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Volumn 13, Issue 17, 2008, Pages 6501-6514

Of alphas and betas: Distinct and overlapping functions of STAT3 isoforms

Author keywords

Acute Phase Response factor; Astrocyte; Cytokine Signaling; GFAP; Nodose; Review; STAT; STAT3; STAT3alpha; STAT3beta

Indexed keywords

MUS;

EID: 52049124749     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/3170     Document Type: Article
Times cited : (35)

References (77)
  • 1
    • 0027441586 scopus 로고
    • Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin-6 at the posttranslational level
    • Wegenka, U. M., J. Buschmann, C. Lutticken, P. C. Heinrich and F. Horn: Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin-6 at the posttranslational level. Mol Cell Biol 13, 276-88 (1993) (Pubitemid 23006905)
    • (1993) Molecular and Cellular Biology , vol.13 , Issue.1 , pp. 276-288
    • Wegenka, U.M.1    Buschmann, J.2    Lutticken, C.3    Heinrich, P.C.4    Horn, F.5
  • 2
    • 0028303977 scopus 로고
    • Molecular cloning of APRF, a novel IFNstimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway
    • Akira, S., Y. Nishio, M. Inoue, X. J. Wang, S. Wei, T. Matsusaka, K. Yoshida, T. Sudo, M. Naruto and T. Kishimoto: Molecular cloning of APRF, a novel IFNstimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway. Cell 77, 63-71 (1994)
    • (1994) Cell , vol.77 , pp. 63-71
    • Akira, S.1    Nishio, Y.2    Inoue, M.3    Wang, X.J.4    Wei, S.5    Matsusaka, T.6    Yoshida, K.7    Sudo, T.8    Naruto, M.9    Kishimoto, T.10
  • 3
    • 0028349735 scopus 로고
    • Stat3: A STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6
    • Zhong, Z., Z. Wen and J. E. Darnell, Jr.: Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science 264, 95-8 (1994) (Pubitemid 24144493)
    • (1994) Science , vol.264 , Issue.5155 , pp. 95-98
    • Zhong, Z.1    Wen, Z.2    Darnell Jr., J.E.3
  • 4
    • 0028274299 scopus 로고
    • The interleukin-6-activated acute-phase response factor is antigenically and functionally related to members of the signal transducer and activator of transcription (STAT) family
    • Wegenka, U. M., C. Lutticken, J. Buschmann, J. Yuan, F. Lottspeich, W. Muller-Esterl, C. Schindler, E. Roeb, P. C. Heinrich and F. Horn: The interleukin-6-activated acutephase response factor is antigenically and functionally related to members of the signal transducer and activator of transcription (STAT) family. Mol Cell Biol 14, 3186-96 (1994) (Pubitemid 24132732)
    • (1994) Molecular and Cellular Biology , vol.14 , Issue.5 , pp. 3186-3196
    • Wegenka, U.M.1    Lutticken, C.2    Buschmann, J.3    Yuan, J.4    Lottspeich, F.5    Muller-Esterl, W.6    Schindler, C.7    Roeb, E.8    Heinrich, P.C.9    Horn, F.10
  • 7
    • 0034658698 scopus 로고    scopus 로고
    • STATs in oncogenesis
    • Bowman, T., R. Garcia, J. Turkson and R. Jove: STATs in oncogenesis. Oncogene 19, 2474-88 (2000) (Pubitemid 30339203)
    • (2000) Oncogene , vol.19 , Issue.21 , pp. 2474-2488
    • Bowman, T.1    Garcia, R.2    Turkson, J.3    Jove, R.4
  • 8
    • 0036338213 scopus 로고    scopus 로고
    • STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation
    • DOI 10.1016/S1074-7613(02)00336-9
    • Lee, C. K., R. Raz, R. Gimeno, R. Gertner, B. Wistinghausen, K. Takeshita, R. A. DePinho and D. E. Levy: STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation. Immunity 17, 63-72 (2002) (Pubitemid 34874619)
    • (2002) Immunity , vol.17 , Issue.1 , pp. 63-72
    • Lee, C.-K.1    Raz, R.2    Gimeno, R.3    Gertner, R.4    Wistinghausen, B.5    Takeshita, K.6    DePinho, R.A.7    Levy, D.E.8
  • 9
    • 33947278297 scopus 로고    scopus 로고
    • IFN regulatory factor-2 regulates macrophage apoptosis through a STAT1/3- and caspase-1-dependent mechanism
    • Cuesta, N., Q. M. Nhu, E. Zudaire, S. Polumuri, F. Cuttitta and S. N. Vogel: IFN regulatory factor-2 regulates macrophage apoptosis through a STAT1/3- and caspase-1- dependent mechanism. J Immunol 178, 3602-11 (2007) (Pubitemid 46417627)
