Flavonoids and intestinal cancers

British Journal of Nutrition

Volumn 99, Issue E-SUPPL. 1, 2008, Pages

  Pierini, Roberto ^a   Gee, Jennifer M ^a   Belshaw, Nigel J ^a   Johnson, Ian T ^a  

^a INSTITUTE OF FOOD RESEARCH   (United Kingdom)

Author keywords

Colon; Neoplasia; Oesophagus; Quercetin; Stomach

Indexed keywords

ACETYLSALICYLIC ACID; AGLYCONE; ANTINEOPLASTIC AGENT; APIGENIN; ASCORBIC ACID; BLACK TEA EXTRACT; CARCINOGEN; CATECHOL DERIVATIVE; CHRYSIN; CURCUMIN; CYCLOOXYGENASE 2 INHIBITOR; EPIGALLOCATECHIN; EPIGALLOCATECHIN GALLATE; FLAVANOL DERIVATIVE; FLAVANONE DERIVATIVE; FLAVONOID; FLAVONOL DERIVATIVE; FLAVOPIRIDOL; GREEN TEA EXTRACT; HESPERETIN; ISOFLAVONE DERIVATIVE; KAEMPFEROL; LUTEOLIN; MYRICETIN; NARINGENIN; PLANT GLYCOSIDE; PLANT MEDICINAL PRODUCT; POLYPHENOL DERIVATIVE; QUERCETIN; UNINDEXED DRUG;

ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; CANCER CELL; CANCER INHIBITION; CANCER RISK; CELL PROLIFERATION; COLORECTAL CARCINOMA; DIETARY INTAKE; DIGESTIVE SYSTEM CANCER; DNA DAMAGE; DNA REPAIR; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG METABOLISM; DRUG SYNTHESIS; DRUG TARGETING; ESOPHAGUS CANCER; FOOD ANALYSIS; FOOD COMPOSITION; FRUIT; GENE EXPRESSION REGULATION; GENETIC RISK; GENOMICS; GROWTH REGULATION; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; LUNG METASTASIS; NONHUMAN; NUTRITIONAL HEALTH; NUTRITIONAL VALUE; OSTEOARTHRITIS; PHARMACOGENETICS; PREDICTION; PROTEIN DETERMINATION; RED WINE; REVIEW; RISK ASSESSMENT; RISK FACTOR; RISK REDUCTION; STOMACH CARCINOGENESIS; STOMACH CARCINOID; TUMOR SUPPRESSOR GENE; VEGETABLE;

ANTICARCINOGENIC AGENTS; COLORECTAL NEOPLASMS; DIET; ESOPHAGEAL NEOPLASMS; FLAVONOIDS; GASTROINTESTINAL NEOPLASMS; HUMANS; STOMACH NEOPLASMS;

ANIMALIA;

EID: 52949093946     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114508965764     Document Type: Review

References (80)

