Defective TCR-mediated signaling in synovial T cells in rheumatoid arthritis

Journal of Immunology

Volumn 159, Issue 6, 1997, Pages 2973-2978

  Maurice, Madelon M ^a   Lankester, Arjan C ^b,c   Bezemer, Anja C ^a   Geertsma, Minke F ^a   Tak, Paul Peter ^a   Breedveld, Ferdinand C ^a   Van Lier, René A W ^b,c   Verweij, Cornelis L ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b CENTRAL LABORATORY   (Netherlands)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN T CELL RECEPTOR, ZETA CHAIN; LYMPHOCYTE ANTIGEN RECEPTOR; MEMBRANE PROTEIN;

ARTICLE; CELL CULTURE; FLOW CYTOMETRY; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; SYNOVIUM; T LYMPHOCYTE;

ARTHRITIS, RHEUMATOID; CELLS, CULTURED; FLOW CYTOMETRY; HUMANS; IMMUNOHISTOCHEMISTRY; MEMBRANE PROTEINS; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; SYNOVIAL MEMBRANE; T-LYMPHOCYTES;

EID: 0031571717     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Hemler, M. E., D. Glass, J. S. Coblyn, and J. G. Jacobson. 1986. Very late activation antigens on rheumatoid synovial T lymphocytes: association with stages of T cell activation. J. Clin. Invest. 78:696.
2. Takahashi, H., K. Söderström, E. Nilsson, R. Kiessling, and M. Patarroyo. 1992. Integrins and other adhesion molecules on lymphocytes from synovial fluid and peripheral blood of rheumatoid arthritis patients. Eur. J. Immunol. 22:2879.
3. Duke, O., G. S. Panayi, G. Janossy, L. W. Poulter, and N. H. Tidman. 1983. Analysis of T cell subsets in the peripheral blood and synovial fluid of patients with rheumatoid arthritis by means of monoclonal antibodies. Ann. Rheum. Dis. 42:357.
4. Afeltra, A., M. Galeazzi, G. M. Ferri, A. Amoroso, O. De Pita, F. Porzio, and L. Bonomo. 1993. Expression of CD69 antigen on synovial fluid T cells in patients with rheumatoid arthritis and chronic synovitis. Ann. Rheum. Dis. 52:457.
5. Galeazzi, M., A. Afeltra, F. Porzio, and L. Bonomo. 1990. The activation markers on synovial T-cells of rheumatoid arthritis. Clin. Rheumatol. 9:561.
6. Laffon, A., R. Garcia Vicuna, A. Humbria, A. A. Postigo, A. L. Corbi, M. O. de Landazuri, and F. Sanchez Madrid. 1991. Upregulated expression and function of VLA-4 fibronectin receptors on human activated T cells in rheumatoid arthritis. J. Clin. Invest. 88:546.
7. + T lymphocyte subsets in inflammatory rheumatic disease. Am. J. Med. 84:817.
8. Cush, J. J., and P. E. Lipsky. 1988. Phenotypic analysis of synovial tissue and peripheral blood lymphocytes isolated from patients with rheumatoid arthritis. Arthritis Rheum. 31:1230.
9. Firestein, G. S., W. D. Xu, K. Townsend, D. Broide, J. Alvaro-Gracia, A. Glasebrook, and N. J. Zvaifler. 1988. Cytokines in chronic inflammatory arthritis. I. Failure to detect T cell lymphokines (IL-2 and IL-3) and presence of macrophage colony-stimulating factor (CSF-1) and a novel mast cell growth factor in rheumatoid synovitis. J. Exp. Med. 168:1573.
10. Firestein, G. S., and N. J. Zvaifler. 1987. Peripheral blood and synovial fluid monocyte activation in inflammatory arthritis. II. Low levels of synovial fluid and synovial tissue interferon suggest that gamma-interferon is not the primary macrophage activating factor. Arthritis Rheum. 30:864.
11. Firestein, G. S., J. M. Alvaro-Garcia, and R. Maki. 1990. Quantitative analysis of cytokine gene expression in rheumatoid arthritis. J. Immunol. 144:3347.
12. Firestein, G. S., and N. J. Zvaifler. 1990. How important are T cells in chronic rheumatoid arthritis? Arthritis Rheum. 33:768.
13. Emery, P., G. S. Panayi, and A. M. E. Nouri. 1984. Interleukin-2 reverses deficient cell-mediated immune responses in rheumatoid arthritis. Clin. Exp. Immunol. 57:123.
14. Verwilghen, J., S. Vertessen, E. A. M. Stevens, J. Dequeker, and J. L. Ceuppens. 1990. Depressed T cell reactivity to recall antigens in rheumatoid arthritis. J. Clin. Immunol. 10:90.
15. Verwilghen, J., V. Corrigall, R. M. Pope, R. Rodrigues, and G. S. Panayi. 1993. Expression and function of CD5 and CD28 in patients with rheumatoid arthritis. Immunology 80:96.
16. Seitz, M., W. Deimann, N. Gram, W. Hunstein, and D. Gemsa. 1982. Characterization of blood mononuclear cells of rheumatoid arthritis. I. Depressed lymphocyte proliferation and enhanced prostanoid release from monocytes. Clin. Immunol. Immunopathol. 25:405.
17. Lockshin, M. D., A. C. Eisenhauer, R. Kohn, M. Weksler, S. Block, and S. B. Mushlin. 1975. Cell-mediated immunity in rheumatic diseases. Arthritis Rheum. 18:245.
18. Maurice, M. M., H. Nakamura, E. A. M. van der Voort, A. I. van Vliet, F. J. T. Staal, P. P. Tak, F. C. Breedveld, and C. L. Verweij. 1997. Evidence for a role of an altered redox state in hyporesponsiveness of synovial T cells in rheumatoid arthritis. J. Immunol. 158:1458.
19. Romain, P. L., G. R. Burmester, R. W. Enlow, and R. J. Winchester. 1982. Multiple abnormalities in immunoregulatory function of synovial compartment T cells in patients with rheumatoid arthritis. Rheumatol. Int. 2:121.
20. Smith, J. B., and R. J. DeHoratius. 1982. Deficient autologous mixed lymphocyte reactions correlate with disease activity in systemic lupus erythematosus and rheumatoid arthritis. Clin. Exp. Immunol. 48:155.