    • (2007) Journal of Immunology , vol.178 , Issue.6 , pp. 3602-3611
    • Cuesta, N.1    Nhu, Q.M.2    Zudaire, E.3    Polumuri, S.4    Cuttitta, F.5    Vogel, S.N.6
  • 12
    • 0035131190 scopus 로고    scopus 로고
    • Essential role of STAT3 in the control of the acute-phase response as revealed by inducible gene activation in the liver
    • DOI 10.1128/MCB.21.5.1621-1632.2001
    • Alonzi, T., D. Maritano, B. Gorgoni, G. Rizzuto, C. Libert and V. Poli: Essential role of STAT3 in the control of the acute-phase response as revealed by inducible geneinactivation [correction of activation] in the liver. Mol Cell Biol 21, 1621-32 (2001) (Pubitemid 32156382)
    • (2001) Molecular and Cellular Biology , vol.21 , Issue.5 , pp. 1621-1632
    • Alonzi, T.1    Maritano, D.2    Gorgoni, B.3    Rizzuto, G.4    Libert, C.5    Poli, V.6
  • 13
    • 1642619154 scopus 로고    scopus 로고
    • Induced somatic inactivation of STAT3 in mice triggers the development of a fulminant form of enterocolitis
    • DOI 10.1016/j.cyto.2003.12.002, PII S1043466603004484
    • Alonzi, T., I. P. Newton, P. J. Bryce, E. Di Carlo, G. Lattanzio, M. Tripodi, P. Musiani and V. Poli: Induced somatic inactivation of STAT3 in mice triggers the development of a fulminant form of enterocolitis. Cytokine 26, 45-56 (2004) (Pubitemid 38410883)
    • (2004) Cytokine , vol.26 , Issue.2 , pp. 45-56
    • Alonzi, T.1    Newton, I.P.2    Bryce, P.J.3    Di Carlo, E.4    Lattanzio, G.5    Tripodi, M.6    Musiani, P.7    Poli, V.8
  • 14
    • 0037799912 scopus 로고    scopus 로고
    • Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice
    • DOI 10.1172/JCI200317085
    • Kobayashi, M., M. N. Kweon, H. Kuwata, R. D. Schreiber, H. Kiyono, K. Takeda and S. Akira: Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice. J Clin Invest 111, 1297-308 (2003) (Pubitemid 36554700)
    • (2003) Journal of Clinical Investigation , vol.111 , Issue.9 , pp. 1297-1308
    • Kobayashi, M.1    Kweon, M.-N.2    Kuwata, H.3    Schreiber, R.D.4    Kiyono, H.5    Takeda, K.6    Akira, S.7
  • 15
    • 0033034365 scopus 로고    scopus 로고
    • Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of stat3 in macrophages and neutrophils
    • DOI 10.1016/S1074-7613(00)80005-9
    • Takeda, K., B. E. Clausen, T. Kaisho, T. Tsujimura, N. Terada, I. Forster and S. Akira: Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity 10, 39-49 (1999) (Pubitemid 29077382)
    • (1999) Immunity , vol.10 , Issue.1 , pp. 39-49
    • Takeda, K.1    Clausen, B.E.2    Kaisho, T.3    Tsujimura, T.4    Terada, N.5    Forster, I.6    Akira, S.7
  • 17
    • 0029075875 scopus 로고
    • Cooperative transcriptional activity of Jun and Stat3 beta, a short form of Stat3
    • Schaefer, T. S., L. K. Sanders and D. Nathans: Cooperative transcriptional activity of Jun and Stat3 beta, a short form of Stat3. Proc Natl Acad Sci U S A 92, 9097-101 (1995)
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 9097-90101
    • Schaefer, T.S.1    Sanders, L.K.2    Nathans, D.3
  • 18
    • 0035895101 scopus 로고    scopus 로고
    • Identification and characterization of cis elements in the STAT3 gene regulating STAT3 alpha and STAT3 beta messenger RNA splicing
    • Shao, H., A. J. Quintero and D. J. Tweardy: Identification and characterization of cis elements in the STAT3 gene regulating STAT3 alpha and STAT3 beta messenger RNA splicing. Blood 98, 3853-6 (2001)
    • (2001) Blood , vol.98 , pp. 3853-3856
    • Shao, H.1    Quintero, A.J.2    Tweardy, D.J.3
  • 19
    • 0029117304 scopus 로고
    • Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation
    • Wen, Z., Z. Zhong and J. E. Darnell, Jr.: Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell 82, 241-50 (1995)
    • (1995) Cell , vol.82 , pp. 241-250
    • Wen, Z.1    Zhong, Z.2    Darnell, Jr.J.E.3
  • 20
    • 0032895874 scopus 로고    scopus 로고
    • Expression of granulocyte colony-stimulating factor- and granulocyte- macrophage colony-stimulating factor-associated signal transduction proteins of the JAK/STAT pathway in normal granulopoiesis and in blast cells of acute myelogenous leukemia
