Quinone-induced apoptosis in human colon adenocarcinoma cells via DT-diaphorase mediated bioactivation

Chemico-Biological Interactions

Volumn 100, Issue 3, 1996, Pages 267-276

  Sun, Xiaoming ^a,b   Ross, David ^b  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Apoptosis; Bioreductive activation; Colon adenocarcinoma; DT diaphorase; NAD(P)H:Quinone oxidoreductase; Quinone

Indexed keywords

DICOUMAROL; MITOMYCIN C; OXIDOREDUCTASE; QUINONE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); RUFOCROMOMYCIN;

APOPTOSIS; ARTICLE; CARCINOMA CELL; CELL POPULATION; COLON ADENOCARCINOMA; CYTOTOXICITY; DRUG ACTIVITY; DRUG INDUCED DISEASE; GENETIC REGULATION; HUMAN; HUMAN CELL; MITOSIS; NUCLEOSOME; OXIDATION REDUCTION REACTION; POINT MUTATION;

ADENOCARCINOMA; ANTINEOPLASTIC AGENTS; APOPTOSIS; AZIRIDINES; BENZOQUINONES; COLONIC NEOPLASMS; ELECTROPHORESIS, AGAR GEL; HUMANS; MITOMYCIN; NAD(P)H DEHYDROGENASE (QUINONE); NADH, NADPH OXIDOREDUCTASES; STREPTONIGRIN; TUMOR CELLS, CULTURED;

EID: 0029982370     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/0009-2797(96)03704-0     Document Type: Article

References (35)

