Asn102 of the gonadotropin-releasing hormone receptor is a critical determinant of potency for agonists containing C-terminal glycinamide

Journal of Biological Chemistry

Volumn 271, Issue 26, 1996, Pages 15510-15514

  Davidson, James S ^a   McArdle, Craig A ^b   Davies, Peter ^a   Elario, Ricardo ^a   Flanagan, Colleen A ^a   Millar, Robert P ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARAGINE; GLYCINAMIDE; GONADORELIN RECEPTOR; DRUG DERIVATIVE; GLYCINE; GONADORELIN; INOSITOL PHOSPHATE; LIGAND; OLIGODEOXYRIBONUCLEOTIDE;

ARTICLE; CARBOXY TERMINAL SEQUENCE; DNA HELIX; DRUG POTENCY; DRUG RECEPTOR BINDING; ENZYME SPECIFICITY; EXOCYTOSIS; GENE MUTATION; HYDROGEN BOND; LIGAND BINDING; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; SECOND MESSENGER; AMINO ACID SEQUENCE; BINDING SITE; CHEMISTRY; HUMAN; METABOLISM; MOLECULAR GENETICS; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ASPARAGINE; BINDING SITES; GLYCINE; GONADOTROPIN-RELEASING HORMONE; HUMANS; INOSITOL PHOSPHATES; LIGANDS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; OLIGODEOXYRIBONUCLEOTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, LHRH; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0029666304     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.26.15510     Document Type: Article

References (29)

1. Tsutsumi, M., Zhou, W., Millar, R. P., Mellon, P. L., Roberts, J. L., Flanagan, C. A., Dong, K., Gillo, B., and Sealfon, S. C. (1992) Mol. Endocrinol. 6, 1163-1169
2. Kakar, S. S., Musgrove, L. C., Devor, D. C., Sellers, J. C., and Neill, J. D. (1992) Biochem. Biophys. Res. Commun. 189, 289-295
3. Kaiser, U. B., Zhao, D., Cardona, G. R., and Chin, W. W. (1992) Biochem. Biophys. Res. Commun. 189, 1645-1652
4. Reinhart, J., Mertz, L. M., and Catt, K. J. (1992) J. Biol. Chem. 267, 21281-21284
5. Chi, L., Zhou, W., Prikhozhan, A., Flanagan, C., Davidson, J. S., Golembo, M., Illing, N., Millar, R. P., and Sealfon, S. C. (1993) Mol. Cell. Endocrinol. 91, R1-R6
6. Illing, N., Jacobs, G. F. M., Becker, I. I., Flanagan, C., Davidson, J. S., and Millar, R. P. (1993) Biochem. Biophys. Res. Commun. 196, 745-751
7. Kakar, S. S., Rahe, C. H., and Neill, J. D. (1993) Domest. Anim. Endocrinol. 10, 335-342
8. Hsieh, K.-P., and Martin, T. F. J. (1992) Mol. Endocrinol. 6, 1673-1681
9. Tse, A., and Hille, B. (1992) Science 255, 462-464
10. Davidson, J., van der Merwe, P. A., Wakefield, I., and Millar, R. P. (1991) Mol. Cell. Endocrinol. 76, C33-C38
11. Karten, M. J., and Rivier, J. E. (1986) Endocr. Rev. 7, 44-66
12. Millar, R. P., King, J. A., Davidson, J. S., and De L. Milton, R. C. (1987) S. Afr. Med. J. 72, 748-755
13. Leslie, F. M. (1987) Pharmacol. Rev. 39, 197-237
14. Gether, U., Johansen, T. E., and Schwartz, T. W. (1993) J. Biol. Chem. 268, 7893-7898
15. Smith, R. D., Chiu, A. T., Wong, P. C., Herblin, W. F., and Timmermans, P. B. M. W. M. (1992) Annu Rev. Pharmacol. Toxicol. 32, 135-165
16. Fujino, M., Kobayashi, S., Obayashi, M., Shinagawa, S., Fukuda, T., Kitada, C., Nakayaga, R., Yamakazi, I., White, W. F., and Rippel, R. H. (1972) Biochem. Biophys. Res. Commun. 49, 863-869
17. Schwartz, T. W. (1994) Curr. Opin. Biotechnol. 5, 434-444
18. Davidson, J. S., Flanagan, C. A., Zhou, W., Becker, I. I., Elario, R., Emeran, W., Sealfon, S. C., and Millar, R. P. (1995) Mol. Cell. Endocrinol. 107, 241-245
19. Kunkel, T. A., Bebenek, K., and McClary, J. (1991) Methods Enzymol. 204, 125-139
20. Keown, W. A., Campbell, C. R., and Kucherlapati, R. S. (1990) Methods Enzymol. 185, 527-537
21. Davidson, J. S., Wakefield, I. K., Sohnius, U., van der Merwe, P. A., and Millar, R. P. (1990) Endocrinology 126, 80-87
22. Kenakin, T. (1993) in Pharmacologic Analysis of Drug-Receptor Interaction, 2nd Ed., pp. 39-68, Raven Press, Ltd., New York
23. Zhou, W., Rodic, V., Kitanovic, S., Flanagan, C. A., Chi, L., Weinstein, H., Maayani, S., Millar, R. P., and Sealfon, S. C. (1995) J. Biol. Chem. 270, 18853-18857
24. Monahan, M. W., Amoss, M. S., Anderson, H. A., and Vale, W. (1973) Biochemistry 12, 4616
25. Freidinger, R. M., Veber, D. F., Perlow, D. S., Brooks, J. R., and Saperstein, R. (1980) Science 210, 656-658
26. Flanagan, C. A., Becker, I. I., Davidson, J. S., Wakefield, I. K., Zhou, W., Sealfon, S. C., and Millar, R. P. (1994) J. Biol. Chem. 269, 22636-22641
27. Baldwin, J. M. (1993) EMBO J. 12, 1693-1703
28. Ballesteros, J. A., and Weinstein, H. (1995) Methods Neurosci. 25, 366-430
29. Zhou, W., Flanagan, C., Ballesteros, J. A., Konvicka, K., Davidson, J. S., Weinstein, H., Millar, R. P., and Sealfon, S. C. (1994) Mol. Pharmacol. 45, 165-170