T cells in rheumatoid arthritis

Arthritis Research and Therapy

Volumn 10, Issue SUPPL. 1, 2008, Pages

  Cope, Andrew P ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD45RO ANTIGEN; CD8 ANTIGEN; INTERLEUKIN 13; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; STROMAL CELL DERIVED FACTOR 1;

AUTOIMMUNITY; BIOLOGICAL THERAPY; CELLULAR IMMUNITY; CHRONIC INFLAMMATION; CYTOKINE PRODUCTION; CYTOLOGY; HUMAN; IMMUNOPATHOLOGY; INDIVIDUALIZATION; LYMPHOCYTIC INFILTRATION; MOLECULAR BIOLOGY; PATHOGENESIS; PATIENT CARE; REVIEW; RHEUMATOID ARTHRITIS; T LYMPHOCYTE; TECHNOLOGY; IMMUNOLOGY;

ARTHRITIS, RHEUMATOID; HUMANS; T-LYMPHOCYTES;

EID: 54049126553     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar2412     Document Type: Review

References (85)

1. Cope AP Rheumatoid arthritis Clinical Immunology New York, NY: Elsevier Rich RR, Fleischer TA, Shearer WT, Schroeder HW, Frew AJ, Weyard CM 3 2008, 52.1-52.23.
2. Furst DE Breedveld FC Kalden JR Smolen JS Burmester GR Sieper J Emery P Keystone EC Schiff MH Mease P van Riel PL Fleischmann R Weisman MH Weinblatt ME Updated consensus statement on biological agents for the treatment of rheumatic diseases, 2007 Ann Rheum Dis 2007, 66(suppl 2):22. 10.1136/ard.2007.081430
3. Müller-Ladner U Ospelt C Gay S Distler O Pap T Cells of the synovium in rheumatoid arthritis. Synovial fibroblasts Arthritis Res Ther 2007, 9:223. 10.1186/ar2337
4. Duke O Panayi GS Janossy G Poulter LW An immunohistological analysis of lymphocyte subpopulations and their microenvironment in the synovial membranes of patients with rheumatoid arthritis using monoclonal antibodies Clin Exp Immunol 1982, 49:22-30.
5. Schröder AE Greiner A Seyfert C Berek C Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with rheumatoid arthritis Proc Natl Acad Sci USA 1996, 93:221-225. 10.1073/ pnas.93.1.221
6. Weyand CM Kurtin PJ Goronzy JJ Ectopic lymphoid organogenesis: A fast track for autoimmunity Am J Pathol 2001, 159:787-793.
7. Takemura S Braun A Crowson C Kurtin PJ Cofield RH O'Fallon WM Goronzy JJ Weyand CM Lymphoid neogenesis in rheumatoid synovitis J Immunol 2001, 167:1072-1080.
8. van Oosterhout M Bajema I Levarht EW Toes RE Huizinga TW van Laar JM Differences in synovial tissue infiltrates between anti-cyclic citrullinated peptide-positive rheumatoid arthritis and anti-cyclic citrullinated peptide-negative rheumatoid arthritis Arthritis Rheum 2008, 58:53-60. 10.1002/art.23148
9. + T cells in the formation of germinal centers in rheumatoid synovitis J Immunol 1998, 161:6390-6397.
10. Kang YM Zhang X Wagner UG Yang H Beckenbaugh RD Kurtin PJ Goronzy JJ Weyand CM CD8 T cells are required for the formation of ectopic germinal centers in rheumatoid synovitis J Exp Med 2002, 195:1325-1336. 10.1084/ jem.20011565
11. Timmer TC Baltus B Vondenhoff M Huizinga TW Tak PP Verweij CL Mebius RE Pouw Kraan van der TC Inflammation and ectopic lymphoid structures in rheumatoid arthritis synovial tissues dissected by genomics technology: identification of the interleukin-7 signaling pathway in tissues with lymphoid neogenesis Arthritis Rheum 2007, 56:2492-2502. 10.1002/art.22748
12. Koetz K Bryl E Spickschen K O'Fallon WM Goronzy JJ Weyand CM T cell homeostasis in patients with rheumatoid arthritis Proc Natl Acad Sci USA 2000, 97:9203-9208. 10.1073/pnas.97.16.9203
13. Ponchel F Morgan AW Bingham SJ Quinn M Buch M Verburg RJ Henwood J Douglas SH Masurel A Conaghan P Gesinde M Taylor J Markham AF Emery P van Laar JM Isaacs JD Dys-regulated lymphocyte proliferation and differentiation in patients with rheumatoid arthritis Blood 2002, 100:4550-4556. 10.1182/blood-2002-03-0671
14. Schönland SO Lopez C Widmann T Zimmer J Bryl E Goronzy JJ Weyand CM Premature telomeric loss in rheumatoid arthritis is genetically determined and involves both myeloid and lymphoid cell lineages Proc Natl Acad Sci USA 2003, 100:13471-13476. 10.1073/pnas.2233561100
15. Salmon M Scheel-Toellner D Huissoon AP Pilling D Shamsadeen N Hyde H D'Angeac AD Bacon PA Emery P Akbar AN Inhibition of T cell apoptosis in the rheumatoid synovium J Clin Invest 1997, 99:439-446. 10.1172/JCI119178
16. - T cells in rheumatoid arthritis Mol Med 1996, 2:608-618.
