Stat-3 is required for pulmonary homeostasis during hyperoxia

Journal of Clinical Investigation

Volumn 113, Issue 1, 2004, Pages 28-37

  Hokuto, Isamu ^a   Ikegami, Machiko ^a   Yoshida, Mitsuhiro ^b   Takeda, Kiyoshi ^b   Akira, Shizuo ^b   Perl, Anne Karina T ^a   Hull, William M ^a   Wert, Susan E ^a   Whitsett, Jeffrey A ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CRE RECOMBINASE; LIPID; STAT3 PROTEIN; SURFACTANT PROTEIN B; SURFACTANT PROTEIN C; DNA BINDING PROTEIN; MESSENGER RNA; PRIMER DNA; STAT3 PROTEIN, HUMAN; STAT3 PROTEIN, MOUSE; TRANSACTIVATOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAPILLARY LEAK SYNDROME; CELL SPECIFICITY; CONTROLLED STUDY; EPITHELIUM CELL; FEMALE; GENE DELETION; HISTOPATHOLOGY; HOMEOSTASIS; HYPEROXIA; IMMUNOHISTOCHEMISTRY; LUNG CAPILLARY; LUNG DEVELOPMENT; LUNG FUNCTION; LUNG INJURY; LUNG LAVAGE; MALE; MORBIDITY; MORPHOGENESIS; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RESPIRATORY DISTRESS; RESPIRATORY EPITHELIUM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SURVIVAL RATE; ADULT; ANIMAL; ANOXIA; CHILD; GENETIC TRANSCRIPTION; GENETICS; HUMAN; LUNG; LUNG DISEASE; MOUSE MUTANT; NUCLEOTIDE SEQUENCE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; POLYMERASE CHAIN REACTION; RESPIRATORY TRACT MUCOSA; TRANSGENIC MOUSE;

ADULT; ANIMALS; ANOXIA; BASE SEQUENCE; CHILD; DNA PRIMERS; DNA-BINDING PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG; LUNG DISEASES; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; POLYMERASE CHAIN REACTION; PULMONARY SURFACTANT-ASSOCIATED PROTEIN B; RESPIRATORY MUCOSA; RNA, MESSENGER; STAT3 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC;

EID: 85047690540     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI19491     Document Type: Article

References (38)