    • DOI 10.1016/S0301-472X(99)00017-X, PII S0301472X9900017X
    • Biethahn, S., F. Alves, S. Wilde, W. Hiddemann and K. Spiekermann: Expression of granulocyte colonystimulating factor- and granulocyte-macrophage colonystimulating factor-associated signal transduction proteins of the JAK/STAT pathway in normal granulopoiesis and in blast cells of acute myelogenous leukemia. Exp Hematol 27, 885-94 (1999) (Pubitemid 29231027)
    • (1999) Experimental Hematology , vol.27 , Issue.5 , pp. 885-894
    • Biethahn, S.1    Alves, F.2    Wilde, S.3    Hiddemann, W.4    Spiekermann, K.5
  • 21
    • 0036493750 scopus 로고    scopus 로고
    • Differential expression and phosphorylation of distinct STAT3 proteins during granulocytic differentiation
    • DOI 10.1182/blood.V99.5.1627
    • Hevehan, D. L., W. M. Miller and E. T. Papoutsakis: Differential expression and phosphorylation of distinct STAT3 proteins during granulocytic differentiation. Blood 99, 1627-37 (2002) (Pubitemid 34533035)
    • (2002) Blood , vol.99 , Issue.5 , pp. 1627-1637
    • Hevehan, D.L.1    Miller, W.M.2    Papoutsakis, E.T.3
  • 22
    • 0030611426 scopus 로고    scopus 로고
    • Functional differences between Stat3alpha and Stat3beta
    • Schaefer, T. S., L. K. Sanders, O. K. Park and D. Nathans: Functional differences between Stat3alpha and Stat3beta. Mol Cell Biol 17, 5307-16 (1997)
    • (1997) Mol Cell Biol , vol.17 , pp. 5307-5316
    • Schaefer, T.S.1    Sanders, L.K.2    Park, O.K.3    Nathans, D.4
  • 23
    • 0034644775 scopus 로고    scopus 로고
    • Dimer stability as a determinant of differential DNA binding activity of Stat3 isoforms
    • Park, O. K., L. K. Schaefer, W. Wang and T. S. Schaefer: Dimer stability as a determinant of differential DNA binding activity of Stat3 isoforms. J Biol Chem 275, 32244-9 (2000)
    • (2000) J Biol Chem , vol.275 , pp. 32244-32249
    • Park, O.K.1    Schaefer, L.K.2    Wang, W.3    Schaefer, T.S.4
  • 24
    • 36849026590 scopus 로고    scopus 로고
    • STAT3 isoforms, alpha and beta , demonstrate distinct intracellular dynamics with prolonged nuclear retention of STAT3beta mapping to itsunique C-terminal end
    • Huang, Y., J. Qiu, S. Dong, M. S. Redell, V. Poli, M. A. Mancini and D. J. Tweardy: STAT3 isoforms, alpha and beta , demonstrate distinct intracellular dynamics with prolonged nuclear retention of STAT3beta mapping to itsunique C-terminal end. J Biol Chem (2007)
    • (2007) J Biol Chem
    • Huang, Y.1    Qiu, J.2    Dong, S.3    Redell, M.S.4    Poli, V.5    Mancini, M.A.6    Tweardy, D.J.7
  • 25
    • 0036008472 scopus 로고    scopus 로고
    • Specific ablation of Stat3β distorts the pattern of stat3-responsive gene expression and impairs recovery from endotoxic shock
    • DOI 10.1016/S0092-8674(02)00636-0
    • Yoo, J. Y., D. L. Huso, D. Nathans and S. Desiderio: Specific ablation of Stat3beta distorts the pattern of Stat3- responsive gene expression and impairs recovery from endotoxic shock. Cell 108, 331-44 (2002) (Pubitemid 34178398)
    • (2002) Cell , vol.108 , Issue.3 , pp. 331-344
    • Yoo, J.-Y.1    Huso, D.L.2    Nathans, D.3    Desiderio, S.4
  • 26
    • 0035917876 scopus 로고    scopus 로고
    • Ser727-dependent transcriptional activation by association of p300 with STAT3 upon IL-6 stimulation
    • DOI 10.1016/S0014-5793(01)02354-7, PII S0014579301023547
    • Schuringa, J. J., H. Schepers, E. Vellenga and W. Kruijer: Ser727-dependent transcriptional activation by association of p300 with STAT3 upon IL-6 stimulation. FEBS Lett 495, 71-6 (2001) (Pubitemid 32367976)
    • (2001) FEBS Letters , vol.495 , Issue.1-2 , pp. 71-76
    • Schuringa, J.-J.1    Schepers, H.2    Vellenga, E.3    Kruijer, W.4
  • 27
    • 0033584297 scopus 로고    scopus 로고
    • Inhibition of pp60(c-Src) reduces Bcl-X(L) expression and reverses the transformed phenotype of cells overexpressing EGF and HER-2 receptors
    • DOI 10.1038/sj.onc.1202835