1. Parkin DM, Bray F, Ferlay J & Pisani P (2005) Global cancer statistics, 2002. CA Cancer J Clin 55, 74-108.
2. World Cancer Research Fund (1997) Food, Nutrition and the Prevention of Cancer: A Global Perspective, pp. 216-251. Washington DC: American Institute for Cancer Research.
3. Hollman PCH & Arts ICW (2000) In Flavonols, flavones and flavanols - nature, occurrence and dietary burden. J Sci Food Agric 80, 1081-1093.
4. Corthesy-Theulaz I, den Dunnen JT, Ferre P, Geurts JM, Muller M, van Belzen N & van Ommen B (2005) Nutrigenomics: The impact of biomics technology on nutrition research. Ann Nutr Metab 49, 355-365.
5. Davis CD & Hord NG (2005) Nutritional "omics" technologies for elucidating the role(s) of bioactive food components in colon cancer prevention. J Nutr 135, 2694-2697.
6. Mariman EC (2006) Nutrigenomics and nutrigenetics: The 'omics' revolution in nutritional science. Biotechnol Appl Biochem 44 119-128.
7. Fuchs D, Winkelmann I, Johnson IT, Mariman E, Wenzel U & Daniel H (2005) Proteomics in nutrition research: Principles, technologies and applications. Br J Nutr 94, 302-314.
8. Day AJ, Gee JM, DuPont MS, Johnson IT & Williamson G (2003) Absorption of quercetin-3-glucoside and quercetin-4′-glucoside in the rat small intestine: The role of lactase phlorizin hydrolase and the sodium-dependent glucose transporter. Biochem Pharmacol 65, 1199-1206.
9. Scalbert A, Morand C, Manach C & Remesy C (2002) Absorption and metabolism of polyphenols in the gut and impact on health. Biomed Pharmacother 56, 276-282.
10. Nelson DR, Kamataki T, Waxman DJ, Guengerich FP, Estabrook RW, Feyereisen R, Gonzalez FJ, Coon MJ, Gunsalus IC, Gotoh O, et al. (1993) The P450 superfamily: Update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. DNA Cell Biol 12, 1-51.
11. Prochaska HJ & Talalay P (1988) Regulatory mechanisms of monofunctional and bifunctional anticarcinogenic enzyme inducers in murine liver. Cancer Res 48, 4776-4782.
12. Chou FP, Chu YC, Hsu JD, Chiang HC & Wang CJ (2000) Specific induction of glutathione S-transferase GSTM2 subunit expression by epigallocatechin gallate in rat liver. Biochem Pharmacol 60, 643-650.
13. Chan AT, Giovannucci EL, Meyerhardt JA, Schernhammer ES, Curhan GC & Fuchs CS (2005) Long-term use of aspirin and nonsteroidal anti-inflammatory drugs and risk of colorectal cancer. JAMA 294 914-923.
14. Ranka S, Gee JM, Johnson IT, Skinner J, Hart AR & Rhodes M (2006) Non-Steroidal Anti-Inflammatory Drugs, Lower Oesophageal Sphincter-Relaxing Drugs and Oesophageal Cancer. A Case-Control Study. Digestion 74, 109-115.
15. Vaughan TL, Dong LM, Blount PL, Ayub K, Odze RD, Sanchez CA, Rabinovitch PS & Reid BJ (2005) Non-steroidal anti-inflammatory drugs and risk of neoplastic progression in Barrett's oesophagus: A prospective study. Lancet Oncol 6, 945-952.
16. Singh S & Aggarwal BB (1995) Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloyl-methane). J Biol Chem 270, 24995-25000.
17. Natarajan K, Singh S, Burke TR Jr, Grunberger D & Aggarwal BB (1996) Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B. Proc Natl Acad Sci U S A 93, 9090-9095.
18. Baumann J, von Bruchhausen F & Wurm G (1980) Flavonoids and related compounds as inhibition of arachidonic acid peroxidation. Prostaglandins 20, 627-639.
19. Liang YC, Tsai SH, Tsai DC, Lin-Shiau SY & Lin JK (2001) Suppression of inducible cyclooxygenase and nitric oxide synthase through activation of peroxisome proliferator-activated receptor-gamma by flavonoids in mouse macrophages. FEBS Lett 496, 12-18.
20. Byun T, Karimi M, Marsh JL, Milovanovic T, Lin F & Holcombe RF (2005) Expression of secreted Wnt antagonists in gastrointestinal tissues: potential role in stem cell homeostasis. J Clin Pathol 58, 515-519.
21. Gregorieff A & Clevers H (2005) Wnt signaling in the intestinal epithelium: From endoderm to cancer. Genes Dev 19, 877-890.
