NMR characterization of the metallo-β-lactamase from Bacteroides fragilis and its interaction with a tight-binding inhibitor: Role of an active-site loop

Biochemistry

Volumn 38, Issue 44, 1999, Pages 14507-14514

  Scrofani, Sergio D B ^a,c   Chung, John ^a   Huntley, James J A ^a   Benkovic, Stephen J ^b   Wright, Peter E ^a   Dyson, H Jane ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

^c Zenyth Therapeutics Limited Australia   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2' BENZYL 3' MERCAPTOPROPANOYL) 4 CARBOXY 5,5 DIMETHYLTHIAZOLIDINE; BETA LACTAMASE; BETA LACTAMASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BACTEROIDES FRAGILIS; ENZYME ACTIVE SITE; ENZYME INHIBITOR INTERACTION; MOLECULAR INTERACTION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL;

BACTERIAL PROTEINS; BACTEROIDES FRAGILIS; BETA-LACTAMASES; CATALYTIC DOMAIN; DRUG RESISTANCE, MICROBIAL; ENZYME INHIBITORS; MAGNETIC RESONANCE SPECTROSCOPY; METALLOPROTEINS; MODELS, MOLECULAR; PROTEIN STRUCTURE, SECONDARY; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS); BACTEROIDES FRAGILIS;

EID: 0033517787     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi990986t     Document Type: Article

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