    • Karni, R., R. Jove and A. Levitzki: Inhibition of pp60c- Src reduces Bcl-XL expression and reverses the transformed phenotype of cells overexpressing EGF and HER-2 receptors. Oncogene 18, 4654-62 (1999) (Pubitemid 29417740)
    • (1999) Oncogene , vol.18 , Issue.33 , pp. 4654-4662
    • Karni, R.1    Jove, R.2    Levitzki, A.3
  • 28
    • 0034676267 scopus 로고    scopus 로고
    • Induction of p21(WAF1/CIP1) and cyclin D1 expression by the Src oncoprotein in mouse fibroblasts: Role of activated STAT3 signaling
    • DOI 10.1038/sj.onc.1203947
    • Sinibaldi, D., W. Wharton, J. Turkson, T. Bowman, W. J. Pledger and R. Jove: Induction of p21WAF1/CIP1 and cyclin D1 expression by the Src oncoprotein in mouse fibroblasts: role of activated STAT3 signaling. Oncogene 19, 5419-27 (2000) (Pubitemid 32000908)
    • (2000) Oncogene , vol.19 , Issue.48 , pp. 5419-5427
    • Sinibaldi, D.1    Wharton, W.2    Turkson, J.3    Bowman, T.4    Pledger, W.J.5    Jove, R.6
  • 30
    • 21544467565 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3α and specificity protein 1 interact to upregulate intercellular adhesion molecule-1 in ischemic-reperfused myocardium and vascular endothelium
    • DOI 10.1161/01.ATV.0000168428.96177.24
    • Yang, X. P., K. Irani, S. Mattagajasingh, A. Dipaula, F. Khanday, M. Ozaki, K. Fox-Talbot, W. M. Baldwin, 3rd and L. C. Becker: Signal transducer and activator of transcription 3alpha and specificity protein 1 interact to upregulate intercellular adhesion molecule-1 in ischemicreperfused myocardium and vascular endothelium. Arterioscler Thromb Vasc Biol 25, 1395-400 (2005) (Pubitemid 40923358)
    • (2005) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.25 , Issue.7 , pp. 1395-1400
    • Yang, X.P.1    Irani, K.2    Mattagajasingh, S.3    Dipaula, A.4    Khanday, F.5    Ozaki, M.6    Fox-Talbot, K.7    Baldwin III, W.M.8    Becker, L.C.9
  • 31
    • 3142728480 scopus 로고    scopus 로고
    • Oxidized phospholipids increase interleukin 8 (IL-8) synthesis by activation of the c-src/signal transducers and activators of transcription (STAT)3 pathway
    • DOI 10.1074/jbc.M312198200
    • Yeh, M., N. M. Gharavi, J. Choi, X. Hsieh, E. Reed, K. P. Mouillesseaux, A. L. Cole, S. T. Reddy and J. A. Berliner: Oxidized phospholipids increase interleukin 8 (IL-8) synthesis by activation of the c-src/signal transducers and activators of transcription (STAT)3 pathway. J Biol Chem 279, 30175-81 (2004) (Pubitemid 38937941)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.29 , pp. 30175-30181
    • Yeh, M.1    Gharavi, N.M.2    Choi, J.3    Hsieh, X.4    Reed, E.5    Mouillesseaux, K.P.6    Cole, A.L.7    Reddy, S.T.8    Berliner, J.A.9
  • 32
    • 0034585879 scopus 로고    scopus 로고
    • STAT3beta does not interfere with granulocyte colony-stimulating factorinduced neutrophilic differentiation
    • de Koning, J. P., A. C. Ward, E. Caldenhoven, R. P. de Groot, B. Lowenberg and I. P. Touw: STAT3beta does not interfere with granulocyte colony-stimulating factorinduced neutrophilic differentiation. Hematol J 1, 220-5(2000)
    • (2000) Hematol J , vol.1 , pp. 220-225
    • De Koning, J.P.1    Ward, A.C.2    Caldenhoven, E.3    De Groot, R.P.4    Lowenberg, B.5    Touw, I.P.6
  • 34
    • 0032845125 scopus 로고    scopus 로고
    • Interacting regions in Stat3 and c-Jun that participate in cooperative transcriptional activation
    • Zhang, X., M. H. Wrzeszczynska, C. M. Horvath and J. E. Darnell, Jr.: Interacting regions in Stat3 and c-Jun that participate in cooperative transcriptional activation. Mol Cell Biol 19, 7138-46 (1999) (Pubitemid 29441894)
    • (1999) Molecular and Cellular Biology , vol.19 , Issue.10 , pp. 7138-7146
    • Zhang, X.1    Wrzeszczynska, M.H.2    Horvath, C.M.3    Darnell Jr., J.E.4
  • 35
    • 0035854687 scopus 로고    scopus 로고
    • Synergistic activity of STAT3 and c-Jun at a specific array of DNA elements in the alpha 2-macroglobulin promoter
