Ligand-specific changes in M3 muscarinic acetylcholine receptor structure detected by a disulfide scanning strategy

Biochemistry

Volumn 47, Issue 9, 2008, Pages 2776-2788

  Jian, Hua Li ^a   Hamdan, Fadi F ^a,b   Kim, Soo Kyung ^a   Jacobson, Kenneth A ^a   Zhang, Xiaohong ^a   Han, Sung Jun ^a,c   Wess, Jürgen ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b UNIVERSITY OF MONTREAL   (Canada)

^c Institute Pasteur Korea   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ENERGY; CELL MEMBRANES; CROSSLINKING; MOLECULAR STRUCTURE; PROTEINS;

G PROTEIN-COUPLED RECEPTOR (GPCR) FUNCTION; MUSCARINIC ACETYLCHOLINE; STRUCTURAL DISTURBANCES;

LIGANDS;

CHOLINERGIC RECEPTOR; CYSTEINE; DISULFIDE; GUANINE NUCLEOTIDE BINDING PROTEIN; LIGAND; MUSCARINIC AGENT; MUSCARINIC M3 RECEPTOR; MUTANT PROTEIN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELL STRAIN COS7; COMPARATIVE STUDY; CROSS REACTION; CYTOPLASM; DISULFIDE BOND; MEMBRANE STRUCTURE; MOLECULAR DYNAMICS; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN STABILITY; PROTEIN STRUCTURE; RECEPTOR UPREGULATION;

AMINO ACID SEQUENCE; ANIMALS; BLOTTING, WESTERN; CARBACHOL; CERCOPITHECUS AETHIOPS; COS CELLS; DISULFIDES; HYDROLYSIS; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PHOSPHATIDYLINOSITOLS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, MUSCARINIC M3;

EID: 40149095112     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi7019113     Document Type: Article

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