The frizzled family: Receptor for multiple signal transduction pathways

Genome Biology

Volumn 5, Issue 7, 2004, Pages

  Huang, Hui Chuan ^a   Klein, Peter S ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FRIZZLED PROTEIN; MEMBRANE PROTEIN; WNT PROTEIN; DROSOPHILA PROTEIN; FZ PROTEIN, DROSOPHILA; G PROTEIN COUPLED RECEPTOR;

CELL POLARITY; CELL PROLIFERATION; EMBRYO DEVELOPMENT; FAMILIAL DISEASE; GENE MUTATION; GENETIC CODE; HUMAN; LIGAND BINDING; MOLECULAR EVOLUTION; NONHUMAN; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; REVIEW; SIGNAL TRANSDUCTION; VITREORETINOPATHY; ANIMAL; GENETICS; PHYSIOLOGY; SEQUENCE HOMOLOGY;

ANIMALIA;

ANIMALS; DROSOPHILA PROTEINS; EVOLUTION, MOLECULAR; FRIZZLED RECEPTORS; HUMANS; MEMBRANE PROTEINS; RECEPTORS, G-PROTEIN-COUPLED; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION;

EID: 4844230621     PISSN: 14656906     EISSN: None     Source Type: Journal    
DOI: 10.1186/gb-2004-5-7-234     Document Type: Review

References (53)

