Expression of secreted Wnt antagonists in gastrointestinal tissues: Potential role in stem cell homeostasis

Journal of Clinical Pathology

Volumn 58, Issue 5, 2005, Pages 515-519

  Byun, T ^a   Karimi, M ^a   Marsh, J L ^b   Milovanovic, T ^a   Lin, F ^b   Holcombe, R F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN; PROTEIN DICKKOPF; PROTEIN DKK1; PROTEIN DKK2; PROTEIN DKK3; PROTEIN FRZB; PROTEIN WIF1; UNCLASSIFIED DRUG; WNT INHIBITORY FACTOR 1; WNT PROTEIN;

ARTICLE; CANCER INHIBITION; COLON CANCER; CONTROLLED STUDY; HOMEOSTASIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IN SITU HYBRIDIZATION; INTESTINE CRYPT; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; RNA HYBRIDIZATION; SIGNAL TRANSDUCTION; STEM CELL; STOMACH CANCER; STOMACH GLAND; TISSUE DISTRIBUTION; UPPER GASTROINTESTINAL TRACT;

CARRIER PROTEINS; CELL LINE, TUMOR; COLON; COLONIC NEOPLASMS; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCOPROTEINS; HOMEOSTASIS; HUMANS; IN SITU HYBRIDIZATION; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; NEOPLASM PROTEINS; PROTEINS; REPRESSOR PROTEINS; RNA, NEOPLASM; STEM CELLS; STOMACH; STOMACH NEOPLASMS; WNT PROTEINS;

EID: 18444385092     PISSN: 00219746     EISSN: None     Source Type: Journal    
DOI: 10.1136/jcp.2004.018598     Document Type: Article

References (34)

1. Cadigan KM, Nusse R. Wnt signaling: a common theme in animal development. Genes Dev 1997;11:3286-305.
2. Wells J, Melton D. Vertebrate endoderm development. Annu Rev Cell Dev Biol 1999;15:393-410.
3. Polakis P. Wnt Signaling and cancer. Genes Dev 2000;14:1839-51.
4. Moon R, Bowerman B, Boutros M, et al. The promise and perils of Wnt signaling through beta-catenin. Science 2002;296:1644-6.
5. Huelsken J, Birchmeier W. New aspects of Wnt signaling pathways in higher vertebrates. Curr Opin Genet Dev 2001;11:547-53.
6. Zorn AM. Wnt signalling: antagonistic dickkopfs. Curr Biol 2001;11:R592-5.
7. Kawano Y, Kypta R. Secreted antagonists of the Wnt signaling pathway. J Cell Sci 2003;116:2627-34.
8. Holcombe RF, Marsh JL, Waterman ML, et al. Expression of Wnt ligands and Frizzled receptors in colonic mucosa and in colon carcinoma. J Mol Pathol 2002;55:220-6.
9. de Santa Barbara P, van den Brink GR, Roberts DJ. Development and differentiation of the intestinal epithelium. Cell Mol Life Sci 2003;60:1322-32.
10. Lickert H, Kispert A, Kutsch S, et al. Expression patterns of Wnt genes in mouse gut development. Mech Dev 2001;105:181-4.
11. Lee YJ, Swencki B, Shoichet S, et al. A possible role for the high mobility group box transcription factor Tcf-4 in vertebrate gut epithelial cell differentiation. J Biol Chem 1999;274:1566-72.
12. Heller RS, Dichmann DS, Jensen J, et al. Expression patterns of Wnts, Frizzleds, sFRPs and misexpression in transgenic mice suggesting a role for Wnts in pancreas and foregut pattern formation. Dev Dyn 2002;225:260-70.
13. Theodosiou NA, Tabin CJ. Wnt signaling during development of the gastrointestinal tract. Dev Biol 2003;259:258-71.
14. Korinek V, Barker N, Moerer P, et al. Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nat Genet 1998;19:379-83.
15. Pinto D, Gregorieff A, Begthel H, et al. Canonical Wnt signals are essential for homeostasis of the intestinal epithelium. Genes Dev 2003;17:1709-13.
16. To KF, Chan MWY, Leung WK, et al. Alterations of frizzled (FzE3) and secreted frizzled related protein (hsFRP) expression in gastric cancer. Life Sci 2001;70:483-9.
17. Caldwell GM, Jones C, Gensberg K, et al. The Wnt antagonist sFRP1 in colorectal tumorigenesis. Cancer Res 2004;64:883-8.
18. Wong SC, Lo SF, Lee KC, et al. Expression of frizzled-related protein and Wnt-signalling molecules in invasive breast tumours. J Pathol 2002;196:145-53.
19. Ko J, Ryu KS, Lee YH, et al. Human secreted frizzled-related protein is down-regulated and induces apoptosis in human cervical cancer. Exp Cell Res 2002;280:280-7.
20. Stoehr R, Wissmann C, Suzuki H, et al. Deletions of chromosome 8p and loss of sFRP1 expression are progression markers of papillary bladder cancer. Lab Invest 2004;84:465-78.
21. Brittan M, Wright NA. Gastrointestinal stem cells. J Pathol 2002;197:492-509.
22. van de Wetering M, Sancho E, Verweij C, et al. The beta-catenin/TCF4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell 2002;111:241-50.
23. Batlle E, Henderson JT, Beghtel H, et al. β-Catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/EphrinB. Cell 2002;111:251-63.
24. Reya T, Duncan AW, Ailles L, et al. A role for Wnt signaling in self-renewal of haematopoietic stem cells. Nature 2003;423:409-14.
25. Willert K, Brown JD, Danenberg E, et al. Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature 2003;423:448-52.
26. Alonso L, Fuchs E. Stem cells in the skin: waste not, Wnt not. Genes Dev 2003;17:1189-200.
27. Ishitani T, Kishida S, Hyodo-Miura J, et al. The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt5a/Ca+2 pathway to antagonize Wnt/β-catenin signaling. Mol Cell Biol 2003;23:131-9.
28. Yamanaka H, Moriguchi T, Masuyama N, et al. JNK functions in the non-canonical Wnt pathway to regulate convergent extension movements in vertebrates. EMBO Rep 2002;3:69-75.
29. Suwa T, Chen M, Hawks CL, et al. Zonal expression of dickkopf-3 and components of the Wnt signaling pathways in the human adrenal cortex. J Endocrinol 2003;178:149-58.
30. Wissmann C, Wild PJ, Kaiser S, et al. WIF1, a component of the Wnt pathway, is down-regulated in prostate, breast, lung and bladder cancer. J Pathol 2003;201:204-12.
31. Hshieh JC, Kodjabachian L, Rebert ML, et al. A new secreted protein that binds to Wnt proteins and inhibits their activities. Nature 1999;398:431-6.
32. Krupnik VE, Sharp JD, Jiang C, et al. Functional and structural diversity of the human Dickkopf gene family. Gene 1999;238:303-13.
33. Li L, Mao J, Sun L, et al. Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of disheveled. J Biol Chem 2002;277:5977-81.
34. Brott BK, Sokol SY. Regulation of Wnt/LRP signaling by distinct domains of Dickkopf proteins. Mol Cell Biol 2002;22:6100-10.