The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 9, 2003, Pages 5063-5068

  Engel, Michael ^a   Hoffmann, Torsten ^b   Wagner, Leona ^b   Wermann, Michael ^b   Heiser, Ulrich ^b   Kiefersauer, Reiner ^a,c   Huber, Robert ^a   Bode, Wolfram ^a   Demuth, Hans Ulrich ^b   Brandstetter, Hans ^a,c  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b PROBIODRUG AG   (Germany)

^c PROTEROS BIOSTRUCTURES GMBH   (Germany)

Author keywords

Diabetes mellitus; Drug design; Oxyanion hole; Serine protease; Substrate channeling

Indexed keywords

AMINOPEPTIDASE; ANION; DIPEPTIDE; DIPEPTIDYL PEPTIDASE IV; ENZYME INHIBITOR; GLUTAMIC ACID; OXYGEN; SERINE PROTEINASE; TETRAMER;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CRYSTAL STRUCTURE; DIABETES MELLITUS; DRUG DESIGN; ENZYME ACTIVE SITE; ENZYME INHIBITOR COMPLEX; ENZYME MECHANISM; ENZYME REGULATION; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; MOLECULAR RECOGNITION; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DOMAIN; SEQUENCE ALIGNMENT;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD26; BINDING SITES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; DNA, COMPLEMENTARY; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEASE INHIBITORS; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID; SWINE;

SUIDAE;

EID: 0037966007     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0230620100     Document Type: Article

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