17. Maurice MM Lankester AC Bezemer AC Geertsma MF Tak PP Breedveld FC van Lier RA Verweij CL Defective TCR-mediated signaling in synovial T cells in rheumatoid arthritis J Immunol 1997, 159:2973-2978.
18. Zhang Z Gorman CL Vermi AC Monaco C Foey A Owen S Amjadi P Vallance A McClinton C Marelli-Berg F Isomäki P Russell A Dazzi F Vyse TJ Brennan FM Cope AP TCRzetadim lymphocytes define populations of circulating effector cells that migrate to inflamed tissues Blood 2007, 109:4328-4335. 10.1182/blood-2006-12-064170
19. Dolhain RJ Heiden van der AN ter Haar NT Breedveld FC Miltenburg AM Shift toward T lymphocytes with a T helper 1 cytokine-secretion profile in the joints of patients with rheumatoid arthritis Arthritis Rheum 1996, 12:1961-1969. 10.1002/art.1780391204
20. + T cells into synovial tissue in patients with rheumatoid arthritis Acta Med Okayama 2006, 60:149-157.
21. Weyand CM Goronzy JJ Medium- and large-vessel vasculitis N Engl J Med 2003, 349:160-169. 10.1056/NEJMra022694
22. Liuzzo G Goronzy JJ Yang H Kopecky SL Holmes DR Frye RL Weyand CM Monoclonal T-cell proliferation and plaque instability in acute coronary syndromes Circulation 2000, 101:2883-2888.
23. Giacomelli R Passacantando A Perricone R Parzanese I Rascente M Minisola G Tonietti G T lymphocytes in the synovial fluid of patients with active rheumatoid arthritis display CD134-OX40 surface antigen Clin Exp Rheumatol 2001, 19:317-320.
24. null T cells clonally expanded in rheumatoid arthritis J Immunol 2000, 165:1138-1145.
25. Snyder MR Nakajima T Leibson PJ Weyand CM Goronzy JJ Stimulatory killer Ig-like receptors modulate T cell activation through DAP12-dependent and DAP12-independent mechanisms J Immunol 2004, 173:3725-3731.
26. Groh V Bruhl A El-Gabalawy H Nelson JL Spies T Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis Proc Natl Acad Sci USA 2003, 100:9452-9457. 10.1073/ pnas.1632807100
27. Courtenay JS Dallman MJ Dayan AD Martin A Mosedale B Immunisation against heterologous type II collagen induces arthritis in mice Nature 1980, 283:666-668. 10.1038/283666a0
28. Verheijden GF Rijnders AW Bos E Coenen-de Roo CJ van Staveren CJ Miltenburg AM Meijerink JH Elewaut D de Keyser F Veys E Boots AM Human cartilage glycoprotein-39 as a candidate autoantigen in rheumatoid arthritis Arthritis Rheum 1997, 40:1115-1125. 10.1002/art.1780400616
29. Szántó S Bárdos T Szabó Z David CS Buzás EI Mikecz K Glant TT Induction of arthritis in HLA-DR4-humanized and HLA-DQ8-humanized mice by human cartilage proteoglycan aggrecan but only in the presence of an appropriate (non-MHC) genetic background Arthritis Rheum 2004, 50:1984-1995. 10.1002/ art.20285
30. Van Eden W Wick G Albani S Cohen I Stress, heat shock proteins, and autoimmunity: How immune responses to heat shock proteins are to be used for the control of chronic inflammatory diseases Ann N Y Acad Sci 2007, 1113:217-237. 10.1196/annals.1391.020
31. Bodman-Smith MD Corrigall VM Berglin E Cornell HR Tzioufas AG Mavragani CP Chan C Rantapää-Dahlqvist S Panayi GS Antibody response to the human stress protein BiP in rheumatoid arthritis Rheumatology 2004, 43:1283-1287. 10.1093/rheumatology/keh312
32. +T cell clones in elderly humans J Immunol 1997, 158:4493-4499.
