Generation of insulin-secreting cells from human embryonic stem cells

Development Growth and Differentiation

Volumn 48, Issue 5, 2006, Pages 323-332

  Baharvand, Hossein ^a   Jafary, Hanieh ^a   Massumi, Mohammad ^a   Ashtiani, Saeid Kazemi ^a  

^a ROYAN INSTITUTE FOR REPRODUCTIVE BIOMEDICINE   (Iran)

Author keywords

Differentiation; Human embryonic stem cells; Insulin secreting cells

Indexed keywords

ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; AMYLIN; C PEPTIDE; DITHIZONE; GLUCAGON ANTIBODY; GLUCOKINASE; GLUCOSE TRANSPORTER 2; GROWTH FACTOR; INSULIN ANTIBODY; PROINSULIN; PROPROTEIN CONVERTASE 2; SOMATOSTATIN; TRANSCRIPTION FACTOR PAX4;

ARTICLE; CELL DIFFERENTIATION; EMBRYONIC STEM CELL; HUMAN; HUMAN CELL; INSULIN RELEASE; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSMISSION ELECTRON MICROSCOPY;

CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL LINE; DIABETES MELLITUS; EMBRYO; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENE EXPRESSION; GLUCOSE; HUMANS; INSULIN; INSULIN-SECRETING CELLS; INTERMEDIATE FILAMENT PROTEINS; ISLETS OF LANGERHANS; NERVE TISSUE PROTEINS; STEM CELLS;

EID: 33744832001     PISSN: 00121592     EISSN: 1440169X     Source Type: Journal    
DOI: 10.1111/j.1440-169X.2006.00867.x     Document Type: Article

References (39)

