Loss of phosphatase and tensin homologue increases transforming growth factor β-mediated invasion with enhanced SMAD3 transcriptional activity

Cancer Research

Volumn 65, Issue 24, 2005, Pages 11276-11281

  Hjelmeland, Anita B ^a   Hjelmeland, Mark D ^a   Shi, Qing ^a   Hart, Janet L ^a   Bigner, Darell D ^a   Wang, Xiao Fan ^a   Kontos, Christopher D ^a   Rich, Jeremy N ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LUCIFERASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; SHORT HAIRPIN RNA; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; CANCER INVASION; CELL MIGRATION; CELL MOTILITY; CONTROLLED STUDY; ENZYME ASSAY; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROTEIN INTERACTION; REPORTER GENE; RETROVIRUS; RNA INTERFERENCE; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; CELL MOVEMENT; CELL NUCLEUS; ENZYME INHIBITORS; HUMANS; MICROFILAMENT PROTEINS; NEOPLASM INVASIVENESS; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA; TUMOR CELLS, CULTURED;

EID: 29244469438     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-05-3016     Document Type: Article

References (20)

1. Siegel PM, Massague J. Cytostatic and apoptotic actions of TGF-β in hsomeostasis and cancer. Nat Rev Cancer 2003;3:807-21.
2. Shi Y, Massague J. Mechanisms of TGFβ signaling from the Cell Membrane to the Nucleus. Cell 2003;113: 685-700.
3. Zawel L, Dai JL, Buckhaults P, et al. Human Smad3 and Smad4 are sequence-specific transcription activators. Mol Cell 1998;1:611-7.
4. Frederick JP, Liberati NT, Waddell DS, Shi Y, Wang XF. Transforming growth factor β-mediated transcriptional repression of c-myc is dependent on direct binding of Smad3 to a novel repressive Smad binding element. Mol Cell Biol 2004;24: 2546-59.
5. Datto MB, Yu Y, Wang XF. Functional analysis of the transforming growth factor β responsive elements in the WAF1/Cip1/p21 promoter. J Biol Chem 1995;270: 28623-8.
6. Westerhausen DR, Jr., Hopkins VVE, Billadello JJ. Multiple transforming growth factor-β-inducible elements regulate expression of the plasminogen activator inhibitor type-1 gene in Hep G2 cells. J Biol Chem 1991;266:1092-100.
7. Conery AR, Cao Y. Thompson EA. et al. Akt interacts directly with SMAD3 to regulate the sensitivity to TGF-β induced apoptosis. Nat Cell Biol 2004;6:366-72.
8. Remy I, Montmarquette A, Michnick SW. PKB/Akt modulates TGF-β signaling through a direct interaction with Smad3. Nat Cell Biol 2004;6:358-65.
9. Seoane J, Le HV, Shen L, Anderson SA, Massague J. Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation. Cell 2004;117:211-23.
10. Haas-Kogan D, Shalev N, Wong M, et al. Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC. Curr Biol 1998;8:1195-8.
11. Hjelmeland MD, Hjelmeland AB, Sathornsumetee S, et al. SB-431542, a small molecule transforming growth factor-β-receptor antagonist, inhibits human glioma cell line proliferation and motility. Mol Cancer Ther 2004;3: 737-45.
12. Li J, Yen C, Liaw D, et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 1997;275:1943-7.
13. Lee JO, Yang H, Georgescu MM, et al. Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell 1999;99:323-34.
14. Georgescu MM, Kirsch KH, Akagi T. Shishido T. Hanafusa H. The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region. Proc Natl Acad Sci U S A 1999;96:10182-7.
15. Vazquez F, Grossman SR, Takahashi Y, et al. Phosphorlation of the PTEN tail acts as an inhibitor switch by preventing its recruitment into a protein complex. J Biol Chem 2001;276:48627-30.
16. Myers MP, Pass I, Batty IH, et al. The lipid phosphatase activity of PTEN is critical for its tumor suppressor function. Proc Natl Acad Sci U S A 1998;95:13513-8.
17. Durand MK, Bodker JS, Christensen A, et al. Plasminogen activator inhibitor-I and tumour growth, invasion, and metastasis. Thromb Haemost 2004;91:438-49.
18. Muracciole X, Romain S, Dufour H, et al. PAI-1 and EGFR expression in adult glioma tumors: toward a molecular prognostic classification. Int J Radiat Oncol Biol Phys 2002;52:592-8.
19. Matsuura I, Denissova NG, Wang G, et al. Cyclin-dependent kinases regulate the antiproliferative function of Smads. Nature 2004;430:226-31.
20. Matsuura I, Wang G. He D, Liu F. Identification and characterization of ERK MAP kinase phosphorylation sites in Smad3. Biochemistry 2005;44: 12546-53.