Quantitative evaluation of mitochondrial calcium content in rat cortical neurones following a glutamate stimulus

Journal of Physiology

Volumn 531, Issue 3, 2001, Pages 793-805

  Brocard, Jacques B ^a   Tassetto, Michel ^b   Reynolds, Ian J ^a,c  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b ECOLE NORMALE SUPÉRIEURE   (France)

^c W1351 Biomedical Science Tower ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CARBONYL CYANIDE 4 (TRIFLUOROMETHOXY)PHENYLHYDRAZONE; FURA 2; GLUTAMIC ACID; KAINIC ACID; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROTON; CALCIUM; GLUTAMATE RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN CELL; CALCIUM TRANSPORT; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOPLASM; CYTOTOXICITY; DEPOLARIZATION; EXPOSURE; FEMALE; MITOCHONDRION; NERVE CELL STIMULATION; NONHUMAN; PRIORITY JOURNAL; RAT; STIMULUS; TECHNIQUE; CONCENTRATION RESPONSE; EMBRYO;

ANIMALS; CALCIUM; CELLS, CULTURED; CEREBRAL CORTEX; GLUTAMIC ACID; MITOCHONDRIA; NEURONS; OSMOLAR CONCENTRATION; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

EID: 0035868972     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.2001.0793h.x     Document Type: Article

References (50)

1. 2+-induced permeabilization of rat liver mitochondria
2. 2+ in cultured cortical neurons
3. 2+ homeostasis
4. Mitochondria, calcium regulation, and acute glutamate excitotoxicity in cultured cerebellar granule cells
5. Mitochondrial control of acute glutamate excitotoxicity in cultured cerebellar granule cells
6. Ionic dependence of glutamate neurotoxicity
7. Glutamate neurotoxicity in cortical cell culture
8. i elevations in sympathetic neurons
9. Ruthenium red protects against glutamate-induced neuronal death in cerebellar culture
10. Effects of metabolic inhibition on the membrane properties of isolated mouse primary sensory neurones
11. Contributions of mitochondria to animal physiology: From homeostatic sensor to calcium signalling and cell death
12. 2+ indicators with greatly improved fluorescence properties
13. 2+ accumulation in cortical cell culture correlated with subsequent neuronal degeneration
14. Excitatory amino acids and synaptic transmission: Evidence for a physiological function
15. 2+-induced membrane transition in mitochondria. I. The protective mechanisms
16. Imaging the permeability pore transition in single mitochondria
17. Ionized intracellular calcium concentration predicts excitotoxic neuronal death: Observations with low-affinity fluorescent calcium indicators
18. Ionic selectivity of low-affinity ratiometric calcium indicators: Mag-Fura-2, Fura-2FF and BTC
19. 2+ concentrations in single Swiss 3T3 fibroblasts
20. Glycine potentiates the NMDA response in cultured mouse brain neurons
21. Excitotoxic mitochondrial depolarisation requires both calcium and nitric oxide in rat hippocampal neurons
22. Mitochondrial deenergization underlies neuronal calcium overload following a prolonged glutamate challenge
23. Glutamate-induced destabilization of intracellular calcium concentration homeostasis in cultured cerebellar granule cells: Role of mitochondria in calcium buffering
24. 2+ by mitochondria
25. i studied in isolated rat cardiomyocytes
26. 2+ influx elicited by glutamate: Role in neuronal death
27. 2+ by rat liver mitochondria
28. Mitochondrial calcium transport
29. Mitochondria and neuronal survival
30. Privileged access to mitochondria of calcium influx through N-methyl-D-aspartate receptors
31. Visualization of NMDA receptor-induced mitochondrial calcium accumulation in striatal neurons
32. 2+ accumulation in sympathetic neurons: Spatial and temporal characteristics
33. 2+ concentrations associated with glutamate excitotoxicity in cultured rat brain neurons
34. A fluorescent indicator for measuring cytosolic free magnesium
35. Glutamate-induced calcium transient triggers delayed calcium overload and neurotoxicity in rat hippocampal neurons
36. Calcium-dependent inactivation of synaptic NMDA receptors in hippocampal neurons
37. Glutamate and the pathophysiology of hypoxic-ischaemic brain damage
38. Distinct influx pathways, not calcium load, determine neuronal vulnerability to calcium neurotoxicity
39. Mitochondrial dysfunction is a primary event in glutamate excitotoxicity
40. Energy transduction in intact synaptosomes. Influence of plasma-membrane depolarization on the respiration and membrane potential of internal mitochondria determined in situ
41. 2+ efflux in rat forebrain neurones in culture
42. Glutamate-induced neuron death requires mitochondrial calcium uptake
43. High-affinity calcium indicators underestimate increases in intracellular calcium concentrations associated with excitotoxic glutamate stimulations
44. Oxygen/glucose deprivation in hippocampal slices: Altered intraneuronal elemental composition predicts structural and functional damage
45. Regulation of the intracellular free calcium concentration in single rat dorsal root ganglion neurones in vitro
46. Glutamate-induced mitochondrial depolarisation and perturbation of calcium homeostasis in cultured rat hippocampal neurones
47. 2+ exchange buffer glutamate-induced calcium loads in cultured cortical neurons
48. Mitochondrial depolarization in glutamate-stimulated neurons: An early signal specific to excitotoxin exposure
49. 2+ following intense glutamate stimulation of cultured rat forebrain neurones
50. 2+ efflux pathway of liver mitochondria