15N NMR relaxation studies of free and inhibitor-bound 4-oxalocrotonate tautomerase: Backbone dynamics and entropy changes of an enzyme upon inhibitor binding

Biochemistry

Volumn 35, Issue 50, 1996, Pages 16036-16047

  Stivers, James T ^a   Abeygunawardana, Chitrananda ^a   Mildvan, Albert S ^a   Whitman, Christian P ^b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 OXALOCROTONATE TAUTOMERASE; 4-OXALOCROTONATE TAUTOMERASE; DRUG DERIVATIVE; ENZYME INHIBITOR; ISOMERASE; MUCONIC ACID; NITROGEN; PROLINE; SORBIC ACID; CROTONIC ACID DERIVATIVE;

ARTICLE; AUDIOVISUAL EQUIPMENT; BINDING SITE; CHEMICAL MODEL; CHEMISTRY; DRUG ANTAGONISM; ENTROPY; KINETICS; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN SECONDARY STRUCTURE; STEREOISOMERISM; CHEMICAL STRUCTURE; COMPETITIVE INHIBITION; ENZYME INHIBITOR INTERACTION; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SYNTHESIS;

BINDING SITES; ENTROPY; ENZYME INHIBITORS; ISOMERASES; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; MODELS, STRUCTURAL; NITROGEN ISOTOPES; PROLINE; PROTEIN STRUCTURE, SECONDARY; SORBIC ACID; STEREOISOMERISM;

EID: 0030299991     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi961834q     Document Type: Article

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