22. Kundu JY, Choi K-Y & Surh Y-J (2006) Beta-catenin-mediated sinalling: A novel molecular target for chemoprevention with anti-inflammatory substances. Biochimica et Biophysica Acta 1765, 14-24.
23. Park CH, Chang JY, Hahm ER, Park S, Kim HK & Yang CH (2005) Quercetin, a potent inhibitor against beta-catenin/Tcf signaling in SW480 colon cancer cells. Biochem Biophys Res Commun 328, 227-234.
24. Hara H, Gee JM & Johnson IT (1999) Antiproliferative effects of quercetin in the rat gastrointestinal tract. In Antiproliferative Effects of Quercetin in the Rat Gastrointestinal Tract, pp. 49-53 [A Krogdahl, SD Mathieson and IF Pryme, editors]. Brussels: European Commission.
25. Jaiswal AS, Marlow BP, Gupta N & Narayan S (2002) Beta-catenin-mediated transactivation and cell-cell adhesion pathways are important in curcumin (diferuylmethane)-induced growth arrest and apoptosis in colon cancer cells. Oncogene 21, 8414-8427.
26. Joe AK, Liu H, Suzui M, Vural ME, Xiao D & Weinstein IB (2002) Resveratrol induces growth inhibition, S-phase arrest, apoptosis, and changes in biomarker expression in several human cancer cell lines. Clin Cancer Res 8, 893-903.
27. Agullo G, Gamet-Payrastre L, Fernandez Y, Anciaux N, Demigne C & Remesy C (1996) Comparative effects of flavonoids on the growth, viability and metabolism of a colonic adenocarcinoma cell line (HT29 cells). Cancer Lett 105, 61-70.
28. Wenzel U, Kuntz S, Brendel MD & Daniel H (2000) Dietary flavone is a potent apoptosis inducer ih human colon carcinoma cells. Cancer Res 60, 3823-3831.
29. Kim MJ, Kim DH, Na HK, Oh TY, Shin CY & Surh Ph DPYJ (2005) Eupatilin, a pharmacologically active flavone derived from Artemisia plants, induces apoptosis in human gastric cancer (AGS) cells. J Environ Pathol Toxicol Oncol 24, 261-269.
30. Musk SR, Stephenson P, Smith TK, Stening P, Fyfe D & Johnson IT (1995) Selective toxicity of compounds naturally present in food toward the transformed phenotype of human-colorectal cell line HT29. Nutr Cancer 24, 289-298.
31. Winawer SJ (1999) Natural history of colorectal cancer. Am J Med 106, 3S-6S, discussion 50S-51S.
32. Vogelstein B, Fearon ER, Hamilton SR, Kern SE, Preisinger AC, Leppert M, Nakamura Y, White R, Smits AM & Bos JL (1998) Genetic alterations during colorectal-tumor development. N Engl J Med 319, 525-532.
33. Jubb AM, Bell SM & Quirke T (2001) Methylation and colorectal cancer. J Pathol 195, 111-134.
34. Bestor TH (1998) Gene silencing. Methylation meets acetylation. Nature 393, 311-312.
35. Esteller M, Corn PG, Baylin SB & Herman JG (2001) A gene hypermethylation profile of human cancer. Cancer Res 61, 3225-3229.
36. Issa JP (2000) The epigenetics of colorectal cancer. Ann N Y Acad Sci 910, 140-153.
37. Lin J, Zhang SM, Wu K, Willett WC, Fuchs CS & Giovannucci E (2006) Flavonoid intake and colorectal cancer risk in men and women. Am J Epidemiol 164, 644-651.
38. Lodovici M, Casalini C, De Filippo C, Copeland E, Xu X, Clifford M & Dolara P (2000) Inhibition of 1,2-dimethylhydrazine-induced oxidative DNA damage in rat colon mucosa by black tea complex polyphenols. Food Chem Toxicol 38, 1085-1088.
39. Sengupta A, Ghosh S & Das S (2003) Tea can protect against aberrant crypt foci formation during azoxymethane induced rat colon carcinogenesis. J Exp Clin Cancer Res 22, 185-191.
40. Ogasawara M, Matsunaga T & Suzuki H (2007) Differential effects of antioxidants on the in vitro invasion, growth and lung metastasis of murine colon cancer cells. Biol Pharm Bull 30, 200-204.
41. Orner GA, Dashwood WM, Blum CA, Diaz GD, Li Q & Dashwood RH (2003) Suppression of tumorigenesis in the Apc(min) mouse: Down-regulation of beta-catenin signaling by a combination of tea plus sulindac. Carcinogenesis 24, 263-267.