1. A.H. Wyllie, J.F.R. Kerr and A.R. Currie, Cell death: the significance of apoptosis, Int. Rev. Cytol., 68 (1980) 251-306.
2. J.A. Hickman, Apoptosis induced by anticancer drugs, Cancer Metastasis Rev., 11 (1992) 121-139.
3. C. Dive and J.A. Hickman, Drug-target interactions: only the first step in the commitment to a programmed cell death? Br. J. Cancer, 64 (1991) 192-196.
4. D.E. Fisher, Apoptosis in cancer therapy: crossing the threshold, Cell, 78 (1994) 539-542.
5. G. Powis, Metabolism and reactions of quinoid anticancer agents, Pharmacol. Ther., 35 (1987) 57-162.
6. D. Ross, D. Siegel, H. Beall, A.S. Prakash, R.T. Mulcahy and N.W. Gibson, DT-diaphorase in activation and detoxification of quinones, Cancer Metastasis Rev., 12 (1993) 83-101.
7. D. Ross, H. Beall, R.D. Traver, D. Siegel, R.M. Philips and N.W. Gibson, Bioactivation of quinones by DT-diapborase, molecular, biochemical and chemical studies, Oncol. Res., 6 (1994) 493-500.
8. J.J. Schlager and G. Powis, Cytosolic NAD(P)H:(quinone acceptor)-oxidoreductase in human normal and tumor tissue: effect of cigarette smoking and alcohol, Int. J. Cancer, 45 (1990) 403-409.
9. T. Cresteil and A.K. Jaiswal, High levels of expression of the NAD(P)H:quinone oxidoreductase (NQO1) gene in tumor cells compared to normal cells of the same origin, Biochem. Pharmacol., 42 (1991) 1021-1027.
10. A.M. Malkinson, D. Siegel, G.L. Forrest, A.F. Gazdar, H.K. Oie, D.C. Chan, P.A. Bunn, M. Mabry, D.J. Dykes, S.D. Harrison Jr. and D. Ross, Elevated DT-diaphorase activity and messenger RNA content in human non-small cell lung carcinoma: relationship to the response of lung tumor xenografts to mitomycin C, Cancer Res., 52 (1992) 4752-4757.
11. R.J. Riley and P. Workman, DT-diaphorase and cancer chemotherapy. Biochem. Pharmacol., 43 (1992) 1657-1669.
12. H.R. Hendriks, P.E. Pizao, D.P. Berger, K.L. Kooistra, M.C. Bibby, E. Boven, H.C. Dreef-van der Meulen, R.E.C. Henrar, H.H. Fiebig, J.A. Double, H.W. Hornstra, H.M. Pinedo, P. Workman and G. Schwartsmann, EO9: A novel bioreductive alkylating indoloquinone with preferential solid tumour activity and lack of bonemarrow toxicity in preclinical models, Eur. J. Cancer, 29A (1993) 879-906.
13. H.D. Beall, R.T. Mulcahy, D. Siegel, R.D. Traver, N.W. Gibson and D. Ross, Metabolism of bioreductive antitumor compounds by purified rat and human DT-diaphorases, Cancer Res., 54 (1994) 3196-3201.
14. D. Siegel, N.W. Gibson, P.C. Preusch and D. Ross, Metabolism of diaziquone by NAD(P)H:(quinone acceptor) oxidoreductase (DT-diaphorase): role in diaziquone induced DNA damage and cytotoxicity in human colon carcinoma cells, Cancer Res., 50 (1990) 7293-7300.
15. D. Siegel, N.W. Gibson, P.C. Preusch and D. Ross, Metabolism of mitomycin C by DT-diaphorase: role in mitomycin C-induced DNA damage and cytotoxicity in human colon carcinoma cells, Cancer Res., 50 (1990) 7483-7489.
16. M.I. Walton, M.C. Bibby, J.A. Double, J.A. Plumb and P. Workman, DT-diaphorase activity correlates with sensitivity to the indoloquinone EO9 in mouse and human colon carcinomas, Eur. J. Cancer, 28A (1992) 1597-1600.
17. N. Robertson, I.J. Stratford, S. Houlbrook, J. Carmichael and G.E. Adams, The sensitivity of human tumor cells to quinone bioreductive drugs: what role for DT-diaphorase? Biochem. Pharmacol., 44 (1992) 409-412.
18. H.D. Beall, A.M. Murphy, D. Siegel and D. Ross, DT-diaphorase as a target for bioreductive antitumor quinones. qinone cytotoxicity and selectivity in human lung and breast cancer cell lines, Mol. Pharmacol., 48 (1995) 499-504.
19. C.M. Sorenson, M.A. Barry and A. Eastman, Analysis of events associated with cell cycle arrest at G2 phase and cell death induced by cisplatin, J. Natl. Cancer Inst., 82 (1990) 749-755.
20. G.M. Cohen, X-M. Sun, S.T. Snowden, D. Dinsdale and D.N. Skilleter, Key morphological features of apoptosis may occur in the absence of internucleosomal DNA fragmentation, Biochem. J., 286 (1992) 331-334.
21. D. Barbieri, L. Troiano, E. Grassilli, C. Agnesini, E.A. Cristofalo, D. Monti, M. Capri, A. Cossarizza and C. Franceschi, Inhibition of apoptosis by zinc: a reappraisal, Biochem. Biophys. Res. Commun., 187 (1992) 1256-1261.
22. F. Oberhammer, J.W. Wilson, C. Dive, I.D. Morris, J.A. Hickman, A.E. Wakeling, P.R. Walker and M. Sikorska, Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation, EMBO J., 12 (1993) 3679-3684.
23. J. Searle, T.A. Lawson, P.J. Abbott, B.V. Harmon and J.F.R. Kerr, An electron microscopy study of the mode of cell death induced by cancer-chemotherapeutic agents in populations of proliferating normal and neoplastic cells, J. Pathol., 116 (1975) 129-138.
24. R. Bertrand, M. Sarang, J. Jenkin, D. Kerrigan and Y. Pommier, Different induction of secondary DNA fragmentation by topoisomerase II inhibitors in human tumor cell lines with amplified c-myc expression, Cancer Res., 51 (1991) 6280-6285.
25. I.B. Shchepotin, V. Soldatenkov, R.R. Buras, R.J. Nauta, M. Shabahang and S.R.T. Evans, Apoptosis of human primary and metastatic colon adenocarcinoma cell lines in vitro induced by 5-fluorouracil, verapamil, and hyperthermia, Anticancer Res., 14 (1994) 1027-1032.
26. B.G. Heerdt, M.A. Houston and L.H. Augenlicht, Potentiation by specific short-chain fatty acids of differentiation and apoptosis in human colonic carcinoma cell lines, Cancer Res., 54 (1994) 3288-3294.
27. L.M. Desjardins and J.P. MacManus, An adherent cell model to study different stages of apoptosis, Exp. Cell Res., 216 (1995) 380-387.
28. R.D. Traver, T. Horikoshi, K.D. Danenberg, T.H.W. Stadbauer, P.V. Danenberg, D. Ross and N.W. Gibson, NAD(P)H:quinone oxidoreductase gene expression in human colon carcinoma cells: characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivity, Cancer Res., 52 (1992) 797-802.
29. K. Paull, R. Camalier, S.A. Fitzsimmons, A.D. Lewis, P. Workman, Correlations of DT-diaphorase expression with cell sensitivity data obtained from the NCI human tumor cell line panel, Proc. Am. Assoc. Cancer Res., 35 (1994) 369.
30. D. Siegel, H. Beall, C. Senekowitsch, M. Kasai, H. Arai, N.W. Gibson and D. Ross, Bioreductive activation of mitomycin C by DT-diaphorase, Biochemistry, 31 (1992) 7879-7885.
31. T.A. Sarafian and D.E. Bredesen, Is apoptosis mediated by reactive oxygen species? Free Radic. Res., 21 (1994) 1-8.
32. J.T. Wolfe, D. Ross and G.M. Cohen, A role for metals and free radicals in the induction of apoptosis in thymocytes, FEBS Lett. 352 (1994) 58-62.
33. N.R. Rodrigues, A. Rowan, M.E.F. Smith, I.B. Kerr, W.F. Bodmer, J.V. Gannon and D.P. Lane, p53 mutation in colorectal cancer, Proc. Natl. Acad. Sci. USA, 87 (1990) 7555-7559.
34. A. Strasser, A.W. Harris, T. Jacks and S. Cory, DNA damgae can induce apoptosis in proliferating lymphoid cells via p53-independent mechanism inhibitable by Bcl-2, Cell, 79 329-339.
35. M.M. Borner, C.E. Myers, O. Sartor, Y. Sei, T. Toko, J.B. Trepel and E. Schneider, Drug-induced apoptosis is not necessarily dependent on macromolecular synthesis or proliferation in the p53-negative human prostate cancer cell line PC-3, Cancer Res., 55 (1995) 2122-2128.