-
1
-
-
0034721255
-
Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen
-
Shapiro AM, Lakey JR, Ryan EA, et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 2000; 343: 230-238.
-
(2000)
N Engl J Med
, vol.343
, pp. 230-238
-
-
Shapiro, A.M.1
Lakey, J.R.2
Ryan, E.A.3
-
2
-
-
1442265579
-
Islet transplantation as a treatment for diabetes - A work in progress
-
Robertson RP. Islet transplantation as a treatment for diabetes - a work in progress. N Engl J Med 2004; 350: 694-705.
-
(2004)
N Engl J Med
, vol.350
, pp. 694-705
-
-
Robertson, R.P.1
-
3
-
-
21344462346
-
Five-year follow-up after clinical islet transplantation
-
Ryan EA, Paty BW, Senior PA, et al. Five-year follow-up after clinical islet transplantation. Diabetes 2005; 54: 2060-2069.
-
(2005)
Diabetes
, vol.54
, pp. 2060-2069
-
-
Ryan, E.A.1
Paty, B.W.2
Senior, P.A.3
-
4
-
-
24944591025
-
New sources of pancreatic β-cells
-
DOI: 10.1038/nbt1115
-
Bonner-Weir S, Weir GC. New sources of pancreatic β-cells. Nat Biotechnol 2005; 23: 857-861, DOI: 10.1038/nbt1115.
-
(2005)
Nat Biotechnol
, vol.23
, pp. 857-861
-
-
Bonner-Weir, S.1
Weir, G.C.2
-
5
-
-
2342519447
-
Can we make surrogate beta-cells better than the original?
-
DOI: 10.1016/j.semcdb.2004.02.004
-
Weir GC. Can we make surrogate beta-cells better than the original? Semin Cell Dev Biol 2004; 15: 347-357, DOI: 10.1016/j.semcdb.2004.02.004.
-
(2004)
Semin Cell Dev Biol
, vol.15
, pp. 347-357
-
-
Weir, G.C.1
-
6
-
-
0034068602
-
Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia
-
DOI: 10.1038/75050
-
Ferber S, Halkin A, Cohen H, et al. Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia. Nat Med 2000; 6: 568-572, DOI: 10.1038/75050.
-
(2000)
Nat Med
, vol.6
, pp. 568-572
-
-
Ferber, S.1
Halkin, A.2
Cohen, H.3
-
7
-
-
0041856137
-
Functional, persistent, and extended liver to pancreas transdifferentiation
-
DOI: 10.1074/jbc.M303127200
-
Ber I, Shtemhall K, Perl S, et al. Functional, persistent, and extended liver to pancreas transdifferentiation. J Biol Chem 2003; 278: 31950-31957, DOI: 10.1074/jbc.M303127200.
-
(2003)
J Biol Chem
, vol.278
, pp. 31950-31957
-
-
Ber, I.1
Shtemhall, K.2
Perl, S.3
-
8
-
-
0038413922
-
NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice
-
DOI: 10.1038/nm867
-
Kojima H, Fujimiya M, Matsumura K, et al. NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice. Nat Med 2003; 9: 96-603, DOI: 10.1038/nm867.
-
(2003)
Nat Med
, vol.9
, pp. 96-603
-
-
Kojima, H.1
Fujimiya, M.2
Matsumura, K.3
-
9
-
-
0038472015
-
Reversal of hyperglycemia in mice by using human expandable insulin-producing cells differentiated from fetal liver progenitor cells
-
DOI: 0.1073/pnas.1136854100
-
Zalzman M, Gupta S, Giri RK, et al. Reversal of hyperglycemia in mice by using human expandable insulin-producing cells differentiated from fetal liver progenitor cells. Proc Natl Acad Sci U S A 2003; 100: 7253-7258, DOI: 0.1073/pnas.1136854100.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 7253-7258
-
-
Zalzman, M.1
Gupta, S.2
Giri, R.K.3
-
10
-
-
24144467428
-
Differentiation of human liver-derived, insulin-producing cells toward the β-cell phenotype
-
Zalzman M, Anker-Kitai L, Efrat S. Differentiation of human liver-derived, insulin-producing cells toward the β-cell phenotype. Diabetes 2005; 54: 2568-2575.
