Mice With a Null Mutation in the NHE1 Na+-H+ Exchanger Are Resistant to Cardiac Ischemia-Reperfusion Injury

Circulation Research

Volumn 93, Issue 8, 2003, Pages 776-782

  Wang, Yigang ^a   Meyer, Jamie W ^a   Ashraf, Muhammad ^a,b   Shull, Gary E ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF CINCINNATI MEDICAL CENTER   (United States)

Author keywords

Cariporide; Ischemia; Na+ H+ exchange; Reperfusion; S1c9a1

Indexed keywords

ADENOSINE TRIPHOSPHATE; CARIPORIDE; ENIPORIDE; LACTATE DEHYDROGENASE; SODIUM PROTON EXCHANGE PROTEIN; SODIUM PROTON EXCHANGE PROTEIN 1; UNCLASSIFIED DRUG; GROWTH FACTOR ACTIVATABLE NA H EXCHANGER NHE 1; GROWTH FACTOR-ACTIVATABLE NA-H EXCHANGER NHE-1; GUANIDINE DERIVATIVE; SULFONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; DRUG EFFECT; DRUG MECHANISM; FEMALE; GENE MUTATION; GENE TARGETING; GENOTYPE; HEART INJURY; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HEART VENTRICLE ENDDIASTOLIC PRESSURE; HEMODYNAMICS; HISTOPATHOLOGY; ISOLATED HEART; MALE; MOUSE; NONHUMAN; NULL ALLELE; PRIORITY JOURNAL; PROTEIN FUNCTION; REPERFUSION INJURY; WILD TYPE; ANIMAL; DRUG ANTAGONISM; GENETICS; HEART; HEART MUSCLE; METABOLISM; MOUSE MUTANT; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

ADENOSINE TRIPHOSPHATE; ANIMALS; FEMALE; GUANIDINES; HEART; L-LACTATE DEHYDROGENASE; MALE; MICE; MICE, KNOCKOUT; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; SODIUM-HYDROGEN ANTIPORTER; SULFONES;

EID: 0142088528     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000094746.24774.DC     Document Type: Article

References (49)

