Early signals after stretch leading to cardiac hypertrophy. Key role of NHE-1

Frontiers in Bioscience

Volumn 13, Issue 18, 2008, Pages 7096-7114

  Cingolani, Horacio E ^a   Perez, Nestor G ^a   Aiello, Ernesto A ^a   Ennis, Irene L ^a   Garciarena, Carolina D ^a   Villa Abrille, Maria C ^a   Dulce, Raul A ^a   Caldiz, Claudia I ^a   Yeves, Alejandra M ^a   Correa, Maria V ^a   Nolly, Mariela B ^a   De Cingolani, Gladys Chiappe ^a  

^a FACULTAD DE CIENCIAS MÉDICAS   (Argentina)

Author keywords

Angiotensin II; Endothelin; Hypertrophy; NHE 1; Reactive Oxygen Species; Review; Slow Force Response

Indexed keywords

ANGIOTENSIN II; GROWTH FACTOR ACTIVATABLE NA H EXCHANGER NHE 1; GROWTH FACTOR-ACTIVATABLE NA-H EXCHANGER NHE-1; REACTIVE OXYGEN METABOLITE; SODIUM PROTON EXCHANGE PROTEIN;

ADULT; BIOMECHANICS; CARDIOMEGALY; GENETICS; HEART RIGHT VENTRICLE HYPERTROPHY; HEART VENTRICLE; HUMAN; METABOLISM; OBESITY; PATHOPHYSIOLOGY; PHYSIOLOGY; PRESSORECEPTOR; REVIEW; SIGNAL TRANSDUCTION;

ADULT; ANGIOTENSIN II; BIOMECHANICS; CARDIOMEGALY; HEART VENTRICLES; HUMANS; HYPERTROPHY, RIGHT VENTRICULAR; OBESITY; PRESSORECEPTORS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SODIUM-HYDROGEN ANTIPORTER;

EID: 52049086649     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/3213     Document Type: Article

References (134)

1. H.E. Cingolani, B.V. Alvarez, I.L. Ennis, M.C. Camilión de Hurtado. Stretch-induced alkalinization of feline papillary muscle: an autocrine-paracrine system. Circ Res 83, 775-780 (1998) (Pubitemid 28489074)
2. B.V. Alvarez, N.G. Pérez, I.L. Ennis, M.C. Camilión de Hurtado, H.E. Cingolani. Mechanisms underlying the increase in force and calcium transient that follows stretch of cardiac muscle: a possible explanation of the Anrep effect. Circ Res 85, 716-722 (1999) (Pubitemid 29480812)
3. N.G. Pérez, M.C. Camilión de Hurtado, H.E. Cingolani. Reverse mode of the Na+-Ca2+ exchange after myocardial stretch: underlying mechanism of the slow force response. Circ Res 88, 376-382 (2001) (Pubitemid 32200109)
4. H.E. Cingolani, G.E. Chiappe de Cingolani, I.L. Ennis, P. Morgan, B.V. Alvarez, J.R. Casey, R.A. Dulce, N.G. Pérez, M.C. Camilión de Hurtado. Influence of Na+-independent Cl-HCO3 - exchange on the slow force response to myocardial stretch. Circ Res 93, 1082-1088 (2003) (Pubitemid 37485039)
5. H.E. Cingolani, N.G. Pérez, E.A. Aiello, M.C. Camilión de Hurtado. Intracellular signaling following myocardial stretch: an autocrine/paracrine loop. Regul Pept 128, 211-220 (2005) (Pubitemid 40544836)
6. I.L. Ennis, C.D. Garciarena, N.G. Perez, R.A. Dulce, M.C. Camilión de Hurtado, H.E. Cingolani. Endothelin isoforms and the response to myocardial stretch. Am J Physiol Heart Circ Physiol 288, H2925-2930 (2005) (Pubitemid 40720676)
7. T. Yamazaki, I. Komuro, S. Kudoh, Y. Zou, I. Shiojima, Y. Hiroi, T. Mizuno, K. Maemura, H. Kurihara, R. Aikawa, H. Takano, Y. Yazaki. Endothelin-1 is involved in mechanical stress-induced cardiomyocyte hypertrophy. J Biol Chem 271, 3221-3228 (1996) (Pubitemid 26055625)
8. M. Schafer, C. Schafer, H. Michael Piper, K.D. Schluter. Hypertrophic responsiveness of cardiomyocytes to alpha- or beta-adrenoceptor stimulation requires sodium-protonexchanger- 1 (NHE-1) activation but not cellular alkalization. Eur J Heart Fail 4(3), 249-254 (2002) (Pubitemid 35190347)
9. A. Baartscheer, C.A. Schumacher, M.M. van Borren, C.N. Belterman, R. Coronel, T. Opthof, J.W. Fiolet. Chronic inhibition of Na+/H+-exchanger attenuates cardiac hypertrophy and prevents cellular remodeling in heart failure. Cardiovasc Res 65, 83-92 (2005) (Pubitemid 40038481)
10. T. Yamazaki, I. Komuro, S. Kudoh, Y. Zou, R. Nagai, R. Aikawa, H. Uozumi, Y. Yazaki. Role of ion channels and exchangers in mechanical stretch-induced cardiomyocyte hypertrophy. Circ Res 82, 430-437 (1998) (Pubitemid 28117324)
11. A.E. Schussheim, G.K. Radda. Altered Na+- H+- exchange activity in the spontaneously hypertensive perfused rat heart. J Mol Cell Cardiol 27, 1475-1481 (1995)
