Expanded CD4+ and CD8+ T Cell Clones in Elderly Humans

Journal of Immunology

Volumn 158, Issue 9, 1997, Pages 4493-4499

  Schwab, Risë ^a,b   Szabo, Paul ^a   Manavalan, John S ^a   Weksler, Marc E ^a,b   Posnett, David N ^a   Pannetier, Christophe ^b   Kourilsky, Philippe ^b   Even, Jos ^b  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CD45 ANTIGEN;

ADULT; AGE; AGED; AMINO ACID SEQUENCE; ARTICLE; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; HUMAN; IMMUNOLOGY; IMMUNOPHENOTYPING; LYMPHOCYTE COUNT; METABOLISM; T LYMPHOCYTE SUBPOPULATION;

ADULT; AGE FACTORS; AGED; AMINO ACID SEQUENCE; ANTIGENS, CD45; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; HUMANS; IMMUNOPHENOTYPING; LYMPHOCYTE COUNT; T-LYMPHOCYTE SUBSETS;

EID: 0031137735     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Hausman, P. B., and M. E. Weksler. 1985. Changes in the immune response with age. In Handbook of the Biology of Aging. C. E. Finch and E. L. Schneider, eds. Van Nostrand Reinhold Company, Inc., New York, pp. 414-432.
2. Freitas, A. A., B. Rocha, and A. Coutinho. 1986. Lymphocyte population kinetics in the mouse. Immunol. Rev. 91:5.
3. Utsuyama, M., M. Kasai, C. Kurashima, and K. Hirokawa. 1991. Age influence on the thymic capacity to promote differentiation of T cells: induction of different composition of T cell subsets by aging thymus. Mech. Ageing Dev. 58:267.
4. Schwab, R., C. L. Staiano, and M. E. Weksler. 1983. Immunological studies of aging. IX. Quantitative differences in T lymphocyte subsets in young and old individuals. Diagn. Immunol. 1:195.
5. DePaoli, P., S. Battistin, and G. G. Santini. 1988. Age-related changes in human lymphocyte subsets: progressive reduction of the CD4CD45R population. Clin. Immunol. Immunopathol. 48:290.
6. Warren. R. P., L. J. Yonk, R. A. Burger, and V. K. Singh. 1990. Age-related changes in CD45R and CDw29 helper T cells in human subjects. Aging Immunol. Infect. Dis. 2:91.
7. + T-cell subsets. Cell. Immunol. 132:17.
8. Cochet, M., C. Pannetier, A. Regnault, S. Darche, C. Leclerc, and P. Kourilsky. 1992. Molecular detection and in vivo analysis of the specific T cell response to a protein antigen. Eur. J. Immunol. 22:2639.
9. Pannetier, C., M. Cochet, S. Darche, A. Casrouge, M. Zoller, and P. Kourilsky. 1993. The sizes of the CDR3 hypervariable regions of the murine T-cell receptor beta chains vary as a function of the recombined germ-line segments. Proc. Natl. Acad. Sci. USA 90:4319.
10. Pannetier, C., J. Even, and P. Kourilsky. 1995. T-cell repertoire diversity and clonal expansions in normal and clinical samples. Immunol. Today 16:176.
11. Davis , M. M., and P. J. Bjorkman. 1988. T-cell antigen receptor genes and T-cell recognition. Nature 334:395.
12. Schwab, R., M. K. Crow, C. Russo, and M. E. Weksler. 1985. Requirements for T cell activation by OKT3 monoclonal antibody: role of modulation of T3 molecules and interleukin 1. J. Immunol. 135:1714.
13. Chirgwin, J. M., A. E. Przybyla, D. R. Mac, and W. J. Rutter. 1979. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294.
14. Genevee, C., A. Diu, J. Nierat, A. Caignard, P. Y. Dietrich, L. Ferradini, R. S. Roman, F. Triebel, and T. Hercend. 1992. An experimentally validated panel of subfamily-specific oligonucleotide primers (V alpha 1-w29/V beta 1-w24) for the study of human T cell receptor variable V gene segment usage by polymerase chain reaction. Eur. J. Immunol. 22:1261.
15. Puisieux, I., J. Even, C. Pannetier, F. Jotereau, M. Favrot, and P. Kourilsky. 1994. Oligoclonality of tumor-infiltrating lymphocytes from human melanomas. J. Immunol. 153:2807.