33. Goronzy JJ Weyand CM Aging, autoimmunity and arthritis: T-cell senescence and contraction of T-cell repertoire diversity-catalysts of autoimmunity and chronic inflammation Arthritis Res Ther 2003, 5:225-234. 10.1186/ar974
34. Fitzgerald JE Ricalton NS Meyer AC West SG Kaplan H Behrendt C Kotzin BL Analysis of clonal CD8+ T cell expansions in normal individuals and patients with rheumatoid arthritis J Immunol 1995, 154:3538-3547.
35. Hingorani R Monteiro J Furie R Chartash E Navarrete C Pergolizzi R Gregersen PK Oligoclonality of V beta 3 TCR chains in the CD8+ T cell population of rheumatoid arthritis patients J Immunol 1996, 156:852-858.
36. Wagner UG Koetz K Weyand CM Goronzy JJ Perturbation of the T cell repertoire in rheumatoid arthritis Proc Natl Acad Sci USA 1998, 95:14447-14452. 10.1073/pnas.95.24.14447
37. Unutmaz D Pileri P Abrignani S Antigen-independent activation of naive and memory resting T cells by a cytokine combination J Exp Med 1994, 180:1159-1164. 10.1084/jem.180.3.1159
38. Gregersen PK Silver J Winchester RJ The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis Arthritis Rheum 1987, 30:1205-1213. 10.1002/ art.1780301102
39. Huizinga TW Amos CI Helm-van Mil van der AH Chen W van Gaalen FA Jawaheer D Schreuder GM Wener M Breedveld FC Ahmad N Lum RF de Vries RR Gregersen PK Toes RE Criswell LA Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteins Arthritis Rheum 2005, 52:3433-3438. 10.1002/art.21385
40. van Venrooij WJ Zendman AJ Pruijn GJ Autoantibodies to citrullinated antigens in (early) rheumatoid arthritis Autoimmun Rev 2006, 6:37-41. 10.1016/j.autrev.2006.03.008
41. Schellekens GA de Jong BA Hoogen van den FH Putte van de LB van Venrooij WJ Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies J Clin Invest 1998, 101:273-281. 10.1172/JCI1316
42. Hill JA Southwood S Sette A Jevnikar AM Bell DA Cairns E Cutting edge: the conversion of arginine to citrulline allows for a high-affinity peptide interaction with the rheumatoid arthritis-associated HLA-DRB1*0401 MHC class II molecule J Immunol 2003, 171:538-541.
43. Klareskog L Rönnelid J Lundberg K Padyukov L Alfredsson L Immunity to citrullinated proteins in rheumatoid arthritis Annu Rev Immunol 2008, 26:651-675. 10.1146/annurev.immunol.26.021607.090244
44. Auger I Roudier C Guis S Balandraud N Roudier J HLA-DRB1*0404 is strongly associated with anticalpastatin antibodies in rheumatoid arthritis Ann Rheum Dis 2007, 66:1588-1593. 10.1136/ard.2006.067231
45. Steenbakkers PG Baeten D Rovers E Veys EM Rijnders AW Meijerink J De Keyser F Boots AM Localization of MHC class II/human cartilage glycoprotein-39 complexes in synovia of rheumatoid arthritis patients using complex-specific monoclonal antibodies J Immunol 2003, 170:5719-5727.
46. Thomas R Davis LS Lipsky PE Rheumatoid synovium is enriched in mature antigen-presenting dendritic cells J Immunol 1994, 152:2613-2623.
47. McInnes IB Schett G Cytokines in the pathogenesis of rheumatoid arthritis Nat Rev Immunol 2007, 7:429-442. 10.1038/nri2094
48. Raza K Scheel-Toellner D Lee CY Pilling D Curnow SJ Falciani F Trevino V Kumar K Assi LK Lord JM Gordon C Buckley CD Salmon M Synovial fluid leukocyte apoptosis is inhibited in patients with very early rheumatoid arthritis Arthritis Res Ther 2006, 8:R120. 10.1186/ar2009
49. Prots I Skapenko A Wendler J Mattyasovszky S Yoné CL Spriewald B Burkhardt H Rau R Kalden JR Lipsky PE Schulze-Koops H Association of the IL4R single-nucleotide polymorphism I50V with rapidly erosive rheumatoid arthritis Arthritis Rheum 2006, 54:1491-500. 10.1002/art.21832
50. Weaver CT Hatton RD Mangan PR Harrington LE IL-17 family cytokines and the expanding diversity of effector T cell lineages Annu Rev Immunol 2007, 25:821-852. 10.1146/annurev.immunol.25.022106.141557
51. Chabaud M Durand JM Buchs N Fossiez F Page G Frappart L Miossec P Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium Arthritis Rheum 1999, 42:963-970. 10.1002/ 1529-0131(199905)42:5<963::AID-ANR15>3.0.CO;2-E
52. + CXC chemokine expression in synoviocytes and are overexpressed in rheumatoid blood J Immunol 2008, 180:655-663.