12. N.G. Pérez, B.V. Alvarez, M.C. Camilión de Hurtado, H.E. Cingolani. pHi regulation in myocardium of the spontaneously hypertensive rat. Compensated enhanced activity of the Na+-H+ exchanger. Circ Res 77, 1192-1200 (1995)
13. K. Kusumoto, J.V. Haist, M. Karmazyn. Na+/H+ exchange inhibition reduces hypertrophy and heart failure after myocardial infarction in rats. Am J Physiol Heart Circ Physiol 280, 738-745 (2001)
14. M.C. Camilión de Hurtado, E.L. Portiansky, N.G. Pérez, O.R. Rebolledo, H.E. Cingolani. Regression of cardiomyocyte hypertrophy in SHR following chronic inhibition of the Na+/H+ exchanger. Cardiovasc Res 53, 862-868 (2002) (Pubitemid 34261024)
15. S. Engelhardt, L. Hein, U. Keller, K. Klambt, M.J. Lohse. Inhibition of Na+/H+ exchange prevents hypertrophy, fibrosis, and heart failure in beta 1-adrenergic receptor transgenic mice. Circ Res 90, 814-819 (2002) (Pubitemid 34633898)
16. I.L. Ennis, E.M. Escudero, G.M. Console, G. Camihort, C.G. Dumm, R.W. Seidler, M.C. Camilión de Hurtado, H.E. Cingolani. Regression of isoproterenol-induced cardiac hypertrophy by Na+/H+ exchanger inhibition. Hypertension 41, 1324-1329 (2003) (Pubitemid 36706084)
17. M.I. Bak, J.S. Ingwall. Contribution of Na+/H+ exchange to Na+ overload in the ischemic hypertrophied hyperthyroid rat heart. Cardiovasc Res 57, 1004-1014 (2003) (Pubitemid 36324605)
18. B. Mrkic, C.M. Tse, J. Forgo, C. Helmle-Kolb, M. Donowitz, H. Murer. Identification of PTH-responsive Na/H-exchanger isoforms in a rabbit proximal tubule cell line (RKPC-2) Pflugers Arch 424, 377-384 (1993) (Pubitemid 23279897)
19. M. Karmazyn, Q. Liu, X.T. Gan, B.J. Brix, L. Fliegel. Aldosterone increases NHE-1 expression and induces NHE- 1-dependent hypertrophy in neonatal rat ventricular myocytes. Hypertension 42, 1171-1176 (2003) (Pubitemid 37549073)
20. G. Fujisawa, K. Okada, S. Muto, N. Fujita, N. Itabashi, E. Kusano, S. Ishibashi. Na/H exchange isoform 1 is involved in mineralocorticoid/salt-induced cardiac injury. Hypertension 41, 493-498 (2003) (Pubitemid 36314622)
21. A. Kilic, A. Velic, L.J. De Windt, L. Fabritz, M. Voss, D. Mitko, M. Zwiener, H.A. Baba, M. van Eickels, E. Schlatter, M. Kuhn. Enhanced activity of the myocardial Na+/H+ exchanger NHE-1 contributes to cardiac remodeling in atrial natriuretic peptide receptor-deficient mice. Circulation 112, 2307-2317 (2005) (Pubitemid 41464574)
22. A. Konstantinou-Tegou, M. Kaloyianni, D. Bourikas, G. Koliakos. The effect of leptin on Na+-H+ antiport (NHE 1) activity of obese and normal subjects erythrocytes. Mol Cell Endocrinol 183, 11-8 (2001) (Pubitemid 32938506)
23. V. Rajapurohitam, X.T. Gan, L.A. Kirshenbaum, M. Karmazyn. The obesity-associated peptide leptin induces hypertrophy in neonatal rat ventricular myocytes. Circ Res 93, 277-9 (2003) (Pubitemid 37048239)
24. V. Rajapurohitam, S. Javadov, D.M. Purdham, L.A. Kirshenbaum, M. Karmazyn. An autocrine role for leptin in mediating the cardiomyocyte hypertrophic effects of angiotensin II and endothelin-1. J Mol Cell Cardiol 41(2), 265-274 (2006) (Pubitemid 44080214)
25. F.P. Xu, M.S. Chen, Y.Z .Wang, Q. Yi, S.B. Lin, A.F. Chen, J.D. Luo. Leptin induces hypertrophy via endothelin- 1-reactive oxygen species pathway in cultured neonatal rat cardiomyocytes. Circulation 110, 1269-1275, (2004) (Pubitemid 39202344)
26. L. Chen, X.T. Gan, J.V. Haist, Q. Feng, X. Lu, S. Chakrabarti, M. Karmazyn. Attenuation of compensatory right ventricular hypertrophy and heart failure following monocrotaline-induced pulmonary vascular injury by the Na+-H+ exchange inhibitor cariporide. J Pharmacol Exp Ther 298, 469-476 (2001) (Pubitemid 32673396)
27. H. Yokoyama, S. Gunasegaram, S.E. Harding, M. Avkiran. Sarcolemmal Na+/H+ exchanger activity and expression in human ventricular myocardium. J Am Coll Cardiol 36: 534-540 (2000)
28. Y. Hayasaki-Kajiwara, Y. Kitano, T. Iwasaki, T. Shimamura, N. Naya, K. Iwaki, M. Nakajima. Na+influx via Na+/H+exchange activates protein kinase C isozymes delta and epsilon in cultured neonatal rat cardiac myocytes. J Mol Cell Cardiol 31, 1559-1572 (1999) (Pubitemid 29361122)
