Crystal structure of Escherichia coli MscS, a voltage-modulated and mechanosensitive channel

Science

Volumn 298, Issue 5598, 2002, Pages 1582-1587

  Bass, Randal B ^a   Strop, Pavel ^b   Barclay, Margaret ^b   Rees, Douglas C ^a,b  

^a California Institute of Technology   (United States)

^b CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; ELECTRIC CONDUCTANCE; ESCHERICHIA COLI;

MECHANOSENSITIVE CHANNELS;

CRYSTAL STRUCTURE;

ARGININE; ION CHANNEL;

COLIFORM BACTERIUM; CRYSTAL STRUCTURE;

ARTICLE; CELL MEMBRANE; CHANNEL GATING; CRYSTAL STRUCTURE; CYTOPLASM; ESCHERICHIA COLI; MECHANOSENSITIVE CHANNEL OF SMALL CONDUCTANCE; MEMBRANE DEPOLARIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING;

AMINO ACID SEQUENCE; ARGININE; CELL MEMBRANE; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; ELECTRIC CONDUCTIVITY; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; ION CHANNEL GATING; ION CHANNELS; MECHANOTRANSDUCTION, CELLULAR; MEMBRANE POTENTIALS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; SEQUENCE ALIGNMENT;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 2242431668     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1077945     Document Type: Article

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57. Supported by NIH (D.C.R.) and by a National Service Research Award postdoctoral fellowship (R.B.B.). Discussions with R. Spencer, K. Locher, A. Lee, O. Einsle, D. Dougherty, and H. Lester are greatly appreciated. We thank the staffs at the Advanced Light Source, Advanced Photon Source, National Synchrotron Light Source, and the Stanford Synchrotron Radiation Laboratory (SSRL) facilities for their invaluable assistance. These facilities are funded by the Office of Basic Energy Sciences, U.S. Department of Energy, and NIH. The coordinates have been deposited in the Protein Data Bank (1MXM) for release upon publication.