    • Yoo, J. Y., W. Wang, S. Desiderio and D. Nathans: Synergistic activity of STAT3 and c-Jun at a specific array of DNA elements in the alpha 2-macroglobulin promoter. J Biol Chem 276, 26421-9 (2001)
    • (2001) J Biol Chem , vol.276 , pp. 26421-26429
    • Yoo, J.Y.1    Wang, W.2    Desiderio, S.3    Nathans, D.4
  • 36
    • 0037085467 scopus 로고    scopus 로고
    • Regulation of Fas expression by STAT3 and c-Jun is mediated by phosphatidylinositol 3-kinase-AKT signaling
    • DOI 10.1074/jbc.M108233200
    • Ivanov, V. N., M. Krasilnikov and Z. Ronai: Regulation of Fas expression by STAT3 and c-Jun is mediated by phosphatidylinositol 3-kinase-AKT signaling. J Biol Chem 277, 4932-44 (2002) (Pubitemid 34968531)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.7 , pp. 4932-4944
    • Ivanov, V.N.1    Krasilnikov, M.2    Ronai, Z.3
  • 37
    • 0033574767 scopus 로고    scopus 로고
    • Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300
    • DOI 10.1126/science.284.5413.479
    • Nakashima, K., M. Yanagisawa, H. Arakawa, N. Kimura, T. Hisatsune, M. Kawabata, K. Miyazono and T. Taga: Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300. Science 284, 479-82 (1999) (Pubitemid 29289619)
    • (1999) Science , vol.284 , Issue.5413 , pp. 479-482
    • Nakashima, K.1    Yanagisawa, M.2    Arakawa, H.3    Kimura, N.4    Hisatsune, T.5    Kawabata, M.6    Miyazono, K.7    Taga, T.8
  • 38
    • 0037040924 scopus 로고    scopus 로고
    • Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a
    • DOI 10.1074/jbc.M111486200
    • Giraud, S., F. Bienvenu, S. Avril, H. Gascan, D. M. Heery and O. Coqueret: Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a. J Biol Chem 277, 8004-11 (2002) (Pubitemid 34968252)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.10 , pp. 8004-8011
    • Giraud, S.1    Bienvenu, F.2    Avril, S.3    Gascan, H.4    Heery, D.M.5    Coqueret, O.6
  • 39
    • 0033590156 scopus 로고    scopus 로고
    • C-Src activates the DNA binding and transcriptional activity of stat3 molecules: Serine 727 is not required for transcriptional activation under certain circumstances
    • DOI 10.1006/bbrc.1999.1853
    • Schaefer, L. K., S. Wang and T. S. Schaefer: c-Src activates the DNA binding and transcriptional activity of Stat3 molecules: serine 727 is not required for transcriptional activation under certain circumstances. Biochem Biophys Res Commun 266, 481-7 (1999) (Pubitemid 30028693)
    • (1999) Biochemical and Biophysical Research Communications , vol.266 , Issue.2 , pp. 481-487
    • Schaefer, L.K.1    Wang, S.2    Schaefer, T.S.3
  • 40
    • 0028938929 scopus 로고
    • Interleukin-6-induced serine phosphorylation of transcription factor APRF: Evidence for a role in interleukin-6 target gene induction
    • Lutticken, C., P. Coffer, J. Yuan, C. Schwartz, E. Caldenhoven, C. Schindler, W. Kruijer, P. C. Heinrich and F. Horn: Interleukin-6-induced serine phosphorylation of transcription factor APRF: evidence for a role in interleukin-6 target gene induction. FEBS Lett 360, 137-43 (1995)
    • (1995) FEBS Lett , vol.360 , pp. 137-143
    • Lutticken, C.1    Coffer, P.2    Yuan, J.3    Schwartz, C.4    Caldenhoven, E.5    Schindler, C.6    Kruijer, W.7    Heinrich, P.C.8    Horn, F.9
  • 41
    • 0030744123 scopus 로고    scopus 로고
    • Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3
    • DOI 10.1093/nar/25.11.2062
    • Wen, Z. and J. E. Darnell, Jr.: Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3. Nucleic Acids Res 25, 2062-7 (1997) (Pubitemid 27303439)
    • (1997) Nucleic Acids Research , vol.25 , Issue.11 , pp. 2062-2067
    • Wen, Z.1    Darnell Jr., J.E.2
  • 42
    • 0030772458 scopus 로고    scopus 로고
    • STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation
    • Chung, J., E. Uchida, T. C. Grammer and J. Blenis: STAT3 serine phosphorylation by ERK-dependent and - independent pathways negatively modulates its tyrosine phosphorylation. Mol Cell Biol 17, 6508-16 (1997) (Pubitemid 27451197)
    • (1997) Molecular and Cellular Biology , vol.17 , Issue.11 , pp. 6508-6516