29. S. Javadov, C. Huang, L. Kirshenbaum, M. Karmazyn. NHE-1 inhibition improves impaired mitochondrial permeability transition and respiratory function during postinfarction remodelling in the rat. J Mol Cell Cardiol 38, 135-143 (2005) (Pubitemid 40038660)
30. G. Marano, A. Vergari, L. Catalano, S. Gaudi, S. Palazzesi, M. Musumeci, T. Stati, A.U. Ferrari. Na+/H+ exchange inhibition attenuates left ventricular remodeling and preserves systolic function in pressure-overloaded hearts. Br J Pharmacol 141, 526-532 (2004) (Pubitemid 38297015)
31. S. Takewaki, M. Kuro-o, Y. Hiroi, T. Yamazaki, T. Noguchi, A. Miyagishi, K. Nakahara, M. Aikawa, I. Manabe, Y. Yazaki. Activation of Na+-H+ antiporter (NHE- 1) gene expression during growth, hypertrophy and proliferation of the rabbit cardiovascular system. J Mol Cell Cardiol 27, 729-742 (1995)
32. L. Chen, C.X. Chen, X.T. Gan, N. Beier, W. Scholz, M. Karmazyn. Inhibition and reversal of myocardial infarctioninduced hypertrophy and heart failure by NHE-1 inhibition. Am J Physiol Heart Circ Physiol 286, H381-387 (2004) (Pubitemid 38049503)
33. H. Yoshida, M. Karmazyn. Na+/H+ exchange inhibition attenuates hypertrophy and heart failure in 1-wk postinfarction rat myocardium. Am J Physiol Heart Circ Physiol 278, H300-304 (2000) (Pubitemid 30101885)
34. F.N. Saleh, H. Schirmer, J. Sundsfjord, R. Jorde. Parathyroid hormone and left ventricular hypertrophy. Eur Heart J 24, 2054-2060 (2003) (Pubitemid 37420453)
35. M. Chahine, G. Bkaily, M. Nader, J. Al-Khoury, D. Jacques, N. Beier, W. Scholz. NHE-1-dependent intracellular sodium overload in hypertrophic hereditary cardiomyopathy: prevention by NHE-1 inhibitor. J Mol Cell Cardiol 38, 571-582 (2005) (Pubitemid 40461821)
36. M. Hori, N. Nakatsubo, T. Kagiya, K. Iwai, H. Sato, K. Iwakura, A. Kitabatake, T. Kamada. The role of Na+/H+ exchange in norepinephrine-induced protein ynthesis in cultured rat cardiomyocytes. Jpn Circ J 54, 535-539 (1990) (Pubitemid 20341258)
37. K.D. Schluter, M. Schafer, C. Balser, G. Taimor, H.M. Piper. Influence of pHi and creatine phosphate on alphaadrenoceptor- mediated cardiac hypertrophy. J Mol Cell Cardiol 30, 763-771 (1998) (Pubitemid 28190720)
38. S. Aker, A.K. Snabaitis, I. Konietzka, A. Van De Sand, K. Böngler, M. Avkiran, G. Heusch, R. Schulz. Inhibition of the Na+/H+ exchanger attenuates the deterioration of ventricular function during pacing-induced heart failure in rabbits. Cardiovasc Res 63, 273-282 (2004) (Pubitemid 38906660)
39. W.F. Bluhm, W.Y. Lew, A. Garfinkel, A.D. McCulloch. Mechanisms of length history-dependent tension in an ionic model of the cardiac myocyte. Am J Physiol Heart Circ Physiol 274, H1032-1040 (1998)
40. J. Sadoshima, Y. Xu, H.S. Slayter, S. Izumo. Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro. Cell 75, 977-984 (1993) (Pubitemid 24014554)
41. H. Ito, Y. Hirata, S. Adachi, M. Tanaka, M. Tsujino, A. Koike, A. Nogami, F. Murumo, M. Hiroe. Endothelin-1 is an autocrine/paracrine factor in the mechanism of angiotensin II-induced hypertrophy in cultured rat cardiomyocytes. J Clin Invest 92, 398-403 (1993) (Pubitemid 23209021)
42. N.G. Pérez, M.C. Villa-Abrille, E.A. Aiello, R.A. Dulce, H.E. Cingolani, M.C. Camilión de Hurtado MC. A low dose of angiotensin II increases inotropism through activation of reverse Na+/Ca2+ exchange by endothelin release. Cardiovasc Res 60, 589-597 (2003)
43. C. Luers, F. Fialka, A. Elgner, D. Zhu, J. Kockskamper, D. von Lewinski, B. Pieske. Stretch-dependent modulation of [Na+]i, [Ca2+]i, and pHi in rabbit myocardium-a mechanism for the slow force response. Cardiovasc Res 68, 454-463 (2005) (Pubitemid 41566565)
44. E.A. Aiello, M.C. Villa-Abrille, R.A. Dulce, H.E. Cingolani, N.G. Perez. Endothelin-1 stimulates the Na+/Ca2+ exchanger reverse mode through intracellular Na+ (Na+ i)- dependent and Na+ i-independent pathways. Hypertension 45, 288-293 (2005) (Pubitemid 40179974)