-
(2005)
Diabetes
, vol.54
, pp. 2568-2575
-
-
Zalzman, M.1
Anker-Kitai, L.2
Efrat, S.3
-
11
-
-
20344394437
-
Cell-replacement therapy for diabetes: Generating functional insulin-producing tissue from adult human liver cells
-
DOI: 10.1073/pnas.0405277102
-
Sapir T, Shternhall K, Meivar-Levy I, et al. Cell-replacement therapy for diabetes: Generating functional insulin-producing tissue from adult human liver cells. Proc Natl Acad Sci U S A 2005; 102: 7964-7969, DOI: 10.1073/pnas.0405277102.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 7964-7969
-
-
Sapir, T.1
Shternhall, K.2
Meivar-Levy, I.3
-
12
-
-
0029928703
-
Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF, EGF and TGFα in a chemically defined (HGM) medium
-
Block GD, Locker J, Bowen WC, et al. Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF, EGF and TGFα in a chemically defined (HGM) medium. J Cell Biol 1996; 132: 1133-1149.
-
(1996)
J Cell Biol
, vol.132
, pp. 1133-1149
-
-
Block, G.D.1
Locker, J.2
Bowen, W.C.3
-
13
-
-
0038045136
-
HGF-, EGF-, and dexamethasone-induced gene expression patterns during formation of tissue in hepatic organoid cultures
-
Michalopoulos GK, Bowen WC, Mule K, Luo J. HGF-, EGF-, and dexamethasone-induced gene expression patterns during formation of tissue in hepatic organoid cultures. Gene Expr 2003; 11: 55-75.
-
(2003)
Gene Expr
, vol.11
, pp. 55-75
-
-
Michalopoulos, G.K.1
Bowen, W.C.2
Mule, K.3
Luo, J.4
-
14
-
-
0030907390
-
Hormonal regulation of an islet-specific enhancer in the pancreatic homeobox gene STF-1
-
Sharma S, Jhala US, Johnson T, Ferreri K, Leonard J, Montminy M. Hormonal regulation of an islet-specific enhancer in the pancreatic homeobox gene STF-1. Mol Cell Biol 1997; 17: 2598-2604.
-
(1997)
Mol Cell Biol
, vol.17
, pp. 2598-2604
-
-
Sharma, S.1
Jhala, U.S.2
Johnson, T.3
Ferreri, K.4
Leonard, J.5
Montminy, M.6
-
15
-
-
0037213587
-
Gene expression cascade in pancreatic development
-
DOI: 10.1016/S0925-4773(02)00333-7
-
Wilson ME, Scheel D, German MS. Gene expression cascade in pancreatic development. Mech Dev 2003; 120: 65-80, DOI: 10.1016/ S0925-4773(02)00333-7.
-
(2003)
Mech Dev
, vol.120
, pp. 65-80
-
-
Wilson, M.E.1
Scheel, D.2
German, M.S.3
-
16
-
-
0025909862
-
Effect of 2% dimethyl sulfoxide on the mitogenic properties of epidermal growth factor and hepatocyte growth factor in primary culture
-
Kost DP, Michalopoulos GK. Effect of 2% dimethyl sulfoxide on the mitogenic properties of epidermal growth factor and hepatocyte growth factor in primary culture. J Cell Physiol 1991; 147: 274-280.
-
(1991)
J Cell Physiol
, vol.147
, pp. 274-280
-
-
Kost, D.P.1
Michalopoulos, G.K.2
-
17
-
-
0017101039
-
Preparation of isolated rat liver cells
-
Seglen PO. Preparation of isolated rat liver cells. Methods Cell Biol 1976; 13: 29-83.