1. Adler PN: Planar signaling and morphogenesis in Drosophila. Dev Cell 2002, 2:525-535.
2. Wang Y, Macke JP, Abella BS, Andreasson K, Worley P, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J: A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. J Biol Chem 1996, 271:4468-4476.
3. Adell T, Nefkens I, Muller WE: Polarity factor 'Frizzled' in the demosponge Suberites domuncula: identification, expression and localization of the receptor in the epithelium/pinacoderm. FEBS Letters 2003, 554:363-368.
4. Minobe S, Fei K, Yan L, Sarras Jr M, Werle M: Identification and characterization of the epithelial polarity receptor " Frizzled" in Hydra vulgaris. Dev Genes Evol 2000, 210:258-262."
5. Bhanot P, Brink M, Samos CH, Hsieh JC, Wang Y, Macke JP, Andrew D, Nathans J, Nusse R: A new member of the frizzled family from Drosaphila functions as a Wingless receptor. Nature 1996, 382:225-230.
6. The Wnt Gene Homepage [http://www.stanford.edu/~rnusse/wntwindow.html]
7. Veeman MT, Axelrod JD, Moon RT: A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling. Dev Cell 2003, 5:367-377.
8. Strutt D: Frizzled signalling and cell polarisation in Drosophila and vertebrates. Development 2003, 130:4501-4513.
9. He X, Semenov M, Tamai K, Zeng X: LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling: arrows point the way. Development 2004, 131:1663-1677.
10. Fredriksson R, Lagerstrom MC, Lundin LG, Schioth HB: The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints. Mal Pharmacol 2003, 63:1256-1272.
11. Dann CE, Hsieh JC, Rattner A, Sharma D, Nathans J, Leahy DJ: Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains. Nature 2001, 412:86-90.
12. Umbhauer M, Djiane A, Goisset C, Penzo-Mendez A, Riou JF, Boucaut JC, Shi DL The C-terminal cytoplasmic Lys-thr-X-X-X-Trp motif in frizzled receptors mediates Wnt/beta-catenin signalling. EMBO J 2000, 19:4944-4954.
13. Wong HC, Bourdelas A, Krauss A, Lee HJ, Shao Y, Wu D, Mlodzik M, Shi DL, Zheng J: Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled. Mol Cell 2003, 12:1251-1260.
14. Thorpe CJ, Schlesinger A, Bowerman B: Wnt signalling in Caenorhabditis elegans: regulating repressors and polarizing the cytoskeleton. Trends Cell Biol 2000, 10:10-17.
15. Hsieh JC, Rattner A, Smallwood PM, Nathans J: Biochemical characterization of Wnt-frizzled interactions using a soluble biologically active vertebrate Wnt protein. Proc Natl Acad Sci USA 1999, 96:3546-3551.
16. Chen W, ten Berge D, Brown J, Ahn S, Hu LA, Miller WE, Caron MG, Barak LS, Nusse R, Lefkowitz RJ: Dishevelled 2 recruits; beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4. Science 2003, 301:1391-1394.
17. Dubois L, Lecourtois M, Alexandre C, Hirst E, Vincent JP: Regulated endocytic routing modulates wingless signaling in Drosophila embryos. Cell 2001, 105:613-624.
18. Gradl D, Kuhl M, Wedlich D: Keeping a close eye on Wnt-1/wg signaling in Xenopus. Mech Dev 1999, 86:3-15.
19. Deardorff MA, Tan C, Conrad LJ, Klein PS: Frizzled-8 is expressed in the Spemann organizer and plays a role in early morphogenesis. Development 1998, 125:2687-2700.
20. Moon RT, Campbell RM, Christian JL, McGrew LL, Shih J, Fraser S: Xwnt-5A: a maternal Wnt that affects morphogenetic movements after overexpression in embryos of Xenopus laevis. Development 1993, 119:97-111.
21. Sokol SY: Analysis of Dishevelled signalling pathways during Xenopus development. Curr Biol 1996, 6:1456-1467.
22. Chen CM, Struhl G: Wingless transduction by the Frizzled and Frizzled2 proteins of Drosophila. Development 1999, 126:5441-5452.
23. Sheldahl LC, Park M, Malbon CC, Moon RT: Protein kinase C is differentially stimulated by wnt and frizzled homologs in a G-protein-dependent manner. Curr Biol 1999, 9:695-698.
24. Winklbauer R, Medina A, Swain RK, Steinbeisser H: Frizzled-7 signalling controls tissue separation during Xenopus gastrulation. Nature 2001, 413:856-860.
25. Robitaille J, MacDonald ML, Kaykas A, Sheldahl LC, Zeisler J, Dube MP, Zhang LH, Singaraja RR, Guernsey DL, Zheng B, et al.: Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy. Nat Genet 2002, 32:326-330.
26. Xu Q, Wang Y, Dabdoub A, Smallwood PM, Williams J, Woods C, Kelley MW, Jiang L, Tasman W, Zhang K, et al.: Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair. Cell 2004, 116:883-895.
27. Rulifson EJ, Wu CH, Nusse R: Pathway specificity by the bifunctional receptor Frizzled is determined by affinity for Wingless. Mol Cell 2000, 6:117-126.