45. M.C. Camilión de Hurtado, B.V. Alvarez, I.L. Ennis, H.E. Cingolani. Stimulation of myocardial Na+-independent Cl-/HCO3 - exchanger by angiotensin II is mediated by endogenous endothelin. Circ Res 86, 622-627 (2000) (Pubitemid 30208428)
46. M.C. Camilión de Hurtado, B.V. Alvarez, N.G. Pérez, I.L. Ennis, H.E. Cingolani. Angiotensin II activates Na+- independent Cl-/HCO3 - exchange in ventricular myocardium. Circ Res 82, 473-481 (1998) (Pubitemid 28117329)
47. M.B. Ganz, G. Boyarsky, W.F. Boron, R.B. Sterzel. Effects of angiotensin II and vasopressin on intracellular pH of glomerular mesangial cells. Am J Physiol Renal Fluid Electrolyte Physiol 254, F787-794 (1998)
48. R.C. Thomas. Cell growth factors. Bicarbonate and pHi response. Nature 337, 601 (1989) (Pubitemid 19054289)
49. B.V. Alvarez, J. Fujinaga, J.R. Casey. Molecular basis for angiotensin II-induced increase of chloride/bicarbonate exchange in the myocardium. Circ Res 89, 1246-1253 (2001) (Pubitemid 34627885)
50. M.B. Ganz, M.C. Perfetto, W.F. Boron. Effects of mitogens and other agents on rat mesangial cell proliferation, pH, and Ca2+. Am J Physiol 259(2 Pt 2), F269- 278 (1990) (Pubitemid 20257487)
51. L.D. Shrode, H. Tapper, S. Grinstein. Role of intracellular pH in proliferation, transformation, and apoptosis. J Bioenerg Biomembr 29(4), 393-399 (1997) (Pubitemid 27498419)
52. L.L. Muldoon, G.A. Jamieson Jr., A.C. Kao, H.C. Palfrey, M.L. Villereal. Mitogen stimulation of Na+-H+ exchange: differential involvement of protein kinase C. Am J Physiol 253(2 Pt 1), C219-229 (1987)
53. S. Grinstein, D. Rotin, M.J. Mason. Na+/H+ exchange and growth factor-induced cytosolic pH changes. Role in cellular proliferation. Biochim Biophys Acta 988(1), 3-97 (1989)
54. G.A. Cox, C.M. Lutz, C.L. Yang, D. Biemesderfer, R.T. Bronson, A. Fu, P.S. Aronson, J.L. Noebels, W.N. Frankel. Sodium/hydrogen exchanger gene defect in slow-wave epilepsy mutant mice. Cell 91(1), 139-148 (1997) (Pubitemid 27431320)
55. S.M. Bell, C.M. Schreiner, P.J. Schultheis, M.L. Miller, R.L. Evans, C.V. Vorhees, G.E. Shull, W.J. Scott. Targeted disruption of the murine Nhe1 locus induces ataxia, growth retardation, and seizures. Am J Physiol 276(4 Pt 1), C788-795 (1999) (Pubitemid 29211306)
56. Y. Wang, J.W. Meyer, M. Ashraf, G.E. Shull. Mice with a null mutation in the NHE1 Na+-H+ exchanger are resistant to cardiac ischemia-reperfusion injury. Circ Res 93(8), 776-782 (2003) (Pubitemid 37288673)
57. S.J. Fuller, C.J. Gaitanaki, P.H. Sugdent. Effects of catecholamines on protein synthesis in cardiac myocytes and perfused hearts isolated from adult rats. Stimulation of translation is mediated through the α1-adrenoceptor. Biochem. J 266, 727-736 (1990) (Pubitemid 20103705)
58. D.M. Bers, W.H. Barry, S. Despa. Intracellular Na+ regulation in cardiac myocytes. Cardiovasc Res 57, 897-912 (2003) (Pubitemid 36324595)
59. H. Kusuoka, M.C. Camilión de Hurtado, E. Marban. Role of sodium/calcium exchange in the mechanism of myocardial stunning: protective effect of reperfusion with high sodium solution. J Am Coll Cardiol 21(1), 240-248 (1993) (Pubitemid 23031322)
60. D.M. Bers DM. In: Excitation-contraction coupling and cardiac contractile force, 2nd ed. Dordrecht: Kluwer (2001)
61. D.M. Bers, S. Despa. Cardiac myocytes Ca2+ and Na+ regulation in normal and failing hearts. J Pharmacol Sci 100(5), 315-322 (2006) (Pubitemid 44609526)
62. F. Kurogouchi, Y. Furukawa, D. Zhao, M. Hirose, K. Nakajima, M. Tsuboi, S. Chiba. A Na+/Ca2+ exchanger inhibitor, KB-R7943, caused negative inotropic responses and negative followed by positive chronotropic responses in isolated, blood-perfused dog heart preparations. Jpn J Pharmacol 82(2) ,155-163 (2000) (Pubitemid 30153598)
63. J.C. Kentish, A. Wrzosek. Changes in force and cytosolic Ca2+ concentration after length changes in isolated rat ventricular trabeculae. J Physiol 506, 431-444 (1998) (Pubitemid 28048371)
64. W.F. Bluhm, W.Y. Lew. Sarcoplasmic reticulum in cardiac length-dependent activation in rabbits. Am J Physiol 269, H965-H972 (1995)
