The molecular mechanism of osteoclastogenesis in rheumatoid arthritis

Arthritis Research

Volumn 4, Issue 5, 2002, Pages 281-289

  Udagawa, Nobuyuki ^a   Kotake, Shigeru ^b   Kamatani, Naoyuki ^b   Takahashi, Naoyuki ^a   Suda, Tatsuo ^c  

^a MATSUMOTO DENTAL UNIVERSITY   (Japan)

^b TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^c SAITAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Granulocyte macrophage colony stimulating factor; IFN ; IL 17; IL 18; RANKL

Indexed keywords

CYTOKINE; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 17; OSTEOCLAST DIFFERENTIATION FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; BONE DESTRUCTION; CELL LINEAGE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FIBROBLAST; HEMATOPOIETIC CELL; HUMAN; IMMUNOPATHOGENESIS; MACROPHAGE; MOLECULAR CLONING; MOLECULAR MECHANICS; MONOCYTE; MOUSE; NONHUMAN; OSTEOBLAST; OSTEOCLAST; OSTEOLYSIS; PROTEIN EXPRESSION; REVIEW; RHEUMATOID ARTHRITIS; SYNOVIOCYTE; T LYMPHOCYTE ACTIVATION;

ANIMAL; ANIMALS; ARTHRITIS, RHEUMATOID; BONE RESORPTION; CARRIER PROTEINS; CELL DIFFERENTIATION; CELLS, CULTURED; CLONING, MOLECULAR; CYTOKINES; FIBROBLASTS; HUMAN; HUMANS; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; MICE; OSTEOCLASTS; RANK LIGAND; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B; SYNOVIAL MEMBRANE; T-LYMPHOCYTES;

EID: 0036024679     PISSN: 14659905     EISSN: None     Source Type: Journal    
DOI: 10.1186/ar431     Document Type: Review

References (60)

1. Osteoblastic cells are involved in osteoclast formation
2. The bone marrow-derived stromal cell lines MC3T3-G2/PA6 and ST2 support osteoclast-like cell differentiation in cocultures with mouse spleen cells
3. Origin of osteoclasts: Mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells
4. Modulation of osteoclast differentiation
5. Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL
6. TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells
7. A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function
8. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
9. Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families
10. Proposed standard nomenclature for new tumor necrosis factor family members involved in the regulation of bone resorption
11. Osteoclast differentiation factor (ODF) induces osteoclast-like cell formation in human peripheral blood mononuclear cell cultures
12. A combination of osteoclast differentiation factor and macrophage-colony stimulating factor is sufficient for both human and mouse osteoclast formation in vitro
13. Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation
14. The role of T cells in the immunopathogenesis of rheumatoid arthritis: New perspectives
15. Interleukin-18 (interferon-γ-inducing factor) is produced by osteoblasts and acts via granulocyte/macrophage colony-stimulating factor and not via interferon-gamma to inhibit osteoclast formation
16. Interleukin 18 inhibits osteoclast formation via T cell production of granulocyte macrophage colony-stimulating factor
17. IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis
18. Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand
19. Activated T lymphocytes support osteoclast formation in vitro
20. Activated human T cells directly induce osteoclastogenesis from human monocytes: Possible role of T cells in bone destruction in rheumatoid arthritis patients
21. T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-γ
22. Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6
23. Interleukin (IL)-6 induction of osteoclast differentiation depends on IL-6 receptors expressed on osteoblastic cells but not on osteoclast progenitors
24. Is interleukin 17, an inducible cytokine that stimulates production of other cytokines, merely a redundant player in a sea of other biomolecules?
25. CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene
26. Mouse IL-17: A cytokine preferentially expressed by αβTCR + CD4-CD8-T cells
27. T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines
28. Enhancing effect of IL-17 on IL-1 -induced IL-6 and leukemia inhibitory factor production by rheumatoid arthritis synoviocytes and its regulation by Th2 cytokines
29. IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis
30. Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium
31. IL-4 gene therapy for collagen arthritis suppresses synovial IL-17 and osteoprotegerin ligand and prevents bone erosion
32. Stimulation of 92-kd gelatinase (matrix metalloproteinase 9) production by interleukin-17 in human monocyte/macrophages: A possible role in rheumatoid arthritis
33. IL-17 stimulates the production and expression of proinflammatory cytokines, IL-β and TNF-α, by human macrophages
34. High levels of IL-17 in rheumatoid arthritis patients: IL-15 triggers in vitro IL-17 production via cyclosporin A-sensitive mechanism
35. Synovial tissue in rheumatoid arthritis is a source of osteoclast differentiation factor
36. Involvement of receptor activator of nuclear factor κB ligand/osteoclast differentiation factor in osteoclastogenesis from synoviocytes in rheumatoid arthritis
37. Expression of osteoclast differentiation factor in rheumatoid arthritis
38. Expression of osteoclast differentiation factor at sites of bone erosion in collagen-induced arthritis
39. TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis
40. Functional human T-cell immunity and osteoprotegerin ligand control alveolar bone destruction in periodontal infection
41. A novel therapeutic vaccine that prevents pathological bone destruction in models of osteoporosis and RA
42. Generation of osteoclast-inductive and osteoclastogenic cell lines from the H-2KbtsA58 transgenic mouse
43. Bone cells required for osteoclastic resorption but not for osteoclastic differentiation
44. Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu
45. IL-12 alone and in synergy with IL-18 inhibits osteoclast formation in vitro
46. A proinflammatory role for IL-18 in rheumatoid arthritis
47. Interleukin-18 upregulates osteoprotegerin expression in stromal/osteoblastic cells
48. Inhibition by interleukin 18 of osteolytic bone metastasis by human breast cancer cells
49. Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice
50. TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling
51. Accelerated collagen-induced arthritis in IFN-γ receptor-deficient mice
52. Tumor necrosis factor-α stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL-RANK interaction
53. Activation of p38 mitogen-activated protein kinase is crucial in osteoclastogenesis induced by tumor necrosis factor
54. Transforming growth factor β affects osteoclast differentiation via direct and indirect actions
55. Tumor necrosis factor-α-induced osteoclastogenesis requires tumor necrosis factor receptor-associated factor 6
56. Interleukin 1 induces multinucleation and bone-resorbing activity of osteoclasts in the absence of osteoblasts/stromal cells
57. Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-α
58. Up-regulation of TNF-producing T cells in the bone marrow: A key mechanism by which estrogen deficiency induces bone loss in vivo
59. Establishment and characterization of nurse cell-like stromal cell lines from synovial tissues of patients with rheumatoid arthritis
60. Differentiation of monocytes into multinucleated giant bone-resorbing cells: Two-step differentiation induced by nurse-like cells and cytokines