Novel N-oxide of naphthalimides as prodrug leads against hypoxic solid tumor: Synthesis and biological evaluation

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 8, 2007, Pages 2166-2170

  Yin, Hong ^a   Xu, Yufang ^a   Qian, Xuhong ^a   Li, Yuanli ^a   Liu, Jianwen ^a  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Biological evaluation; Hypoxic solid tumor; N Oxide of naphthalimides; Prodrug leads; Synthesis

Indexed keywords

1,4 BIS[[2 (DIMETHYLAMINO N OXIDE)ETHYL]AMINO] 5,8 DIHYDROXYANTHRAQUINONE; ACID ANHYDRIDE; ANTINEOPLASTIC AGENT; CHLOROPLAST DNA; IMIDE; NLCQ 1; OXIDE; SN 23862; TIRAPAZAMINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG BINDING; DRUG DESIGN; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYPOXIA; MELANOMA CELL; SOLID TUMOR; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL HYPOXIA; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; NAPHTHALIMIDES; NEOPLASMS; OXIDES; PRODRUGS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33947595807     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.02.015     Document Type: Article

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