    • Chung, J.1    Uchida, E.2    Grammer, T.C.3    Blenis, J.4
  • 43
    • 34247600538 scopus 로고    scopus 로고
    • STAT3 as a central mediator of neoplastic cellular transformation
    • DOI 10.1016/j.canlet.2006.10.017, PII S0304383506005763
    • Frank, D. A.: STAT3 as a central mediator of neoplastic cellular transformation. Cancer Lett 251, 199-210 (2007) (Pubitemid 46680370)
    • (2007) Cancer Letters , vol.251 , Issue.2 , pp. 199-210
    • Frank, D.A.1
  • 44
    • 0034722896 scopus 로고    scopus 로고
    • STAT proteins: Novel molecular targets for cancer drug discovery
    • DOI 10.1038/sj.onc.1204086
    • Turkson, J. and R. Jove: STAT proteins: novel molecular targets for cancer drug discovery. Oncogene 19, 6613-26 (2000) (Pubitemid 32197700)
    • (2000) Oncogene , vol.19 , Issue.56 , pp. 6613-6626
    • Turkson, J.1    Jove, R.2
  • 48
    • 0037050212 scopus 로고    scopus 로고
    • Requirement of Stat3 signaling for HGF/SF-Met mediated tumorigenesis
    • DOI 10.1038/sj.onc.1205004
    • Zhang, Y. W., L. M. Wang, R. Jove and G. F. Vande Woude: Requirement of Stat3 signaling for HGF/SF-Met mediated tumorigenesis. Oncogene 21, 217-26 (2002) (Pubitemid 34102130)
    • (2002) Oncogene , vol.21 , Issue.2 , pp. 217-226
    • Zhang, Y.-W.1    Wang, L.-M.2    Jove, R.3    Vande Woude, G.F.4
  • 49
    • 85047698100 scopus 로고    scopus 로고
    • Inhibition of constitutively active Stat3 suppresses growth of human ovarian and breast cancer cells
    • DOI 10.1038/sj/onc/1204990
    • Burke, W. M., X. Jin, H. J. Lin, M. Huang, R. Liu, R. K. Reynolds and J. Lin: Inhibition of constitutively active Stat3 suppresses growth of human ovarian and breast cancer cells. Oncogene 20, 7925-34 (2001) (Pubitemid 34002969)
    • (2001) Oncogene , vol.20 , Issue.55 , pp. 7925-7934
    • Burke, W.M.1    Jin, X.2    Lin, H.-J.3    Huang, M.4    Liu, R.5    Reynolds, R.K.6    Lin, J.7
  • 51
    • 11244255857 scopus 로고    scopus 로고
    • Implication of STAT3 signaling in human colonic cancer cells during intestinal trefoil factor 3 (TFF3) -and vascular endothelial growth factor-mediated cellular invasion and tumor growth
    • Rivat, C., S. Rodrigues, E. Bruyneel, G. Pietu, A. Robert, G. Redeuilh, M. Bracke, C. Gespach and S. Attoub: Implication of STAT3 signaling in human colonic cancer cells during intestinal trefoil factor 3 (TFF3) -and vascular endothelial growth factor-mediated cellular invasion and tumor growth. Cancer Res 65, 195-202 (2005)
    • (2005) Cancer Res , vol.65 , pp. 195-202
    • Rivat, C.1    Rodrigues, S.2    Bruyneel, E.3    Pietu, G.4    Robert, A.5    Redeuilh, G.6    Bracke, M.7    Gespach, C.8    Attoub, S.9
  • 52
    • 0032718891 scopus 로고    scopus 로고
    • Gene therapy with dominant-negative Stat3 suppresses growth of the murine melanoma B16 tumor in vivo
    • Niu, G., R. Heller, R. Catlett-Falcone, D. Coppola, M. Jaroszeski, W. Dalton, R. Jove and H. Yu: Gene therapy with dominant-negative Stat3 suppresses growth of the murine melanoma B16 tumor in vivo. Cancer Res 59, 5059-63 (1999) (Pubitemid 29503958)
    • (1999) Cancer Research , vol.59 , Issue.20 , pp. 5059-5063
    • Niu, G.1    Heller, R.2    Catlett-Falcone, R.3    Coppola, D.4    Jaroszeski, M.5    Dalton, W.6    Jove, R.7    Yu, H.8
  • 53
    • 0035870249 scopus 로고    scopus 로고
    • Overexpression of a dominant-negative signal transducer and activator of transcription 3 variant in tumor cells leads to production of soluble factors that induce apoptosis and cell cycle arrest
    • Niu, G., K. H. Shain, M. Huang, R. Ravi, A. Bedi, W. S. Dalton, R. Jove and H. Yu: Overexpression of a dominant-negative signal transducer and activator of transcription 3 variant in tumor cells leads to production of soluble factors that induce apoptosis and cell cycle arrest. Cancer Res 61, 3276-80 (2001) (Pubitemid 32695012)
    • (2001) Cancer Research , vol.61 , Issue.8 , pp. 3276-3280
    • Niu, G.1    Shain, K.H.2    Huang, M.3    Ravi, R.4    Bedi, A.5    Dalton, W.S.6    Jove, R.7    Yu, H.8
  • 55