42. Ju J, Hong J, Zhou JN, Pan Z, Bose M, Liao J, Yang GY, Liu YY, Hou Z, Lin Y, Ma J, Shih WJ, Carothers AM & Yang CS (2005) Inhibition of intestinal tumorigenesis in Apcmin/+ mice by (-)-epigallocatechin-3-gallate, the major catechin in green tea. Cancer Res 65, 10623-10631.
43. Sun CL, Yuan JM, Koh WP & Yu MC (2006) Green tea, black tea and colorectal cancer risk: A meta-analysis of epidemiologic studies. Carcinogenesis 27, 1301-1309.
44. Dolara P, Luceri C, Filippo CD, Femia AP, Giovannelli L, Caderni G, Ceechini C, Silvi S, Orpianesi C & Cresci A (2005) Red wine polyphenols influence carcinogenesis, intestinal microflora, oxidative damage and gene expression profiles of colonic mucosa in F344 rats. Mutat Res 591, 237-246.
45. Lauren P (1965) The two histologic main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. Acta Pathol Microbial Scand 64, 31-49.
46. Crew KD & Neugut AI (2006) Epidemiology of gastric cancer. World J Gastroenterol 12, 354-362.
47. Peek RM Jr & Blaser MJ (2002) Helicobacter pylori and gastrointestinal tract adenocarcinomas. Nat Rev Cancer 2, 28-37.
48. Correa P (1992) Human gastric carcinogenesis: A multistep and multifactorial process. Cancer Res 52, 6735-6740.
49. Huang JQ, Sridhar S, Chen Y & Hunt RH (1998) Meta-analysis of the relationship between Helicobacter pylori seropositivity and gastric cancer. Gastroenterology 114, 1169-1179.
50. Ruggiero P, Tombola F, Rossi G, Pancotto L, Lauretti L, Del Giudice G & Zoratti M (2006) Polyphenols reduce gastritis induced by Helicobacter pylori infection or VacA toxin administration in mice. Antimicrob Agents Chemother 50, 2550-2552.
51. Yoshida M, Sakai T, Hosokawa N, Marui N, Matsumoto K, Fujioka A, Nishino H & Aoike A (1990) The effect of quercetin on cell cycle progression and growth of human gastric cancer cells. FEBS Lett 260, 10-13.
52. Yoshimizu N, Otani Y, Saikawa Y, Kubota T, Yoshida M, Furukawa T, Kumai K, Kameyama K, Fujii M, Yano M, Sato T, Ito A & Kitajima M (2004) Anti-tumour effects of nobiletin, a citrus flavonoid, on gastric cancer include: Antiproliferative effects, induction of apoptosis and cell cycle deregulation. Aliment Pharmacol Ther 20, Suppl 1, 95-101.
53. Sun CL, Yuan JM, Lee MJ, Yang CS, Gao YT, Ross RK & Yu MC (2002) Urinary tea polyphenols in relation to gastric and esophageal cancers: A prospective study of men in Shanghai, China. Carcinogenesis 23 1497-1503.
54. Lagiou P, Samoli E, Lagiou A, Peterson J, Tzonou A, Dwyer J & Trichopoulos D (2004) Flavonoids, vitamin C and adenocarcinoma of the stomach. Cancer Causes Control 15, 67-72.
55. Gaspar J, Laires A, Monteiro M, Laureano O, Ramos E & Rueff J (1993) Quercetin and the mutagenicity of wines. Mutagenesis 8, 51-55.
56. Ferlay J, Bray F, Pisani P & Parkin DM (2001) IARC Cancer Base No. 5, GLOBOCAN 2000: Cancer Incidence, Mortality and Prevalence Worldwide. Lyon: IARC.
57. Roth MJ, Strickland KL, Wang GQ, Rothman N, Greenberg A & Dawsey SM (1998) High levels of carcinogenic polycyclic aromatic hydrocarbons present within food from Linxian, China may contribute to that region's high incidence of oesophageal cancer. Eur J Cancer 34, 757-758.
58. Newnham A, Quinn MJ, Babb P, Kang JY & Majeed A (2003) Trends in the subsite and morphology of oesophageal and gastric cancer in England and Wales 1971-1998. Aliment Pharmacol Ther 17, 665-676.
59. Prach AT, MacDonald TA, Hopwood DA & Johnston DA (1997) Increasing incidence of Barrett's oesophagus: Education, enthusiasm, or epidemiology? Lancet 350, 933.
60. Wild CP & Hardie LJ (2003) Reflux; Barrett's oesophagus and adenocarcinoma: Burning questions. Nat Rev Cancer 3, 676-684.
61. Lagergren J, Bergstrom R, Lindgren A & Nyren O (1999) Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma. N Engl J Med 340, 825-831.
62. Lagergren J, Bergstrom R & Nyren O (1999) Association between body mass and adenocarcinoma of the esophagus and gastric cardia. Ann Intern Med 130, 883-890.