65. K. Hongo, E. White, C.H. Orchard. Effect of stretch on contraction and the Ca2+ transient in ferret ventricular muscles during hypoxia and acidosis. Am J Physiol 269, C690-C697 (1995)
66. B.N. Eigel, H. Gursahani, R.W. Hadley. ROS are required for rapid reactivation of Na+/Ca2+ exchanger in hypoxic reoxygenated guinea pig ventricular myocytes. Am J Physiol Heart Circ Physiol 286, H955-963 (2004) (Pubitemid 38248609)
67. C. Zhou, C. Ziegler, L.A. Birder, A.F. Stewart, E.S. Levitan. Angiotensin II and stretch activate NADPH oxidase to destabilize cardiac Kv4.3 channel mRNA. Circ Res 98(8): 1040-1047 (2006)
68. S. Calaghan, E. White. Activation of Na+-H+ exchange and stretch-activated channels underlies the slow inotropic response to stretch in myocytes and muscle from the rat heart. J Physiol 559, 205-214 (2004) (Pubitemid 39206963)
69. D. von Lewinski, B. Stumme, F. Fialka, C. Luers, B. Pieske. Functional relevance of the stretch-dependent slow force response in failing human myocardium. Circ Res 94, 1392-1398 (2004) (Pubitemid 38724486)
70. A. Leri, P.P. Claudio, Q. Li, X. Wang, K. Reiss, S. Wang, A. Malhotra, J. Kajstura, P. Anversa. Stretchmediated release of angiotensin II induces myocyte apoptosis by activating p53 that enhances the local reninangiotensin system and decreases the Bcl-2-to-Bax protein ratio in the cell. J Clin Invest 101, 1326-1342 (1998) (Pubitemid 28166830)
71. S.C. Calaghan, E. White. Contribution of angiotensin II, endothelin 1 and the endothelium to the slow inotropic response to stretch in ferret papillary muscle. Pflügers Arch 441, 514-520 (2001) (Pubitemid 32128147)
72. D. von Lewinski, B. Stumme, L.S. Maier, C. Luers, D.M. Bers, B. Pieske B. Stretch-dependent slow force response in isolated rabbit myocardium is Na+ dependent. 1: Cardiovasc Res 57(4), 1052-1061 (2003) (Pubitemid 36324610)
73. G. Isenberg, D. Kondratev, V. Dyachenko, V. Kazanski, M.F. Gallitelli. In: Kamkin A & Kisileva I Ed, Mechanosensitivity in cells and tissues. Moscow, Academia Moscow, 126-164 (2005)
74. M.G. Petroff, S.H. Kim, S. Pepe, C. Dessy, E. Marbán, J.T. Balligand, S.J. Sollott. Endogenous nitric oxide mechanisms mediate the stretch dependence of Ca2+ release in cardiomyocytes. Nat Cell Biol 3(10), 867-873 (2001) (Pubitemid 32952250)
75. M. Endoh, S. Fujita, H.T. Yang, M.A. Talukder, J. Maruya, I. Norota. Endothelin: receptor subtypes, signal transduction, regulation of Ca2+ transients and contractility in rabbit ventricular myocardium. Life Sci 62(17-18), 1485-1489 (1998) (Pubitemid 28210228)
76. E.A. Aiello, M.C. Villa-Abrille, H.E. Cingolani. Autocrine stimulation of cardiac Na+-Ca2+ exchanger currents by endogenous endothelin released by angiotensin II. Circ Res 2002;90(4):374-376. (Pubitemid 34633904)
77. H.E. Cingolani, M.C. Villa-Abrille, M. Cornelli, A. Nolly, I,L. Ennis, C. Garciarena, A.M. Suburo, V. Torbidoni, M.V. Correa, M.C. Camilión de Hurtado, E.A. Aiello. The positive inotropic effect of angiotensin II: role of endothelin-1 and reactive oxygen species. Hypertension. 2006 Apr;47(4):727-34. (Pubitemid 43740245)
78. Y. Dohi, A.W. Hahn, C.M. Boulanger, F.R. Bühler, T.F. Lüscher. Endothelin stimulated by angiotensin II augments contractility of spontaneously hypertensive rat resistance arteries. Hypertension 19, 131-137 (1992)
79. T. Imai, Y. Hirata, T. Emori, M. Yanagisawa, T. Masaki, F. Marumo. Induction of endothelin-1 gene by angiotensin and vasopressin in endothelial cells. Hypertension 19, 753-757 (1992)
80. B.H. Chua, C.C. Chua, C.A. Diglio, B.B. Siu. Regulation of endothelin-1 mRNA by angiotensin II in rat heart endothelial cells. Biochim Biophys Acta 1178, 201-206 (1993) (Pubitemid 23247999)
81. H. Fujisaki, H. Ito, Y. Hirata, M. Tanaka, M. Hata, M. Lin, S. Adachi, H. Akimoto, F. Marumo, M. Hiroe. Natriuretic peptides inhibit angiotensin II-induced proliferation of rat cardiac fibroblasts by blocking endothelin-1 gene expression. J Clin Invest 96, 1059-1065 (1995)
