A method for rapidly predicting drug tissue distribution using surfactant vesicle electrokinetic chromatography

Electrophoresis

Volumn 29, Issue 17, 2008, Pages 3674-3684

  Jiang, Zhengjin ^a   Reilly, John ^a   Everatt, Brian ^a  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

Inhaled drug; Surfactant vesicle electrokinetics chromatography; Tissue distribution; Tissue to plasma water partitioning coefficient

Indexed keywords

BIOCHEMISTRY; BIOLOGICAL ORGANS; DRUG DOSAGE; ELECTRODYNAMICS; ELECTROHYDRODYNAMICS; ELECTROMAGNETIC FIELDS; RATS; SURFACE ACTIVE AGENTS;

AOT SURFACTANT; ELECTROKINETIC CHROMATOGRAPHY; INHALED DRUG; LUNG TISSUE; PARTITIONING COEFFICIENTS; SURFACTANT VESICLE ELECTROKINETIC CHROMATOGRAPHY; SURFACTANT VESICLES; TISSUE DISTRIBUTIONS; TISSUE-TO-PLASMA WATER PARTITIONING COEFFICIENT; WATER PARTITIONING;

TISSUE;

ACEBUTOLOL; ADRENALIN; AMLEXANOX; BAMBUTEROL; BUDESONIDE; CLENBUTEROL; CROMOGLYCATE DISODIUM; DOCUSATE SODIUM; FENOTEROL; FLUNISOLIDE; FLUTICASONE; FORMOTEROL; INDACATEROL; IPRATROPIUM BROMIDE; ISOETARINE; ISOPRENALINE; METOPROLOL; MOMETASONE FUROATE; NICOTINE; ORCIPRENALINE; OXPRENOLOL; PIRBUTEROL; PLASMA PROTEIN; SALBUTAMOL; SALMETEROL; TERBUTALINE; TIMOLOL; TRIAMCINOLONE; TULOBUTEROL; UNINDEXED DRUG;

ANIMAL TISSUE; ARTICLE; ARTIFICIAL MEMBRANE; BRAIN TISSUE; CONTROLLED STUDY; DISTRIBUTION VOLUME; DRUG DISTRIBUTION; DRUG PROTEIN BINDING; DRUG RETENTION; DRUG TISSUE LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INTERMETHOD COMPARISON; LIQUID CHROMATOGRAPHY; LUNG PARENCHYMA; MICELLAR ELECTROKINETIC CHROMATOGRAPHY; NONHUMAN; PHYSICAL CHEMISTRY; PREDICTION; RAT; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; STEADY STATE; SURFACTANT VESICLE ELECTROKINETIC CHROMATOGRAPHY; TISSUE DISTRIBUTION; TISSUE SPECIFICITY;

EID: 53149123260     PISSN: 01730835     EISSN: 15222683     Source Type: Journal    
DOI: 10.1002/elps.200800236     Document Type: Article

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