Mice lacking multidrug resistance protein 3 show altered morphine pharmacokinetics and morphine-6-glucuronide antinociception

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 20, 2005, Pages 7274-7279

  Zelcer, Noam ^a,e   Van De Wetering, Koen ^a,e   Hillebrand, Michel ^b   Sarton, Elise ^c   Kuil, Annemieke ^a   Wielinga, Peter R ^a   Tephly, Thomas ^d   Dahan, Albert ^c   Beijnen, Jos H ^b   Borst, Piet ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b SLOTERVAART HOSPITAL   (Netherlands)

^c LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^d UNIVERSITY OF IOWA   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Analgesia; Glucuronides; Morphine 3 glucuronide; Transport

Indexed keywords

MORPHINE; MORPHINE 6 GLUCURONIDE; MULTIDRUG RESISTANCE PROTEIN 3;

ANALGESIA; ANIMAL CELL; ANTINOCICEPTION; ARTICLE; BASOLATERAL MEMBRANE; BILE LEVEL; BLOOD FLOW; CELL FUNCTION; CONTROLLED STUDY; DETOXIFICATION; DRUG BILE LEVEL; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG LIVER LEVEL; DRUG POTENCY; GLUCURONIDATION; HUMAN; HUMAN CELL; IN VITRO STUDY; MEMBRANE TRANSPORT; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BILE; CELL LINE; GLUCURONOSYLTRANSFERASE; HUMANS; LIVER; MICE; MICE, KNOCKOUT; MORPHINE; MORPHINE DERIVATIVES; P-GLYCOPROTEINS; PAIN MEASUREMENT; PROTEIN TRANSPORT; SPODOPTERA; TISSUE DISTRIBUTION; TRANSPORT VESICLES;

MAMMALIA; STAPHYLOCOCCUS PHAGE 3A;

EID: 21044435938     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0502530102     Document Type: Article

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