1. Akira, S. 1997. IL-6-regulated transcription factors. Int. J. Biochem. Cell Biol. 29:1401-1418.
2. Darnell, J.E., Jr. 1997. STATs and gene regulation. Science. 277:1630-1635.
3. Boccaccio, C., et al. 1998. Induction of epithelial tubules by growth factor HGF depends on the STAT pathway. Nature. 391:285-288.
4. Takeda, K., et al. 1997. Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. Proc. Natl. Acad Sci. U. S. A. 94:3801-3804.
5. Levy, D.E., and Lee, C.K. 2002. What does Stat3 do? J. Clin. Invest. 109:1143-1148. doi:10.1172/JC1200215650.
6. Yan, C., et al. 2002. Transcriptional stimulation of the surfactant protein B gene by STAT3 in respiratory epithelial cells. J. Biol. Chem. 277:10967-10972.
7. Riley, S. et al. 2003. Transmission dynamics of the aetiological agent of severe acute respiratory syndrome (SARS) in Hong Kong: The impact of public health interventions. Science. 300:1961-1966.
8. Gregory, T.J., et al. 1991. Surfactant chemical composition and biophysical activity in acute respiratory distress syndrome. J. Clin. Invest. 88:1976-1981.
9. Poulain, F.R., Allen, L., Williams, M.C., Hamilton, R.L., and Hawgood, S. 1992. Effects of surfactant apolipoproteins on liposome structure: implications for tubular myelin formation. Am. J. Physiol. 262:L730-L739.
10. Clark, J.C., et al. 1995. Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failure in newborn mice. Proc. Natl. Acad. Sci. U. S. A. 92:7794-7798.
11. Nogee, L.M. 1997. Surfactant protein B deficiency. Chest. 111(Suppl. 6):129S-135S.
12. Tichelaar, J.W., Lu, W., and Whitsett, J.A. 2000. Conditional expression of fibroblast growth factor-7 in the developing and mature lung. J. Biol. Chem. 275:11858-11864.
13. Perl, A.K., Wert, S.E., Nagy, A., Lobe, C.G., and Whitsett, J.A. 2002. Early restriction of peripheral and proximal cell lineages during formation of the lung. Proc. Natl. Acad. Sci. U. S. A. 99:10482-10487.
14. Takeda, K., et al. 1998. Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptoxis: generation and characterization of T cell-specific Stat3-deficient mice. J. Immunol. 181:4652-4660.
15. Rice, W.R., et al. 2002. Maintenance of the mouse type II cell phenotype in vitro. Am. J. Physiol. 283:L256-L264.
16. Shi, S.R., Key, M.E., and Kalra, K.L. 1991. Antigen retrieval in formalin-fixed, paraffin-embedded tissues: an enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections. J. Histochem. Cytochem. 39:741-748.
17. Zhou, L., Lim, L., Costa, R.H., and Whitsett, J.A. 1996. Thyroid transcription factor-1, hepatocyte nuclear factor-3beta, surfactant protein B, C, and Clara cell secretory protein in developing mouse lung. J. Histochem. Cytochem. 44:1183-1193.
18. Dranoff, G., et al. 1994. Involvement of granulocyte-macrophage colony stimulating factor in normal pulmonary homeostasis. Science. 264:713-716.
19. Tokieda, K., et al. 1999. Surfactant protein B corrects oxygen-induced pulmonary dysfunction in heterozygous surfactant protein B-deficient mice. Pediatr. Res. 46:708-714.
20. Schuessler, T.F., and Bates, J.H. 1995. A computer-controlled research ventilator for small animals: design and evaluation. IEEE Trans. Biomed. Eng. 42:860-866.
21. Hantos, Z., Daroczy, B., Suki, B., Nagy, S., and Fredberg, J.J. 1992. Input impedance and peripheral inhomogeneity of dog lungs. J. Appl. Physiol. 72:168-178.
22. Lowry, O.H., Rosebrough, N.J., Farr, A.L., and Randall, R.J. 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:265-275.
23. Mason, R.J., Nellenbogen, J., and Clements, J.A. 1976. Isolation of disaturated phosphatidylcholine with osmium terroxide. J. Lipid. Res. 17:281-284.
24. Bartlett, G.R. 1959. Phosphorus assay in column chromatography. J. Biol. Chem. 234:466-468.
25. Ohashi, T., Pinkerton, K., Ikegami, M., and Jobe, A.H. 1994. Changes in alveolar surface area, surfactant protein A, and saturared phosphatidylcholine with postnatal rat lung growth. Pediatr. Res. 35:685-689.
26. Sano, S., et al. 1999. Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis. EMBO J. 18:4657-4668.
27. Smith, L.J., Frank, L., and Massaro, D. 1980. Oxygen toxicity. Am. J. Med. 69:117-126.
28. Smith, L.J. 1985. Hyperoxic lung injury: biochemical, cellular, and morphologic characterization in the mouse. J. Lab. Clin. Med. 106:269-278.
29. Glasser, S.W., et al. 2001. Altered stability of pulmonary surfactant in SP-C-deficient mice. Proc. Natl. Acad. Sci. U. S. A. 98:6366-6371.
30. Korfhagen, T.R., et al. 1996. Altered surfactant function and structure in SP-A gene targeted mice. Proc. Natl. Acad. Sci. U. S. A. 93:9594-9599.
31. Tokieda, K., et al. 1999 Surfactant protein-B-deficient mice are susceptible to hyperoxic lung injury. Am. J. Respir. Cell Mol. Biol. 21:463-472.
32. Melton, K.R., et al. 2003. SP-B-deficiency causes respiratory failure in adult mice. Am. J. Physiol. 285:L543-L549.
33. Akira, S. 2000. Roles of STAT3 defined by tissue-specific gene targeting. Oncogene. 19:2607-2611.
34. Ward, N.S., et al. 2000. Interleukin-6-induced protection in hyperoxic acute lung injury. Am. J. Respir. Cell. Mol. Biol. 22:535-542.
35. Waxman, A.B., et al. 1998. Targeted lung expression of interleukin-11 enhances murine tolerance of 100% oxygen and diminishes hyperoxia-induced DNA fragmentation. J. Clin. Invest. 101:1970-1982.
36. Hardie, W.D., Prows, D.R., Leikauf, G.D., and Korfhagen, T.R. 1999 Attenuation of acute lung injury in transgenic mice expressing human transforming growth factor-alpha. Am. J. Physiol. 277:L1045-L1050.
37. 2 induced cell death. Am. Respir. Cell. Mol. Biol. 29:513-522.
38. Pison, U., et al. 1989. Surfactant abnormalities in patients with respiratory failure after multiple trauma. Am. Rev. Respir. Dis. 140:1033-1039.