Imaging the mitochondrial permeability transition pore in intact cells

BioFactors

Volumn 8, Issue 3-4, 1998, Pages 263-272

  Petronilli, Valeria ^a   Miotto, Giovanni ^a   Canton, Marcella ^a   Colonna, Raffaele ^a   Bernardi, Paolo ^a   Di Lisa, Fabio ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

Calcein; Calcium; Cyclosporin; Mitochondria; Permeability transition pore

Indexed keywords

CALCEIN;

CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CELL DEATH; CELL MEMBRANE PERMEABILITY; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; OXIDATIVE PHOSPHORYLATION; PATCH CLAMP; PRIORITY JOURNAL; REVIEW;

EID: 0032435391     PISSN: 09516433     EISSN: None     Source Type: Journal    
DOI: 10.1002/biof.5520080314     Document Type: Review

References (38)

1. T.M. Allen and L.G. Cleland, Serum-induced leakage of liposome contents, Biochim. Biophys. Acta 597 (1980), 418-426.
2. P. Bernardi, Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore by the proton electrochemical gradient. Evidence that the pore can be opened by membrane depolarization, J. Biol. Chem, 267 (1992), 8834-8839.
3. P. Bernardi, R. Colonna, P. Costantini, O. Eriksson, E. Fontaine, F. Ichas, S. Massan, A. Nicolli, V. Petronilli and L. Scorrano, The mitochondrial permeability transition, BioFactors (1998, this issue).
4. P. Bernardi and V. Petronilli, The permeability transition pore as a mitochondrial calcium release channel: a critical appraisal, J. Bioenerg. Biomembr. 28 (1996), 131-138.
5. E. Bossy Wetzel, D.D. Newmeyer and D.R. Green, Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization, EMBO J. 17 (1998), 37-49.
6. E. Carafoli, Intracellular calcium homeostasis, Ann. Rev. Biochem. 56 (1987), 395-433.
7. A.M. Davidson and A.P. Halestrap, Inorganic pyrophosphate is located primarily in the mitochondria of the hepatocyte and increases in parallel with the decrease in light-scattering induced by gluconeogenic hormones, butyrate and ionophore A23187, Biochem. J. 254 (1988), 379-384.
8. S.P. Elmore, T. Qian, L.C. Trost, Y. Nishimura, B. Herman and J.J. Lemasters, Detection of mitochondrial depolarization during autophagy by confocal fluorescence resonance energy transfer (CFRET), Cell Vision - J. Anal. Morphol. 4 (1997), 170-171.
9. G.D. Eytan, R. Regev, G. Oren, C.D. Hurwitz and Y.G. Assaraf, Efficiency of P-glycoprotein-mediated exclusion of rhodamine dyes from multidrug-resistant cells is determined by their passive transmembrane movement rate, Eur. J. Biochem. 248 (1997), 104-112.
10. D.A. Fruman, S.J. Burakoff and B.E. Bierer, Immunophilins in protein folding and immunosuppression, FASEB J. 8 (1994), 391-400.
11. C. Giulivi, M. Sarcansky, E. Rosenfeld and A. Boveris, The photodynamic effect of rose bengal on proteins of the mitochondrial inner membrane, Photochem. Photobiol. 52 (1990), 745-751.
12. 2+ chelate of bathophenanthroline with the sensitizer, Acta Chem. Scand. B 42 (1988), 175-182.
13. E.J. Griffiths and A.P. Halestrap, Mitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusion, Biochem. J. 307 (1995), 93-98.
14. T.E. Gunter, K.K. Gunter, S.S. Sheu and C.E. Gavin, Mitochondrial calcium transport: physiological and pathological relevance, Am. J. Physiol. 267 (1994), C313-C339.
15. P.A. Henkart and S. Grinstein, Apoptosis: mitochondria resurrected?, J. Exp. Med. 183 (1996), 1293-1295.
16. J. Hüser, C.E. Rechenmacher and L.A. Blatter, Imaging the permeability pore transition in single mitochondria, Biophys. J. 74 (1998), 2129-2137.
17. F. Ichas, L.S. Jouaville and J.P. Mazat, Mitochondria are excitable organelles capable of generating and conveying electrical and calcium signals, Cell 89 (1997), 1145-1153.