1. + exchange. Am J Physiol. 1988;255:H608-H615.
2. + exchangers. J Biol Chem. 2000;275:1-4.
3. + exchange structure, regulation, and its role in heart disease. Circ Res. 1999;85:777-786.
4. Orlowski J, Kandasamy RA, Shull GE. Molecular cloning of putative members of the Na/H exchanger gene family: cDNA cloning, deduced amino acid sequence, and mRNA tissue expression of the rat Na/H exchanger NHE-1 and two structurally related proteins. J Biol Chem. 1992;267:9331-9339.
5. Wang Z, Orlowski J, Shull GE. Primary structure and functional expression of a novel gastrointestinal isoform of the rat Na/H exchanger. J Biol Chem. 1993;268:11925-11928.
6. + exchanger isoform 5 (NHE5) from human brain. J Biol Chem. 1999;274:4377-4382.
7. + exchanger (NHE5) highly expressed in brain. J Biol Chem. 1999;274:4383-4388.
8. + exchange inhibitors against cardiac injury produced by ischemia/reperfusion, hypoxia/reoxygenation, and the calcium paradox. J Cardiovasc Pharmacol. 1993;21:172-178.
9. Moffat MP, Karmazyn M. Protective effects of the potent Na/H exchange inhibitor methylisobutyl amiloride against post-ischemic contractile dysfunction in rat and guinea-pig hearts. J Mol Cell Cardiol. 1993;25:959-971.
10. + exchange inhibitor, on ischemia-reperfusion-injured hearts. J Cardiovasc Pharmacol. 2001;37:143-154.
11. + exchange inhibitor and its effects in cardiac ischaemia. Br J Pharmacol. 1993;109:562-568.
12. 2+ overload in isolated perfused rabbit heart. Circulation. 1994;89:2787-2798.
13. Scholz W, Albus U, Counillon L, Gogelein H, Lang HJ, Linz W, Weichert A, Scholkens BA. Protective effects of HOE642, a selective sodium-hydrogen exchange subtype 1 inhibitor, on cardiac ischaemia and reperfusion. Cardiovasc Res. 1995;29:260-268.
14. +-overload in ischemia and is cardioprotective. J Mol Cell Cardiol. 1999;31:1985-1995.
15. 2+ overload and prolonged acidosis on reperfusion. Circulation. 2000;101:2749-2755.
16. Gumina RJ, Mizumura T, Beier N, Schelling P, Schultz JJ, Gross GJ. A new sodium/hydrogen exchange inhibitor, EMD 85131, limits infarct size in dogs when administered before or after coronary artery occlusion. J Pharmacol Exp Ther. 1998;286:175-183.
17. + exchanger confers greater cardioprotection against 90 minutes of myocardial ischemia than ischemic preconditioning in dogs. Circulation. 1999;100:2519-2526.
18. Knight DR, Smith AH, Flynn DM, MacAndrew JT, Ellery SS, Kong JX, Marala RB, Wester RT, Guzman-Perez A, Hill RJ, Magee WP, Tracey WR. A novel sodium-hydrogen exchanger isoform-1 inhibitor, zoniporide, reduces ischemic myocardial injury in vitro and in vivo. J Pharmacol Exp Ther. 2001;297:254-259.
19. Lazdunski M, Frelin C, Vigne P. The sodium/hydrogen exchange system in cardiac cells: its biochemical and pharmacological properties and its role in regulating internal concentrations of sodium and internal pH. J Mol Cell Cardiol. 1985;17:1029-1042.
20. 2+ exchange. Circ Res. 1989;65:1045-1056.
21. Murphy E, Perlman M, London RE, Steenbergen C. Amiloride delays the ischemia induced rise in cytosolic free calcium. Circ Res. 1991;68:1250-1258.
22. i load after ischemia and improves function in intact hearts. Am J Physiol. 2001;281: H2398-H2409.
23. + exchange preserves viability, restores mechanical function, and prevents the pH paradox in reperfusion injury to rat neonatal myocytes. Basic Res Cardiol. 1993;88:430-442.
24. + exchange. Am J Physiol. 1995;268:H1531-H1539.
25. +-exchanger in ischemia-reperfusion. Basic Res Cardiol. 1996;91:191-202.
26. Gold MR, Strichartz GR. Use-dependent block of atrial sodium current by ethylisopropylamiloride. J Cardiovasc Pharmacol. 1991;17:792-799.
27. 2+ exchange in membrane vesicle and papillary muscle preparations from guinea pig heart by analogs of amiloride. Proc Natl Acad Sci USA. 1984;81:3238-3242.
28. Pushkin A, Abuladze N, Lee I, Newman D, Hwang J, Kurtz I. Cloning, tissue distribution, genomic organization, and functional characterization of NBC3, a new member of the sodium bicarbonate cotransporter family. J Biol Chem. 1999;274:16569-16575.
29. - salvage mechanisms in the submandibular gland acinar and duct cells. J Biol Chem. 2001;276:9808-9816.
30. Choi I, Aalkjaer C, Boulpaep EL, Boron WF. An electroneutral sodium/ bicarbonate cotransporter NBCn1 and associated sodium channel. Nature. 2000;405:571-575.
31. - cotransporter from rat kidney. Am J Physiol. 1998;274:F425-F432.
32. Pushkin A, Abuladze N, Newman D, Lee I, Xu G, Kurtz I. Two C-terminal variants of NBC4, a new member of the sodium bicarbonate cotransporter family: cloning, characterization, and localization. IUBMB Life. 2000;50:13-19.
33. - cotransporter isoform NBC-3 (kNBC-3): cloning, expression, and renal distribution. Kidney Int. 2001;59:1405-1414.
34. - cotransport in determining myocardial pHi after an increase in heart rate. Circ Res. 1996;79:698-704.
35. Kusuoka H, Matsuda S, Ishikawa M, Koga K, Mori T, Yamaguchi H, Nishimura T. Difference in the mechanisms for compensating ischemic acidosis in diabetic rat hearts. J Mol Cell Cardiol. 1998;30:1643-1649.
36. Meiltz A, Kucera P, de Ribaupierre Y, Raddatz E. Inhibition of bicarbonate transport protects embryonic heart against reoxygenation-induced dysfunction. J Mol Cell Cardiol. 1998;30:327-335.
37. Schafer C, Ladilov YV, Siegmund B, Piper HM. Importance of bicarbonate transport for protection of cardiomyocytes against reoxygenation injury. Am J Physiol. 2000;278:H1457-H1463.
38. Khandoudi N, Albadine J, Robert P, Krief S, Berrebi-Bertrand I, Martin X, Bevensee MO, Boron WF, Bril A. Inhibition of the cardiac electrogenic sodium bicarbonate cotransporter reduces ischemic injury. Cardiovasc Res. 2001;52:387-396.
39. Theroux P, Chaitman BR, Danchin N, Erhardt L, Meinertz T, Schroeder JS, Tognoni G, White HD, Willerson JT, Jessel A. Inhibition of the sodium-hydrogen exchanger with cariporide to prevent myocardial infarction in high-risk ischemic situations: main results of the GUARDIAN trial. Guard During Ischemia Against Necrosis (GUARDIAN) Investigators. Circulation. 2000;102:3032-3038.
40. Bell SM, Schreiner CM, Schultheis PJ, Miller ML, Evans RL, Vorhees CV, Shull GE, Scott WJ. Targeted disruption of the murine Nhe1 locus induces ataxia, growth retardation, and seizures. Am J Physiol. 1999;276: C788-C795.
41. ATP channel as an end effector of cardioprotection during late preconditioning: triggering role of nitric oxide. J Mol Cell Cardiol. 2001;33: 2037-2046.
42. + exchanger isoform NHE1 by a novel aminoguanidine derivative T-162559. Eur J Pharmacol. 2001;420:1-8.
43. + channel for cardiac protection against ischemic injury is dependent on protein kinase C activity. Circ Res. 1999;85:731-741.
44. Cox GA, Lutz CM, Yang CL, Biemesderfer D, Bronson RT, Fu A, Aronson PS, Noebels JL, Frankel WN. Sodium/hydrogen exchanger gene defect in slow-wave epilepsy mutant mice. Cell. 1997;91:139-148.
45. Ganote CE, Humphrey SM, Effects of anoxic or oxygenated reperfusion in globally ischemic, isovolumic, perfused rat hearts. Am J Pathol. 1985;120:129-145.
46. Fabiato A, Fabiato F. Effects of pH on the myofilaments and the sarcoplasmic reticulum of skinned cells from cardiac skeletal muscles. J Physiol. 1978;276:233-255.
47. 1-adrenergic receptor transgenic mice. Circ Res. 2002;90:814-819.
48. + exchange inhibition attenuates hypertrophy and heart failure in 1-wk postinfarction rat myocardium. Am J Physiol. 2000;278:H300-H304.
49. + exchanger induced by chronic treatment with a selective inhibitor. J Mol Cell Cardiol. 2002;34:1539-1547.