    • 0032915401 scopus 로고    scopus 로고
    • Identification of a novel Stat3 recruitment and activation motif within the granulocyte colony-stimulating factor receptor
    • Chakraborty, A., K. F. Dyer, M. Cascio, T. A. Mietzner and D. J. Tweardy: Identification of a novel Stat3 recruitment and activation motif within the granulocyte colony-stimulating factor receptor. Blood 93, 15-24 (1999) (Pubitemid 29019383)
    • (1999) Blood , vol.93 , Issue.1 , pp. 15-24
    • Chakraborty, A.1    Dyer, K.F.2    Cascio, M.3    Mietzner, T.A.4    Tweardy, D.J.5
  • 57
    • 0035102228 scopus 로고    scopus 로고
    • STAT-3 activation is required for normal G-CSF-dependent proliferation and granulocytic differentiation
    • McLemore, M. L., S. Grewal, F. Liu, A. Archambault, J. Poursine-Laurent, J. Haug and D. C. Link: STAT-3 activation is required for normal G-CSF-dependent proliferation and granulocytic differentiation. Immunity 14, 193-204 (2001) (Pubitemid 32206521)
    • (2001) Immunity , vol.14 , Issue.2 , pp. 193-204
    • McLemore, M.L.1    Grewal, S.2    Liu, F.3    Archambault, A.4    Poursine-Laurent, J.5    Haug, J.6    Link, D.C.7
  • 60
    • 0029796380 scopus 로고    scopus 로고
    • Granulocyte colony-stimulating factor activation of Stat3α and Stat3β in immature normal and leukemic human myeloid cells
    • Chakraborty, A., S. M. White, T. S. Schaefer, E. D. Ball, K. F. Dyer and D. J. Tweardy: Granulocyte colonystimulating factor activation of Stat3 alpha and Stat3 beta in immature normal and leukemic human myeloid cells. Blood 88, 2442-9 (1996) (Pubitemid 26327492)
    • (1996) Blood , vol.88 , Issue.7 , pp. 2442-2449
    • Chakraborty, A.1    White, S.M.2    Schaefer, T.S.3    Ball, E.D.4    Dyer, K.F.5    Tweardy, D.J.6
  • 61
    • 34848862409 scopus 로고    scopus 로고
    • Conditional overexpression of Stat3α in differentiating myeloid cells results in neutrophil expansion and induces a distinct, antiapoptotic and pro-oncogenic gene expression pattern
    • DOI 10.1189/jlb.1206766
    • Redell, M. S., A. Tsimelzon, S. G. Hilsenbeck and D. J. Tweardy: Conditional overexpression of Stat3alpha in differentiating myeloid cells results in neutrophil expansion and induces a distinct, antiapoptotic and pro-oncogenic gene expression pattern. J Leukoc Biol 82, 975-85 (2007) (Pubitemid 47511058)
    • (2007) Journal of Leukocyte Biology , vol.82 , Issue.4 , pp. 975-985
    • Redell, M.S.1    Tsimelzon, A.2    Hilsenbeck, S.G.3    Tweardy, D.J.4
  • 64
    • 0033962518 scopus 로고    scopus 로고
    • Recent techniques for tracing pathways in the central nervous system of developing and adult mammals
    • DOI 10.1016/S0361-9230(99)00229-4, PII S0361923099002294
    • Vercelli, A., M. Repici, D. Garbossa and A. Grimaldi: Recent techniques for tracing pathways in the central nervous system of developing and adult mammals. Brain Res Bull 51, 11-28 (2000) (Pubitemid 30029063)
    • (2000) Brain Research Bulletin , vol.51 , Issue.1 , pp. 11-28
    • Vercelli, A.1    Repici, M.2    Garbossa, D.3    Grimaldi, A.4
  • 65
    • 0347624595 scopus 로고    scopus 로고
    • Essential role of STAT3 in postnatal survival and growth revealed by mice lacking STAT3 serine 727 phosphorylation
    • DOI 10.1128/MCB.24.1.407-419.2004
    • Shen, Y., K. Schlessinger, X. Zhu, E. Meffre, F. Quimby, D. E. Levy and J. E. Darnell, Jr.: Essential role of STAT3 in postnatal survival and growth revealed by mice lacking STAT3 serine 727 phosphorylation. Mol Cell Biol 24, 407-19 (2004) (Pubitemid 38010065)
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.1 , pp. 407-419
    • Shen, Y.1    Schlessinger, K.2    Zhu, X.3    Meffre, E.4    Quimby, F.5    Levy, D.E.6    Darnell Jr., J.E.7
  • 66
    • 0034868746 scopus 로고    scopus 로고
    • Stat3 in thymic epithelial cells is essential for postnatal maintenance of thymic architecture and thymocyte survival
    • DOI 10.1016/S1074-7613(01)00180-7