-
(1976)
Methods Cell Biol
, vol.13
, pp. 29-83
-
-
Seglen, P.O.1
-
18
-
-
0032478271
-
A simplified system for generating recombinant adenoviruses
-
He TC, Zhou S, da Costa LT, Yu J, Kinzler KW, Vogelstein B. A simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci U S A 1998; 95: 2509-2514.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 2509-2514
-
-
He, T.C.1
Zhou, S.2
da Costa, L.T.3
Yu, J.4
Kinzler, K.W.5
Vogelstein, B.6
-
19
-
-
15944417831
-
PDX-1/VP16 fusion protein, together with NeuroD or Ngn3, markedly induces insulin gene transcription and ameliorates glucose tolerance
-
Kaneto H, Nakatani Y, Miyatsuka T, et al. PDX-1/VP16 fusion protein, together with NeuroD or Ngn3, markedly induces insulin gene transcription and ameliorates glucose tolerance. Diabetes 2005; 54: 1009-1022.
-
(2005)
Diabetes
, vol.54
, pp. 1009-1022
-
-
Kaneto, H.1
Nakatani, Y.2
Miyatsuka, T.3
-
20
-
-
0033553462
-
Chronic hyperglycemia triggers loss of pancreatic beta cell differentiation in an animal model of diabetes
-
Jonas JC, Sharma A, Hasenkamp W, et al. Chronic hyperglycemia triggers loss of pancreatic beta cell differentiation in an animal model of diabetes. J Biol Chem 1999; 274: 14112-14121.
-
(1999)
J Biol Chem
, vol.274
, pp. 14112-14121
-
-
Jonas, J.C.1
Sharma, A.2
Hasenkamp, W.3
-
21
-
-
0141594641
-
The origin and liver repopulating capacity of murine oval cells
-
DOI: 10.1073/pnas.1734199100
-
Wang X, Foster M, Al-Dhalimy M, Lagasse E, Finegold M, Grompe M. The origin and liver repopulating capacity of murine oval cells. Proc Natl Acad Sci U S A 2003; 100(Suppl. 1): 11881-11888, DOI: 10.1073/ pnas.1734199100.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, Issue.SUPPL. 1
, pp. 11881-11888
-
-
Wang, X.1
Foster, M.2
Al-Dhalimy, M.3
Lagasse, E.4
Finegold, M.5
Grompe, M.6
-
22
-
-
0025059398
-
Selective expression and developmental regulation of the ancestral rat insulin II gene in fetal liver
-
Giddings SJ, Carnaghi LR. Selective expression and developmental regulation of the ancestral rat insulin II gene in fetal liver. Mol Endocrinol 1990; 4: 1363-1369.
-
(1990)
Mol Endocrinol
, vol.4
, pp. 1363-1369
-
-
Giddings, S.J.1
Carnaghi, L.R.2
-
23
-
-
0027398295
-
Differential expression of the two nonallelic proinsulin gene in the developing mouse embryo
-
Deltour L, Leduque P, Blume N, et al. Differential expression of the two nonallelic proinsulin gene in the developing mouse embryo. Proc Natl Acad Sci U S A 1993; 90: 527-531.
-
(1993)
Proc Natl Acad Sci U S A
, vol.90
, pp. 527-531
-
-
Deltour, L.1
Leduque, P.2
Blume, N.3
-
24
-
-
0027486662
-
Insulin II gene expression in rat central nervous system
-
Devaskar SU, Singh BS, Carnaghi LR, Rajakumar PA, Giddings SJ. Insulin II gene expression in rat central nervous system. Regul Pept 1993; 48: 55-63.
-
(1993)
Regul Pept
, vol.48
, pp. 55-63
-
-
Devaskar, S.U.1
Singh, B.S.2
Carnaghi, L.R.3
Rajakumar, P.A.4
Giddings, S.J.5
-
25
-
-
0031755882
-
Intrathymic expression of genes involved in organ specific autoimmune disease
-
DOI: 10.1006/jaut.1998.0210
-
Heath VL, Moore NC, Parnell SM, Mason DW. Intrathymic expression of genes involved in organ specific autoimmune disease. J Autoimmun 1998; 11: 309-318, DOI: 10.1006/jaut.1998.0210.