63. Bosetti C, La Vecchia C, Talamini R, Simonato L, Zambon P, Negri E, Trichopoulos D, Lagiou P, Bardini R & Franceschi S (2000) Food groups and risk of squamous cell esophageal cancer in northern Italy. Int J Cancer 87, 289-294.
64. Zhao Y, Cao J, Ma H & Liu J (1997) Apoptosis induced by tea polyphenols in HL-60 cells. Cancer Lett 121, 163-167.
65. Engel LS, Chow WH, Vaughan TL, Gammon MD, Risch HA, Stanford JL, Schoenberg JB, Mayne ST, Dubrow R, Rotterdam H, West AB, Blaser M, Blot WJ, Gail MH & Fraumeni JF Jr (2003) Population attributable risks of esophageal and gastric cancers. J Natl Cancer Inst 95, 1404-1413.
66. Liang YC, Huang YT, Tsai SH, Lin-Shiau SY, Chen CF & Lin JK (1999) Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages. Carcinogenesis 20, 1945-1952.
67. O'Leary KA, de Pascual-Tereasa S, Needs PW, Bao YP, O'Brien NM & Williamson G (2004) Effect of flavonoids and vitamin E on,cyclooxygenase-2 (COX-2) transcription. Mutat Res 551, 245-254.
68. Cheong E, Ivory K, Doleman J, Parker ML, Rhodes M & Johnson IT (2004) Synthetic and naturally, occurring COX-2 inhibitors suppress proliferation in a human oesophageal adenocarcinoma cell line (OE33) by inducing apoptosis and cell cycle arrest. Carcinogenesis 25, 1945-1952.
69. Li ZG, Shimada Y, Sato F, Maeda M, Itami A, Kaganoi J, Komoto I, Kawabe A & Imamura M (2002) Inhibitory effects of epigallocatechin-3-gallate on N-nitrosomethylbenzylamine-induced esophageal tumorigenesis in F344 rats. Int J Oncol 21, 1275-1283.
70. Nie Y, Liao J, Zhao X, Song Y, Yang GY, Wang LD & Yang CS (2002) Detection of multiple gene hypermethylation in the development of esophageal squamous cell carcinoma. Carcinogenesis 23, 1713-1720.
71. Fang MZ, Wang Y, Ai N, Hou Z, Sun Y, Lu H, Welsh W & Yang CS (2003) Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines. Cancer Res 63, 7563-7570.
72. Fang MZ, Jin Z, Wang Y, Liao J, Yang GY, Wang LD & Yang CS (2005) Promoter hypermethylation and inactivation of O(6)-methylguanine-DNA methyltransferase in esophageal squamous cell carcinomas and its reactivation in cell lines. Int J Oncol 216, 615-622.
73. Carlson BA, Dubay MM, Sausville EA, Brizuela L & Worland PJ (1996) Flavopiridol induces G1, arrest with inhibition of cyclin-dependent kinase (CDK) 2 and CDK4 in human breast carcinoma cells. Cancer Res 56, 2973-2978.
74. Schrump DS, Matthews W, Chen GA, Mixon A & Altorki NK (1998) Flavopiridol mediates cell cycle arrest and apoptosis in esophageal cancer cells. Clin Cancer Res 4, 2885-2890.
75. Blagosklonny MV (2004) Flavopiridol, an inhibitor of transcription: implications, problems and solutions. Cell Cycle 3, 1537-1542.
76. Raju U, Ariga H, Koto M, Lu X, Pickett J, Valdecanas D, Mason KA & MiJas L (2006) Improvement of esophageal adenocarcinoma cell and xenograft responses to radiation by targeting, cyclin-dependent kinases. Radiother Oncol 80, 185-191.
77. Sato S, Kajiyama Y, Sugano M, Iwanuma Y & Tsurumaru M (2004) Flavopiridol as a radio-sensitizer for esophageal cancer cell lines. Dis Esophagus 17, 338-344.
78. Cooke DN, Thomasset S, Boocock DJ, Schwarz M, Winter-halter P, Steward WP, Gescher AJ & Marczylo TH (2006) Development of analyses by high-performance liquid chromatography and liquid chromatography/tandem mass spectrometry of bilberry (Vaccinium myrtilus) anthocyanins in human plasma and urine. J Agric Food Chem 54, 7009-7013.
79. Ranka S, Gee JM, Biro L, Brett G, Saha S, Kroon P, Skinner J, Hart AR, Cassidy A, Rhodes M & Johnson IT (2007) Development of a food frequency questionnaire for the assessment of quercetin and naringenin intake. Eur J Clin Nutr (Epub ahead of print 30 May 2007).
80. Shapiro H, Singer P, Halpern Z & Bruck R (2007) Polyphenols in the treatment of inflammatory bowel disease and acute pancreatitis. Gut 56, 426-436.