Mitochondrial complex I inhibition is not required for dopaminergic neuron death induced by rotenone, MPP+, or paraquat

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 39, 2008, Pages 15136-15141

  Choi, Won Seok ^a   Kruse, Shane E ^b   Palmiter, Richard D ^b   Xia, Zhengui ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Apoptosis; Cell death; Dopamine neurons; Ndufs4; Parkinson's disease

Indexed keywords

MPP; PARAQUAT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); ROTENONE; TOXIN; UNCLASSIFIED DRUG; DOPAMINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL CULTURE; CELL DEATH; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; DRUG INHIBITION; EMBRYO; ENZYME ACTIVITY; ENZYME INHIBITION; GENE; GENE DELETION; MESENCEPHALON; MOUSE; MOUSE STRAIN; NDUFS4 GENE; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN FUNCTION; SURVIVAL; ANIMAL; APOPTOSIS; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENETICS; METABOLISM; MOUSE MUTANT; NERVE CELL; PARKINSON DISEASE; PATHOLOGY;

MUS;

ANIMALS; APOPTOSIS; DOPAMINE; GENE DELETION; MICE; MICE, MUTANT STRAINS; NADH DEHYDROGENASE; NEURONS; PARAQUAT; PARKINSON DISEASE; ROTENONE;

EID: 54449089025     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0807581105     Document Type: Article

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