16. Wei, S., P. Charmley, M. A. Robinson, and P. Concannon. 1994. The extent of the human germline T-cell receptor V beta gene segment repertoire. Immunogenetics 40:27.
17. Kabat, E. A., T. T. Wu, M. Perry, K. S. Gottesman, and C. Foeller, eds. 1991. Sequences of Proteins of Immunological Interest, National Institutes of Health, Bethesda, MD.
18. Chothia, C., D. R. Boswell, and A. M. Lesk. 1988. The outline structure of the T-cell alpha beta receptor. EMBO J. 7:3745.
19. + subset in normal human subjects. J. Immunol. 151:5762.
20. Casanova, J. L., C. Pannetier, C. Jaulin, and P. Kourilsky. 1990. Optimal conditions for directly sequencing double-stranded PCR products with sequenase. Nucleic Acids Res. 18:4028.
21. Sparshott, S. M., E. B. Bell, and S. R. Sarawar. 1991. CD45R CD4 T cell subset-reconstituted nude rats: subset-dependent survival of recipients and bi-directional isoform switching. Eur. J. Immunol. 21:993.
22. Sparshott, S. M., and E. B. Bell. 1994. Membrane CD45R isoform exchange on CD4 T cells is rapid, frequent and dynamic in vivo. Eur. J. Immunol. 24:2573.
23. Morimoto, C., and S. F. Schlossman. 1993. Human naive and memory T cells revisited: new markers (CD31 and CD27) that help define CD4+ T cell subsets. Clin. Exp. Rheumatol. 11:241.
24. Grunewald, J., T. M. Jeddi, H. Dersimonian, R. Andersson, and H. Wigzell. 1992. A persistent T cell expansion in the peripheral blood of a normal adult male: a new clinical entity? Clin. Exp. Immunol. 89:279.
25. Callahan, J. E., J. W. Kappler, and P. Marrack. 1993. Unexpected expansions of CD8-bearing cells in old mice. J. Immunol. 151:6657.
26. Posnett, D. N., R. Sinha, S. Kabak, and C. Russo. 1994. Clonal populations of T cells in normal elderly humans: the T cell equivalent to "benign monoclonal gammapathy". J. Exp. Med. 179:609.
27. + T cell expansions in normal individuals and patients with rheumatoid arthritis. J. Immunol. 154:3538.
28. + T cells in rheumatoid arthritis. J. Clin. Invest. 94:2068.
29. Walser-Kuntz, D. R., C. M. Weyend, A. J. Weaver, W. M. O'Fallon, and J. J. Goronzy. 1995. Mechanisms underlying the formation of the T cell receptor repertoire in rheumatoid arthritis. Immunity. 2:597.
30. Lehner, P. J., E. C. Wang, P. A. Moss, S. Williams, K. Platt, S. M. Friedman, J. I. Bell, and L. K. Borysiewicz. 1995. Human HLA-A0201-restricted cytotoxic T lymphocyte recognition of influenza A is dominated by T cells bearing the V beta 17 gene segment. J. Exp. Med. 181:79.
31. Argaet, V. P., C. W. Schmidt, S. R. Burrows, S. L. Silins, M. G. Kurilla, D. L. Doolan, A. Suhrbier, D. J. Moss, E. Kieff, T. B. Suclley, and I. S. Misko, 1994. Dominant selection of an invariant T cell antigen receptor in response to persistent infection by Epstein-Barr virus. J. Exp. Med. 180:2335.
32. Zhou, T., C. K. Edwards III, and J. D. Mountz. 1995. Prevention of age-related T cell apoptosis defect in CD2-fas-transgenic mice. J. Exp. Med. 182:129.
33. Wang, E. 1995. Senescent human fibroblasts resist programmed cell death and failure to suppress Bcl 2 is involved. Cancer Res. 55:2284.
34. Posnett, D. N., S. Kabak, A. S. Hodtsev, E. A. Goldberg, and A. Asch. 1993. T-cell antigen receptor Vβ subsets are not preferentially deleted in AIDS. AIDS 7:625.
35. Choi, Y., B. Kotzin, J. Lafferty, J. White, M. Pigeon, R. Kubo, J. Kappler, and P. Marrack. 1991. A method for production of antibodies to human T-cell receptor beta chain variable regions. Proc. Natl. Acad. Sci. USA 88:8357.
36. Ricalton, N. S., X. Paliard, J. Kappler, P. Marrack, and B. L. Kotzin. 1996. Analysis of TcR BV expression in Human populations for evidence of superantigen exposure. Immunologist 4/3:106.