Kluwer Academic, 1991.
2. Levi A.J., Spitzer K.W., Kohmoto O. Depolarization-induced Ca entry via Na-Ca exchange triggers SR release in guinea pig cardiac myocytes. Am J Physiol. 266:1994;H1422-H1433.
3. Terracciano C.M.N., De Souza A.I., Philipson K.D. Na-Ca exchange and sarcoplasmic reticular Ca regulation in ventricular myocytes from transgenic mice overexpressing the Na-Ca exchanger. J Physiol. 512:1998;651-677.
4. Bers D.M. Calcium fluxes involved in control of cardiac myocyte contraction. Circ Res. 87:2000;275-281.
5. Hasenfuss G., Reinecke H., Studer R. Relation between myocardial function and expression of sarcoplasmic reticulum Ca(2+)-ATPase in failing and nonfailing human myocardium. Circ Res. 75:1994;434-442.
6. Schwinger R.H., Bohm M., Schmidt U. Unchanged protein levels of SERCA II and phospholamban but reduced Ca2+ uptake and Ca(2+)-ATPase activity of cardiac sarcoplasmic reticulum from dilated cardiomyopathy patients compared with patients with nonfailing hearts. Circulation. 92:1995;3220-3228.
7. Schmidt U., Hajjar R.J., Helm P.A. Contribution of abnormal sarcoplasmic reticulum ATPase activity to systolic and diastolic dysfunction in human heart failure. J Mol Cell Cardiol. 30:1998;1929-1937.
8. Studer R., Reinecke H., Bilger J. Gene expression of the cardiac Na(+)-Ca2+ exchanger in end-stage human heart failure. Circ Res. 75:1994;443-453.
9. Flesch M., Schwinger R.H., Schiffer F. Evidence for functional relevance of an enhanced expression of the Na(+)-Ca2+ exchanger in failing human myocardium. Circulation. 94:1996;992-1002.
10. Litwin S.E., Bridge J.H. Enhanced Na(+)-Ca2+ exchange in the infarcted heart. Implications for excitation-contraction coupling. Circ Res. 81:1997;1083-1093.
11. 2+ exchanger expression and function in an arrhythmogenic rabbit model of heart failure. Circ Res. 85:1999;1009-1019.
12. Schackow T.E., Decker R.S., Ten Eick RE. Electrophysiology of adult cat cardiac ventricular myocytes: changes during primary culture. Am J Physiol. 268:1995;C1002-C1017.
13. Jacobson S.L., Piper H.M. Cell cultures of adult cardiomyocytes as models of the myocardium. J Mol Cell Cardiol. 18:1986;661-678.
14. Davia K., Hajjar R.J., Terracciano C.M.N. Functional alterations in adult rat myocytes after overexpression of phospholamban using adenovirus. Physiological Genomics. 1:1999;41-50.
15. Singh Kent N., Davia K., Harding S.E. Characterisation of the function of adult guinea-pig ventricular myocytes following coculture with neonatal rat myocytes. Basic Res Cardiol. 94:1999;9-14.
16. del Monte F., Harding S.E., Schmidt U. Restoration of contractile function in isolated cardiomyocytes from failing human hearts by gene transfer of SERCA2a. Circulation. 100:1999;2308-2311.
17. 2+ exchanger. Circ Res. 87:2000;581-587.
18. Terracciano C.M., Bernobich E., Davia K., Ranu H.K., MacLeod K.M., Hajjar R.J., Harding S.E. Adenovirus-mediated Na/Ca exchanger overexpression reduces sarcoplasmic reticulum (SR) Ca content in adult rabbit cardiomyocytes. Biophys J. 78:2000;A373A (Abstract).
19. Harding S.E., Vescovo G., Kirby M. Contractile responses of isolated rat and rabbit myocytes to isoproterenol and calcium. J Mol Cell Cardiol. 20:1988;635-647.
20. He T.C., Zhou S., da Costa L.T. A simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci USA. 95:1998;2509-2514.
21. Terracciano C.M., MacLeod K.T. Measurements of Ca entry and SR Ca content during the cardiac cycle in guinea-pig and rat ventricular myocytes. Biophys J. 72:1997;1319-1326.