-
(1998)
J Autoimmun
, vol.11
, pp. 309-318
-
-
Heath, V.L.1
Moore, N.C.2
Parnell, S.M.3
Mason, D.W.4
-
26
-
-
0033979603
-
Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice
-
Soria B, Roche E, Berna G, Leon-Quinto T, Reig JA, Martin F. Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice. Diabetes 2000; 49: 157-162.
-
(2000)
Diabetes
, vol.49
, pp. 157-162
-
-
Soria, B.1
Roche, E.2
Berna, G.3
Leon-Quinto, T.4
Reig, J.A.5
Martin, F.6
-
27
-
-
0037058934
-
Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells
-
DOI: 10.1073/pnas.252618999
-
Hori Y, Rulifson IC, Tsai BC, Heit JJ, Cahoy JD, Kim SK. Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells. Proc Natl Acad Sci U S A 2002; 99: 16105-16110, DOI: 10.1073/pnas.252618999.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 16105-16110
-
-
Hori, Y.1
Rulifson, I.C.2
Tsai, B.C.3
Heit, J.J.4
Cahoy, J.D.5
Kim, S.K.6
-
28
-
-
0035434048
-
Insulin production by human embryonic stem cells
-
Assady S, Maor G, Amit M, Itskovitz-Eldor J, Skorecki KL, Tzukerman M. Insulin production by human embryonic stem cells. Diabetes 2001; 50: 1691-1697.
-
(2001)
Diabetes
, vol.50
, pp. 1691-1697
-
-
Assady, S.1
Maor, G.2
Amit, M.3
Itskovitz-Eldor, J.4
Skorecki, K.L.5
Tzukerman, M.6
-
29
-
-
4444320484
-
Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages
-
DOI: 10.1073/pnas.252618999
-
Seaberg RM, Smukler SR, Kieffer TJ, et al. Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages. Nat Biotechnol 2004; 22: 1115-1124, DOI: 10.1073/pnas.252618999.
-
(2004)
Nat Biotechnol
, vol.22
, pp. 1115-1124
-
-
Seaberg, R.M.1
Smukler, S.R.2
Kieffer, T.J.3
-
30
-
-
3242784831
-
Prospective isolation of multipotent pancreatic progenitors using flow-cytometric cell sorting
-
Suzuki A, Nakauchi H, Taniguchi H. Prospective isolation of multipotent pancreatic progenitors using flow-cytometric cell sorting. Diabetes 2004; 53: 2143-2152.
-
(2004)
Diabetes
, vol.53
, pp. 2143-2152
-
-
Suzuki, A.1
Nakauchi, H.2
Taniguchi, H.3
-
31
-
-
3042785984
-
In vivo and in vitro characterization of insulin-producing cells obtained from murine bone marrow
-
Tang DQ, Cao LZ, Burkhardt BR, et al. In vivo and in vitro characterization of insulin-producing cells obtained from murine bone marrow. Diabetes 2004; 53: 1721-1732.
-
(2004)
Diabetes
, vol.53
, pp. 1721-1732
-
-
Tang, D.Q.1
Cao, L.Z.2
Burkhardt, B.R.3
-
32
-
-
2942594624
-
Adult bone marrow-derived cells trans-differentiating into insulin-producing cells for the treatment of type 1 diabetes
-
DOI: 10.1038/labinvest.3700074
-
Oh SH, Muzzonnigro TM, Bae SH, LaPlante JM, Hatch HM, Petersen BE. Adult bone marrow-derived cells trans-differentiating into insulin-producing cells for the treatment of type 1 diabetes. Lab Invest 2004; 84: 607-617, DOI: 10.1038/labinvest.3700074.