82. M. Barton, S. Shaw, L.V. d'Uscio, P. Moreau, T.F. Lüscher. Angiotensin II increases vascular and renal endothelin-1 and functional endothelin converting enzyme activity in vivo: role of ETA receptors for endothelin regulation. Biochem Biophys Res Commun 238, 861-865 (1997) (Pubitemid 27472667)
83. S. Rajagopalan, J.B. Laursen, A. Borthayre, S. Kurz, J. Keiser, S. Haleen, A. Giaid, D.G. Harrison. Hypertension 30, 29-34 (1997)
84. G.G. Serneri, P.A. Modesti, M. Boddi, I. Cecioni, R. Paniccia, M. Coppo, G. Galanti, I. Simonetti, S. Vanni, L. Papa, B. Bandinelli, A. Migliorini, A. Modesti, M. Maccherini, G. Sani, M. Toscano. Cardiac growth factors in human hypertrophy. Relations with myocardial contractility and wall stress. Circ Res 85(1), 57-67 1999) (Pubitemid 29321042)
85. D.N. Muller, E.M. Mervaala, F. Schmidt, J.K. Park, R. Dechend, E. Genersch, V. Breu, B.M. Löffler, D. Ganten, W. Schneider, H. Haller, F.C. Luft. Effect of bosentan on NF-kappaB, inflammation, and tissue factor in angiotensin II-induced end-organ damage. Hypertension 36, 282-290 (2000) (Pubitemid 30627001)
86. S. Ficai, A. Herizi, A. Mimran, B. Jover. Endothelin blockade in angiotensin II hypertension: prevention and treatment studies in the rat. Clin Exp Pharmacol Physiol 28, 1100-1103 (2001) (Pubitemid 34053533)
87. M.C. Ortiz, E. Sanabria, M.C. Manriquez, J.C. Romero, L.A. Juncos. Role of endothelin and isoprostanes in slow pressor responses to angiotensin II. Hypertension 37, 505-510 (2001) (Pubitemid 32199019)
88. D.N. Muller, A. Mullally, R. Dechend, J.K. Park, A. Fiebeler, B. Pilz, B.M. Löffler, D. Blum-Kaelin, S. Masur, H. Dehmlow, J.D. Aebi, H. Haller, F.C. Luft. Endothelinconverting enzyme inhibition ameliorates angiotensin IIinduced cardiac damage. Hypertension 40, 840-846 (2002) (Pubitemid 35434904)
89. T.M. Seccia, A.S. Belloni, R. Kreutz, M. Paul, G.G. Nussdorfer, A.C. Pessina, G.P. Rossi. Cardiac fibrosis occurs early and involves endothelin and AT-1 receptors in hypertension due to endogenous angiotensin II. J Am Coll Cardiol 41, 666-673 (2003) (Pubitemid 36223335)
90. M. Tamamori, H. Ito, S. Adachi, H. Akimoto, F. Marumo, M. Hiroe. Endothelin-3 induces hypertrophy of cardiomyocytes by the endogenous endothelin-1-mediated mechanism. J Clin Invest 97, 366-372 (1996) (Pubitemid 26039399)
91. D.G. Allen, S. Kurihara. The effects of muscle length on intracellular calcium transients in mammalian cardiac muscle. J Physiol (Lond) 327, 79-94 (1982) (Pubitemid 12086440)
92. G. Von Anrep: On the part played by the suprarenals in the normal vascular reactions on the body. J Physiol (Lond) 45, 307-317 (1912)
93. A. Rosenblueth, J. Alanais, E. Lopez, R. Rubio. The adaptation of ventricular muscle to different circulatory conditions. Arch Int Physiol Biochem 67, 358-373 (1959)
94. S.J. Sarnoff, J.H. Mitchell, J.P. Gilmore, J.P. Remensnyder. Homeometric autoregulation in the heart. Circ Res 8, 1077-1091 (1960)
95. R.G. Monroe, W.J. Gamble, C.G. LaFarge, A.E. Kumar, J. Stark, G.L. Sanders, C. Phornphutkul, M. Davis. The Anrep effect reconsidered. J Clin Invest 51, 2573-2583 (1972)
96. W.W. Parmley, L. Chuck. Length-dependent changes in myocardial contractile state. Am J Physiol 224, 1195-1199 (1972)
97. Caldiz CI, Garciarena CD, Dulce RA, Novaretto LP, Yeves AM, Ennis IL, Cingolani HE, Chiappe de Cingolani G, Pérez NG. Mitochondrial reactive oxygen species activate the slow force response to stretch in feline myocardium. J Physiol 584.3, 895-905 (2007) (Pubitemid 350031930)
98. Lavigne MC, Malech HL, Holland SM, Leto TL. Genetic demonstration of p47phox-dependent superoxide anion production in murine vascular smooth muscle cells. Circulation 104, 79-84 (2001) (Pubitemid 32623293)
99. Giordano FJ. Oxygen, oxidative stress, hypoxia, and heart failure. J Clin Invest 115, 500-508 (2005) (Pubitemid 40322219)
100. Kimura S, Zhang GX, Nishiyama A, Shokoji T, Yao L, Fan YY, Rahman M, Suzuki T, Maeta H, Abe Y. Role of NAD(P)H oxidase- and mitochondria-derived reactive oxygen species in cardioprotection of ischemic reperfusion injury by angiotensin II. Hypertension 45, 860-866 (2005) (Pubitemid 40628929)
