Effects of acidic N + 1 residues on asparagine deamidation rates in solution and in the solid state

Journal of Pharmaceutical Sciences

Volumn 94, Issue 3, 2005, Pages 666-675

  Li, Bei ^a   Gorman, Eric M ^b   Moore, Kimberly D ^a   Williams, Todd ^a   Schowen, Richard L ^a   Topp, Elizabeth M ^a   Borchardt, Ronald T ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b DRAKE UNIVERSITY   (United States)

Author keywords

Deamidation; Peptides; Solid state stability

Indexed keywords

ACETYLGLYCYLGLUTAMINYLASPARAGINYLASPARTYLGLYCINE; ACETYLGLYCYLGLUTAMINYLASPARAGINYLGLUTAMINYLGLYCINE; ACETYLGLYCYLGLUTAMINYLASPARAGINYLGLUTAMYLGYCINE; ACETYLGLYCYLGLUTAMINYLASPARAGINYLGLYCYLGLYCINE; AMMONIA; ASPARAGINE; CARBONYL DERIVATIVE; PEPTIDE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION KINETICS; DEAMINATION; DRUG FORMULATION; FREEZE DRYING; HYDRATION; ISOMERIZATION; PH; SOLID STATE; SOLUTION AND SOLUBILITY; STEREOCHEMISTRY;

EID: 16444383511     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.20263     Document Type: Article

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