Inhibition and reversal of myocardial infarction-induced hypertrophy and heart failure by NHE-1 inhibition

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 286, Issue 1 55-1, 2004, Pages

  Chen, Ling ^a   Chen, Chang Xun ^a   Gan, Xiaohong Tracey ^a   Beier, Norbert ^b   Scholz, Wolfgang ^b   Karmazyn, Morris ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b MERCK KGAA   (Germany)

Author keywords

Atrial natriuretic peptide; Coronary artery ligation; EMD 87580; Na H exchange

Indexed keywords

ATRIAL NATRIURETIC FACTOR; EMD 87580; PROTEIN INHIBITOR; SODIUM PROTON EXCHANGE PROTEIN 1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; CELL SIZE; CONTROLLED STUDY; CORONARY ARTERY LIGATION; DRUG BLOOD LEVEL; GENE EXPRESSION; HEART AFTERLOAD; HEART FAILURE; HEART INFARCTION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART LEFT VENTRICLE HYPERTROPHY; HEART VENTRICLE REMODELING; HEART WEIGHT; IC 50; MALE; MORTALITY; NONHUMAN; PRIORITY JOURNAL; RAT; SYSTOLE;

EID: 0347628954     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.00602.2003     Document Type: Article

References (31)

1. + exchange inhibitors for cardioprotective therapy: progress, problems and prospects. J Am Coll Cardiol 39: 747-753, 2002.
2. + exchanger induced by chronic treatment with a selective inhibitor. J Mol Cell Cardiol 34: 1539-1547, 2002.
3. + exchange inhibitor cariporide. J Pharmacol Exp Ther 298: 469-476, 2001.
4. Cingolani HE, Alvarez BV, Ennis IL, and Camilion de Hurtado MC. Stretch-induced alkalinization of feline papillary muscle: an autocrine-paracrine system. Circ Res 83: 775-780, 1998.
5. + antiporter isoforms using amiloride analogs and a new inhibitor exhibiting anti-ischemic properties. Mol Pharmacol 44: 1041-1045, 1993.
6. + exchanger and cardiac hypertrophy. Circ Res 83: 870-873, 1998.
7. + exchange prevents hypertrophy, fibrosis, and heart failure in β1-adrenergic receptor transgenic mice. Circ Res 90: 814-819, 2002.
8. + exchanger inhibition. Hypertension 41: 1324-1329, 2003.
9. + antiporter gene transfected into antiporter-deficient mouse L cells. Proc Natl Acad Sci USA 83: 9388-9392, 1986.
10. + exchanger confers greater cardioprotection against 90 min of myocardial ischemia than ischemic preconditioning in dogs. Circulation 100: 2519-2526; 2469-2572, 1999.
11. Gumina RJ and Gross GJ. If ischemic preconditioning is the gold standard, has a platinum standard of cardioprotection arrived? Comparison with NHE inhibition. J Thromb Thrombolysis 8: 39-44, 1999.
12. + exchange activates protein kinase C isozymes δ and ε in cultured neonatal rat cardiac myocytes. J Mol Cell Cardiol 31: 1559-1572, 1999.
13. + exchange in norepinephrine-induced protein synthesis in neonatal cultured rat cardiomyocytes. Jpn Circ J 54: 535-539, 1990.
14. Karmazyn M. Role of sodium-hydrogen exchange in cardiac hypertrophy and heart failure: a novel and promising therapeutic target. Basic Res Cardiol 96: 325-328, 2001.
15. + exchange: structure, regulation, and its role in heart disease. Circ Res 85: 777-786, 1999.
16. + exchanger: a potential therapeutic target for the prevention of myocardial ischaemic and reperfusion injury and attenuation of postinfarction heart failure. Drugs 61: 375-389, 2001.
17. + exchange in mediating effects of endothelin-1 on normal and ischemic/reperfused hearts. Circ Res 75: 369-378, 1994.
18. + exchange inhibition reduces hypertrophy and heart failure after myocardial infarction in rats. Am J Physiol Heart Circ Physiol 280: H738-H745, 2001.
19. Loennechen JP, Wisloff U, Falck G, and Ellingsen O. Effects of cariporide and losartan on hypertrophy, calcium transients, contractility, and gene expression in congestive heart failure, Circulation 105: 1380-1386, 2002.
20. Matsui H, Barry WH, Livsey C, and Spitzer KW. Angiotensin II stimulates sodium-hydrogen exchange in adult rabbit ventricular myocytes. Cardiovasc Res 29: 215-221, 1995.
21. Mulder P, Devaux B, Richard V, Henry JP, Wimart MC, Thibout E, Mace B, and Thuillez C. Early versus delayed angiotensin-converting enzyme inhibition in experimental chronic heart failure. Effects on Survival, hemodynamics, and cardiovascular remodeling. Circulation 95: 1314-1319, 1997.
22. Orlowski J, Kandasamy RA, and Shull GE. Molecular cloning of putative members of the Na/H exchanger gene family. cDNA cloning, deduced amino acid sequence, and mRNA tissue expression of the rat Na/H exchanger NHE-1 and two structurally related proteins. J Biol Chem 267: 9331-9339, 1992.
23. + exchange inhibitor cariporide in patients with acute anterior myocardial infarction undergoing direct PTCA. Circulation 101: 2902-2908, 2000.
24. + antiporter. Cell 56: 271-280, 1989.
25. Schafer M, Schafer C, Michael Piper H, and Schluter KD. Hypertrophic responsiveness of α- or β-adrenoceptor stimulation requires sodium-proton-exchanger-1 (NHE-1) activation but not cellular alkalization. Eur J Heart Fail 4: 249-254, 2002.
26. Theroux P, Chaitman BR, Danchin N, Erhardt L, Meinertz T, Schroeder JS, Tognoni G, White HD, Willerson JT, and Jessel A. Inhibition of the sodium-hydrogen exchanger with cariporide to prevent myocardial infarction in high-risk ischemic situations. Main results of the GUARDIAN Trial Guard During Ischemia Against Necrosis (GUARDIAN) Investigators. Circulation 102: 3032-3038, 2000.
27. + exchanger isoform (NHE-2). J Biol Chem 268: 11917-11924, 1993.
28. 1-Adrenergic stimulation of Na-H exchange in cardiac myocytes. Am J Physiol Cell Physiol 263: C1096-C1102, 1992.
29. Yamazaki T, Komuro I, Kudoh S, Zou Y, Nagai R, Aikawa R, Uozumi H, and Yazaki Y. Role of ion channels and exchangers in mechanical stretch-induced cardiomyocyte hypertrophy. Circ Res 82: 430-437, 1998.
30. + exchange inhibition attenuates hypertrophy and heart failure in 1-wk postinfarction rat myocardium. Am J Physiol Heart Circ Physiol 278: H300-H304, 2000.
31. + exchange inhibitor eniporide as an adjunct to early reperfusion therapy for acute myocardial infarction. Results of the Evaluation of the Safety and Cardioprotective Effects of Emporide in Acute Myocardial Infarction (ESCAMI) Trial. J Am Coll Cardiol 38: 1644-1650, 2001.