Elevated systemic antibodies towards commensal gut microbiota in autoinflammatory condition

PLoS ONE

Volumn 3, Issue 9, 2008, Pages

  Manukyan, Gayane P ^a   Ghazaryan, Karine A ^a   Ktsoyan, Zhanna A ^a   Khachatryan, Zaruhi A ^a   Arakelova, Karine A ^a   Kelly, Denise ^b   Grant, George ^b   Aminov, Rustam I ^b  

^a INSTITUTE OF MOLECULAR BIOLOGY   (Armenia)

^b ROWETT RESEARCH INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ANTIGEN; BACTERIAL PROTEIN; COLCHICINE; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; ANTIBODY; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G;

ADOLESCENT; ADULT; ANTIGEN ANTIBODY REACTION; ARTICLE; AUTOINFLAMMATORY DISEASE; BACTERIUM; BACTEROIDES; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ACTIVITY; ENTEROCOCCUS; ENZYME LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA; FAMILIAL MEDITERRANEAN FEVER; FEMALE; HUMAN; INTESTINE FLORA; LACTOBACILLUS; MALE; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; PARABACTEROIDES; REMISSION; SEROLOGY; WESTERN BLOTTING; CHEMISTRY; GENE LIBRARY; IMMUNOLOGY; INFLAMMATION; INTESTINE; METHODOLOGY; MICROBIOLOGY; MIDDLE AGED;

BACTERIA (MICROORGANISMS); BACTEROIDES; ESCHERICHIA;

ADOLESCENT; ADULT; ANTIBODIES; CLONING, MOLECULAR; ENZYME-LINKED IMMUNOSORBENT ASSAY; FAMILIAL MEDITERRANEAN FEVER; FEMALE; GENE LIBRARY; HUMANS; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; INFLAMMATION; INTESTINES; MALE; MIDDLE AGED;

EID: 52649091852     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0003172     Document Type: Article

References (51)