53. Chabaud M Garnero P Dayer JM Guerne PA Fossiez F Miossec P Contribution of interleukin 17 to synovium matrix destruction in rheumatoid arthritis Cytokine 2000, 12:1092-1099. 10.1006/cyto.2000.0681
54. Miossec P Interleukin-17 in fashion, at last: Ten years after its description, its cellular source has been identified Arthritis Rheum 2007, 56:2111-2115. 10.1002/art.22733
55. Yamada H Nakashima Y Okazaki K Mawatari T Fukushi JI Kaibara N Hori A Iwamoto Y Yoshikai Y Th1 but not Th17 cells predominate in the joints of patients with rheumatoid arthritis Ann Rheum Dis 2007.
56. McInnes IB Leung BP Sturrock RD Field M Liew FY Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-alpha production in rheumatoid arthritis Nat Med 1997, 3:189-195. 10.1038/nm0297-189
57. Beech JT Andreakos E Ciesielski CJ Green P Foxwell BM Brennan FM T-cell contact-dependent regulation of CC and CXC chemokine production in monocytes through differential involvement of NFkappaB: Implications for rheumatoid arthritis Arthritis Res Ther 2006, 8:R168. 10.1186/ar2077
58. Lacraz S Isler P Vey E Welgus HG Dayer JM Direct contact between T lymphocytes and monocytes is a major pathway for induction of metalloproteinase expression J Biol Chem 1994, 269:22027-22033.
59. Burger D Dayer JM The role of human T-lymphocyte-monocyte contact in inflammation and tissue destruction Arthritis Res 2002, 4(suppl):S169-S176. 10.1186/ar558
60. Rezzonico R Burger D Dayer JM Direct contact between T lymphocytes and human dermal fibroblasts or synoviocytes down-regulates types I and III collagen production via cell-associated cytokines J Biol Chem 1998, 273:18720-18728. 10.1074/jbc.273.30.18720
61. Yamamura Y Gupta R Morita Y He X Pai R Endres J Freiberg A Chung K Fox DA Effector function of resting T cells: Activation of synovial fibroblasts J Immunol 2001, 166:2270-2275.
62. Tran CN Lundy SK White PT Endres JL Motyl CD Gupta R Wilke CM Shelden EA Chung KC Urquhart AG Fox DA Molecular interactions between T cells and fibroblast-like synoviocytes: Role of membrane tumor necrosis factor-alpha on cytokine-activated T cells Am J Pathol 2007, 171:1588-1598. 10.2353/ajpath.2007.070004
63. Udagawa N Kotake S Kamatani N Takahashi N Suda T The molecular mechanism of osteoclastogenesis in rheumatoid arthritis Arthritis Res 2002, 4:281-289. 10.1186/ar431
64. Zheng Y Rudensky AY Foxp3 in control of the regulatory T cell lineage Nat Immunol 2007, 8:457-462. 10.1038/ni1455
65. Wang J Ioan-Facsinay A Voort van der EI Huizinga TW Toes RE Transient expression of FOXP3 in human activated non-regulatory CD4+ T cells Eur J Immunol 2007, 37:129-138. 10.1002/eji.200636435
66. + regulatory T cells are enriched in inflamed joints of patients with chronic rheumatic disease Arthritis Res Ther 2004, 6:R335-R346. 10.1186/ar1192
67. Baecher-Allan C Hafler DA Human regulatory T cells and their role in autoimmune disease Immunol Rev 2006, 212:203-216. 10.1111/ j.0105-2896.2006.00417.x
68. + regulatory T cell-mediated suppression in rheumatoid arthritis Arthritis Rheum 2007, 56:732-742. 10.1002/art.22414
69. Valencia X Stephens G Goldbach-Mansky R Wilson M Shevach EM Lipsky PE TNF downmodulates the function of human CD4+CD25hi T-regulatory cells Blood 2006, 108:253-261. 10.1182/blood-2005-11-4567
70. Nadkarni S Mauri C Ehrenstein MR Anti-TNF-alpha therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-beta J Exp Med 2007, 204:33-39. 10.1084/jem.20061531
71. + regulatory T cells in rheumatoid arthritis: Differences in the presence, phenotype, and function between peripheral blood and synovial fluid Arthritis Rheum 2004, 50:2775-2785. 10.1002/art.20499
72. Zhu L Ji F Wang Y Zhang Y Liu Q Zhang JZ Matsushima K Cao Q Zhang Y Synovial autoreactive T cells in rheumatoid arthritis resist IDO-mediated inhibition J Immunol 2006, 177:8226-8233.