22. Varro A., Negretti N., Hester S.B. An estimate of the calcium content of the sarcoplasmic reticulum in rat ventricular myocytes. Pflügers Archiv. 423:1993;158-160.
23. Baumer A.T., Flesch M., Kilter H. Overexpression of the Na(+)-Ca2+ exchanger leads to enhanced inotropic responsiveness to Na(+)-channel agonist without sarcoplasmic reticulum protein changes in transgenic mice. Biochem Biophys Res Commun. 249:1998;786-790.
24. Mitcheson J.S., Hancox J.C., Levi A.J. Action potentials, ion channel currents and transverse tubule density in adult rabbit ventricular myocytes maintained for 6 days in cell culture. Pflügers Archiv. 431:1996;814-827.
25. Terracciano C.M., Naqvi R.U., MacLeod K.T. Effects of rest interval on the release of calcium from the sarcoplasmic reticulum in isolated guinea-pig ventricular myocytes. Circ Res. 77:1995;354-360.
26. Bassani J.W., Yuan W., Bers D.M. Fractional SR Ca release is regulated by trigger Ca and SR Ca content in cardiac myocytes. Am J Physiol. 268:1995;C1313-C1319.
27. Janiak R., Lewartowski B. The source of contractile calcium in guinea-pig cardiac myocytes treated with thapsigargin. J Physiol Pharmacol. 47:1996;411-423.
28. Goldhaber J.I., Lamp S.T., Walter D.O. Local regulation of the threshold for calcium sparks in rat ventricular myocytes: role of sodium-calcium exchange. J Physiol. 520:1999;431-438.
29. Janiak R., Lewartowski B., Langer G.A. Functional coupling between sarcoplasmic reticulum and Na/Ca exchange in single myocytes of guinea-pig and rat heart. J Mol Cell Cardiol. 28:1996;253-264.
30. Blaustein M.P., Lederer W.J. Sodium/calcium exchange: its physiological implications. Physiol Rev. 79:1999;763-854.
31. Adachi Akahane S., Lu L., Li Z. Calcium signaling in transgenic mice overexpressing cardiac Na(+)-Ca2+ exchanger. J Gen Physiol. 109:1997;717-729.
32. Yao A., Su Z., Nonaka A. Effects of overexpression of the Na+-Ca2+ exchanger on [Ca2+]i transients in murine ventricular myocytes. Circ Res. 82:1998;657-665.
33. Bassani J.W.M., Bassani R.A., Bers D. Relaxation in rabbit and rat cardiac cells: species-dependent differences in cellular mechanisms. J Physiol. 476:1994;279-293.
34. Shattock M.J., Bers D.M. Rat vs. rabbit ventricle: Ca flux and intracellular Na assessed by ion-selective microelectrodes. Am J Physiol. 256:1989;C813-C822.
35. ORourke B., Kass D., Tomaselli G.F. Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, I: experimental studies. Circ Res. 84:1999;562-570.
36. Schwinger R.H., Wang J., Frank K. Reduced sodium pump alpha1, alpha3, and beta1-isoform protein levels and Na+,K+-ATPase activity but unchanged Na+-Ca2+ exchanger protein levels in human heart failure. Circulation. 99:1999;2105-2112.
37. 2+-exchanger protein level and diastolic function of failing human myocardium. Circulation. 99:1999;641-648.
38. Beuckelmann D.J., Nabauer M., Erdmann E. Alterations of K+ currents in isolated human ventricular myocytes from patients with terminal heart failure. Circ Res. 73:1993;379-385.
39. Muller Ehmsen J., Brixius K., Schwinger R.H. Positive inotropic effects of the novel Na+-channel modulator BDF 9198 in human nonfailing and failing myocardium. J Cardiovasc Pharmacol. 31:1998;684-689.
40. Danielsen W., v der L.H., Meyer W. Basal and isoprenaline-stimulated cAMP content in failing versus nonfailing human cardiac preparations. J Cardiovasc Pharmacol. 14:1989;171-173.
41. del Monte F., OGara P., Poole-Wilson P.A. Cell geometry and contractile abnormalities of myocytes from failing human left ventricle. Cardiovasc Res. 30:1995;281-290.