-
(2004)
Lab Invest
, vol.84
, pp. 607-617
-
-
Oh, S.H.1
Muzzonnigro, T.M.2
Bae, S.H.3
LaPlante, J.M.4
Hatch, H.M.5
Petersen, B.E.6
-
33
-
-
27144462791
-
Human cord blood-derived cells generate insulin-producing cells in vitro
-
DOI: 10.1634/stemcells.2005-0079
-
Yoshida S, Ishikawa F, Kawano N, et al. Human cord blood-derived cells generate insulin-producing cells in vitro. Stem Cells 2005; 23: 1409-1416, DOI: 10.1634/stemcells.2005-0079.
-
(2005)
Stem Cells
, vol.23
, pp. 1409-1416
-
-
Yoshida, S.1
Ishikawa, F.2
Kawano, N.3
-
34
-
-
11144283080
-
Redifferentiation of insulin-secreting cells after in vitro expansion of adult human pancreatic islet tissue
-
DOI: 10.1016/j.bbrc.2004.12.043
-
Lechner A, Nolan AL, Blacken RA, Habener JF. Redifferentiation of insulin-secreting cells after in vitro expansion of adult human pancreatic islet tissue. Biochem Biophys Res Commun 2005; 327: 581-588, DOI: 10.1016/j.bbrc.2004.12.043.
-
(2005)
Biochem Biophys Res Commun
, vol.327
, pp. 581-588
-
-
Lechner, A.1
Nolan, A.L.2
Blacken, R.A.3
Habener, J.F.4
-
35
-
-
11144315998
-
Epithelial-to-mesenchymal transition generates proliferative human islet precursor cells
-
DOI: 10.1126/science.1101968
-
Gershengorn MC, Hardikar AA, Wei C, Geras-Raaka E, Marcus-Samuels B, Raaka BM. Epithelial-to-mesenchymal transition generates proliferative human islet precursor cells. Science 2004; 306: 2261-2264, DOI: 10.1126/ science.1101968.
-
(2004)
Science
, vol.306
, pp. 2261-2264
-
-
Gershengorn, M.C.1
Hardikar, A.A.2
Wei, C.3
Geras-Raaka, E.4
Marcus-Samuels, B.5
Raaka, B.M.6
-
36
-
-
13844283358
-
Redox-mediated enrichment of self-renewing adult human pancreatic cells that possess endocrine differentiation potential
-
Linning KD, Tai MH, Madhukar BV, et al. Redox-mediated enrichment of self-renewing adult human pancreatic cells that possess endocrine differentiation potential. Pancreas 2004; 29: e64-76.
-
(2004)
Pancreas
, vol.29
-
-
Linning, K.D.1
Tai, M.H.2
Madhukar, B.V.3
-
37
-
-
19344362213
-
Differentiation of insulin-producing cells from human neural progenitor cells
-
e103: DOI: 10.1371/journal.pmed.0020103
-
Hori Y, Gu X, Xie X, Kim SK. Differentiation of insulin-producing cells from human neural progenitor cells. PloS Med 2005; 2 e103: 347-356, DOI: 10.1371/journal.pmed.0020103.
-
(2005)
PloS Med
, vol.2
, pp. 347-356
-
-
Hori, Y.1
Gu, X.2
Xie, X.3
Kim, S.K.4
-
38
-
-
33947305191
-
Isolation, immortalization and characterization of multipotent mesenchymal stem cells from human islets of Langerhans that express nestin, ABCG2 and islet-1 (Abstract)
-
Eberhardt M, Salmon P, Mach MV, et al. Isolation, immortalization and characterization of multipotent mesenchymal stem cells from human islets of Langerhans that express nestin, ABCG2 and islet-1 (Abstract). Diabetes 2005; 54(Suppl. 1): A57.
