Roles of Wnt signaling in bone formation and resorption

Japanese Dental Science Review

Volumn 44, Issue 1, 2008, Pages 76-82

  Kobayashi, Yasuhiro ^a   Maeda, Kazuhiro ^a   Takahashi, Naoyuki ^a  

^a MATSUMOTO DENTAL UNIVERSITY   (Japan)

Author keywords

Bone; LRP; Osteoblasts; Osteoclasts; Wnt; catenin

Indexed keywords

EID: 53549125811     PISSN: 18827616     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jdsr.2007.11.002     Document Type: Review

References (43)

1. Friedenstein A., and Kuralesova A.I. Osteogenic precursor cells of bone marrow in radiation chimeras. Transplantation 12 (1971) 99-108
2. Tenenbaum H.C., and Heersche J.N. Dexamethasone stimulates osteogenesis in chick periosteum in vitro. Endocrinology 117 (1985) 2211-2217
3. Takahashi N., Akatsu T., Udagawa N., Sasaki T., Yamaguchi A., Moseley J.M., et al. Osteoblastic cells are involved in osteoclast formation. Endocrinology 123 (1988) 2600-2602
4. Suda T., Takahashi N., Udagawa N., Jimi E., Gillespie M.T., and Martin T.J. Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr Rev 20 (1999) 345-357
5. Simonet W.S., Lacey D.L., Dunstan C.R., Kelley M., Chang M.S., Lüthy R., et al. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 89 (1997) 309-319
6. Gordon M.D., and Nusse R. Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors. J Biol Chem 281 (2006) 22429-22433
7. Miller J.R. The Wnts. Genome Biol 3 (2002) 3001.1-3001.15
8. Mikels A.J., and Nusse R. Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context. PLoS Biol 4 (2006) e115
9. Huang H.-C., and Klein P.S. The Frizzled family: receptors for multiple signal transduction pathways. Genome Biol 5 (2004) 234.1-234.7
10. He X., Semenov M., Tamai K., and Zeng X. LDL receptor-related proteins 5 and 6 in Wnt/b-catenin signaling: arrows point the way. Development 131 (2004) 1663-1677
11. Forrester W.C. The Ror receptor tyrosine kinase family. Cell Mol Life Sci 59 (2002) 83-96
12. Kawano Y., and Kypta R. Secreted antagonists of the Wnt signalling pathway. J Cell Sci 116 (2003) 2627-2634
13. Niehrs C. Function and biological roles of the Dickkopf family of Wnt modulators. Oncogene 25 (2006) 7469-7481
14. Mao B., Wu W., Davidson G., Marhold J., Li M., Mechler B.M., et al. Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling. Nature 417 (2002) 664-667
15. Weeraratna A.T., Jiang Y., Hostetter G., Rosenblatt K., Duray P., Bittner M., et al. Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma. Cancer Cell 1 (2002) 279-288
16. 2+-induced NFAT activity is counteracted by Wnt-5a/Yes-Cdc42-casein kinase 1alpha signaling in human mammary epithelial cells. Mol Cell Biol 26 (2006) 6024-6036
17. Ishitani T., Kishida S., Hyodo-Miura J., Ueno N., Yasuda J., Waterman M., et al. The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling. Mol Cell Biol 23 (2003) 131-139
18. 2+ flux, PKC, and CamKII in vertebrate embryos. J Cell Biol 161 (2003) 769-777
19. Qian D., Jones C., Rzadzinska A., Mark S., Zhang X., Steel K.P., et al. Wnt5a functions in planar cell polarity regulation in mice. Dev Biol 306 (2007) 121-133
20. Boutros M., Paricio N., Strutt D.I., and Mlodzik M. Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling. Cell 94 (1998) 109-118
21. Li L., Yuan H., Xie W., Mao J., Caruso A.M., Sussman D.J., et al. Dishevelled proteins lead to two signaling pathways. Regulation of LEF-1 and c-Jun N-terminal kinase in mammalian cells. J Biol Chem 274 (1999) 129-134
22. Oishi I., Suzuki H., Onishi N., Takada R., Kani S., Ohkawara B., et al. The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway. Genes Cells 8 (2003) 645-654
23. Gong Y., et al. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell 16 (2001) 513-523
