Activation of Tyk2 and Stat3 is required for the apoptotic actions of interferon-β in primary pro-B cells

Journal of Biological Chemistry

Volumn 281, Issue 24, 2006, Pages 16238-16244

  Gamero, Ana M ^a,b   Potla, Ramesh ^b,f   Wegrzyn, Joanna ^b,e   Szelag, Magdelena ^b,e   Edling, Andrea E ^b   Shimoda, Kazuya ^c   Link, Daniel C ^d   Dulak, Jozef ^e   Baker, Darren P ^g   Tanabe, Yoshinari ⁱ   Grayson, Jason M ^h   Larner, Andrew C ^b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

^c KYUSHU UNIVERSITY   (Japan)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e JAGIELLONIAN UNIVERSITY   (Poland)

^f CLEVELAND STATE UNIVERSITY   (United States)

^g BIOGEN   (United States)

^h WAKE FOREST SCHOOL OF MEDICINE   (United States)

ⁱ NIIGATA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; BONE; CELLS; INTERFERONS;

APOPTOSIS; MURINE; PROGRAMMED CELL DEATH (PCD); TYROSINE;

ENZYMES;

ALPHA INTERFERON; BETA INTERFERON; FOCAL ADHESION KINASE 1; INTERLEUKIN 7; STAT1 PROTEIN; STAT2 PROTEIN; STAT3 PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; B LYMPHOCYTE; BONE MARROW; CONTROLLED STUDY; ENZYME ACTIVATION; IN VIVO STUDY; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SPLEEN; VIRUS INFECTION; VIRUS MENINGITIS; WILD TYPE;

ANIMALS; ANNEXIN A5; APOPTOSIS; B-LYMPHOCYTES; CYTOPLASM; IMMUNOBLOTTING; INTERFERON-BETA; INTERLEUKIN-7; MICE; MICE, TRANSGENIC; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; STAT3 TRANSCRIPTION FACTOR; TYK2 KINASE; TYROSINE;

LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MURINAE;

EID: 33745256484     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M509516200     Document Type: Article

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