Cell-based treatments for diabetes

Drug Discovery Today

Volumn 13, Issue 19-20, 2008, Pages 888-893

  Jones, Peter M ^a   Courtney, Monica L ^b   Burns, Christopher J ^b   Persaud, Shanta J ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b NATIONAL INSTITUTE FOR BIOLOGICAL STANDARDS AND CONTROL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELL POPULATION; CELL THERAPY; EMBRYONIC STEM CELL; HUMAN; IMMUNE RESPONSE; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; PANCREAS ISLET TRANSPLANTATION; REVIEW; SIGNAL TRANSDUCTION; STEM CELL; TREATMENT INDICATION; XENOGRAFT;

ANIMALS; CELL TRANSPLANTATION; DIABETES MELLITUS; HUMANS; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS TRANSPLANTATION; STEM CELL TRANSPLANTATION; TRANSPLANTATION, HETEROLOGOUS;

EID: 52049110072     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.drudis.2008.06.014     Document Type: Review

References (60)

1. Gaglia J.L., et al. Islet transplantation: progress and challenge. Arch. Med. Res. 36 (2005) 273-280
2. Marzorati S., et al. Allogeneic islet transplantation. Expert. Opin. Biol. Ther. 7 (2007) 1627-1645
3. Burns C.J., et al. Stem cell therapy for diabetes: do we need to make beta cells?. J. Endocrinol. 183 (2004) 437-443
4. Burns C.J., et al. Diabetes Mellitus: a potential target for stem cell therapy. Curr. Stem. Cell Res. Ther. 1 (2006) 255-266
5. Parnaud G., et al. Proliferation of sorted human and rat beta cells. Diabetologia 51 (2008) 91-100
6. Narushima M., et al. A human beta-cell line for transplantation therapy to control type 1 diabetes. Nat. Biotechnol. 23 (2005) 1274-1282
7. Newgard C.B., et al. Engineered cell lines for insulin replacement in diabetes: current status and future prospects. Diabetologia 40 (1997) S42-S47
8. Shaw J.A., et al. Secretion of bioactive human insulin following plasmid-mediated gene transfer to non-neuroendocrine cell lines, primary cultures and rat skeletal muscle in vivo. J. Endocrinol. 172 (2002) 653-672
9. Ratanamart J., and Shaw J.A. Plasmid-mediated muscle-targeted gene therapy for circulating therapeutic protein replacement: a tale of the tortoise and the hare?. Curr. Gene Ther. 6 (2006) 93-110
10. Trucco M., et al. The pig as the donor of pancreatic islets for men. Vet. Res. Commun. 31 (2007) 27-33
11. van der Laan L.J., et al. Infection by porcine endogenous retrovirus after islet xenotransplantation in SCID mice. Nature 407 (2000) 90-94
12. Hering B.J., et al. Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates. Nat. Med. 12 (2006) 301-303
13. Denner J., et al. No transmission of porcine endogenous retroviruses (PERVs) in a long-term pig to rat xenotransplantation model and no infection of immunosuppressed rats. Ann. Transplant. 13 (2008) 20-31
14. Elliott R.B., et al. Live encapsulated porcine islets from a type 1 diabetic patient 9.5 yr after xenotransplantation. Xenotransplantation 14 (2007) 157-161
15. Grose S. Critics slam Russian trial to test pig pancreas for diabetics. Nat. Med. 13 (2007) 390-391
16. Valdes-Gonzalez R.A., et al. Three-yr follow-up of a type 1 diabetes mellitus patient with an islet xenotransplant. Clin. Transplant. 21 (2007) 352-357
17. Sykes M., and Cozzi E. Xenotransplantation of pig islets into Mexican children: were the fundamental ethical requirements to proceed with such a study really met?. Eur. J. Endocrinol. 154 (2006) 921-922
18. Limbert C., et al. Beta-cell replacement and regeneration: Strategies of cell-based therapy for type 1 diabetes mellitus. Diabetes Res. Clin. Pract. 79 (2008) 389-399
19. Burke Z.D., et al. Stem cells in the adult pancreas and liver. Biochem. J. 404 (2007) 169-178
20. Efrat S. Beta-cell replacement for insulin-dependent diabetes mellitus. Adv. Drug Deliv. Rev. 60 (2008) 114-123
21. Dor Y., et al. Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 429 (2004) 41-46
22. Teta M., et al. Growth and regeneration of adult beta cells does not involve specialized progenitors. Dev. Cell 12 (2007) 817-826
23. Russ H., et al. In vitro proliferation of cells derived from adult human β-cells revealed by cell-lineage tracing. Diabetes 57 (2008) 1575-1583
24. Xu X., et al. Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas. Cell 132 (2008) 197-207
25. Zhao M., et al. Evidence for the presence of stem cell-like progenitor cells in human adult pancreas. J. Endocrinol. 195 (2007) 407-414
26. Bonner-Weir S., et al. In vitro cultivation of human islets from expanded ductal tissue. Proc. Natl. Acad. Sci. U.S.A. 97 (2000) 7999-8004
