-
1
-
-
0016832598
-
Steady-state analysis of kinetic isotope effects in enzymic reactions
-
Northrop, D. B., Steady-state analysis of kinetic isotope effects in enzymic reactions, Biochemistry, 14, 2644-2651, 1975.
-
(1975)
Biochemistry
, vol.14
, pp. 2644-2651
-
-
Northrop, D.B.1
-
2
-
-
0019524346
-
pH variation of isotope effects in enzyme-catalyzed reactions. 1. Isotope- and pH-dependent steps the same
-
Cook, P. F. and Cleland, W. W., pH variation of isotope effects in enzyme-catalyzed reactions. 1. Isotope- and pH-dependent steps the same, Biochemistry, 20, 1797-1805, 1981.
-
(1981)
Biochemistry
, vol.20
, pp. 1797-1805
-
-
Cook, P.F.1
Cleland, W.W.2
-
3
-
-
0018971732
-
Kinetic isotope effects in cytochrome P-450-catalyzed oxidation reactions. Intermolecular and intramolecular deuterium isotope effects during the N-demethylation of N, N-dimethylphentermine
-
Miwa, G. T., Garland, W. A., Hodshon, B. J., Lu, A. Y. H., and Northrop, D. B., Kinetic isotope effects in cytochrome P-450-catalyzed oxidation reactions. Intermolecular and intramolecular deuterium isotope effects during the N-demethylation of N, N-dimethylphentermine, J. Biol. Chem., 255, 6049-6054, 1980.
-
(1980)
J. Biol. Chem.
, vol.255
, pp. 6049-6054
-
-
Miwa, G.T.1
Garland, W.A.2
Hodshon, B.J.3
Lu, A.Y.H.4
Northrop, D.B.5
-
4
-
-
0000497670
-
Isotopically sensitive branching and its effect on the observed intramolecular isotope effects in cytochrome P-450 catalyzed reactions: A new method for the estimation of intrinsic isotope effects
-
Jones, J. P., Korzekwa, K., Rettie, A. E., and Trager, W., Isotopically sensitive branching and its effect on the observed intramolecular isotope effects in cytochrome P-450 catalyzed reactions: a new method for the estimation of intrinsic isotope effects, J. Am. Chem. Soc., 108, 7074-7078, 1986.
-
(1986)
J. Am. Chem. Soc.
, vol.108
, pp. 7074-7078
-
-
Jones, J.P.1
Korzekwa, K.2
Rettie, A.E.3
Trager, W.4
-
5
-
-
0024451771
-
Theory for the observed isotope effects from enzymatic systems that form multiple products via branched reaction patyways: Cytochrome P-450
-
Korzekwa, K. R., Trager, W. F., and Gillette, J. R., Theory for the observed isotope effects from enzymatic systems that form multiple products via branched reaction patyways: Cytochrome P-450, Biochemistry, 28, 9012-9018, 1989.
-
(1989)
Biochemistry
, vol.28
, pp. 9012-9018
-
-
Korzekwa, K.R.1
Trager, W.F.2
Gillette, J.R.3
-
6
-
-
0001674240
-
2
-
2, J. Am. Chem., 107, 7164-7167, 1985.
-
(1985)
J. Am. Chem.
, vol.107
, pp. 7164-7167
-
-
Hanzlik, R.P.1
Hogberg, K.2
Moon, J.B.3
Judson, C.M.4
-
7
-
-
0039812510
-
Heme-containing oxygenases
-
Sono, M., Roach, M. P., Coulter, E. D., and Dawson, J. H., Heme-containing oxygenases, Chem. Rev., 96, 2841-2888, 1996.
-
(1996)
Chem. Rev.
, vol.96
, pp. 2841-2888
-
-
Sono, M.1
Roach, M.P.2
Coulter, E.D.3
Dawson, J.H.4
-
8
-
-
0024980098
-
Deuterium isotope effects on toluene metabolism. Product release as a rate-limiting step in cytochrome P-450 catalysis
-
Ling, K.-H. J. and Hanzlik, R. P., Deuterium isotope effects on toluene metabolism. Product release as a rate-limiting step in cytochrome P-450 catalysis, Biochem. Biophys. Res. Commun., 160, 844-849, 1989.
-
(1989)
Biochem. Biophys. Res. Commun.
, vol.160
, pp. 844-849
-
-
Ling, K.-H.J.1
Hanzlik, R.P.2
-
9
-
-
0017392344
-
Intramolecular determination of primary kinetic isotope effects in hydroxylations catalyzed by cytochrome P-450
-
Hjelmeland, L. M., Aronow, L., and Trudell, J. R., Intramolecular determination of primary kinetic isotope effects in hydroxylations catalyzed by cytochrome P-450, Biochem. Biophys. Res. Commun., 76, 541-549, 1977.
