Investigation of vesicle electrokinetic chromatography as an in vitro assay for the estimation of intestinal permeability of pharmaceutical drug candidates

Electrophoresis

Volumn 27, Issue 4, 2006, Pages 793-804

  Pascoe, Robert J ^a   Masucci, John A ^b   Foley, Joe P ^c  

^a MERCK RESEARCH LABORATORIES   (United States)

^b JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^c DREXEL UNIVERSITY   (United States)

Author keywords

Permeability; Surfactant; Vesicle electrokinetic chromatography

Indexed keywords

BIOACTIVITY; COST EFFECTIVENESS; ELECTRODYNAMICS; MOLECULES; SURFACE ACTIVE AGENTS; THROUGHPUT;

BI-LAYER STRUCTURE; DRUG CANDIDATES; ELECTROKINETIC CHROMATOGRAPHY; HIGH-THROUGHPUT; IN-VITRO ASSAYS; INTESTINAL PERMEABILITIES; PASSIVE DIFFUSIONS; PERMEABILITY; PHARMACEUTICAL DRUGS; VESICLE ELECTROKINETIC CHROMATOGRAPHY;

PHOSPHOLIPIDS;

ACETOPHENONE; ACETYLSALICYLIC ACID; ACICLOVIR; ALPRENOLOL; ATENOLOL; BENZALDEHYDE; BENZYL ALCOHOL; BROMOBENZENE; BUTYROPHENONE; CAFFEINE; ESTRADIOL; GRISEOFULVIN; HYDROCHLOROTHIAZIDE; METOPROLOL; NICOTINE; PROGESTERONE; SURFACTANT; TIMOLOL; WARFARIN;

ARTICLE; AUTOMATION; CORRELATION ANALYSIS; COST EFFECTIVENESS ANALYSIS; DRUG ABSORPTION; DRUG PENETRATION; DRUG RETENTION; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROPHOBICITY; IN VITRO STUDY; IN VIVO STUDY; INTESTINE MUCOSA PERMEABILITY; MICELLAR ELECTROKINETIC CHROMATOGRAPHY; PHOSPHOLIPID BILAYER; PHOSPHOLIPID VESICLE; PREDICTION; STATISTICAL MODEL; STATISTICAL SIGNIFICANCE;

EID: 33644684597     PISSN: 01730835     EISSN: 15222683     Source Type: Journal    
DOI: 10.1002/elps.200500647     Document Type: Article

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