-
(2005)
Diabetes
, vol.54
, Issue.SUPPL. 1
-
-
Eberhardt, M.1
Salmon, P.2
Mach, M.V.3
-
39
-
-
33947324142
-
In vitro generation insulin-producing cells from adult spleen (Abstract)
-
Tang DQ, Cao LZ, Sun Y, Yang LJ. In vitro generation insulin-producing cells from adult spleen (Abstract). Diabetes 2005; 54(Suppl. 1): A395.
-
(2005)
Diabetes
, vol.54
, Issue.SUPPL. 1
-
-
Tang, D.Q.1
Cao, L.Z.2
Sun, Y.3
Yang, L.J.4
-
40
-
-
33947314260
-
Differentiation of human preadipocytes into insulin, amylin, somatostatin and glucagons expressing islet-like clusters in vitro (Abstract)
-
Timper K, Seboek D, Linscheid P, et al. Differentiation of human preadipocytes into insulin, amylin, somatostatin and glucagons expressing islet-like clusters in vitro (Abstract). Diabetes 2005; 54(Suppl. 1): A396.
-
(2005)
Diabetes
, vol.54
, Issue.SUPPL. 1
-
-
Timper, K.1
Seboek, D.2
Linscheid, P.3
-
41
-
-
33947313115
-
Turning human blood monocytes to islet β-cells: A feasible challenge?
-
(Abstract) 65th ADA Scientific Sessions. Late breaking abstract 80-LB
-
Gauthier BR, Corcelle V, Zulewski H, Burger D, Dayer JM, Wollheim CB. Turning human blood monocytes to islet β-cells: A feasible challenge? (Abstract) 65th ADA Scientific Sessions. 2005; Late breaking abstract 80-LB.
-
(2005)
-
-
Gauthier, B.R.1
Corcelle, V.2
Zulewski, H.3
Burger, D.4
Dayer, J.M.5
Wollheim, C.B.6
-
42
-
-
23644438592
-
Relative contribution of PDX-1, Maf-A and E47/β2 to regulation of the human insulin promoter
-
Docherty HM, Hay CW, Ferguson LA, Barrow J, Durward E, Docherty K. Relative contribution of PDX-1, Maf-A and E47/β2 to regulation of the human insulin promoter. Biochem J 2005; 389: 813-820.
-
(2005)
Biochem J
, vol.389
, pp. 813-820
-
-
Docherty, H.M.1
Hay, C.W.2
Ferguson, L.A.3
Barrow, J.4
Durward, E.5
Docherty, K.6
-
44
-
-
0037062515
-
In vitro trans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells
-
DOI: 10.1073/pnas.122210699
-
Yang L, Li S, Hatch H, et al. In vitro trans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells. Proc Natl Acad Sci U S A 2002; 99: 8078-8083, DOI: 10.1073/ pnas.122210699.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 8078-8083
-
-
Yang, L.1
Li, S.2
Hatch, H.3
-
45
-
-
9444255761
-
High glucose is necessary for complete maturation of Pdx-1-VP16-expressing hepatic cells into functional insulin-producing cells
-
Cao LZ, Tang DQ, Horb ME, Li SW, Yang LJ. High glucose is necessary for complete maturation of Pdx-1-VP16-expressing hepatic cells into functional insulin-producing cells. Diabetes 2004; 53: 3168-3178.
-
(2004)
Diabetes
, vol.53
, pp. 3168-3178
-
-
Cao, L.Z.1
Tang, D.Q.2
Horb, M.E.3
Li, S.W.4
Yang, L.J.5
-
46
-
-
20444406125
-
In vitro transdifferentiation of hepatoma cells into functional pancreatic cells
-
DOI: 10.1016/j.mod.2005.01.001
-
Li WC, Horb ME, Tosh D, Slack JM. In vitro transdifferentiation of hepatoma cells into functional pancreatic cells. Mech Dev 2005; 122: 835-847, DOI: 10.1016/j.mod.2005.01.001.
-
(2005)
Mech Dev
, vol.122
, pp. 835-847
-
-
Li, W.C.1
Horb, M.E.2
Tosh, D.3
Slack, J.M.4
|