Novel Cu(II) quinoxaline N1,N4-dioxide complexes as selective hypoxic cytotoxins

European Journal of Medicinal Chemistry

Volumn 40, Issue 5, 2005, Pages 473-480

  Torre, María H ^a   Gambino, Dinorah ^a   Araujo, Jeannette ^a   Cerecetto, Hugo ^a   González, Mercedes ^a   Lavaggi, María Laura ^a   Azqueta, Amaya ^b   López De Cerain, Adela ^b   Vega, Antonio Monge ^b   Abram, Ulrich ^c   Costa Filho, Antonio J ^d  

^a UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^b UNIVERSITY OF NAVARRA   (Spain)

^c FREIE UNIVERSITÄT BERLIN   (Germany)

^d UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Antitumoral agents; Copper complexes; Hypoxic selective cytotoxins

Indexed keywords

3 AMINO 6(7) BROMOQUINOXALINE 2 CARBONITRILE N1,N4 DIOXIDE; 3 AMINO 6(7) CHLOROQUINOXALINE 2 CARBONITRILE N1,N4 DIOXIDE; 3 AMINO 6(7) METHYLQUINOXALINE 2 CARBONITRILE N1,N4 DIOXIDE; COPPER DERIVATIVE; CYTOTOXIN; LIGAND; QUINOXALINE DERIVATIVE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANIMAL CELL; ARTICLE; CHINESE HAMSTER; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; DRUG EFFICACY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTRON SPIN RESONANCE; ELECTRONICS; ELEMENTAL ANALYSIS; HYPOXIA; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE ANALYSIS; THERMAL ANALYSIS;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL HYPOXIA; COPPER; CRICETINAE; CRICETULUS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRON SPIN RESONANCE SPECTROSCOPY; FIBROBLASTS; MODELS, MOLECULAR; ORGANOMETALLIC COMPOUNDS; QUINOXALINES; SPECTROMETRY, MASS, FAST ATOM BOMBARDMENT; SPECTROPHOTOMETRY, INFRARED; SURFACE PROPERTIES;

EID: 21044444841     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejmech.2004.11.012     Document Type: Article

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