-
(1977)
Biochem. Biophys. Res. Commun.
, vol.76
, pp. 541-549
-
-
Hjelmeland, L.M.1
Aronow, L.2
Trudell, J.R.3
-
10
-
-
0017800253
-
Aliphatic hydroxylation by highly purified liver microsomal cytochrome P-450. Evidence for a carbon radical intermediate
-
Groves, J. T., McClusky, G. A., White, R. E., and Coon, M. J., Aliphatic hydroxylation by highly purified liver microsomal cytochrome P-450. Evidence for a carbon radical intermediate, Biochem. Biophys. Res. Commun., 81, 154-160, 1978.
-
(1978)
Biochem. Biophys. Res. Commun.
, vol.81
, pp. 154-160
-
-
Groves, J.T.1
McClusky, G.A.2
White, R.E.3
Coon, M.J.4
-
11
-
-
12044258092
-
Active site dynamics of xylene hydroxylation by cytochrome P-450 as revealed by kinetic deuterium isotope effects
-
Hanzlik, R. P. and Ling, K.-H. J., Active site dynamics of xylene hydroxylation by cytochrome P-450 as revealed by kinetic deuterium isotope effects, J. Am. Chem. Soc., 115, 9363-9370, 1993.
-
(1993)
J. Am. Chem. Soc.
, vol.115
, pp. 9363-9370
-
-
Hanzlik, R.P.1
Ling, K.-H.J.2
-
12
-
-
0033550491
-
Experimental theoretical study of the effect of active-site constrained substrate motion on the magnitude of the observed intramolecular isotope effect for the p450 101 catalyzed benzylic hydroxylation of isomeric xylenes and 4,40-dimethylbiphenyl
-
Audergon, C., Iyer, K. R., Jones, J. P., Darbyshire, J. F., and Trager, W. F., Experimental theoretical study of the effect of active-site constrained substrate motion on the magnitude of the observed intramolecular isotope effect for the p450 101 catalyzed benzylic hydroxylation of isomeric xylenes and 4,40-dimethylbiphenyl, J. Am. Chem. Soc., 121, 41-47, 1999.
-
(1999)
J. Am. Chem. Soc.
, vol.121
, pp. 41-47
-
-
Audergon, C.1
Iyer, K.R.2
Jones, J.P.3
Darbyshire, J.F.4
Trager, W.F.5
-
13
-
-
0024991656
-
Active site dynamics of toluene hydroxylation by cytochrome P-450
-
Hanzlik, R. P. and Ling, K.-H. J., Active site dynamics of toluene hydroxylation by cytochrome P-450, J. Org. Chem., 55, 3992-3997, 1990.
-
(1990)
J. Org. Chem.
, vol.55
, pp. 3992-3997
-
-
Hanzlik, R.P.1
Ling, K.-H.J.2
-
14
-
-
0000385707
-
The separation of the intramolecular isotope effect for the cytochrome P-450 catalyzed hydroxylation of n-octane into its primary and secondary components
-
Jones, J. P. and Trager, W., The separation of the intramolecular isotope effect for the cytochrome P-450 catalyzed hydroxylation of n-octane into its primary and secondary components, J. Am. Chem. Soc., 109, 2171-2173, 1987.
-
(1987)
J. Am. Chem. Soc.
, vol.109
, pp. 2171-2173
-
-
Jones, J.P.1
Trager, W.2
-
15
-
-
0021100472
-
The use of intramolecular isotope effects to distinguish between deprotonation and hydrogen atom abstraction mechanisms in cytochrome P-450-and peroxidase-catalyzed N-demethylation reactions
-
Miwa, G. T., Walsh, J. S., Kedderis, G. L., and Hollenberg, P. F., The use of intramolecular isotope effects to distinguish between deprotonation and hydrogen atom abstraction mechanisms in cytochrome P-450-and peroxidase-catalyzed N-demethylation reactions, J. Biol. Chem., 258, 14445-14449, 1983.
-
(1983)
J. Biol. Chem.
, vol.258
, pp. 14445-14449
-
-
Miwa, G.T.1
Walsh, J.S.2
Kedderis, G.L.3
Hollenberg, P.F.4
-
16
-
-
0000901543
-
On isotope effects for the cytochrome P-450 oxidation of substituted N, N-dimethylanilines
-
Dinnocenzo, J. P., Karki, S. B., and Jones, J. P., On isotope effects for the cytochrome P-450 oxidation of substituted N, N-dimethylanilines, J. Am. Chem. Soc., 115, 7111-7116, 1993.