101. D.B. Zorov, C.R. Filburn, L.O. Klotz, J.L. Zweier, S.J. Sollott. Reactive oxygen species (ROS)-induced ROS release: a new phenomenon accompanying induction of the mitochondrial permeability transition in cardiac myocytes. J Exp Med 192, 1001-1014 (2000)
102. S. Kimura, G.X. Zhang, A. Nishiyama, T. Shokoji, L. Yao, Y.Y. Fan, M. Rahman, Y. Abe. Mitochondrial-derived reactive oxygen species and vascular MAP kinases. Hypertension 45, 438-444 (2005)
103. X. Wu, T. Zhang, J. Bossuyt, X. Li, T.A. McKinsey, J.R. Dedman, E.N. Olson, J. Chen, J.H. Brown, D.M. Bers. Local InsP3-dependent perinuclear Ca2+ signaling in cardiac myocyte excitation-transcription coupling. J Clin Invest 116(3), 675-682 (2006) (Pubitemid 43326876)
104. D. Rosskopf, R. Dusing, W. Siffert. Membrane sodium-proton exchange and primary hypertension. Hypertension 21, 607-617 (1993) (Pubitemid 23120214)
105. A. Garciandia, R. Lopez, J. Tisaire, A. Arrázola, A. Fortuno, J. Bueno, J. Diez. Enhanced Na+-H+ exchanger activity and NHE-1 mRNA expression in lymphocytes from patients with essential hypertension. Hypertension 25, 356-364 (1995)
106. A. Livne, J.W. Balfe, R. Veitch, A. Marquez-Julio, S. Grinstein, A. Rothstein. Increased platelet Na+/H+ exchange rate in essential hypertension: application of a novel test. Lancet 1, 533-536 (1987) (Pubitemid 17020738)
107. I.L. Ennis, B.V. Alvarez, M.C. Camilión de Hurtado, H.E. Cingolani. Enalapril induces regression of cardiac hypertrophy and normalization of pHi regulatory mechanisms. Hypertension 31, 961-967 (1998) (Pubitemid 28185574)
108. H.E. Cingolani, O.R. Rebolledo, E.L. Portiansky, N.G. Pérez, M.C. Camilión de Hurtado. Regression of hypertensive myocardial fibrosis by Na+/H+ exchange inhibition. Hypertension 41, 373-377 (2003) (Pubitemid 36204917)
109. K.T. Weber, C.G. Brilla. Pathological hypertrophy and cardiac interstitium: fibrosis and renin-angiotensinaldosterone system. Circulation 83, 1849-1865 (1991)
110. L. Fliegel, M. Karmazyn. The cardiac Na-H exchanger: a key downstream mediator for the cellular hypertrophic effects of paracrine, autocrine and hormonal factors. Biochem Cell Biol 82, 626-635 (2004) (Pubitemid 40486141)
111. J.D. Molkentin, J.R. Lu, C.L. Antos, B. Markham, J. Richardson, J. Robbins, S.R. Grant, E.N. Olson. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell 93, 215-228 (1998) (Pubitemid 28180855)
112. T. Taigen, L.J. De Windt, H.W. Lim, J.D. Molkentin. Targeted inhibition of calcineurin prevents agonist-induced cardiomyocyte hypertrophy. Proc Natl Acad Sci USA 97, 1196-1201 (2000) (Pubitemid 30080835)
113. S. Haq, G. Choukroun, H. Lim, K.M. Tymitz, F. del Monte, J. Gwathmey, L. Grazette, A. Michael, R. Hajjar, T. Force, J.D. Molkentin. Differential activation of signal transduction pathways in human hearts with hypertrophy versus advanced heart failure. Circulation 103, 670-677 (2001) (Pubitemid 32144195)
114. O.F. Bueno, B.J. Wilkins, K.M. Tymitz, B.J. Glascock, T.F. Kimball, J.N. Lorenz, J.D. Molkentin. Impaired cardiac hypertrophic response in calcineurin Aβ- deficient mice. Proc Natl Acad Sci USA 99, 4586-4591 (2002) (Pubitemid 34286028)
115. K. Nagata, F. Somura, K. Obata, M. Odashima, H. Izawa, S. Ichihara, T. Nagasaka, M. Iwase, Y. Yamada, N. Nakashima, M. Yokota. AT1 receptor blockade reduces cardiac calcineurin activity in hypertensive rats. Hypertension 40, 168-174 (2002) (Pubitemid 34840093)
116. B.J. Wilkins, Y.S. Dai, O.F. Bueno, S.A. Parsons, J. Xu, D.M. Plank, F. Jones, T.R. Kimball, J.D. Molkentin. Calcineurin/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy. Circ Res 94, 110-118 (2004) (Pubitemid 38064105)
117. Y. Zou, T. Yamazaki, K. Nakagawa, H. Yamada, N. Iriguchi, H. Toko, H. Takano, H. Akazawa, R. Nagai, I. Komuro. Continuous blockade of L-type Ca2+ channels suppresses activation of calcineurin and development of cardiac hypertrophy in spontaneously hypertensive rats. Hypertens Res 25, 117-124 (2002) (Pubitemid 34196304)