18. F. Ichas, L.S. Jouaville, S.S. Sidash, J.P. Mazat and E.L. Holmuhamedov, Mitochondrial calcium spiking: a transduction mechanism based on calcium-induced permeability transition involved in cell calcium signalling, FEBS Lett. 348 (1994), 211-215.
19. G. Kroemer, P. Petit, N. Zamzami, J.L. Vayssiere and B. Mignotte, The biochemistry of programmed cell death, FASEB J. 9 (1995), 1277-1287.
20. J.J. Lemasters, A.L. Nieminen, T. Qian, L.C. Trost, S.P. Elmore, Y. Nishimura, R.A. Crowe, W.E. Cascio, C.A. Bradham, B.A. Brenner and B. Herman, The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy, Biochim. Biophys. Acta 1366 (1998), 177-196.
21. T. Litman, T. Zeuthen, T. Skovsgaard and W.D. Stein, Competitive, non-competitive and cooperative interactions between substrates of P-glycoprotein as measured by its ATPase activity, Biochim. Biophys. Acta 1361 (1997), 169-176.
22. A.R. Marks, Cellular functions of immunophilins, Physiol. Rev. 76 (1996), 631-649.
23. 2+ concentration in living single rat cardiac myocytes, Am. J. Physiol. 261 (1991), H1123-H1134.
24. A.L. Nieminen, A.K. Saylor, S.A. Tesfai, B. Herman and J.J. Lemasters, Contribution of the mitochondrial permeability transition to lethal injury after exposure of hepatocytes to t-butylhydroperoxide, Biochem. J. 307 (1995), 99-106.
25. J.G. Pastorino, J.W. Snyder, A. Serroni, J.B. Hoek and J.L. Farber, Cyclosporin and carnitine prevent the anoxic death of cultured hepatocytes by inhibiting the mitochondrial permeability transition, J. Biol. Chem. 268 (1993), 13 791-13 798.
26. V. Petronilli, P. Bernardi, M. Canton, R. Colonna, G. Miotto and F. Di Lisa, Direct evidence of the mitochondrial permeability transition pore (MTP) in single living cells, Biophys. J. 74 (1998), A383.
27. V. Petronilli, G. Miotto, M. Canton, M. Brini, R. Colonna, P. Bernardi and F. Di Lisa, Transient and long-lasting openings of the mitochondrial permeability transition pore can be monitored directly in intact cells by mitochondrial calcein release, submitted.
28. V. Petronilli, G. Miotto, R. Colonna, P. Bernardi and F. Di Lisa, Tetramethylrhodamine (TMRM) quenching of calcein fluorescence limits the evaluation of intracellular distribution of calcein, Biophys. J. 70 (1997), A210.
29. V. Petronilli, I. Szabo and M. Zoratti, The inner mitochondrial membrane contains ion-conducting channels similar to those found in bacteria, FEBS Lett. 259 (1989), 137-143.
30. D. Pietrobon, F. Di Virgilio and T. Pozzan, Structural and functional aspects of calcium homeostasis in eukaryotic cells, Eur. J. Biochem. 193 (1990), 599-622.
31. 2+ revealed by specifically targeted recombinant aequorin, Nature 358 (1992), 325-327.
32. C. Salet, G. Moreno, F. Ricchelli and P. Bernardi, Singlet oxygen produced by photodynamic action causes inactivation of the mitochondrial permeability transition pore, J. Biol. Chem. 272 (1997), 21 938-21 943.
33. A.F. Schinder, E.C. Olson, N.C. Spitzer and M. Montai, Mitochondrial dysfunction is a primary event in glutamate neurotoxicity, J. Neurosci. 16 (1996), 6125-6133.
34. I. Szabo, P. Bernardi and M. Zoratti, Modulation of the mitochondrial megachannel by divalent cations and protons, J. Biol. Chem. 267 (1992), 2940-2946.
35. I. Szabo and M. Zoratti, The mitochondrial megachannel is the permeability transition pore, J. Bioenerg. Biomembr. 24 (1992), 111-117.
36. D.F.H. Wallach and T.L. Steck, Fluorescence techniques in the microdetermination of metals in biological materials, Anal. Chem. 35 (1963), 1035-1044.
37. N. Zamzami, P. Marchetti, M. Castedo, D. Decaudin, A. Macho, T. Hirsch, S.A. Susin, P.X. Petit, B. Mignotte and G. Kroemer, Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death, J. Exp. Med. 182 (1995), 367-377.
38. M. Zoratti and I. Szabo, The mitochondrial permeability transition, Biochim. Biophys. Acta 1241 (1995), 139-176.