-
(1993)
J. Am. Chem. Soc.
, vol.115
, pp. 7111-7116
-
-
Dinnocenzo, J.P.1
Karki, S.B.2
Jones, J.P.3
-
17
-
-
0029970784
-
Evidence for a 1-electron oxidation mechanism in N-dealkylation of N, N-dialkylanilines by cytochrome P450 2B1. Kinetic hydrogen isotope effects, linear free energy relationships, comparisons with horseradish peroxidase, and studies with oxygen surrogates
-
Guengerich, F. P., Yun, C.-H., and MacDonald, T. L., Evidence for a 1-electron oxidation mechanism in N-dealkylation of N, N-dialkylanilines by cytochrome P450 2B1. Kinetic hydrogen isotope effects, linear free energy relationships, comparisons with horseradish peroxidase, and studies with oxygen surrogates, J. Biol. Chem., 271, 27321-27329, 1996.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 27321-27329
-
-
Guengerich, F.P.1
Yun, C.-H.2
MacDonald, T.L.3
-
18
-
-
0025279722
-
Kinetic deuterium isotope effects on the N-demethylation of tertiary amides by cytochrome P-450
-
Hall, L. R. and Hanzlik, R. P., Kinetic deuterium isotope effects on the N-demethylation of tertiary amides by cytochrome P-450, J. Biol. Chem., 265, 12349-12355, 1990.
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 12349-12355
-
-
Hall, L.R.1
Hanzlik, R.P.2
-
19
-
-
0028947612
-
Mechanism of oxidative amine dealkylation of substituted N, N-dimethylanilines by cytochrome P-450: Application of isotope effects profiles
-
Karki, S. B., Dinnocenzo, J. P., Jones, J. P., and Korzekwa, K. R., Mechanism of oxidative amine dealkylation of substituted N, N-dimethylanilines by cytochrome P-450: application of isotope effects profiles, J. Am. Chem. Soc., 117, 3657-3664, 1995.
-
(1995)
J. Am. Chem. Soc.
, vol.117
, pp. 3657-3664
-
-
Karki, S.B.1
Dinnocenzo, J.P.2
Jones, J.P.3
Korzekwa, K.R.4
-
20
-
-
0024843596
-
Deprotonation of tertiary amine cation radicals. A direct experimental approach
-
Dinnocenzo, J. P. and Banach, T. E., Deprotonation of tertiary amine cation radicals. A direct experimental approach, J. Am. Chem. Soc., 111, 8646-8653, 1989.
-
(1989)
J. Am. Chem. Soc.
, vol.111
, pp. 8646-8653
-
-
Dinnocenzo, J.P.1
Banach, T.E.2
-
21
-
-
0032852842
-
The tetrahydropterin-dependent amino acid hydroxylases
-
Fitzpatrick, P. F., The tetrahydropterin-dependent amino acid hydroxylases, Annu. Rev. Biochem., 68, 355-381, 1999.
-
(1999)
Annu. Rev. Biochem.
, vol.68
, pp. 355-381
-
-
Fitzpatrick, P.F.1
-
22
-
-
0345492036
-
Mechanism of aromatic amino acid hydroxylation
-
Fitzpatrick, P. F., Mechanism of aromatic amino acid hydroxylation, Biochemistry, 42, 14083-14091, 2003.
-
(2003)
Biochemistry
, vol.42
, pp. 14083-14091
-
-
Fitzpatrick, P.F.1
-
23
-
-
0034679014
-
On the catalytic mechanism of tryptophan hydroxylase
-
Moran, G. R., Derecskei-Kovacs, A., Hillas, P. J., and Fitzpatrick, P. F., On the catalytic mechanism of tryptophan hydroxylase, J. Am. Chem. Soc., 122, 4535-4541, 2000.
-
(2000)
J. Am. Chem. Soc.
, vol.122
, pp. 4535-4541
-
-
Moran, G.R.1
Derecskei-Kovacs, A.2
Hillas, P.J.3
Fitzpatrick, P.F.4
-
24
-
-
0033534158
-
The influence of steric bulk and electrostatics on the hydroxylation regiospecificity of tryptophan hydroxylase: Characterization of methyltryptophans and azatryptophans as substrates
-
Moran, G. R., Phillips, R. S., and Fitzpatrick, P. F., The influence of steric bulk and electrostatics on the hydroxylation regiospecificity of tryptophan hydroxylase: characterization of methyltryptophans and azatryptophans as substrates, Biochemistry, 38, 16283-16289, 1999.
-
(1999)
Biochemistry
, vol.38
, pp. 16283-16289
-
-
Moran, G.R.1
Phillips, R.S.2
Fitzpatrick, P.F.3
-
25
-
-
0025777217
-
The steady state kinetic mechanism of rat tyrosine hydroxylase
-
Fitzpatrick, P. F., The steady state kinetic mechanism of rat tyrosine hydroxylase, Biochemistry, 30, 3658-3662, 1991.