27. Yatoh S., et al. Differentiation of affinity-purified human pancreatic duct cells to beta-cells. Diabetes 56 (2007) 1802-1809
28. Zulewski H., et al. Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes. Diabetes 50 (2001) 521-533
29. Davani B., et al. Human islet-derived precursor cells are mesenchymal stromal cells that differentiate and mature to hormone-expressing cells in vivo. Stem Cells 25 (2007) 3215-3222
30. Ianus A., et al. In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. J. Clin. Invest. 111 (2003) 843-850
31. Hasegawa Y., et al. Bone marrow (BM) transplantation promotes beta-cell regeneration after acute injury through BM cell mobilization. Endocrinology 148 (2007) 2006-2015
32. Urban V.S., et al. Mesenchymal stem cells cooperate with bone marrow cells in therapy of diabetes. Stem Cells 26 (2008) 244-253
33. Tang D.Q., et al. In vivo and in vitro characterization of insulin-producing cells obtained from murine bone marrow. Diabetes 53 (2004) 1721-1732
34. Karnieli O., et al. Generation of insulin-producing cells from human bone marrow mesenchymal stem cells by genetic manipulation. Stem Cells 25 (2007) 2837-2844
35. Sun B., et al. Induction of human umbilical cord blood-derived stem cells with embryonic stem cell phenotypes into insulin producing islet-like structure. Biochem. Biophys. Res. Commun. 354 (2007) 919-923
36. Ferber S., et al. Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia. Nat. Med. 6 (2000) 568-572
37. Elsner M., et al. Diabetes therapy by lentiviral hepatic insulin gene expression without transformation of the liver. Diabetologia 51 (2008) 694-695
38. Kojima H., et al. Neuro d-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice. Nat. Med. 9 (2003) 596-603
39. Li W.C., et al. In vitro transdifferentiation of hepatoma cells into functional pancreatic cells. Mech. Dev. 122 (2005) 835-847
40. Yatoh S., et al. NeuroD and reaggregation induce beta-cell specific gene expression in cultured hepatocytes. Diabetes Metab. Res. Rev. 23 (2007) 239-249
41. Yang X.J., et al. Hypothalamic glucose sensor: similarities to and differences from pancreatic beta-cell mechanisms. Diabetes 48 (1999) 1763-1772
42. Burns C.J., et al. The in vitro differentiation of rat neural stem cells into an insulin-expressing phenotype. Biochem. Biophys. Res. Commun. 326 (2005) 570-577
43. Hori Y., et al. Differentiation of insulin-producing cells from human neural progenitor cells. PLoS. Med. 2 (2005) 103
44. Zhao C., et al. Mechanisms and functional implications of adult neurogenesis. Cell 132 (2008) 645-660
45. Lumelsky N., et al. Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets. Science 292 (2001) 1389-1394
46. Rajagopal J., et al. Insulin staining of ES cell progeny from insulin uptake. Science 299 (2003) 363
47. Colman A. Making new beta cells from stem cells. Semin. Cell Dev. Biol. 15 (2004) 337-345
48. Madsen O.D. Stem cells and diabetes treatment. APMIS 113 (2005) 858-875
49. Docherty K., et al. Embryonic stem cell therapy for diabetes mellitus. Semin. Cell Dev. Biol. 18 (2007) 827-838
50. Assady S., et al. Insulin production by human embryonic stem cells. Diabetes 50 (2001) 1691-1697
51. Segev H., et al. Differentiation of human embryonic stem cells into insulin-producing clusters. Stem Cells 22 (2004) 265-274
52. Baharvand H., et al. Generation of insulin-secreting cells from human embryonic stem cells. Dev. Growth Diff. 48 (2006) 323-332
53. Brolen G.K., et al. Signals from the embryonic mouse pancreas induce differentiation of human embryonic stem cells into insulin-producing beta-cell-like cells. Diabetes 54 (2005) 2867-2874
54. D'Amour K.A., et al. Efficient differentiation of human embryonic stem cells to definitive endoderm. Nat. Biotechnol. 23 (2005) 1534-1541
55. Xu X., et al. Endoderm and pancreatic islet lineage differentiation from human embryonic stem cells. Cloning Stem Cells 8 (2006) 96-107
56. Jiang W., et al. In vitro derivation of functional insulin-producing cells from human embryonic stem cells. Cell Res. 17 (2007) 333-344
57. Shim J.H., et al. Directed differentiation of human embryonic stem cells towards a pancreatic cell fate. Diabetologia 50 (2007) 1228-1238
58. Micallef S.J., et al. Endocrine cells develop within pancreatic bud-like structures derived from mouse ES cells differentiated in response to BMP4 and retinoic acid. Stem Cell Res. 1 (2007) 25-36
59. D'Amour K.A., et al. Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat. Biotechnol. 24 (2006) 1392-1401
60. Kroon E., et al. Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo. Nat. Biotechnol. 26 (2008) 443-452