Effect of metal cations on the conformation and inactivation of recombinant human factor VIII

Journal of Pharmaceutical Sciences

Volumn 93, Issue 10, 2004, Pages 2549-2557

  Derrick, Tiffany S ^a   Kashi, Ramesh S ^b   Durrani, Manzer ^b   Jhingan, Ashish ^b   Middaugh, C Russell ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b BAXTER HEALTHCARE CORPORATION   (United States)

Author keywords

FVIII; Metal induced aggregation; Proteins; Thermal analysis

Indexed keywords

ALUMINUM; BLOOD CLOTTING FACTOR 8; COBALT; IRON; METAL ION; TERBIUM;

ARTICLE; CIRCULAR DICHROISM; COMPLEX FORMATION; CONFORMATION; FLUORESCENCE; LIGHT SCATTERING; MOLECULAR INTERACTION; PROTEIN AGGREGATION; PROTEIN STRUCTURE; THERMOSTABILITY; ULTRAVIOLET SPECTROSCOPY;

EID: 4844230143     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.20167     Document Type: Article

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