-
(1991)
Biochemistry
, vol.30
, pp. 3658-3662
-
-
Fitzpatrick, P.F.1
-
26
-
-
0025900994
-
Studies of the rate-limiting step in the tyrosine hydroxylase reaction: Alternate substrates, solvent isotope effects, and transition state analogs
-
Fitzpatrick, P. F., Studies of the rate-limiting step in the tyrosine hydroxylase reaction: alternate substrates, solvent isotope effects, and transition state analogs, Biochemistry, 30, 6386-6391, 1991.
-
(1991)
Biochemistry
, vol.30
, pp. 6386-6391
-
-
Fitzpatrick, P.F.1
-
27
-
-
0346434118
-
Uncoupled forms of tyrosine hydroxylase unmask kinetic isotope effects on chemical steps
-
Frantom, P. A. and Fitzpatrick, P. F., Uncoupled forms of tyrosine hydroxylase unmask kinetic isotope effects on chemical steps, J. Am. Chem. Soc., 125, 16190-16191, 2003.
-
(2003)
J. Am. Chem. Soc.
, vol.125
, pp. 16190-16191
-
-
Frantom, P.A.1
Fitzpatrick, P.F.2
-
28
-
-
3643061399
-
A mechanism for hydroxylation by tyrosine hydroxylase based on partitioning of substituted phenylalanines
-
Hillas, P. J. and Fitzpatrick, P. F., A mechanism for hydroxylation by tyrosine hydroxylase based on partitioning of substituted phenylalanines, Biochemistry, 35, 6969-6975, 1996.
-
(1996)
Biochemistry
, vol.35
, pp. 6969-6975
-
-
Hillas, P.J.1
Fitzpatrick, P.F.2
-
29
-
-
0037165727
-
Intrinsic deuterium isotope effects on benzylic hydroxylation by tyrosine hydroxylase
-
Frantom, P. A., Pongdee, R., Sulikowski, G. A., and Fitzpatrick, P. F., Intrinsic deuterium isotope effects on benzylic hydroxylation by tyrosine hydroxylase, J. Am. Chem. Soc., 124, 4202-4203, 2002.
-
(2002)
J. Am. Chem. Soc.
, vol.124
, pp. 4202-4203
-
-
Frantom, P.A.1
Pongdee, R.2
Sulikowski, G.A.3
Fitzpatrick, P.F.4
-
30
-
-
7744231498
-
Mechanisms whereby mononuclear copper proteins functionalize organic substrates
-
Klinman, J. P., Mechanisms whereby mononuclear copper proteins functionalize organic substrates, Chem. Rev., 96, 2541-2562, 1996.
-
(1996)
Chem. Rev.
, vol.96
, pp. 2541-2562
-
-
Klinman, J.P.1
-
31
-
-
0021861145
-
Secondary isotope effects and structure-reactivity correlations in the dopamine b-monooxygenase reaction: Evidence for a chemical mechanism
-
Miller, S. M. and Klinman, J. P., Secondary isotope effects and structure-reactivity correlations in the dopamine b-monooxygenase reaction: evidence for a chemical mechanism, Biochemistry, 24, 2114-2127, 1985.
-
(1985)
Biochemistry
, vol.24
, pp. 2114-2127
-
-
Miller, S.M.1
Klinman, J.P.2
-
32
-
-
0021109407
-
Magnitude of intrinsic isotope effects in the dopamine β-monooxygenase reaction
-
Miller, S. M. and Klinman, J. P., Magnitude of intrinsic isotope effects in the dopamine β-monooxygenase reaction, Biochemistry, 22, 3091-3096, 1983.
-
(1983)
Biochemistry
, vol.22
, pp. 3091-3096
-
-
Miller, S.M.1
Klinman, J.P.2
-
33
-
-
0021799987
-
3-Phenylpropenes as mechanism-based inhibitors of dopamine b-hydroxylase: Evidence for a radical mechanism
-
Fitzpatrick, P. F., Flory, D. R. Jr., and Villafranca, J. J., 3-Phenylpropenes as mechanism-based inhibitors of dopamine b-hydroxylase: evidence for a radical mechanism, Biochemistry, 24, 2108-2114, 1985.
-
(1985)
Biochemistry
, vol.24
, pp. 2108-2114
-
-
Fitzpatrick, P.F.1
Flory, D.R.2
Villafranca, J.J.3
-
34
-
-
0023002228
-
The mechanism of inactivation of dopamine b-hydroxylase by hydrazines
-
Fitzpatrick, P. F. and Villafranca, J. J., The mechanism of inactivation of dopamine b-hydroxylase by hydrazines, J. Biol. Chem., 261, 4510-4518, 1986.
-
(1986)
J. Biol. Chem.
, vol.261
, pp. 4510-4518
-
-
Fitzpatrick, P.F.1
Villafranca, J.J.2
|