Kinetic isotope effects on aromatic and benzylic hydroxylation by Chromobacterium violaceum phenylalanine hydroxylase as probes of chemical mechanism and reactivity

Biochemistry

Volumn 47, Issue 42, 2008, Pages 11118-11124

  Panay, Aram J ^a   Fitzpatrick, Paul F ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINATION; AMINES; AROMATIC COMPOUNDS; AROMATIZATION; CARRIER MOBILITY; CHEMICAL REACTIONS; CHEMICAL REACTIVITY; DEUTERIUM; ENZYMES; HYDROCARBONS; HYDROGEN; HYDROXYLATION; ISOTOPES; ORGANIC ACIDS; OXYGEN; PORPHYRINS; REACTION KINETICS;

AROMATIC AMINO ACID HYDROXYLASES; AROMATIC HYDROXYLATIONS; BACTERIAL; BENZYLIC; CHEMICAL MECHANISMS; CHROMOBACTERIUM VIOLACEUM; DEUTERIUM KINETIC ISOTOPE EFFECTS; HEME IRONS; HYDROXYLASES; INTRINSIC EFFECTS; IRON CENTERS; ISOTOPE EFFECTS; KINETIC ISOTOPE EFFECTS; MEASURING; METHYL GROUPS; MONOOXYGENASE; MUTANT ENZYMES; PHENYLALANINE HYDROXYLASE; TAUTOMERIZATION; TEMPERATURE DEPENDENCES;

AMINO ACIDS;

6 METHYLTETRAHYDROPTERIN; 6,7 METHYLTETRAHYDROPTERIN; AMINO ACID; AROMATIC CARBOXYLIC ACID; BENZILIC ACID; DEUTERIUM; IRON; ISOTOPE; OXYGEN; PHENYLALANINE 4 MONOOXYGENASE; PTERIN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; CHROMOBACTERIUM VIOLACEUM; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME STRUCTURE; EUKARYOTIC CELL; HYDROXYLATION; NONHUMAN; PRIORITY JOURNAL; PROKARYOTIC CELL; TEMPERATURE DEPENDENCE;

CHROMOBACTERIUM; HYDROXYLATION; ISOTOPES; KINETICS; MODELS, CHEMICAL; PHENYLALANINE HYDROXYLASE; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

BACTERIA (MICROORGANISMS); CHROMOBACTERIUM VIOLACEUM; EUKARYOTA; PROKARYOTA;

EID: 54349093029     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi801295w     Document Type: Article

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