1. Assady S. Maor G. Amit M. Itskovitz-Eldor J. Skorecki K. L. Tzukerman M. 2001. Insulin production by human embryonic stem cells. Diabetes 50, 1691 1697.
2. Baharvand H. Ashtiani S. K. Valojerdi M. R. Shahverdi A. Taee A. Sabour D. 2004. Establishment and in vitro differentiation of a new embryonic stem cell line from human blastocyst. Differentiation 72, 224 229.
3. Baharvand H. Azarnia M. Parivar K. Ashtiani S. K. 2005. The effect of extracellular matrix on embryonic stem cell-derived cardiomyocytes. J. Mol. Cell Cardiol. 38, 495 503.
4. Blyszczuk P. Asbrand C. Rozzo A. et al. 2004. Embryonic stem cells differentiate into insulin-producing cells without selection of nestin-expressing cells. Int. J. Dev. Biol. 48, 1095 1104.
5. Blyszczuk P. Czyz J. Kania G. et al. 2003. Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulin-producing cells. Proc. Natl Acad. Sci. USA 100, 998 1003.
6. Bonner-Weir S. Taneja M. Weir G. C. et al. 2000. In vitro cultivation of human islets from expanded ductal tissue. Proc. Natl Acad. Sci. USA 97, 7999 8004.
7. Charollais A. Gjinovci A. Huarte J. et al. 2000. Junctional communication of pancreatic beta cells contributes to the control of insulin secretion and glucose tolerance. J. Clin. Invest. 106, 235 243.
8. Delacour A. Nepote V. Trumpp A. Herrera P. L. 2004. Nestin expression in pancreatic exocrine cell lineages. Mech. Dev. 121, 3 14.
9. Eiges R. Schuldiner M. Drukker M. Yanuka O. Itskovitz-Eldor J. Benveniste H. 2001. Establishment of human embryonic stem cell-transfected clones carrying a marker for undifferentiated cell. Curr. Biol. 11, 514 518.
10. Esni F. Stoffers D. A. Takeuchi T. Leach S. D. 2004. Origin of exocrine pancreatic cells from nestin-positive precursors in developing mouse pancreas. Mech. Dev. 121, 15 25.
11. Hansson M. Tonning A. Frandsen U. et al. 2004. Artifactual insulin release from differentiated embryonic stem cells. Diabetes 53, 2603 2609.
12. Hori Y. Rulifson I. C. Tsai B. C. Heit J. J. Cahoy J. D. Kim S. K. 2002. Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells. Proc. Natl Acad. Sci. USA 99, 16 105 16 110.
13. Jonkers F. C. Jonas J. C. Gilon P. Henquin J. C. 1999. Influence of cell number on the characteristics and synchrony of Ca2+ oscillations in clusters of mouse pancreatic islet cells. J. Physiol. 520, 839 849.
14. Klug M. G. Soonpaa M. H. Koh G. Y. Field L. J. 1996. Genetically selected cardiomyocytes from differentiating embronic stem cells form stable intracardiac grafts. J. Clin. Invest. 98, 216 224.
15. Ku H. T. Zhang N. Kubo A. et al. 2004. Committing embryonic stem cells to early endocrine pancreas in vitro. Stem Cells 22, 1205 1217.
16. Lee S. H. Lumelsky N. Studer L. Auerbach J. M. McKay R. D. 2000. Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells. Nat. Biotechnol. 18, 675 679.
17. Lendahl U. Zimmerman L. B. McKay R. D. 1990. CNS stem cells express a new class of intermediate filament protein. Cell 60, 585 595.
18. Leon-Quinto T. Jones J. Skoudy A. Burcin M. Soria B. 2004. In vitro directed differentiation of mouse embryonic stem cells into insulin-producing cells. Diabetologia 47, 1442 1451.
19. Lester L. B. Kuo H. C. Andrews L. Nauert B. Wolf D. P. 2004. Directed differentiation of rhesus monkey ES cells into pancreatic cell phenotypes. Reprod. Biol. Endocrinol. 2, 42 45.
20. Li M. Pevny L. Lovell-Badge R. Smith A. 1998. Generation of purified neural precursors from embryonic stem cells by lineage selection. Curr. Biol. 8, 971 974.
21. Lumelsky N. Blondel O. Laeng P. Velasco I. Ravin R. McKay R. 2001. Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets. Science 292, 1389 1394.
22. McWhir J. Schnieke A. E. Ansell R. et al. 1996. Selective ablation of differentiated cells permits isolation of embryonic stem cell lines from murine embryos with a non-permissive genetic background. Nat. Genet. 14, 223 226.
23. Miyazaki S. Yamato E. Miyazaki J. 2004. Regulated expression of pdx-1 promotes in vitro differentiation of insulin-producing cells from embryonic stem cells. Diabetes 53, 1030 1037.
24. Moritoh Y. Yamato E. Yasui Y. Miyazaki S. Miyazaki J. 2003. Analysis of insulin-producing cells during in vitro differentiation from feeder-free embryonic stem cells. Diabetes 52, 1163 1168.
25. Otonkoski T. Beattie G. M. Mally M. I. Ricordi C. Hayek A. 1993. Nicotinamide is a potent inducer of endocrine differentiation in cultured human fetal pancreatic cells. J. Clin. Invest. 92, 1459 1466.
26. Rajagopal J. Anderson W. J. Kume S. Martinez O. I. Melton D. A. 2003. Insulin staining of ES cell progeny from insulin uptake. Science. 299, 363.
27. Ramiya V. K. Maraist M. Arfors K. E. Schatz D. A. Peck A. B. Cornelius J. G. 2000. Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells. Nat. Med. 6, 278 282.
28. Reubinoff B. E. Pera M. F. Fong C. Y. Trounson A. Bongso A. 2000. Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro. Nat. Biotechnol. 18, 399 404.
29. Segev H. Fishman B. Ziskind A. Shulman M. Itskovitz-Eldor J. 2004. Differentiation of human embryonic stem cells into insulin-producing clusters. Stem Cells 22, 265 274.
30. Shapiro A. M. Lakey J. R. Ryan E. A. et al. 2000. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N. Engl. J. Med. 343, 230 238.
31. Shi Y. Hou L. Fuchou T. et al. 2005. Inducing Embryonic Stem Cells to Differentiate into Pancreatic β Cells by a Novel Three-Step Approach with Activin A and All-Trans Retinoic Acid. Stem Cells 23, 656 662.
32. Shiroi A. Ueda S. Ouji Y. et al. 2005. Differentiation of embryonic stem cells into insulin-producing cells promoted by Nkx2.2 gene transfer. World J. Gastroenterol. 21, 4161 4166.
33. Shiroi A. Yoshikawa M. Yokota H. et al. 2002. Identification of insulin-producing cells derived from embryonic stem cells by zinc-chelating dithizone. Stem Cells 20, 284 292.
34. Sipione S. Eshpeter A. Lyon J. G. Korbutt G. S. Bleackley R. C. 2004. Insulin expressing cells from differentiated embryonic stem cells are not beta cells. Diabetologia 47, 499 508.
35. Soria B. Roche E. Berna G. Leon-Quinto T. Reig J. A. Martin F. 2000. Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice. Diabetes 49, 157 162.
36. Street C. N. Lakey J. R. Seeberger K. et al. 2004. Heterogenous expression of nestin in human pancreatic tissue precludes its use as an islet precursor marker. J. Endocrinol. 180, 213 225.
37. Thomson J. A. Itskovitz-Eldor J. Shapiro S. S. et al. 1998. Embryonic stem cell lines derived from human blastocysts. Science 282, 1145 1147.
38. Tourrel C. Bailbe D. Lacorne M. Meile M. J. Kergoat M. Portha B. 2002. Persistent Improvement of Type 2 Diabetes in the Goto-Kakizaki Rat Model by Expansion of the β-Cell Mass During the Prediabetic Period With Glucagon-Like Peptide-1 or Exendin-4. Diabetes 51, 1443 1452.
39. Zhang L. Hong T. P. Hu J. Liu Y. N. Wu Y. H. Li L. S. 2005. Nestin-positive progenitor cells isolated from human fetal pancreas have phenotypic markers identical to mesenchymal stem cells. World J. Gastroenterol. 11, 2906 2911.