Identification and quantification of phenolic compounds in grapes by HPLC-PDA-ESI-MS on a semimicro separation scale

Journal of Agricultural and Food Chemistry

Volumn 56, Issue 19, 2008, Pages 8801-8808

  Nicoletti, Isabella ^a   Bello, Cristiano ^a   De Rossi, Antonella ^a   Corradini, Danilo ^a  

^a CNR   (Italy)

Author keywords

ESI MS detection; Grape berries; Narrow bore columns; Phenolic compounds; Photodiode array detection; RP HPLC

Indexed keywords

FLAVONOID; PHENOL DERIVATIVE; POLYPHENOLS;

ARTICLE; CHEMISTRY; ELECTROSPRAY MASS SPECTROMETRY; FRUIT; GRAPE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METHODOLOGY; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FLAVONOIDS; FRUIT; PHENOLS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; VITIS;

VITACEAE; VITIS VINIFERA;

EID: 54349123153     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf801411m     Document Type: Article

References (36)

1. Manach, C.; Scalbert, A.; Morand, C.; Jimenez, C. Bioavailability and bioefficacy of polyphenols in humans. Am. J. Clin. Nutr. 2004, 79, 727-747.
2. Hadacek, F. Secondary metabolites as plant traits: Current assessment and future perspectives. Crit. Rev. Plant Sci. 2002, 21, 273-322.
3. Meyer, A. S.; Heinonen, M.; Frankel, E. N. Antioxidant interactions of catechin, cyanidin, caffeic acid, quercetin, and ellagic acid on human LDL oxidation. Food Chem. 1998, 61, 71-75.
4. Ashida, H.; Fukuda, I.; Yamashita, T.; Kanazawa, K. Flavones and flavonols at dietary levels inhibit a transformation of aryl hydrocarbon receptor induced by dioxin. FEBS Lett. 2000, 476, 213-217.
5. kip1, and Cdc2C expression. Biochem. Pharmacol. 2001, 61, 979-989.
6. Yang, C. S.; Landau, J. M.; Huang, M. T.; Newmark, H. L. Inhibition of carcinogenesis by dietary polyphenolic compounds. Annu. Rev. Nutr. 2001, 21, 381-406.
7. Duffy, S. J.; Keaney, J. F.; Holbrook, M.; Gokce, N.; Swerdloff, P. L.; Frei, B.; Vita, J. A. Short- and long-term black tea consumption reverses endothelial dysfunction in patients with coronary artery disease. Circulation 2001, 104, 151-156.
8. Yamada, K.; Shoji, K.; Mori, M.; Ueyama, T.; Matsuo, N.; Oka, S.; Nishiyama, K.; Sugano, M. Structure-activity relationship of polyphenols on inhibition of chemical mediator release from rat peritoneal exudates cells. In Vitro Cell. Dev. Biol. 1999, 35, 169-174.
9. Downey, M. O.; Dokoozlian, N. K.; Krstic, M. P. Cultural practice and environmental impacts on the flavonoid composition of grapes and wine: A review of recent research. Am. J. Enol. Vitic. 2006, 57, 257-268.
10. Hufnagel, J. C.; Hofmann, T. Orosensory-directed identification of astringent mouthfeel and bitter-testing compounds in red wine. J. Agric. Food Chem. 2008, 56, 1376-1386.
11. Cantos, E.; Espín, J. C.; Tomás-Barberan, F. A. Varietal differences among the polyphenol profiles of seven table grape cultivars studied by LC-DAD-MS-MS. J. Agric. Food Chem. 2002, 48, 220-230.
12. Ojeda, H.; Andary, C.; Creaba, E.; Carbonneau, A.; Deloire, A. Influence of pre- and postveraison water deficit on synthesis and concentration of skin phenolic compounds during berry growth of Vitis vinifera var. Shiraz. Am. J. Enol. Vitic. 2002, 53, 261-267.
13. Castello-Munoz, N.; Gomez-Alonso, S.; Garcia-Romero, E.; Hermosin-Gutierrez, I. Flavonol profile of Vitis vinifera red grapes and their single-cultivar wines. J. Agric. Food Chem. 2007, 55, 992-1002.
14. Hermosín Gutiérrez, I.; García-Romero, E. Anthocyanins of red wine grape cultivars grown in the Spain region of La Mancha: characteristic cultivar patterns of grape and single cultivar wines, and evolution during the ripening of the berry. Alimentaria 2004, 41, 127-139.
15. Ryan, J. M.; Revilla, E. Anthocyanin composition of Cabernet Sauvignon and Tempranillo grapes at different stages of ripening. J. Agric. Food Chem. 2003, 51, 3372-3378.
16. Esterban, M. A.; Villanueva, M. J.; Lisarrague, J. R. Effect of irrigation on changes in the anthocyanin composition of the skin of cv. Tempranillo (Vitis vinifera L.) grape berries during ripening. J. Sci. Food Agric. 2001, 81, 409-420.
