Enantioselective tissue distribution of the basic drugs disopyramide, flecainide and verapamil in rats: Role of plasma protein and tissue phosphatidylserine binding

Pharmaceutical Research

Volumn 15, Issue 8, 1998, Pages 1250-1256

  Hanada, Kazuhiko ^a   Akimoto, Satoko ^a   Mitsui, Keiko ^a   Mihara, Kiyoshi ^a   Ogata, Hiroyasu ^a  

^a MEIJI PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Disopyramide; Phosphatidylserine; Stereoselectivity; Tissue distribution; Verapamil

Indexed keywords

DISOPYRAMIDE; FLECAINIDE; VERAPAMIL;

ANIMAL EXPERIMENT; ARTICLE; BRAIN; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG PROTEIN BINDING; ENANTIOMER; HEART; INTRAVENOUS DRUG ADMINISTRATION; LUNG; MALE; MUSCLE; NONHUMAN; PARTITION COEFFICIENT; PRIORITY JOURNAL; RACEMIC MIXTURE; RAT; STEREOCHEMISTRY; TISSUE DISTRIBUTION;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; BLOOD PROTEINS; DISOPYRAMIDE; FLECAINIDE; MALE; PHOSPHATIDYLSERINES; PROTEIN BINDING; RATS; RATS, WISTAR; STEREOISOMERISM; TISSUE DISTRIBUTION; VERAPAMIL;

EID: 0031664814     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011948126170     Document Type: Article

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