    • Sano, S., Y. Takahama, T. Sugawara, H. Kosaka, S. Itami, K. Yoshikawa, J. Miyazaki, W. van Ewijk and J. Takeda: Stat3 in thymic epithelial cells is essential for postnatal maintenance of thymic architecture and thymocyte survival. Immunity 15, 261-73 (2001) (Pubitemid 32816875)
    • (2001) Immunity , vol.15 , Issue.2 , pp. 261-273
    • Sano, S.1    Takahama, Y.2    Sugawara, T.3    Kosaka, H.4    Itami, S.5    Yoshikawa, K.6    Miyazaki, J.-I.7    Van Ewijk, W.8    Takeda, J.9
  • 67
    • 29544436671 scopus 로고    scopus 로고
    • Use of transgenic mice to study lung morphogenesis and function
    • Bridges, J. P. and T. E. Weaver: Use of transgenic mice to study lung morphogenesis and function. Ilar J 47, 22-31 (2006) (Pubitemid 43013509)
    • (2006) ILAR Journal , vol.47 , Issue.1 , pp. 22-31
    • Bridges, J.P.1    Weaver, T.E.2
  • 68
    • 34250663188 scopus 로고    scopus 로고
    • Inherited surfactant protein-B deficiency and surfactant protein-C associated disease: Clinical features and evaluation
    • DOI 10.1053/j.semperi.2005.11.002, PII S0146000505001060, Inherited Respiratory Disorders in the Neonate
    • Hamvas, A.: Inherited surfactant protein-B deficiency and surfactant protein-C associated disease: clinical features and evaluation. Semin Perinatol 30, 316-26 (2006) (Pubitemid 44827225)
    • (2006) Seminars in Perinatology , vol.30 , Issue.6 , pp. 316-326
    • Hamvas, A.1
  • 69
    • 0029096591 scopus 로고
    • Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failure in newborn mice
    • Clark, J. C., S. E. Wert, C. J. Bachurski, M. T. Stahlman, B. R. Stripp, T. E. Weaver and J. A. Whitsett: Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failure in newborn mice. Proc Natl Acad Sci U S A 92, 7794-8 (1995)
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 7794-7798
    • Clark, J.C.1    Wert, S.E.2    Bachurski, C.J.3    Stahlman, M.T.4    Stripp, B.R.5    Weaver, T.E.6    Whitsett, J.A.7
  • 70
    • 0037192781 scopus 로고    scopus 로고
    • Transcriptional stimulation of the surfactant protein B gene by STAT3 in respiratory epithelial cells
    • DOI 10.1074/jbc.M109986200
    • Yan, C., A. Naltner, M. Martin, M. Naltner, J. M. Fangman and O. Gurel: Transcriptional stimulation of the surfactant protein B gene by STAT3 in respiratory epithelial cells. J Biol Chem 277, 10967-72 (2002) (Pubitemid 34952852)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.13 , pp. 10967-10972
    • Yan, C.1    Naltner, A.2    Martin, M.3    Naltner, M.4    Fangman, J.M.5    Gurel, O.6
  • 74
    • 0029620955 scopus 로고
    • Essential function of LIF receptor in motor neurons
    • DOI 10.1038/378724a0
    • Li, M., M. Sendtner and A. Smith: Essential function of LIF receptor in motor neurons. Nature 378, 724-7 (1995) (Pubitemid 26001944)
    • (1995) Nature , vol.378 , Issue.6558 , pp. 724-727
    • Li, M.1    Sendtner, M.2    Smith, A.3
  • 75
    • 0030708523 scopus 로고    scopus 로고
    • Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway
    • DOI 10.1126/science.278.5337.477
    • Bonni, A., Y. Sun, M. Nadal-Vicens, A. Bhatt, D. A. Frank, I. Rozovsky, N. Stahl, G. D. Yancopoulos and M. E. Greenberg: Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway. Science 278,477-83 (1997) (Pubitemid 27454434)
    • (1997) Science , vol.278 , Issue.5337 , pp. 477-483
    • Bonni, A.1    Sun, Y.2    Nadal-Vicens, M.3    Bhatt, A.4    Frank, D.A.5    Rozovsky, I.6    Stahl, N.7    Yancopoulos, G.D.8    Greenberg, M.E.9
  • 77
    • 0037986366 scopus 로고    scopus 로고
    • Postnatal development of radial glia and the ventricular zone (VZ): A continuum of the neural stem cell compartment
    • DOI 10.1093/cercor/13.6.580
    • Tramontin, A. D., J. M. Garcia-Verdugo, D. A. Lim and A. Alvarez-Buylla: Postnatal development of radial glia and the ventricular zone (VZ): a continuum of the neural stem cell compartment. Cereb Cortex 13, 580-7 (2003) (Pubitemid 36613164)
    • (2003) Cerebral Cortex , vol.13 , Issue.6 , pp. 580-587
    • Tramontin, A.D.1    Garcia-Verdugo, J.M.2    Lim, D.A.3    Alvarez-Buylla, A.4


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