24. Little R.D., Carulli J.P., Del Mastro R.G., Dupuis J., Osbornem M., Folz C., et al. A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait. Am J Hum Genet 70 (2002) 11-19
25. Van Wesenbeeck L., Cleiren E., Gram J., Beals R.K., Bénichou O., Scopelliti D., et al. Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density. Am J Hum Genet 72 (2003) 763-771
26. Mani A., Radhakrishnan J., Wang H., Mani A., Mani M.A., Nelson-Williams C., et al. LRP6 mutation in a family with early coronary disease and metabolic risk factors. Science 315 (2007) 1278-1282
27. Kato M., Patel M.S., Levasseur R., Lobov I., Chang B.H., Glass II D.A., et al. Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor. J Cell Biol 157 (2002) 303-314
28. Holmen S.L., Giambernardi T.A., Zylstra C.R., Buckner-Berghuis B.D., Resau J.H., Hess J.F., et al. Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6. J Bone Miner Res 19 (2004) 2033-2040
29. Kokubu C., Heinzmann U., Kokubu T., Sakai N., Kubota T., Kawai M., et al. Skeletal defects in ringelschwanz mutant mice reveal that Lrp6 is required for proper somitogenesis and osteogenesis. Development 131 (2004) 5469-5480
30. Clément-Lacroix P., Ai M., Morvan F., Roman-Roman S., Vayssière B., and Belleville C. Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice. Proc Natl Acad Sci USA 102 (2005) 17406-17411
31. Bodine P.V., Zhao W., Kharode Y.P., Bex F.J., Lambert A.J., Goad M.B., et al. The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice. Mol Endocrinol 18 (2004) 1222-1237
32. Morvan F., Boulukos K., Clément-Lacroix P., Roman-Roman S., Suc-Royer I., Vayssière B., et al. Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass. J Bone Miner Res 21 (2006) 934-945
33. Li X., Liu P., Liu W., Maye P., Zhang J., Zhang Y., et al. Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation. Nat Genet 37 (2005) 945-952
34. Tu X., Joeng K.S., Nakayama K.I., Nakayama K., Rajagopal J., Carroll T.J., et al. Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation. Dev Cell 12 (2007) 113-127
35. Yamane T., Kunisada T., Tsukamoto H., Yamazaki H., Niwa H., Takada S., et al. Wnt signaling regulates hemopoiesis through stromal cells. J Immunol 167 (2001) 765-772
36. Glass II D.A., Bialek P., Ahn J.D., Starbuck M., Patel M.S., Clevers H., et al. Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell 8 (2005) 751-764
37. Spencer G.J., Utting J.C., Etheridge S.L., Arnett T.R., and Genever P.G. Wnt signalling in osteoblasts regulates expression of the receptor activator of NFkappaB ligand and inhibits osteoclastogenesis in vitro. J Cell Sci 119 (2006) 1283-1296
38. Häusler K.D., Horwood N.J., Chuman Y., Fisher J.L., Ellis J., Martin T.J., et al. Secreted frizzled-related protein-1 inhibits RANKL-dependent osteoclast formation. J Bone Miner Res 19 (2004) 1873-1881
39. Maeda K., Kobayashi Y., Mizoguchi T., Nakamichi Y., Yamashita T., Kinugawa S., et al. Wnt5a enhances RANKL-induced osteoclastogenesis. J Bone Miner Res 22 Suppl. 1 (2007) S43
40. Sen M., Lauterbach K., El-Gabalawy H., Firestein G.S., Corr M., and Carson D.A. Expression and function of wingless and frizzled homologs in rheumatoid arthritis. Proc Natl Acad Sci USA 97 (2000) 2791-2796
41. Nakamura Y., Nawata M., and Wakitani S. Expression profiles and functional analyses of Wnt-related genes in human joint disorders. Am J Pathol 167 (2005) 97-105
42. Diarra D., Stolina M., Polzer K., Zwerina J., Ominsky M.S., Dwyer D., et al. Dickkopf-1 is a master regulator of joint remodeling. Nat Med 13 (2007) 156-163
43. Sen M., Chamorro M., Reifert J., Corr M., and Carson D.A. Blockade of Wnt-5A/frizzled 5 signaling inhibits rheumatoid synoviocyte activation. Arthritis Rheum 44 (2001) 772-781