118. I.L. Ennis, C.D. Garciarena, E.M. Escudero, N.G. Pérez, R.A. Dulce, M.C. Camilión de Hurtado, H.E. Cingolani. Normalization of the calcineurin pathway underlies the regression of hypertensive hypertrophy induced by NHE-1 inhibition. Can J Physiol Pharmacol 85(3-4), 301-310 (2007) (Pubitemid 47262234)
119. T. Miura, Y. Liu, M. Goto, A. Tsuchida, T. Miki, A. Nakano, Y. Nishino, Y. Ohnuma, K. Shimamoto. Mitochondrial ATP-sensitive K+ channels play a role in cardioprotection by Na+-H+ exchange inhibition against ischemia/reperfusion injury. J Am Coll Cardiol 37, 957-963 (2001) (Pubitemid 32202469)
120. M. Ruiz-Meana, D. Garcia-Dorado, P. Pina, J. Inserte, L. Agulló, J. Soler-Soler. Cariporide preserves mitochondrial proton gradient and delays ATP depletion in cardiomyocytes during ischemic conditions. Am J Physiol Heart Circ Physiol 285, H999-1006 (2003)
121. Y. Teshima, M. Akao, S.P. Jones, E. Marbán. Cariporide (HOE 642), a selective Na+-H+ exchange inhibitor, inhibits the mitochondrial death pathway. Circulation 108, 2275-2281 (2003) (Pubitemid 37363047)
122. B.V. Alvarez, I.L. Ennis, M.C. Camilión de Hurtado, H.E. Cingolani. Effects of antihypertensive therapy on cardiac sodium/hydrogen ion exchanger activity and hypertrophy in spontaneously hypertensive rats. Can J Cardiol 18(6), 667-672 (2002)
123. X. Li, A.J. Misik, C.V. Rieder, R.J. Solaro, A. Lowen, L. Fliegel. Thyroid hormone receptor alpha 1 regulates expression of the Na+/H+ exchanger (NHE1) J Biol Chem 277, 28656-28662 (2002)
124. J.D. Harnett, P.S. Parfrey, S.M. Griffiths, M.H. Gault, P. Barre, R.D. Guttmann. Left ventricular hypertrophy in end-stage renal disease. Nephron 48, 107-115 (1988)
125. A. Piovesan, N. Molineri, F. Casasso, I. Emmolo, G. Ugliengo, F. Cesario, G. Borretta. Left ventricular hypertrophy in primary hyperparathyroidism. Effects of successful parathyroidectomy. Clin Endocrinol (Oxf) 50, 321-328 (1999) (Pubitemid 29166711)
126. F.R. Bauwens, D.A. Duprez, M.L. De Buyzere, T.L. De Backer, J.M. Kaufman, J. Van Hoecke, A. Vermeulen, D.L. Clement. Influence of the arterial blood pressure and nonhemodynamic factors on left ventricular hypertrophy in moderate essential hypertension. Am J Cardiol 68(9), 925-929 (1991)
127. K.D. Schlüter, H.M. Piper. Trophic effects of catecholamines and parathyroid hormone on adult ventricular cardiomyocytes. Am J Physiol 263(6 Pt 2), H1739-H1746 (1992) (Pubitemid 23030726)
128. A. Azarani, J. Orlowski, D. Goltzman. Parathyroid hormone and parathyroid hormone-related peptide activate the Na+/H+ exchanger NHE-1 isoform in osteoblastic cells (UMR-106) via a cAMP-dependent pathway. J Biol Chem 270, 23166-23172 (1995)
129. Arakelyan KP, Sahakyan YA, Hayrapetyan LR, Khudaverdyan DN, Ingelman-Sundberg M, Mkrtchian S, Ter-Markosyan AS. Calcium-regulating peptide hormones and blood electrolytic balance in chronic heart failure. Regul Pept 142(3), 95-100 (2007) (Pubitemid 46899239)
130. M. Tajima, J. Bartunek, E.O. Weinberg, N. Ito, B.H. Lorell. Atrial natriuretic peptide has different effects on contractility and intracellular pH in normal and hypertrophied myocytes from pressure-overloaded hearts. Circulation 98, 2760-2764 (1998) (Pubitemid 28564013)
131. M.C. Camilión de Hurtado, I.L. Ennis, N.G. Perez, G.E. Chiappe de Cingolani, P. Morgan, H.E. Cingolani. Upregulation of myocardial Na+/H+ exchanger induced by chronic treatment with a selective inhibitor. J Mol Cell Cardiol 34, 1539-1547 (2002) (Pubitemid 35373676)
132. Cingolani OH. Cardiac hypertrophy and the Wnt/Frizzled pathway. Hypertension 49, 427-428 (2007)
133. van de Schans VAM, van den Borne SWM, Strzelecka AE, Janssen BJA, van der Velden JLJ, Langen RCJ, Wynshaw-Boris A, Smits JFM, Blankesteijn WM. Interruption of Wnt signaling attenuates the onset of pressure overload-induced cardiac hypertrophy. Hypertension 49, 473-480 (2007)
134. N.G. Pérez, M.R. Piaggio, I.L. Ennis, C.D Garciarena, C. Morales, E.M. Escudero, O.H. Cingolani, G. Chiappe de Cingolani, X-P. Yang, H.E. Cingolani. Phosphodiesterase 5A inhibition induces Na+/H+ exchanger blockade and