17. Lin, L. Z.; Harnly, J. M. A screening method for the identification of glycosylated flavonoids and other phenolic compounds using a standard analytical approach for all plant materials. J. Agric. Food Chem. 2007, 55, 1084-1096.
18. García-Falcón, M. S.; Pérez-Lamela, C.; Martínez-Carballo, E.; Simal-Gándara, J. Determination of phenolic compounds in wines: influence of bottle storage of young red wines in their evolution. Food Chem. 2007, 105, 248-259.
19. Abad-García, B.; Berrueta, L. A.; López-Márquez, D. M.; Crespo-Ferrer, I.; Gallo, B.; Vicente, F. Optimization and validation of a methodology based on solvent extraction and liquid chromatography for the simultaneous determination of several polyphenolic families in fruit juices. J. Chromatogr., A 2007, 1154, 87-96.
20. Makris, D. P.; Kallithraka, S.; Kefalas, P. Critical review flavonols in grape, grape products and wines: burden, profile and influential parameters. J. Food Compos. Anal. 2006, 19, 396-404.
21. van Straten, M. A.; Vermeer, E. A.; Claessens, H. A. A first step towards miniaturized HPLC systems in analytical routine analysis. LC-GC Int. 1996, 9, 42-50.
22. Careri, M.; Corradini, C.; Elviri, L.; Nicoletti, I.; Zagnoni, I. Direct HPLC analysis of quercetin and trans-resveratrol in red wine, grape, and winemaking byproducts. J. Agric. Food Chem. 2003, 51, 5226-5231.
23. Vrhovšek, U. Extraction of hydroxycinnamoyltartaric acids from berries of different grape varieties. J. Agric. Food Chem. 1998, 46, 4203-4208.
24. Iriti, M.; Faoro, F. Grape phytochemicals: a bouquet of old and new nutraceuticals for human hearts. Med. Hypotheses 2006, 67, 833-838.
25. Ortega-Regules, A.; Romero-Cascales, I.; Lopez-Roca, J. M.; Ros-Garcia, J. M.; Gomez-Plaza, E. Anthocyanin fingerprint of grapes: environmental and genetic variations. J. Sci. Food Agric. 2006, 86, 1460-1467.
26. Rauha, J. P.; Vuorela, H.; Kostiainen, R. Effect of eluent on the ionization efficiency of flavonoids by ion spray, atmospheric pressure chemical ionization, and atmospheric pressure photoionization mass spectrometry. J. Mass Spectrom. 2001, 36, 1269-1280.
27. Cuyckens, F.; Claeys, M. Optimization of a liquid chromatography method based on simultaneous electrospray ionization mass spectrometry and ultraviolet photodiode array detection for analysis of flavonoid glycosides. Rapid Commun. Mass Spectrom. 2002, 16, 2341-2348.
28. Snyder, L. R. Gradient Elution. In High-Performance Liquid Chromatography: Advances and Perspectives; Horváth, C., Ed.; Academic Press: New York, NY, 1980; Vol. 1, pp 294-298.
29. Law, B.; Temesi, D. Factors to consider in the development of generic bioanalytical high-performance liquid chromatographic-mass spectrometric methods to support drug discovery. J. Chromatogr., B 2000, 748, 21-30.
30. Rodríguez Montealegre, R.; Romero Peces, R.; Chacón Vozmediano, J. L.; Martínez Gascueña, J.; García Romero, E. Phenolic compounds in skins and seeds of ten grape Vitis vinifera varieties grown in a warm climate. J. Food Comp. Anal. 2006, 19, 687-693.
31. Lovino, R.; Baiano, A.; Pati, S.; Faccia, M.; Gambacorta, G. Phenolic composition of red grapes grown in southern Italy. Ital. Food Sci. 2006, 18, 177-186.
32. Sun, B.; Ribes, A. M.; Leandro, M. C.; Belchior, A. P.; Spranger, M. I. Stilbenes: quantitative extraction from grape skins, contribution to wine and variation during wine maturation. Anal. Chim. Acta 2006, 563, 382-390.
33. Mazza, G. Anthocyanins in grapes and grape products. Crit. Rev. Food Sci. Nutr. 1995, 35, 341-371.
34. Nuñez, V.; Monagas, M.; Gomez-Cordoves, M. C.; Bartolome, B. Vitis vinifera L. cv. Postharvest Biol. Technol. 2004, 31, 69-79.
35. Mattivi, F.; Guzzon, R.; Vrhovsek, U.; Stefanini, M.; Velasco, R. Metabolite profilino of grape: flavonols and anthocyanins. Agric. Food Chem. 2006, 54, 7692-7702.
36. Kallithraka, S.; Mohdaly, A. A. A.; Makris, D. P.; Kefalas, P. Determination of major anthocyanin pigments in Hellenic native grape varieties (Vitis vinifera sp.): association with antiradical activity. J. Food Compos. Anal. 2005, 18, 375-386.