1. Ting JP, Kastner DL, Hoffman HM (2006) CATERPILLERs, pyrin and hereditary immunological disorders. Nat Rev Immunol 6: 183-195.
2. Centola M, Wood G, Frucht DM, Galon J, Aringer M, et al. (2000) The gene for familial Mediterranean fever, MEFV, is expressed in early leukocyte development and is regulated in response to inflammatory mediators. Blood 95: 3223-3231.
3. Diaz A, Hu C, Kastner DL, Schaner P, Reginato AM, et al. (2004) Lipopolysaccharide-induced expression of multiple alternatively spliced MEFV transcripts in human synovial fibroblasts: a prominent splice isoform lacks the C-terminal domain that is highly mutated in familial Mediterranean fever. Arthritis Rheum 50: 3679-3689.
4. The International FMF Consortium (1997) Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever. Cell 90: 797-807.
5. The French FMF Consortium (1997) A candidate gene for familial Mediterranean fever. Nat Genet 17: 25-31.
6. Manukyan GP, Ghazaryan KA, Ktsoyan ZhA, Tatyan MV, Khachatryan ZA, et al. (2008) Cytokine profile of Armenian patients with familial Mediterranean fever. Clin Biochem 41: 920-922.
7. Touitou I (2001) The spectrum of Familial Mediterranean Fever (FMF) mutations. Eur J Hum Genet 9: 473-483.
8. Kastner DL (1998) Familial Mediterranean fever: the genetics of inflammation. Hosp Pract 33: 131-4, 139-40, 143-6 passim.
9. Salzman NH, Underwood MA, Bevins CL (2007) Paneth cells, defensins, and the commensal microbiota: a hypothesis on intimate interplay at the intestinal mucosa. Semin Immunol 19: 70-83.
10. Suzuki K, Ha SA, Tsuji M, Fagarasan S (2006) Intestinal IgA synthesis: a primitive form of adaptive immunity that regulates microbial communities in the gut. Semin Immonol 19: 127-135.
11. Mazmanian SK, Liu CH, Tzianabos AO, Kasper DL (2005) An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell 122: 107-118.
12. Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, Edberg S, Medzhitov R (2004) Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 118: 229-241.
13. Cario E, Gerken G, Podolsky DK (2004) Toll-like receptor 2 enhances ZO-I-associated intestinal epithelial barrier integrity via protein kinase C. Gastroenterology 127: 224-238.
14. Cario E, Germen G, Podolsky DK (2007) Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function. Gastroenterology 132: 1359-1374.
15. Hugot JP, Chamaillard M, Zouali H, Lesage S, Cezard JP, et al. (2001) Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411: 599-603.
16. Ogura Y, Bonen DK, Inohara N, Nicolae DL, Chen FF, et al. (2001) A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 411: 603-606.
17. Inohara N, Ogura Y, Fontalba A, Gutierrez O, Pons F, et al. (2003) Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease. J Biol Chem 278: 5509-5512.
18. Girardin SE, Boneca IG, Viala J, Chamaillard M, Labigne A, et al. (2003) Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem 278: 8869-8872.
19. Landers CJ, Cohavy O, Misra R, Yang H, Lin YC, et al. (2002) Selected loss of tolerance evidenced by Crohn's discase-associated immune responses to auto- and microbial antigens. Gastroenterology 123: 689-699.
20. Lodes MJ, Cong Y, Elson CO, Mohamath R, Landers CJ, et al. (2004a) Bacterial flagellin is a dominant antigen in Crohn disease. J Clin Invest 113: 1296-1306.
21. Sitaraman SV, Klapproth JM, Moore DA 3rd, Landers C, Targan S, et al. (2005) Elevated flagellin-specific immunoglobulins in Crohn's disease. Am J Physiol Gastrointest Liver Physiol 288: G403-406.
22. Adams RJ, Heazlewood SP, Gilshenan KS, O'Brien M, McGuckin MA, et al. (2008) IgG antibodies against common gut bacteria are more diagnostic for Crohn's disease than IgG against mannan or flagellin. Am J Gastroenterol 103: 386-396.
23. Brydges S, Kastner DL (2006) the systemic autoinflammatory diseases: inborn errors of the innate immune system. Curr Top Microbiol Immunol 305: 127-160.
24. Chae JJ, Komarow HD, Cheng J, Wood G, Raben N, et al. (2003) Targeted disruption of pyrin, the FMF protein, causes heightened sensitivity to endotoxin and a defect in macrophage apoptosis. Mol Cell 11: 591-604.
25. Chae JJ, Wood G, Masters SL, Richard K, Park G, et al. (2006) The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-I to modulate IL-1beta production. Proc Natl Acad Sci U S A 103: 9982-9987.
26. Papin S, Cuenin S, Agostini L, Martinon F, Werner S, et al. (2007) The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing. Cell Death Differ 14: 1457-1466.
27. Notarnicola C, Didelot MN, Kone-Paut I, Seguret F, Demaille J, et al. (2002) Reduced MEFV messenger RNA expression in patients with familial Mediterranean fever. Arthritis Rheum 46: 2785-2793.
28. Martinon F, Agostini L, Meylan E, Tschopp J (2004) Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome. Curr Biol 14: 1929-1934.
29. Mariathasan S, Weiss DS, Newton K, McBride J, O'Rourke K, et al. (2006) Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 440: 228-232.
30. Kanneganti TD, Ozoren N, Body-Malapel M, Amer A, Park JH, et al. (2006a) Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. Nature 440: 233-236.
31. Kanneganti TD, Body-Malapel M, Amer A, Park JH, Whitfield J, et al. (2006b) Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA. J Biol Chem 281: 36560-36568.
32. Martinon F, Petrilli V, Mayor A, Tardivel A, Tschopp J (2006) Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440: 237-241.
33. Petrilli V, Papin S, Dostert C, Mayor A, Martinon F, et al. (2007) Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration. Cell Death Differ 14: 1583-1589.
34. Davtyan TK, Hakopyan GS, Avetisyan SA, Mkrtchyan NR (2006) Impaired endotoxin tolerance induction in patients with familial Mediterranean fever. Pathobiology 73: 26-39.
35. Mariathasan S, Monack DM (2007) Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation. Nat Rev Immunol 7: 31-40.
36. Livneh A, Langevitz P, Zemer D, Zaks N, Kees S, et al. (1997) Criteria for the diagnosis of familial Mediterranean fever. Arthritis Rheum 40: 1879-1885.
37. Weisburg WG, Barns SM, Pelletier DA, Lane DJ (1991) 16S ribosomal DNA amplification for phylogenctic study. J Bacteriol 173: 697-703.
38. Lane DJ, Pace B, Olsen GJ, Stahl DA, Sogin ML, et al. (1985) Rapid determination of 16S ribosomal RNA sequences for phylogenetic analyses. Proc Natl Acad Sci U S A 82: 6955-6959.
39. Lodes NU, Dillon DC, Houghton RL, Skeiky YA (2004b) Expression cloning. Methods Mol Med 94: 91-106.
40. Van der Sluis M, De Koning BA, De Bruijn AC, Velcich A, Meijerink JP, et al. (2006) Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection. Gastroenterology 131: 117-129.
41. Fagarasan S, Muramatsu M, Suzuki K, Nagaoka H, Hiai H, et al. (2002) Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora. Science 298: 1424-1427.
42. Wehkamp, J, Harder J, Weichenthal M, Schwab M, Schäffeler E, et al. (2004) NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression. Gut 53: 1658-1664.
43. Eckburg PB, Bik EM, Bernstein CN, Purdom E, Dethlefsen L, et al. (2005) Diversity of the human intestinal microbial flora. Science 308: 1635-1638.
44. van Egmond M, Damen CA, van Spriel AB, Vidarsson G, van Garderen E, et al. (2001) IgA and the IgA Fc receptor. Trends Immunol 22: 205-211.
45. Keith MP, Gilliland WR (2007) Updates in the management of gout. Am J Med 120: 221-224.
46. Ben-Chetrit E, Levy M (1998) Colchicine: 1998 update. Semin Arthritis Rheum 28: 48-59.
47. Nazli A, Wang A, Steen O, Prescott D, Lu J, et al. (2006) Enterocyte cytoskeleton changes are crucial for enhanced translocation of nonpathogenic Escherichia coli across metabolically stressed gut epithelia. Infect Immun 74: 192-201.
48. Sedman PC, Macfie J, Sagar P, Mitchell CJ, May J, et al. (1994) The prevalence of gut translocation in humans. Gastroenterology 107: 643-649.
49. Nadler EP, Ford HR (2000) Regulation of bacterial translocation by nitric oxide. Pediatr Surg Int 16: 165-168.
50. Xu DZ, Lu Q Deitch EA (2002) Nitric oxide directly impairs intestinal barrier function. Shock 17: 139-145.
51. Yang R, Han X, Uchiyama. T, Watkins SK, Yaguchi A, et al. (2003) IL-6 is essential for development of gut barrier dysfunction after hemorrhagic shock and resuscitation in mice. Am J Physiol Gastrointest Liver Physiol 285: G621-629.