28. Wu CH, Nusse R: Ligand receptor interactions in the Wnt signaling pathway in Drosophila. J Biol Chem 2002, 277:41762-41769.
29. Carron C, Pascal A, Djiane A, Boucaut JC, Shi DL, Umbhauer M: Frizzled receptor dimerization is sufficient to activate the Wnt/beta-catenin pathway. J Cell Sci 2003, 116:2541-2550.
30. Boutros M, Mihaly J, Bouwmeester T, Mlodzik M: Signaling specificity by frizzled receptors in Drosophila. Science 2000, 288:1825-1828.
31. Tan C, Deardorff MA, Saint-Jeannet JP, Yang J, Arzoumanian A, Klein PS: Kermit, a frizzled interacting protein, regulates frizzled 3 signaling in neural crest development. Development 2001, 128:3665-3674.
32. Hering H, Sheng M: Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95. FEBS Lett 2002, 521:185-189.
33. Yao R, Maeda T, Takada S, Noda T: Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of Frizzled. Biochem Biophys Res Commun 2001, 286:771-778.
34. Wehrli M, Dougan ST, Caldwell K, O'Keefe L, Schwartz S, Vaizel-Ohayon D, Schejter E, Tomlinson A, DiNardo S: arrow encodes an LDL-receptor-related protein essential for Wingless signalling. Nature 2000, 407:527-530.
35. Tolwinski NS, Wehrli M, Rives A, Erdeniz N, DiNardo S, Wieschaus E: Wg/Wnt signal can be transmitted through arrow/LRP5,6 and Axin independently of Zw3/Gsk3beta activity. Dev Cell 2003, 4:407-418.
36. Mao J, Wang J, Liu B, Pan W, Farr GH 3rd, Flynn C, Yuan H, Takada S, Kimelman D, Li L, et al: Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway. Mal Cell 2001, 7:801-809.
37. Malbon CC, Wang H, Moon RT: Wnt signaling and heterotrimeric G-proteins: strange bedfellows or a classic romance? Biochem Biophys Res Commun 2001, 287:589-593.
38. Cohen ED, Mariol MC, Wallace RM, Weyers J, Kamberov YG, Pradel J, Wilder EL: DWnt4 regulates cell movement and focal adhesion kinase during Drosophila ovarian morphogenesis. Dev Cell 2002, 2:437-448.
39. Gubb D, Garcia-Bellido A: A genetic analysis of the determination of cuticular polarity during development in Drosophila melanogaster. J Embryol Exp Morphol 1982, 68:37-57.
40. Muller H, Samanta R, Wieschaus E: Wingless signaling in the Drosophila embryo: zygotic requirements and the role of the frizzled genes. Development 1999, 126:577-586.
41. Bhanot P, Fish M, Jemison JA, Nusse R, Nathans J, Cadigan KM: Frizzled and DFrizzled-2 function as redundant receptors for Wingless during Drosophiia embryonic development. Development 1999, 126:4175-4186.
42. Bhat KM: frizzled and frizzled 2 play a partially redundant role in wingless signaling and have similar requirements to wingless in neurogenesis. Cell 1998, 95: 1027-1036.
43. Kennerdell JR, Carthew RW: Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway. Cell 1998, 95:1017-1026.
44. Sato A, Kojima T, Ui-Tei K, Miyata Y, Saigo K: Dfrizzled-3, a new Drosophila Wnt receptor, acting as an attenuator of Wingless signaling in wingless hypomorphic mutants. Development 1999, 126:4421-4430.
45. Rocheleau CE, Downs WD, Lin R, Wittmann C, Bei Y, Cha YH, Ali M, Priess JR, Mello CC: Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos. Cell 1997, 90:707-716.
46. Harris J, Honigberg L, Robinson N, Kenyon C: Neuronal cell migration in C elegans: regulation of Hox gene expression and cell position. Development 1996, 122:3117-3131.
47. Sawa H, Lobel L, Horvitz HR: The Caenorhabditis elegans gene lin-17, which is required for certain asymmetric cell divisions, encodes a putative seven-transmembrane protein similar to the Drosophila frizzled protein. Genes Dev 1996, 10:2189-2197.
48. Wang Y, Thekdi N, Smallwood PM, Macke JP, Nathans J: Frizzled-3 is required for the development of major fiber tracts in the rostral CNS. J Neurosci 2002, 22:8563-8573.
49. Wang Y, Huso D, Cahill H, Ryugo D, Nathans J: Progressive cerebellar, auditory, and esophageal dysfunction caused by targeted disruption of the frizzled-4 gene. J Neurosci 2001, 21:4761-4771.
50. Ishikawa T, Tamai Y, Zorn AM, Yoshida H, Seldin MF, Nishikawa S, Taketo MM: Mouse Wnt receptor gene Fzd5 is essential for yolk sac and placental angiogenesis. Development 2001, 128:25-33.
51. Deardorff MA, Tan C, Saint-Jeannet JP, Klein PS: A role for frizzled 3 in neural crest development. Development 2001, 128:3655-3663.
52. Sumanas S, Strege P, Heasman J, Ekker SC: The putative wnt receptor Xenopus frizzled-7 functions upstream of beta-catenin in vertebrate dorsoventral mesoderm patterning. Development 2000, 127:1981-1990.
53. HBG006977 phylogenetic tree in Hoverplot [http://pbil.univ-lyon1.fr/cgi-bin/ acnuc-link-ac2tree?db=Hoverprot&query=O00144]