73. Nguyen LT Jacobs J Mathis D Benoist C Where FoxP3-dependent regulatory T cells impinge on the development of inflammatory arthritis Arthritis Rheum 2007, 56:509-520. 10.1002/art.22272
74. Swanberg M Lidman O Padyukov L Eriksson P Akesson E Jagodic M Lobell A Khademi M Börjesson O Lindgren CM Lundman P Brookes AJ Kere J Luthman H Alfredsson L Hillert J Klareskog L Hamsten A Piehl F Olsson T MHC2TA is associated with differential MHC molecule expression and susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction Nat Genet 2005, 37:486-494. 10.1038/ng1544
75. Suzuki A Yamada R Chang X Tokuhiro S Sawada T Suzuki M Nagasaki M Nakayama-Hamada M Kawaida R Ono M Ohtsuki M Furukawa H Yoshino S Yukioka M Tohma S Matsubara T Wakitani S Teshima R Nishioka Y Sekine A Iida A Takahashi A Tsunoda T Nakamura Y Yamamoto K Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis Nat Genet 2003, 34:395-402. 10.1038/ ng1206
76. Plenge RM Padyukov L Remmers EF Purcell S Lee AT Karlson EW Wolfe F Kastner DL Alfredsson L Altshuler D Gregersen PK Klareskog L Rioux JD Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4 Am J Hum Genet 2005, 1044-1060. 10.1086/498651
77. Lin SC Yen JH Tsai JJ Tsai WC Ou TT Liu HW Chen CJ Association of a programmed death 1 gene polymorphism with the development of rheumatoid arthritis, but not systemic lupus erythematosus Arthritis Rheum 2004, 50:770-775. 10.1002/art.20040
78. Remmers EF Plenge RM Lee AT Graham RR Hom G Behrens TW de Bakker PI Le JM Lee HS Batliwalla F Li W Masters SL Booty MG Carulli JP Padyukov L Alfredsson L Klareskog L Chen WV Amos CI Criswell LA Seldin MF Kastner DL Gregersen PK STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus N Engl J Med 2007, 357:977-986. 10.1056/NEJMoa073003
79. Begovich AB Carlton VE Honigberg LA Schrodi SJ Chokkalingam AP Alexander HC Ardlie KG Huang Q Smith AM Spoerke JM Conn MT Chang M Chang SY Saiki RK Catanese JJ Leong DU Garcia VE McAllister LB Jeffery DA Lee AT Batliwalla F Remmers E Criswell LA Seldin MF Kastner DL Amos CI Sninsky JJ Gregersen PK A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis Am J Hum Genet 2004, 75:330-337. 10.1086/422827
80. Wu J Katrekar A Honigberg LA Smith AM Conn MT Tang J Jeffery D Mortara K Sampang J Williams SR Buggy J Clark JM Identification of substrates of human protein-tyrosine phosphatase PTPN22 J Biol Chem 2006, 281:11002-11010. 10.1074/jbc.M600498200
81. Vang T Congia M Macis MD Musumeci L Orrú V Zavattari P Nika K Tautz L Taskén K Cucca F Mustelin T Bottini N Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant Nat Genet 2005, 37:1317-1319. 10.1038/ng1673
82. Bottini N Vang T Cucca F Mustelin T Role of PTPN22 in type 1 diabetes and other autoimmune diseases Semin Immunol 2006, 18:207-213. 10.1016/ j.smim.2006.03.008
83. Sakaguchi N Takahashi T Hata H Nomura T Tagami T Yamazaki S Sakihama T Matsutani T Negishi I Nakatsuru S Sakaguchi S Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice Nature 2003, 426:454-460. 10.1038/nature02119
84. + Th cells that cause autoimmune arthritis J Exp Med 2007, 204:41-47. 10.1084/jem.20062259
85. Rieck M Arechiga A Onengut-Gumuscu S Greenbaum C Concannon P Buckner JH Genetic variation in PTPN22 corresponds to altered function of T and B lymphocytes J Immunol 2007, 179:4704-4710.