Chemical instability of protein pharmaceuticals: Mechanisms of oxidation and strategies for stabilization

Biotechnology and Bioengineering

Volumn 48, Issue 5, 1995, Pages 490-500

  Li, Shihong ^a   Schöneich, Christian ^a   Borchardt, Ronald T ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

chelator; metal catalysis; oxidation; peptide; photooxidation; protein

Indexed keywords

ADDITIVES; CATALYSIS; CHELATION; COMPOSITION EFFECTS; DRUG PRODUCTS; FREE RADICALS; OXIDATION; PH EFFECTS; PHOTOCHEMICAL REACTIONS; THERMAL EFFECTS;

CHELATOR; CHEMICAL INSTABILITY; OXIDANTS; PEPTIDE; PHOTOOXIDATION; PROTEIN PHARMACEUTICALS;

PROTEINS;

CYSTEINE; HISTIDINE; METHIONINE; TRYPTOPHAN; TYROSINE;

ARTICLE; CONFORMATIONAL TRANSITION; PHOTOOXIDATION; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN PROCESSING; PROTEIN STABILITY;

LETHRINIDAE;

EID: 0029637161     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.260480511     Document Type: Article

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