Atomistic insight into the origin of the temperature-dependence of kinetic isotope effects and H-tunnelling in enzyme systems is revealed through combined experimental studies and biomolecular simulation

Biochemical Society Transactions

Volumn 36, Issue 1, 2008, Pages 16-21

  Hay, Sam ^a   Pudney, Christopher ^a   Hothi, Parvinder ^a   Johannissen, Linus O ^b   Masgrau, Laura ^b   Pang, Jiayun ^b   Leys, David ^a   Sutcliffe, Michael J ^b   Scrutton, Nigel S ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Enzyme mechanism; H tunnelling; Kinetic isotope effect; Protein dynamics; Redox catalysis; Temperature dependence

Indexed keywords

ISOTOPE; QUINONE DERIVATIVE;

ARTICLE; BIOLOGICAL MONITORING; CATALYSIS; COMPUTER SIMULATION; ENERGY; KINETICS; MATHEMATICAL COMPUTING; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTON TRANSPORT; QUANTUM MECHANICS; TEMPERATURE DEPENDENCE;

COMPUTER SIMULATION; ENZYMES; ISOTOPES; KINETICS; MODELS, MOLECULAR; TEMPERATURE;

EID: 39449086415     PISSN: 03005127     EISSN: None     Source Type: Journal    
DOI: 10.1042/BST0360016     Document Type: Article

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